Repetitive Transcranial Magnetic Stimulation for the Treatment of the Tardive Dyskinesia.
Study Details
Study Description
Brief Summary
The purpose of this study is to explore the therapeutic effect and mechanism of transcranial magnetic stimulation (rTMS) in the treatment of the tardive dyskinesia.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
The study was a parallel control design trial for 2 weeks. Patients with schizophrenia were treated with 10-Hz rTMS on left motor cortex (added to the ongoing treatment). Clinical symptoms and MEP were assessment before and after rTMS treatment.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Active Comparator: tardive dyskinesia group tardive dyskinesia group will be delivered at an intensity that is 80% of the resting motor threshold (RMT). Stimulation will be delivered at 10 Hz with 60 stimulation trains of 30 stimuli each (i.e., 1800 stimuli) and an intertrain interval of 12 sec in primary motor cortex（M1）. |
Device: Repetitive Transcranial Magnetic Stimulation
Stimulate the primary motor cortex for 2 weeks.
|
| No Intervention: Healthy control group
|
Outcome Measures
Primary Outcome Measures
- Change from baseline in motor evoked potential(MEP) [2 times (Before treatment,immediately after treatment)]
- Change from baseline in Abnormal Involuntary Movement Scale(AIMS） [2 times (Before treatment,immediately after treatment)]
Secondary Outcome Measures
- Change from baseline in cortical silent period [2 times (Before treatment,immediately after treatment)]
- Change from baseline in short interval intracortical inhibition(SICI） [2 times (Before treatment,immediately after treatment)]
- Change from baseline in intracortical facilitation(ICF） [2 times (Before treatment,immediately after treatment)]
- Change from baseline in Simpson-Angus Scale（SAS） [2 times (Before treatment,immediately after treatment)]
- Change from baseline in Barnes Akathisia Rating Scale（BARS） [2 times (Before treatment,immediately after treatment)]
- Change from baseline in Positive and Negative Syndrome Scale（PANSS） [2 times (Before treatment,immediately after treatment)]
- Change from baseline in clinical global impression (CGI) [2 times (Before treatment,immediately after treatment)]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
The diagnosis of schizophrenia according to DSM-IV；
-
At least two item of Abnormal Involuntary Movement Scale（AIMS） must be 2 points or higher
-
these symptoms are not from Parkinson，tourette's syndrome,huntington disease
-
Signed an informed consent
Exclusion Criteria:
-
rTMS contraindications: intracranial metal substance, with heart pacemakers and cochlear implants, intracranial pressure
-
patients to be diagnosed according to DSM-IV for substance abused, development delayed
-
current treatment with anticonvulsant acting drugs such as anticonvulsants, benzodiazepines
-
Acute risk of suicide and impulse
-
history of epileptic seizures or the presence of epileptic activity documented on the basis of EEG
-
pregnant and lactant women
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine | Shanghai | Shanghai | China | 200030 |
Sponsors and Collaborators
- Shanghai Mental Health Center
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 15ZR1435600