Survival and Predictive Factors of Clinical Outcome in Patients With Acquired Brain Injury
Study Details
Study Description
Brief Summary
The prediction of the final neurological and functional status of patients with acquired brain injury remains very uncertain despite the findings of current medicine. The aim of the study is to evaluate the clinical outcomes in patients with the most severe degree of brain injury hospitalized in the long-term intensive care unit of the Military University Hospital Prague.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
The prediction of the final neurological and functional status of patients with acquired brain injury remains very uncertain despite the findings of current medicine. Current medical knowledge is particularly limited in patients with the most severe brain injury who had to be tracheostomized and admitted to long-term intensive care unit. In the Czech Republic, there is a complete lack of data on clinical outcomes in these patients.
Some recent studies has not confirmed the long-standing better outcome in patients with traumatic brain injury compared to non-traumatic etiologies. The aim of the study is to evaluate the clinical outcomes in patients with the most severe degree of brain injury hospitalized in the long-term intensive care unit of the Military University Hospital Prague.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Trauma brain injury Patients with acquired brain injury of traumatic etiology. |
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| Non-trauma brain injury Patients with acquired brain injury of non-traumatic etiology. |
Outcome Measures
Primary Outcome Measures
- Level of consciousness achieved [three months]
Initial Glasgow coma scale (GCS) and GCS at discharge. Minimal points 3, maximal point 15. The higher the score the better the outcome.
- Level of self-sufficiency [three months]
Initial level of self-sufficiency and self-sufficiency at discharge using Barthel score. 0-100 points. A patient scoring 100 points is continent, feeds himself, dresses himself, gets up out of bed and chairs, bathes himself, walks at least a block, and can ascend and descend stairs. A score of 0 means that the patient does not meet any of the activities described above.
Secondary Outcome Measures
- Length of survival after discharge from intensive care. [three months]
Length of survival after discharge from intensive care. In days.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Acquired brain injury
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Initial Glasgow Coma Scale (GCS) score less than 8 points
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Tracheostomy for persistent impairment of consciousness
Exclusion Criteria:
- none
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Military University Hospital Prague | Praha | Czechia | 16209 |
Sponsors and Collaborators
- Charles University, Czech Republic
Investigators
- Study Chair: Ilona Trtíková, Mgr., Ph.D., CHARLES UNIVERSITY, FIRST FACULTY OF MEDICINE AND GENERAL UNIVERSITY HOSPITAL IN PRAGUE
Study Documents (Full-Text)
None provided.More Information
Publications
- Magliacano A, De Bellis F, Panico F, Sagliano L, Trojano L, Sandroni C, Estraneo A. Long-term clinical evolution of patients with prolonged disorders of consciousness due to severe anoxic brain injury: A meta-analytic study. Eur J Neurol. 2023 May 29. doi: 10.1111/ene.15899. Online ahead of print.
- Multi-Society Task Force on PVS. Medical aspects of the persistent vegetative state (1). N Engl J Med. 1994 May 26;330(21):1499-508. doi: 10.1056/NEJM199405263302107.
- Wabl R, Williamson CA, Pandey AS, Rajajee V. Long-term and delayed functional recovery in patients with severe cerebrovascular and traumatic brain injury requiring tracheostomy. J Neurosurg. 2018 Jul 6;131(1):114-121. doi: 10.3171/2018.2.JNS173247.
- ABI_UVN