Does Topical Lidocaine Decrease Sweat During Exercise in the Heat?

• Sponsor: San Diego State University (Other)
• Overall Status: Not yet recruiting
• CT.gov ID: NCT05379283
• Collaborator: (none)
• Enrollment: 22
• Arms: 2
• Anticipated Duration (Months): 12

Study Details

Study Description

Brief Summary

Subjects will walk on a treadmill at 3 mph and sweat will be collected from both forearms. One arm will be pretreated with topical lidocaine, and the other will act as the control.

Condition or Disease	Intervention/Treatment	Phase
Sweat Pore Closure	Drug: Lidocaine; Other: control	N/A

Detailed Description

Subjects will walk on a treadmill at 3 mph and sweat will be collected from both forearms. One arm will be pretreated with topical lidocaine, and the other will act as the control. Sweat will be collected via macroducts attached to each arm. Sweat production on each arm will be compared using t-tests.

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 22 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: None (Open Label)
• Primary Purpose: Treatment
• Official Title: Does Topical Lidocaine Decrease Sweat During Exercise in the Heat?
• Anticipated Study Start Date: May 15, 2022
• Anticipated Primary Completion Date: May 15, 2023
• Anticipated Study Completion Date: May 15, 2023

Arms and Interventions

Arm	Intervention/Treatment
Experimental: lidocaine pretreated skin one arm will be pretreated with lidocaine before exercise in the heat	Drug: Lidocaine; effect of lidocaine on sweat production during exercise in the heat; Other: control; one arm will be pretreated with topical lidocaine, the other arm will not
No Intervention: control skin the other arm will act as the control condition

Outcome Measures

Primary Outcome Measures

1. volume of sweat produced during exercise following topical lidocaine [one hour of exercise]

   Volume of sweat produced during exercise following tipocal lidocaine

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 35 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Inclusion Criteria: 18-35 years of age -

Exclusion Criteria: pregnant females

-

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

• San Diego State University

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Michael J. Buono, Professor, San Diego State University
• ClinicalTrials.gov Identifier: NCT05379283
• Other Study ID Numbers: ENS2
• First Posted: May 18, 2022
• Last Update Posted: May 18, 2022
• Last Verified: May 1, 2022

• Individual Participant Data (IPD) Sharing Statement: No
• Plan to Share IPD: No
• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Keywords provided by Michael J. Buono, Professor, San Diego State University: thermoregulation, sweating, exercise
• Additional relevant MeSH terms: Lidocaine

Study Results

No Results Posted as of May 18, 2022