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Is There Intravascular Hemolysis in Patients With Pulmonary Hypertension?

Sponsor
Rabin Medical Center (Other)
Overall Status
Unknown status
CT.gov ID
NCT00502398
Collaborator
(none)
1
Location

Study Details

Study Description

Brief Summary

Patients with hemolytic disorders (e.g. sickle cell anemia or thalassemia) are known to develop pulmonary hypertension. Hemolysis is where red blood cells are destroyed and their contents released into the circulation. It is thought that these red-cell contents cause constriction and thrombosis of the blood vessels in the lungs. Conversely, it is possible that patients with pulmonary hypertension have hemolysis.

In this study we will be drawing blood from a range of patients and normal controls for a panel of blood tests related to hemolysis.

Condition or Disease Intervention/Treatment Phase
  • Procedure: Blood test

Study Design

Study Type:
Observational
Time Perspective:
Prospective
Study Start Date :
Sep 1, 2007

Outcome Measures

Primary Outcome Measures

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:
    One of the following four conditions :

    • Pulmonary artery hypertension

    • Obstructive sleep apnea with pulmonary hypertension

    • Lung transplant candidates without pulmonary hypertension

    • Normal Controls

    Exclusion Criteria:

    • Known hemolytic disorder

    • Recent blood loss (<3 months)

    • Recent blood transfusion (<3 months)

    • Liver disease

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Pulmonary Institute, Rabin Medical Center (Beilinson campus) Petach Tikva Israel 49100

    Sponsors and Collaborators

    • Rabin Medical Center

    Investigators

    • Principal Investigator: Mordechai Kramer, MD, Rabin Medical Center

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    , ,
    ClinicalTrials.gov Identifier:
    NCT00502398
    Other Study ID Numbers:
    • RMC074490CTIL
    First Posted:
    Jul 17, 2007
    Last Update Posted:
    Oct 16, 2007
    Last Verified:
    Oct 1, 2007
    Additional relevant MeSH terms:
    Pulmonary Arterial Hypertension
    Hypertension

    Study Results

    No Results Posted as of Oct 16, 2007