Testosterone and Vascular Function in Reproductive-Aged Females With Chronic Kidney Disease
Study Details
Study Description
Brief Summary
Cardiovascular disease (CVD) is the leading cause of death among women and women with chronic kidney disease are at an even greater risk of CVD. The aim of this observational study is to examine the relationship between total testosterone levels and measures of vascular function (pulse wave velocity, aortic augmentation index, flow mediated dilation and velocity time integral) in reproductive-aged women living with chronic kidney disease.
Condition or Disease | Intervention/Treatment | Phase |
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|
Study Design
Outcome Measures
Primary Outcome Measures
- Pulse wave velocity [Measured at baseline]
- Aortic augmentation index [Measured at baseline]
- Flow mediated dilation [Measured at baseline]
- Velocity time integral [Measured at baseline]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
female sex
-
a diagnosis of chronic kidney disease or end stage kidney disease
-
age 18-51
Exclusion Criteria:
Pregnancy, breastfeeding, current use of menopausal hormone therapy or gender affirming hormone therapy, or factors that would affect ovarian function, such as polycystic ovarian syndrome, premature ovarian insufficiency, ovarian malignancy, gonadotoxic chemotherapy, surgical oophorectomy, or previous radiation to the pelvis.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | University of Calgary | Calgary | Alberta | Canada | T2N1N4 |
Sponsors and Collaborators
- University of Calgary
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- REB18-0642