Thyroid Profiles in Patients With Acute Illness
Study Details
Study Description
Brief Summary
Patients admitted to the hospital with acute illness may have a wide spectrum of thyroid function abnormalities. It is largely unknown whether such aberrations are temporary or persist for a long time, and whether they impact prognosis of such patients.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Recently, there has been a growing body of evidence that subclinical thyroid dysfunction as a contributor to the increase of cardiovascular events. Elevated serum thyroid-stimulating hormone (TSH) levels and normal free thyroxine (FT4) and free triiodothyronine (FT3) levels have been associated with worse heart failure and dyslipidemia. Furthermore, higher risk of atrial fibrillation has been linked tp thyroid abnormalities in these patients.
Patients admitted to the hospital with acute illness may have a wide spectrum of thyroid function abnormalities. It is largely unknown whether such aberrations are temporary or persist for a long time, and whether they impact prognosis of such patients. This study aimed at evaluating the prevalence of thyroid function abnormalities in patients admitted to hospital with acute illness and their temporal changes and impact on mortality during hospitalization and at 1 year. Serum level of thyroid stimulating hormone and free T4 and T3 measured on admission. Clinical and laboratory profiles of patients with abnormal thyroid function (ATF group) will be compared to those with normal thyroid function (NTF group). Short and long term survival of both groups were compares as well.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| GROUP 1: Acute illness and abnormal thyroid function Patients admitted to the hospital with acute illness and found to have thyroid function abnormalities. |
Other: Performing blood thyroid test (TSH, FT4, FT3)
Blood test as above
|
| GROUP 2: Acute illness and normal thyroid function Patients admitted to the hospital with acute illness and found to have normal thyroid function. |
Other: Performing blood thyroid test (TSH, FT4, FT3)
Blood test as above
|
Outcome Measures
Primary Outcome Measures
- In hospital mortality [From time of study entry until the date of death from any cause, assessed up to 2 weeks.]
All-cause death rate in patients with abnormal thyroid function compared with death in those with no abnormal thyroid function during the patients hospital stay..
Secondary Outcome Measures
- 6-month mortality rate [From date of study entry until the date of death from any cause, assessed up to two weeks.]
All-cause death rate in patients with abnormal thyroid function compared with death in those with no abnormal thyroid function at 6 months.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Hospital admission
-
Adults aged 18 years and above
-
Willing to sign an informed consent
-
Diagnosis on admission is acute illness that includes: heart failure, acute coronary syndrome, sepsis, acute stroke, hypotension, acute system-organ failure including renal and hepatic failure.
Exclusion Criteria:
-
Age less than 18 years.
-
Refusal to sign consent.
-
Admission for a reason not classified as acute illness.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Istishari Hospital | Amman | Jordan | 11888 |
Sponsors and Collaborators
- Jordan Collaborating Cardiology Group
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- DCR2023/1.ThyrAcuteIll