Percutaneous Ethanol Injection for Benign Cystic Thyroid Nodules
Study Details
Study Description
Brief Summary
Use of ethanol injection in treatment of cystic thyroid nodule
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 1 |
Detailed Description
Thyroid nodules are common discreet lesions in the parenchyma of thyroid gland which can either be palpated or made out during imaging like ultrasonography (USG).Clinically palpable thyroid nodules have a prevalence of 4-7% in the general population . However, the prevalence increases to 20-76% when USG is used for detection.
Goiter and the associated thyroid nodules result in anxiety, cosmetic disfigurement, and rarely compressive symptoms necessitating surgical removal, a procedure inherently associated with risks and complications Percutaneous sclerotherapy has been suggested to be an effective alternative, especially in patients with cystic nodules. Simple cystic (purely cystic) constitutes 6-28% of all thyroid nodules, are usually benign, filled with cellular debris or blood, and are a result of degeneration or hemorrhage into a hyperplastic nodule.
Among the various compounds (sodium tetradocyl sulfate, hydroxypolyethoxydodecan, tetracycline, and ethanol) tried for sclerosis of cystic thyroid nodules, outcomes are best and most studied with ethanol. However, data on outcomes of percutaneous aspiration and ethanol injection (PEI) in resolution of thyroid nodules is highly variable in different studies (success rate: 38-85%), which may be due to different populations studied and the heterogeneous nature of thyroid nodules evaluated.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: injection of ethanol use of ethanol injection in the treatment of cystic thyroid nodule |
Drug: ethanol injection
inject ethanol in cystic thyroid nodule and follow up until complete recovery
|
Outcome Measures
Primary Outcome Measures
- Reduction of volume of the cyst about 96.9% [Reduction of volume of the cyst about 96.9% within 6 month]
Reduction of volume of the cyst about 96.9%
Secondary Outcome Measures
- symptomatic improvement [3 month]
cosmetic improvement of the ugly appearance of the cyst from the neck
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Adult male or female patient with cystic thyroid nodule
-
Presence of pressure symptoms or cosmetic problems
-
Benign lesions confirmed by histopathological examination by FNAC.
-
Serum levels of thyroid hormone thyrotropin, within normal limits.
Exclusion Criteria:
-
Nodules showing malignant features(ie, speculated margin, markedly hypo echoic, micro- or macro calcifications) at US
-
solid thyroid nodule
-
mixed thyroid nodule(cystic with solid component)
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Assiut University | Assiut | Egypt | 71511 |
Sponsors and Collaborators
- hassan harby mohamed
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
- Monzani F, Lippi F, Goletti O, Del Guerra P, Caraccio N, Lippolis PV, Baschieri L, Pinchera A. Percutaneous aspiration and ethanol sclerotherapy for thyroid cysts. J Clin Endocrinol Metab. 1994 Mar;78(3):800-2.
- Vogel D, Durham AC, de Marcillac GD. Metastable aggregates in the polymerisation of tobacco-mosaic-virus protein. Eur J Biochem. 1977 Sep 15;79(1):161-71.
- Ethanol Injection