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Titan: Thrombus Imaging and Treatment Analytics in Neurology

Sponsor
Chinese PLA General Hospital (Other)
Overall Status
Not yet recruiting
CT.gov ID
NCT05663281
Collaborator
(none)
100
Enrollment
1
Location
60.5
Anticipated Duration (Months)
1.7
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

In the present study, we use high-resolution MR vessel wall imaging, select patients with cerebral and cervical artery occlusion to investigate the relationship between imaging appearance of thrombus and the various outcome of recanalization treatment.

Condition or Disease Intervention/Treatment Phase
  • Diagnostic Test: thrombus imaging appearance

Detailed Description

Cerebral ischemic stroke resulting from thrombosis cause high disability and mortality. There are few biomarkers to evaluate the arterial thrombophilia until now. Previous studies have demonstrated that atherosclerotic plaque rupture and erosion are major etiologies initiating thrombosis. Based on our previous works targeting plaque and blood flow in cerebrovascular disease, in the present study, we use high-resolution MR vessel wall imaging, select patients with cerebral and cervical artery occlusion to investigate the relationship between imaging appearance of thrombus and the various outcome of recanalization treatment. The study's objective was to solve the challenges in mechanism of thrombus features and outcome of recanalization therapy, thus to help improve the primary and secondary prevention in cerebrovascular disease.

Study Design

Study Type:
Observational
Anticipated Enrollment :
100 participants
Observational Model:
Cohort
Time Perspective:
Prospective
Official Title:
Thrombus Imaging and Treatment Analytics in Neurology
Anticipated Study Start Date :
Dec 15, 2022
Anticipated Primary Completion Date :
Dec 31, 2027
Anticipated Study Completion Date :
Dec 31, 2027

Outcome Measures

Primary Outcome Measures

  1. Rate of Successful Recanalization [1-3 Years]

    Antegrade blood flow through the recanalized portion was assessed by thrombolysis in myocardial infarction (TIMI) score or thrombolysis in cerebral infarction (TICI) score. TIMI≥2 or TICI≥2b was defined as successful recanalization.

  2. Ischemic Stroke Occurrence [1-3 Years]

    Ischemic stroke occurrence during follow-up period which was confirmed by neuroimaging

Secondary Outcome Measures

  1. Number of Participants with Adverse Events [1-3 Years]

    hemorrhagic or ischemic stroke after recanalization treatment

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:

  • Age ≥ 18 years

  • Extracranial and/or intracranial artery occlusion confirmed by angiography

  • Available for magnetic resonance high-resolution vessel wall imaging

  • Written informed consent obtained

Exclusion Criteria:

  • Extracranial and/or intracranial artery mild to moderate stenosis

  • Pregnant women

  • Restenosis or occlusion after artery stenting placement

Contacts and Locations

Locations

Site City State Country Postal Code
1 Chinese PLA General Hospital Beijing Beijing China 100853

Sponsors and Collaborators

  • Chinese PLA General Hospital

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Jinhao Lyu, Attending physician, Chinese PLA General Hospital
ClinicalTrials.gov Identifier:
NCT05663281
Other Study ID Numbers:
  • 301Titan
First Posted:
Dec 23, 2022
Last Update Posted:
Dec 23, 2022
Last Verified:
Dec 1, 2022
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by Jinhao Lyu, Attending physician, Chinese PLA General Hospital
Thrombus
Neuroimaging
High-resolution vessel wall imaging
Cerebral ischemia
Cerebral artery
Additional relevant MeSH terms:
Intracranial Thrombosis
Thrombosis

Study Results

No Results Posted as of Dec 23, 2022