Anaesthetic Efficacy of 2% Mepivacaine Versus 4% Articaine With Symptomatic Irreversible Pulpitis
Study Details
Study Description
Brief Summary
The aim of this randomized, double-blinded, clinical trial was to assess the effect of 3.6 mL 2% mepivacaine hydrochloride with 1:100,000 epinephrine compared to 3.4 mL 4% articaine hydrochloride with 1:100,000 epinephrine on the success of the inferior alveolar nerve block for patients with symptomatic irreversible pulpitis in mandibular molars.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
| N/A |
Detailed Description
The aim of this randomized, double-blinded, clinical trial was to assess the effect of 3.6 mL 2% mepivacaine hydrochloride with 1:100,000 epinephrine compared to 3.4 mL 4% articaine hydrochloride with 1:100,000 epinephrine on the success of the inferior alveolar nerve block for patients with symptomatic irreversible pulpitis in mandibular molars. Patients were clinically and radiographically examined and their eligibility assessed and preoperative pain was measured using the numerical rating scale (NRS). Patients were randomly assigned to one of 2 groups: experimental group (2% mepivacaine) and the control group (4% articaine). After 15 minutes of the inferior alveolar nerve block (IANB), patients reporting lip numbness had their molars accessed. No-to-mild pain response was considered success during root canal preparation.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Mepivacaine IANB using 3.6 ml of 2% mepivacaine hydrochloride with 1:100,000 epinephrine. |
Drug: Mepivacaine
IANB using 3.6 ml of 2% mepivacaine hydrochloride with 1:100,000 epinephrine.
|
| Active Comparator: Articaine IANB using 3.4 ml of 4% articaine hydrochloride with 1:100,000 epinephrine. |
Drug: Articaine
IANB using 3.4 ml of 4% articaine hydrochloride with 1:100,000 epinephrine.
|
Outcome Measures
Primary Outcome Measures
- Anaesthetic success [Intraoperative]
Success of mandibular inferior alveolar nerve block anesthesia during access cavity preparation and instrumentation measured using the 11-point numerical rating scale (NRS) so that no-or-mild pain is considered as anesthetic success and moderate-to-severe pain is considered anesthetic failure.
Secondary Outcome Measures
- Need for Supplemental anaesthesia [Intraoperative]
The need for supplemental anaesthesia to complete treatment (Yes/No).
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Patients in good health (American Society of Anesthesiologists Class I or II).
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Patients having symptomatic irreversible pulpitis in one of their mandibular molars.
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Age range between 18 to 50 years.
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Patients who can understand Numerical Rating Scale (NRS).
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Positive patient acceptance and the ability to sign an informed consent.
Exclusion Criteria:
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Pregnant females.
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Patients allergic to articaine, mepivacaine and/or any used medication or material.
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Patients having active sites of pathosis in the area of injection.
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Patients having active pain in more than one molar.
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Patients who had taken analgesics in the 12 hours preceding treatment.
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Cairo University
Investigators
- Study Director: Randa ElBoghdadi, PhD, Cairo University
Study Documents (Full-Text)
None provided.More Information
Publications
- Allegretti CE, Sampaio RM, Horliana AC, Armonia PL, Rocha RG, Tortamano IP. Anesthetic Efficacy in Irreversible Pulpitis: A Randomized Clinical Trial. Braz Dent J. 2016 Jul-Aug;27(4):381-6. doi: 10.1590/0103-6440201600663.
- Nagendrababu V, Pulikkotil SJ, Suresh A, Veettil SK, Bhatia S, Setzer FC. Efficacy of local anaesthetic solutions on the success of inferior alveolar nerve block in patients with irreversible pulpitis: a systematic review and network meta-analysis of randomized clinical trials. Int Endod J. 2019 Jun;52(6):779-789. doi: 10.1111/iej.13072. Epub 2019 Feb 12.
- ENDO-CU-2014-06-09