High-Resolution Solid-State Manometry of the Effect of Succinylcholine on Barrier Pressure

Sponsor

China-Japan Friendship Hospital (Other)

Overall Status

Completed

CT.gov ID

NCT05556408

Collaborator

(none)

Enrollment

Arm

Actual Duration (Months)

Study Details

Study Description

Brief Summary

The lower esophageal sphincter（LES）plays a key role in preventing regurgitation and aspiration. The pressure of LES partly comes from striated muscles derived from the crural portion of the diaphragm. The effect of succinylcholine on esophagogastric junction during anesthesia induction is not clear. We conducted a prospective interventional study on the effect of succinylcholine on the barrier pressure (BrP) of the esophagogastric junction.

Condition or Disease	Intervention/Treatment	Phase
the Effect of Succinylcholine on Barrier Pressure	Drug: Succinylcholine	Phase 4

Detailed Description

14 patients participated in the study. Propofol and succinylcholine were used for anesthesia induction. High-resolution solid-state manometry (HRM) was used to monitor the changes of the LES pressure and the intragastric pressure (IGP).The administration of propofol could significantly increase the LES pressure during end expiration and during inspiration. The application of succinylcholine had no effect on the LES pressure during end expiration, but significantly reduced the LES pressure during inspiration. Propofol had no effect on BrP. After the application of succinylcholine, BrP decreased significantly during inspiration.

Propofol significantly increased the LES pressure. Succinylcholine significantly reduced the pressure of LES and BrP during inspiration.

Study Design

Study Type:

Interventional

Actual Enrollment :

14 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Prevention

Official Title:

High-Resolution Solid-State Manometry of the Effect of Succinylcholine on Barrier Pressure

Actual Study Start Date :

Mar 1, 2015

Actual Primary Completion Date :

Dec 30, 2015

Actual Study Completion Date :

Dec 30, 2015

Arms and Interventions

Arm	Intervention/Treatment
Other: High-Resolution Solid-State Manometry Before catheterization, the patients were monitored by pulse oximetry, electrocardiogram, automatic noninvasive arterial blood pressure and bispectral index (BIS). Before the insertion of the manometric catheter an intravenous cannula was inserted. The manometric catheter was placed through the nose until the pressure from the lower esophageal sphincter to the stomach could be recorded. After confirming the position of the catheter, the catheter was taped to the nose.	Drug: Succinylcholine 1.5mg/kg was given intravenously Other Names: propofol

Arm

Intervention/Treatment

Other: High-Resolution Solid-State Manometry

Before catheterization, the patients were monitored by pulse oximetry, electrocardiogram, automatic noninvasive arterial blood pressure and bispectral index (BIS). Before the insertion of the manometric catheter an intravenous cannula was inserted. The manometric catheter was placed through the nose until the pressure from the lower esophageal sphincter to the stomach could be recorded. After confirming the position of the catheter, the catheter was taped to the nose.

Drug: Succinylcholine

1.5mg/kg was given intravenously

Other Names:

propofol

Outcome Measures

Primary Outcome Measures

pressure of lower esophageal sphincter [15 minutes]
On the isocontour plots, the esophageal sphincter can be located as abrupt transitions in the pressure pattern (Fig. 2). The proximal edge of the LES was defined by sudden transition to the intra-esophageal pressure, and the distal edge was defined by sudden transition to the IGP. The pressure of the LES measured during end expiration was defined as the pressure of intrinsic sphincter to avoid the influence from the rural component of the LES. The rural component of the LES was defined as the highest pressure point at the esophagogastric junction during inspiration.
pressure of intragastric [15 minutes]
IGP was measured at 2 cm below the crural diaphragmatic component of the LES

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 70 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Exclusion criteria：patients who classified as American Society of Anesthesiologists classification system (ASA) II were included. Patients were included in the study if they had on history of diabetes, pharynx and digestive diseases.

Exclusion criteria：currently pregnant or breastfeeding, a body mass index (BMI) over 30 kg/m2. All patients underwent preoperative preparation according to clinical routine and did not give preoperative drugs.

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

China-Japan Friendship Hospital

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Yanting Cao, PhD, China-Japan Friendship Hospital

ClinicalTrials.gov Identifier:

NCT05556408

Other Study ID Numbers:

the Effect of Succinylcholine

First Posted:

Sep 27, 2022

Last Update Posted:

Sep 27, 2022

Last Verified:

Sep 1, 2022

Individual Participant Data (IPD) Sharing Statement:

Plan to Share IPD:

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Keywords provided by Yanting Cao, PhD, China-Japan Friendship Hospital

lower esophageal sphincter

intragastric pressure

succinylcholine

Additional relevant MeSH terms:

Propofol

Succinylcholine

Study Results

No Results Posted as of Sep 27, 2022