Relationship Between Computed Tomography Manifestation and Histopathological Classification of Thymic Epithelial Tumors

Sponsor

Military Hospital 103 (Other)

Overall Status

Completed

CT.gov ID

NCT03288662

Collaborator

Nguyen Truong Giang (Other)

Enrollment

Arm

Actual Duration (Months)

Study Details

Study Description

Brief Summary

the World Health Organization (WHO) has proposed a classification of histopathological thymic tumor and it significance in prognosis. Chest computed tomography (CT) is the most common method to evaluate thymic epithelial tumors before operation. Therefore, the question is to predict the histopathological type of thymic epithelial tumors before surgery based on CT-scan images , to help determine treatment strategy and prognosis. In Vietnam, there are no published literature on this issue.

Condition or Disease	Intervention/Treatment	Phase
Thymoma	Other: CT and histopathological classification	N/A

Detailed Description

Introduction: the World Health Organization (WHO) has proposed a classification of histopathological thymic tumor and it significance in prognosis. Chest computed tomography (CT) is the most common method to evaluate thymic epithelial tumors before operation. Therefore, the question is to predict the histopathological type of thymic epithelial tumors before surgery based on CT-scan images , to help determine treatment strategy and prognosis. In Vietnam, there are no published literature on this issue.
Materials and methods:

2.1. Cross-sectional descriptive study on 53 patients with diagnosed of thymoma by CT and had postoperative histopathology results as thymic epithelial tumors

2.2. Time and Place: in Departement of CTVS, Military Hospital 103, Vietnam from 10/2013 to 7/2017.

2.3. methods:

study in chest CT scan:
Measure the maximun diameter of the tumor
The contour: smooth contour or irregular contour
The shape: round, oval and plaque base on the ratio between long axis and short axis of the tumor
Some other characteristics: Degree of enhancement, Level of drug absorbed, Calcification, Invasion the local organs and Capsular destruction.
Histopathological study: based on the 2004 WHO classification:
Thymoma: type A, AB, B1, B2, B3
Thymic carcinoma
Data processing: use software Epi Info 2000.

Expectation of results

Relationship between the size and histopathological type of thymic epithelial tumors.
Comparison of some characteristics of the tumor on preoperative chest CT scans and histopathological type of thymic epithelial tumors

Study Design

Study Type:

Interventional

Actual Enrollment :

2 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Intervention Model Description:

Cross-sectional descriptive study on 53 patients with diagnosed of thymoma by CT and had postoperative histopathology results as thymic epithelial tumorsCross-sectional descriptive study on 53 patients with diagnosed of thymoma by CT and had postoperative histopathology results as thymic epithelial tumors

Masking:

None (Open Label)

Primary Purpose:

Diagnostic

Official Title:

Evaluate the Relationship Between Computed Tomography Manifestation and Histopathological Classification of Thymic Epithelial Tumors

Actual Study Start Date :

Oct 1, 2013

Actual Primary Completion Date :

Jul 1, 2017

Actual Study Completion Date :

Jul 31, 2017

Arms and Interventions

Arm	Intervention/Treatment
Experimental: CT and histopathological classification With each histopathological type of thymic epithelial tumors, we measure the maximun diameter in chest CT scan. Comparison of some characteristics of the tumor on preoperative chest CT scans and histopathological type of thymic epithelial tumors .	Other: CT and histopathological classification Cross-sectional descriptive study on 53 patients with diagnosed of thymoma by CT and had postoperative histopathology results as thymic epithelial tumors. Base on the characteristics in Chest CT scan in each postoperative histopathology results.

Arm

Intervention/Treatment

Experimental: CT and histopathological classification

With each histopathological type of thymic epithelial tumors, we measure the maximun diameter in chest CT scan. Comparison of some characteristics of the tumor on preoperative chest CT scans and histopathological type of thymic epithelial tumors .

Other: CT and histopathological classification

Cross-sectional descriptive study on 53 patients with diagnosed of thymoma by CT and had postoperative histopathology results as thymic epithelial tumors. Base on the characteristics in Chest CT scan in each postoperative histopathology results.

Outcome Measures

Primary Outcome Measures

maximun diameter of the tumor [1 month]
Measure the maximun diameter of the tumor in chest CT scan

Eligibility Criteria

Criteria

Ages Eligible for Study:

21 Years to 71 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

All of patient have a chest CT scan pre-operation and a result of thymic epithelial tumors postoperative histopathology

Exclusion Criteria:

Incomplete or loss the CT and postoperative histopathology

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

Military Hospital 103
Nguyen Truong Giang

Investigators

Study Chair: Truong Giang Nguyen, PhD, VMMU

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Le Viet Anh, MD, Principal Investigator, Military Hospital 103

ClinicalTrials.gov Identifier:

NCT03288662

Other Study ID Numbers:

LAnh

First Posted:

Sep 20, 2017

Last Update Posted:

Sep 20, 2017

Last Verified:

Sep 1, 2017

Individual Participant Data (IPD) Sharing Statement:

Undecided

Plan to Share IPD:

Undecided

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Keywords provided by Le Viet Anh, MD, Principal Investigator, Military Hospital 103

Computed tomography

thymic epithelial tumors

Additional relevant MeSH terms:

Thymoma

Study Results

No Results Posted as of Sep 20, 2017