Thoracic Fluid Content and Acute Lung Injury

• Sponsor: National Taiwan University Hospital (Other)
• Overall Status: Completed
• CT.gov ID: NCT01922557
• Collaborator: (none)
• Enrollment: 22
• Location: 1
• Duration (Months): 17
• Patients Per Site Per Month: 1.3

Study Details

Study Description

Brief Summary

To study the association of the thoracic fluid content and acute lung injury during liver transplantation.

Condition or Disease	Intervention/Treatment	Phase
Acute Lung Injury	Device: NICOM

Detailed Description

Acute lung injury is not uncommon after liver transplantation. A new monitor non-invasive cardiac output monitor (NICOM) is designed to measure thoracic fluid content. The investigators attempt to use the parameter thoracic fluid content to investigate its relationship with acute lung injury in liver transplant recipients.

Study Design

• Study Type: Observational
• Actual Enrollment: 22 participants
• Observational Model: Case-Control
• Time Perspective: Prospective
• Official Title: The Association of Thoracic Fluid Content and Acute Lung Injury in Liver Transplantation
• Study Start Date: Jan 1, 2011
• Actual Primary Completion Date: Jan 1, 2011
• Actual Study Completion Date: Jun 1, 2012

Arms and Interventions

Arm	Intervention/Treatment
NICOM	Device: NICOM; NICOM monitoring thoracic fluid content at baseline(T1), anhepatic phase(T2), 30 mins after reperfusion(T3) and 2 hrs after reperfusion(T4).

Outcome Measures

Primary Outcome Measures

1. Cardiac index [one day]

   Participants will be followed for the duration the operation. Cardiac index was measured by non-invasive cardiac output monitor at different time points as baseline(T1), anhepatic phase(T2), 30 mins after reperfusion(T3) and 2 hrs after reperfusion(T4)

Secondary Outcome Measures

1. Thoracic fluid content [one day]

   Participants will be followed for the duration the operation.Thoracic fluid content was measured in liver transplant recipients at different time points as baseline(T1), anhepatic phase(T2), 30 mins after reperfusion(T3) and 2 hrs after reperfusion(T4).

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 65 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• end stage liver disease scheduled for liver transplantation in National Taiwna University Hospital.

Exclusion Criteria:

• allergic reaction

• history of aortic regurgitation

• pre-existing pulmonary disease

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Department of Anesthesiology, NTUH	Taipei		Taiwan	100

Sponsors and Collaborators

• National Taiwan University Hospital

Investigators

• Principal Investigator: Kuang Cheng Chan, M.D., Department of Anesthesiology, NTUH, Taipei, Taiwan

Study Documents (Full-Text)

None provided.

More Information

Publications

• Hong SK, Hwang S, Lee SG, Lee LS, Ahn CS, Kim KH, Moon DB, Ha TY. Pulmonary complications following adult liver transplantation. Transplant Proc. 2006 Nov;38(9):2979-81.

• Responsible Party: National Taiwan University Hospital
• ClinicalTrials.gov Identifier: NCT01922557
• Other Study ID Numbers: 201012081RC
• First Posted: Aug 14, 2013
• Last Update Posted: Aug 14, 2013
• Last Verified: Aug 1, 2013

• Additional relevant MeSH terms: Lung Injury; Acute Lung Injury; Wounds and Injuries

Study Results

No Results Posted as of Aug 14, 2013