RHABDURGENCE: Support for the Rhabdomyolysis in an Emergency Department
Study Details
Study Description
Brief Summary
Rhabdomyolysis is a common condition in the UAA. Support is heterogeneous, it is in most cases a mass hyperhydration. The idea is to initially with an EPP simultaneously screened for the most affected by this disease and aggravating factors population, associated comorbidities.
The rhabdomyolysis prognosis depends mainly on the etiology and associated comorbidities.
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Acute renal failure and hyperkalemia are the major complications that worsen the prognosis.
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In most cases, acute renal failure is reversible. Acute renal failure caused by renal vasoconstriction with ischemia, precipitation of myoglobin in the tubules and direct cytotoxic action of myoglobin.
If the prime mover of rhabdomyolysis is ischemia (or hypoxia) cell, we now know that the tissue damage is greatly aggravated during muscle reperfusion, creating ischemia-reperfusion. Reperfusion will not only cause the release into the bloodstream of the cell contents myocytes but also an increase in necrotic areas. Indeed, the massive arrival of oxygen at the myocyte will cause significant production of free radicals, increasing their toxic effects.
Predictive factors of acute renal failure is creatinine and urea. The urine alkalinisation by bicarbonates is questionable oral alkalizing seems to be an alternative when possible (oral alkaline solution) but not used to this day.
The track N-acetyl cysteine as an antioxidant that can possibly have an effect on release of the free radicals during reperfusion by decreasing their toxicity is still not considered clinically.
| Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
Main objective / secondary:
Evaluation of current professional practice:
- Identify the most common etiologies encountered in our SAU. II. Identify the / types of people most affected by this disease III. Detect the most common complications of H0 support and evolution H48 if the patient not transferred IV. Evaluate the emergency treatment at the initial charge.
Methodology :
DESIGN:
It is a non-interventional retrospective single-center study, within the Department of Emergency GHPSJ, to an EPP and output the results regarding the type of population most affected by this disease with the most common etiologies in our support (what we are doing).
Time study:
Study on patient records being passed on to the emergency 12 months out with a diagnosis of rhabdomyolysis.
Study Design
Outcome Measures
Primary Outcome Measures
- Assessment of change of patient complication by answering a questionary [Hour 0, Hour 48]
Detect the most common complications of Hour 0 support and evolution Hour 48 if the patient not transferred. Hour 0 support and evolution at Hour 48
Eligibility Criteria
Criteria
Inclusion Criteria:
- All adults with CPK greater than 5N or 500 IU / L in sera to emergencies
Exclusion Criteria:
- No exclusion criteria
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Groupe Hospitalier Paris Saint Joseph | Paris | Ile-de-France | France | 75014 |
Sponsors and Collaborators
- Groupe Hospitalier Paris Saint Joseph
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- RHABDURGENCE