CONVASC-I: Systemic Inflammation During Recanalization of Cerebral Arterial Occlusion
Study Details
Study Description
Brief Summary
Strokes management, secondary to proximal arterial occlusion, by endovascular thrombectomy (TM) is now well established. The immuno-inflammatory events of reperfusion after TM are discussed. Systemic inflammation is a major factor suggested to explain the limited recovery of the ischemic parenchyma. Understanding these phenomena is necessary before developing an immunomodulatory strategy.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| AVC Patients hospitalized for TM after a proximal ischemic stroke of the middle cerebral artery and whose reperfusion is satisfactory (TICI 2b, 2c and 3). Additional blood sample will be taken during usual treatment the day of the stroke. |
Biological: Blood sample
Patients from 2 groups will undergo blood sample (during a blood sample for there care) and inflammation parameters will be measure the day of the stroke
|
| Control Population of control patients, consisting of patients admitted on an outpatient basis for a diagnostic cerebral arteriography. |
Biological: Blood sample
Patients from 2 groups will undergo blood sample (during a blood sample for there care) and inflammation parameters will be measure the day of the stroke
|
Outcome Measures
Primary Outcome Measures
- Inflammation parameters description [1 day]
Inflammatory parameters such as CRP, IL-6, IL-10, HLA-DR, TNF-alpha, polymorphonuclear chemotaxis, CD-4, T-lymphocytes will be measure in blood sample
Eligibility Criteria
Criteria
GROUP "AVC" :
Inclusion Criteria:
-
Adults patient (s)
-
Ischemic stroke by occlusion of a middle cerebral artery (proximal portion M1)
-
Initial diagnostic MRI infusion
-
TM with complete reperfusion (TICI 2b, 2c or 3)
-
TM performed under local anesthesia +/- anxiolysis, or sedation including propofol
-
mRS prior to stroke <2
-
Barthel index <90
-
Included in the HIBISCUS cohort
-
Patient who was informed and did not object to participating in the study OR included through the emergency procedure then collection of his non-objection or that of his trusted person as soon as possible
Exclusion Criteria:
-
NIHSS awareness score> or = 2
-
Haemorrhagic complication before thrombectomy
-
Pregnant woman
-
Multiple vascular occlusions
-
Occlusions of posterior or anterior cerebral territories other than M1
-
Protected major
-
TM performed under general anesthesia
-
Other vital failure than neurological failure
GROUP "CONTROL" :
Inclusion Criteria:
-
Adults patient (s)
-
mRS <2
-
Barthel index <90
-
Requiring diagnostic arteriography for routine check-up of a cerebrovascular malformation
-
Patient who was informed and did not object to participating in the study
Exclusion Criteria:
-
NIHSS awareness score> or = 2
-
Pregnant woman
-
Protected major
-
Exam performed under general anesthesia
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Service d'Anesthésie Réanimation Hôpital - Neurologique/Groupement Est | Bron | France | 69500 | |
| 2 | Service de Neurologie vasculaire - Hôpital Neurologique/Groupement Est | Bron | France | 69500 | |
| 3 | Service de Neuroradiologie interventionnelle - Hôpital Neurologique/Groupement Est | Bron | France | 69500 | |
| 4 | Service d'Anesthésie Réanimation - Hôpital Edouard Herriot/Groupement Centre | Lyon | France | 69437 |
Sponsors and Collaborators
- Hospices Civils de Lyon
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 69HCL20_1080