SWOG-8819 Collecting, Analyzing, and Storing Tissue Samples From Patients With Non-Hodgkin's Lymphoma

Sponsor

Southwest Oncology Group (Other)

Overall Status

Completed

CT.gov ID

NCT00900484

Collaborator

National Cancer Institute (NCI) (NIH)

458

Enrollment

191

Locations

271.9

Duration (Months)

2.4

Patients Per Site

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

RATIONALE: Collecting and storing samples of tissue from patients with cancer to study in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer. It may also help doctors learn how patients respond to treatment.

PURPOSE: This laboratory study is collecting, analyzing, and storing tissue samples from patients with non-Hodgkin's lymphoma.

Condition or Disease	Intervention/Treatment	Phase
Lymphoma	Other: biologic sample preservation procedure Other: immunohistochemistry staining method Other: laboratory biomarker analysis

Detailed Description

OBJECTIVES:

Establish a central lymphoma tissue repository of fresh snap-frozen tissue from patients with previously untreated non-Hodgkin's lymphoma (NHL).
Determine a standard set of procedures for routine acquisition, banking, and study of these tissue samples.
Correlate presently activated phenotyping studies and future projected molecular studies of the DNA and RNA status of these tissue samples with clinical results.
Correlate pretreatment phenotype or genotype of tissue samples from patients with intermediate- or high-grade NHL with patient outcome, in terms of complete response rate, time to progression, and survival.
Correlate the lymphoma lineage (T-cell vs B-cell), loss of class II human histocompatibility antigen status (HLA-DR-positive vs HLA-DR-negative), proliferative index (as measured by Ki-67), and B- or T-cell antigen aberrancy (e.g., lack of Pan B or T antigen expression) with outcome in patients with intermediate- or high-grade NHL.

OUTLINE: Patients are treated on the SWOG study on which they are enrolled.

Tissue samples obtained before treatment began are banked in a tissue repository.

Samples from patients with intermediate- or high-grade non-Hodgkin's lymphoma are analyzed by three-stage immunohistochemistry using monoclonal antibodies to B-cell antigens, T-cell antigens, immunoglobulins, CALLA, HLA-DR, anti-interleukin-2 receptor, and Ki-67 (for the proliferative index). Phenotype (immune marker status, proliferation status, and activation status) is correlated with response to treatment, relapse, and overall survival.

PROJECTED ACCRUAL: Approximately 495 patients will be accrued for this study.

Study Design

Study Type:

Observational

Actual Enrollment :

458 participants

Official Title:

Central Lymphoma Repository Tissue Procurement Protocol

Study Start Date :

Feb 1, 1989

Actual Primary Completion Date :

Jul 1, 2011

Actual Study Completion Date :

Oct 1, 2011

Outcome Measures

Primary Outcome Measures

Establishment of a central lymphoma tissue repository of fresh snap-frozen tissue from patients with previously untreated non-Hodgkin's lymphoma (NHL) [July 2011]
feasibility of collecting specimens

Eligibility Criteria

Criteria

Ages Eligible for Study:

16 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

DISEASE CHARACTERISTICS:

Registered on an active Southwest Oncology Group (SWOG)-coordinated treatment protocol for previously untreated non-Hodgkin's lymphoma
Adequate pretreatment diagnostic tissue available meeting the following requirements:
Fresh snap-frozen pretreatment diagnostic biopsy from any site (initial biopsy or rebiopsy)
1 Hematoxylin and Eosin stained slide
1 paraffin block and surgery pathology report

PATIENT CHARACTERISTICS:

Not specified

PRIOR CONCURRENT THERAPY:

See Disease Characteristics

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Alaska Regional Hospital Cancer Center	Anchorage	Alaska	United States	99508
2	Alta Bates Summit Comprehensive Cancer Center	Berkeley	California	United States	94704
3	Peninsula Medical Center	Burlingame	California	United States	94010
4	North Bay Cancer Center	Fairfield	California	United States	94533
5	California Pacific Medical Center - California Campus	San Francisco	California	United States	94118
6	Sutter Health - Western Division Cancer Research Group	San Rafael	California	United States	94903
7	Sutter Solano Medical Center	Vallejo	California	United States	94589
8	Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center	Hartford	Connecticut	United States	06105
9	H. Lee Moffitt Cancer Center and Research Institute at University of South Florida	Tampa	Florida	United States	33612-9497
10	Piedmont Hospital	Atlanta	Georgia	United States	30309
11	Northside Hospital Cancer Center	Atlanta	Georgia	United States	30342-1611
12	Saint Joseph's Hospital of Atlanta	Atlanta	Georgia	United States	30342-1701
13	CCOP - Atlanta Regional	Atlanta	Georgia	United States	30342
14	WellStar Cobb Hospital	Austell	Georgia	United States	30106
15	John B. Amos Cancer Center	Columbus	Georgia	United States	31904
16	Charles B. Eberhart Cancer Center at DeKalb Medical Center	Decatur	Georgia	United States	30033
17	Piedmont Fayette Hospital	Fayetteville	Georgia	United States	30214
18	Gwinnett Medical Center	Lawrenceville	Georgia	United States	30045
19	Kennestone Cancer Center at Wellstar Kennestone Hospital	Marietta	Georgia	United States	30060
20	Southern Regional Medical Center	Riverdale	Georgia	United States	30274-2600
21	Harbin Clinic Cancer Center - Medical Oncology	Rome	Georgia	United States	30165
22	Mountain States Tumor Institute at St. Luke's Regional Medical Center	Boise	Idaho	United States	83712
23	Regional Cancer Center at Memorial Medical Center	Springfield	Illinois	United States	62781-0001
24	St. Francis Hospital and Health Centers - Beech Grove Campus	Beech Grove	Indiana	United States	46107
25	Reid Hospital & Health Care Services	Richmond	Indiana	United States	47374
26	Genesis Regional Cancer Center at Genesis Medical Center	Davenport	Iowa	United States	52803
27	Cancer Center of Kansas, PA - Chanute	Chanute	Kansas	United States	66720
28	Cancer Center of Kansas, PA - Dodge City	Dodge City	Kansas	United States	67801
29	Cancer Center of Kansas, PA - El Dorado	El Dorado	Kansas	United States	67042
30	Cancer Center of Kansas - Fort Scott	Fort Scott	Kansas	United States	66701
31	Cancer Center of Kansas-Independence	Independence	Kansas	United States	67301
32	Cancer Center of Kansas, PA - Kingman	Kingman	Kansas	United States	67068
33	Lawrence Memorial Hospital	Lawrence	Kansas	United States	66044
34	Cancer Center of Kansas, PA - Liberal	Liberal	Kansas	United States	67905
35	Cancer Center of Kansas, PA - Newton	Newton	Kansas	United States	67114
36	Menorah Medical Center	Overland Park	Kansas	United States	66209
37	Saint Luke's Hospital - South	Overland Park	Kansas	United States	66213
38	Cancer Center of Kansas, PA - Parsons	Parsons	Kansas	United States	67357
39	CCOP - Kansas City	Prairie Village	Kansas	United States	66208
40	Cancer Center of Kansas, PA - Pratt	Pratt	Kansas	United States	67124
41	Cancer Center of Kansas, PA - Salina	Salina	Kansas	United States	67401
42	Tammy Walker Cancer Center at Salina Regional Health Center	Salina	Kansas	United States	67401
43	Cotton-O'Neil Cancer Center	Topeka	Kansas	United States	66606
44	Cancer Center of Kansas, PA - Wellington	Wellington	Kansas	United States	67152
45	Associates in Womens Health, PA - North Review	Wichita	Kansas	United States	67208
46	Cancer Center of Kansas, PA - Medical Arts Tower	Wichita	Kansas	United States	67208
47	Cancer Center of Kansas, PA - Wichita	Wichita	Kansas	United States	67214
48	CCOP - Wichita	Wichita	Kansas	United States	67214
49	Via Christi Cancer Center at Via Christi Regional Medical Center	Wichita	Kansas	United States	67214
50	Wesley Medical Center	Wichita	Kansas	United States	67214
51	Cancer Center of Kansas, PA - Winfield	Winfield	Kansas	United States	67156
52	Lucille P. Markey Cancer Center at University of Kentucky	Lexington	Kentucky	United States	40536-0093
53	Feist-Weiller Cancer Center at Louisiana State University Health Sciences	Shreveport	Louisiana	United States	71130-3932
54	Saint Joseph Mercy Cancer Center	Ann Arbor	Michigan	United States	48106-0995
55	CCOP - Michigan Cancer Research Consortium	Ann Arbor	Michigan	United States	48106
56	Battle Creek Health System Cancer Care Center	Battle Creek	Michigan	United States	49017
57	Mecosta County Medical Center	Big Rapids	Michigan	United States	49307
58	Oakwood Cancer Center at Oakwood Hospital and Medical Center	Dearborn	Michigan	United States	48123-2500
59	Barbara Ann Karmanos Cancer Institute	Detroit	Michigan	United States	48201-1379
60	Genesys Hurley Cancer Institute	Flint	Michigan	United States	48503
61	Hurley Medical Center	Flint	Michigan	United States	48503
62	Butterworth Hospital at Spectrum Health	Grand Rapids	Michigan	United States	49503
63	CCOP - Grand Rapids	Grand Rapids	Michigan	United States	49503
64	Lacks Cancer Center at Saint Mary's Health Care	Grand Rapids	Michigan	United States	49503
65	Van Elslander Cancer Center at St. John Hospital and Medical Center	Grosse Pointe Woods	Michigan	United States	48236
66	Foote Memorial Hospital	Jackson	Michigan	United States	49201
67	Breslin Cancer Center at Ingham Regional Medical Center	Lansing	Michigan	United States	48910
68	Sparrow Regional Cancer Center	Lansing	Michigan	United States	48912-1811
69	St. Mary Mercy Hospital	Livonia	Michigan	United States	48154
70	Mercy General Health Partners	Muskegon	Michigan	United States	49443
71	St. Joseph Mercy Oakland	Pontiac	Michigan	United States	48341-2985
72	Mercy Regional Cancer Center at Mercy Hospital	Port Huron	Michigan	United States	48060
73	Seton Cancer Institute at Saint Mary's - Saginaw	Saginaw	Michigan	United States	48601
74	Munson Medical Center	Traverse City	Michigan	United States	49684
75	St. John Macomb Hospital	Warren	Michigan	United States	48093
76	Metro Health Hospital	Wyoming	Michigan	United States	49519
77	University of Mississippi Cancer Clinic	Jackson	Mississippi	United States	39216
78	Truman Medical Center - Hospital Hill	Kansas City	Missouri	United States	64108
79	Saint Luke's Cancer Institute at Saint Luke's Hospital	Kansas City	Missouri	United States	64111
80	St. Joseph Medical Center	Kansas City	Missouri	United States	64114
81	North Kansas City Hospital	Kansas City	Missouri	United States	64116
82	Parvin Radiation Oncology	Kansas City	Missouri	United States	64116
83	Research Medical Center	Kansas City	Missouri	United States	64132
84	Saint Luke's East - Lee's Summit	Lee's Summit	Missouri	United States	64086
85	Liberty Hospital	Liberty	Missouri	United States	64068
86	Heartland Regional Medical Center	Saint Joseph	Missouri	United States	64506
87	CCOP - Cancer Research for the Ozarks	Springfield	Missouri	United States	65802
88	St. John's Regional Health Center	Springfield	Missouri	United States	65804
89	Hulston Cancer Center at Cox Medical Center South	Springfield	Missouri	United States	65807
90	CCOP - Montana Cancer Consortium	Billings	Montana	United States	59101
91	Northern Rockies Radiation Oncology Center	Billings	Montana	United States	59101
92	St. Vincent Healthcare Cancer Care Services	Billings	Montana	United States	59101
93	Hematology-Oncology Centers of the Northern Rockies - Billings	Billings	Montana	United States	59102
94	Billings Clinic - Downtown	Billings	Montana	United States	59107-7000
95	Bozeman Deaconess Cancer Center	Bozeman	Montana	United States	59715
96	St. James Healthcare Cancer Care	Butte	Montana	United States	59701
97	Big Sky Oncology	Great Falls	Montana	United States	59405-5309
98	Great Falls Clinic - Main Facility	Great Falls	Montana	United States	59405
99	Sletten Cancer Institute at Benefis Healthcare	Great Falls	Montana	United States	59405
100	Northern Montana Hospital	Havre	Montana	United States	59501
101	St. Peter's Hospital	Helena	Montana	United States	59601
102	Glacier Oncology, PLLC	Kalispell	Montana	United States	59901
103	Kalispell Medical Oncology at KRMC	Kalispell	Montana	United States	59901
104	Kalispell Regional Medical Center	Kalispell	Montana	United States	59901
105	Montana Cancer Specialists at Montana Cancer Center	Missoula	Montana	United States	59807-7877
106	Montana Cancer Center at St. Patrick Hospital and Health Sciences Center	Missoula	Montana	United States	59807
107	Good Samaritan Cancer Center at Good Samaritan Hospital	Kearney	Nebraska	United States	68848-1990
108	Falck Cancer Center at Arnot Ogden Medical Center	Elmira	New York	United States	14905
109	Highland Hospital of Rochester	Rochester	New York	United States	14620
110	Interlakes Oncology/Hematology PC	Rochester	New York	United States	14623
111	James P. Wilmot Cancer Center at University of Rochester Medical Center	Rochester	New York	United States	14642
112	Blumenthal Cancer Center at Carolinas Medical Center	Charlotte	North Carolina	United States	28232-2861
113	Presbyterian Cancer Center at Presbyterian Hospital	Charlotte	North Carolina	United States	28233-3549
114	Wayne Memorial Hospital, Incorporated	Goldsboro	North Carolina	United States	27534
115	Pardee Memorial Hospital	Hendersonville	North Carolina	United States	28791
116	Rutherford Hospital	Rutherfordton	North Carolina	United States	28139
117	Mary Rutan Hospital	Bellefontaine	Ohio	United States	43311
118	Adena Regional Medical Center	Chillicothe	Ohio	United States	45601
119	Cleveland Clinic Taussig Cancer Center	Cleveland	Ohio	United States	44195
120	Riverside Methodist Hospital Cancer Care	Columbus	Ohio	United States	43214-3998
121	CCOP - Columbus	Columbus	Ohio	United States	43215
122	Grant Medical Center Cancer Care	Columbus	Ohio	United States	43215
123	Mount Carmel Health - West Hospital	Columbus	Ohio	United States	43222
124	Doctors Hospital at Ohio Health	Columbus	Ohio	United States	43228
125	Grandview Hospital	Dayton	Ohio	United States	45405
126	Good Samaritan Hospital	Dayton	Ohio	United States	45406
127	David L. Rike Cancer Center at Miami Valley Hospital	Dayton	Ohio	United States	45409
128	Samaritan North Cancer Care Center	Dayton	Ohio	United States	45415
129	CCOP - Dayton	Dayton	Ohio	United States	45420
130	Grady Memorial Hospital	Delaware	Ohio	United States	43015
131	Blanchard Valley Medical Associates	Findlay	Ohio	United States	45840
132	Middletown Regional Hospital	Franklin	Ohio	United States	45005-1066
133	Wayne Hospital	Greenville	Ohio	United States	45331
134	Charles F. Kettering Memorial Hospital	Kettering	Ohio	United States	45429
135	Fairfield Medical Center	Lancaster	Ohio	United States	43130
136	MedCentral - Mansfield Hospital	Mansfield	Ohio	United States	44903
137	Strecker Cancer Center at Marietta Memorial Hospital	Marietta	Ohio	United States	45750
138	Knox Community Hospital	Mount Vernon	Ohio	United States	43050
139	Licking Memorial Cancer Care Program at Licking Memorial Hospital	Newark	Ohio	United States	43055
140	Community Hospital of Springfield and Clark County	Springfield	Ohio	United States	45505
141	UVMC Cancer Care Center at Upper Valley Medical Center	Troy	Ohio	United States	45373-1300
142	Mount Carmel St. Ann's Cancer Center	Westerville	Ohio	United States	43081
143	Clinton Memorial Hospital	Wilmington	Ohio	United States	45177
144	Ruth G. McMillan Cancer Center at Greene Memorial Hospital	Xenia	Ohio	United States	45385
145	Genesis - Good Samaritan Hospital	Zanesville	Ohio	United States	43701
146	Clackamas Radiation Oncology Center	Clackamas	Oregon	United States	97015
147	Providence Milwaukie Hospital	Milwaukie	Oregon	United States	97222
148	Providence Newberg Medical Center	Newberg	Oregon	United States	97132
149	Willamette Falls Hospital	Oregon City	Oregon	United States	97045
150	Providence Cancer Center at Providence Portland Medical Center	Portland	Oregon	United States	97213-2967
151	Adventist Medical Center	Portland	Oregon	United States	97216
152	CCOP - Columbia River Oncology Program	Portland	Oregon	United States	97225
153	Providence St. Vincent Medical Center	Portland	Oregon	United States	97225
154	Knight Cancer Institute at Oregon Health and Science University	Portland	Oregon	United States	97239-3098
155	AnMed Cancer Center	Anderson	South Carolina	United States	29621
156	McLeod Regional Medical Center	Florence	South Carolina	United States	29501
157	CCOP - Upstate Carolina	Spartanburg	South Carolina	United States	29303
158	Gibbs Regional Cancer Center at Spartanburg Regional Medical Center	Spartanburg	South Carolina	United States	29303
159	Thompson Cancer Survival Center	Knoxville	Tennessee	United States	37916
160	Veterans Affairs Medical Center - San Antonio (Murphy)	San Antonio	Texas	United States	78209
161	University of Texas Health Science Center at San Antonio	San Antonio	Texas	United States	78229-3900
162	Cancer Therapy and Research Center	San Antonio	Texas	United States	78229
163	University Hospital - San Antonio	San Antonio	Texas	United States	78229
164	Danville Regional Medical Center	Danville	Virginia	United States	24541
165	St. Joseph Cancer Center	Bellingham	Washington	United States	98225
166	Olympic Hematology and Oncology	Bremerton	Washington	United States	98310
167	Providence Centralia Hospital	Centralia	Washington	United States	98531-9027
168	St. Francis Hospital	Federal Way	Washington	United States	98003
169	Columbia Basin Hematology	Kennewick	Washington	United States	99336
170	Skagit Valley Hospital Cancer Care Center	Mt. Vernon	Washington	United States	98273
171	Providence St. Peter Hospital Regional Cancer Center	Olympia	Washington	United States	98506-5166
172	Harrison Poulsbo Hematology and Onocology	Poulsbo	Washington	United States	98370
173	Good Samaritan Cancer Center	Puyallup	Washington	United States	98372
174	Harborview Medical Center	Seattle	Washington	United States	98104
175	Minor and James Medical, PLLC	Seattle	Washington	United States	98104
176	Fred Hutchinson Cancer Research Center	Seattle	Washington	United States	98109
177	Group Health Central Hospital	Seattle	Washington	United States	98112
178	Swedish Cancer Institute at Swedish Medical Center - First Hill Campus	Seattle	Washington	United States	98122-4307
179	Polyclinic First Hill	Seattle	Washington	United States	98122
180	University Cancer Center at University of Washington Medical Center	Seattle	Washington	United States	98195
181	Cancer Care Northwest - Spokane South	Spokane	Washington	United States	99202
182	Evergreen Hematology and Oncology, PS	Spokane	Washington	United States	99218
183	Franciscan Cancer Center at St. Joseph Medical Center	Tacoma	Washington	United States	98405-3004
184	Allenmore Hospital	Tacoma	Washington	United States	98405
185	CCOP - Northwest	Tacoma	Washington	United States	98405
186	MultiCare Regional Cancer Center at Tacoma General Hospital	Tacoma	Washington	United States	98405
187	St. Clare Hospital	Tacoma	Washington	United States	98499
188	Southwest Washington Medical Center Cancer Center	Vancouver	Washington	United States	98668
189	Wenatchee Valley Medical Center	Wenatchee	Washington	United States	98801-2028
190	Rocky Mountain Oncology	Casper	Wyoming	United States	82609
191	Welch Cancer Center at Sheridan Memorial Hospital	Sheridan	Wyoming	United States	82801