Tissue Resistivity in Breast Cancer Patients
Study Details
Study Description
Brief Summary
The resistivity measurements will be done by introducing a needle-probe into fresh healthy, peritumoral, and tumoral ex vivo tissues.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Patients affected by breast cancer will have their tissue analysed immediately following their surgical excision for the treatment of breast cancer. Two probes will be used: a linear probe of 4 needle-electrodes positioned in a row that is able to perform Electrical Impedance Spectroscopy (EIS) measurements and a circular probe of 8 needle-electrodes arranged into a circular pattern that is able to generate cross sectional images (Electrical Impedance Tomography maps). Firstly, the linear probe will be inserted in the tumor parenchyma at a penetration depth of about 2 mm and the tissue impedance measurement will be performed along a broad spectrum of frequencies for few minutes. Approximately 10 seconds for each measurement will be needed. Subsequently, if the size of the tissue will allow it, the circular probe will be inserted in the tumor parenchyma at the same penetration depth and 10 cross sectional maps will be generated (approximately 30 seconds in total). Both information obtained using the linear and the circular probes will be integrated for a full characterization of the tissue under examination.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Resistivity measurements The resistivity measurements will be done by introducing the needle-probe into fresh healthy, peritumoral, and tumoral ex vivo tissues |
Diagnostic Test: Resistivity measurement
To measure and compare the tissue impedance values obtained by analysing ex vivo non-neoplastic (healthy and peritumoral) and neoplastic breast tissues
|
Outcome Measures
Primary Outcome Measures
- Breat tissue characterization [30 minutes from surgery]
Use of Electrical Impedance Spectroscopyuse (EIS) to characterize ex vivo non-neoplastic (healthy and peritumoral) and neoplastic breast tissues
Secondary Outcome Measures
- Evaluation of the precision of each EIS measurement [30 minutes from surgery]
To evaluate the precision of each EIS measurement (healthy, peritumoral, cancerous) performed by the tissue impedance analyser in the same subject
- Correlation between electrical and biological results [30 minutes from surgery]
To correlate the electrical behaviour of the breast cancer tissue to pathological and biological information
Eligibility Criteria
Criteria
Inclusion Criteria:
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Age >18 years
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First radiological diagnosis of breast adenocarcinoma needing a histological confirmation
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Written Informed Consent
Exclusion Criteria:
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Tumor mass diameter < 1 cm
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Surgical specimen (harbouring tumoral + peritumoral tissue) diameter < 2 cm
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Ospedale Regionale di Mendrisio | Mendrisio | Switzerland | 6850 |
Sponsors and Collaborators
- Ente Ospedaliero Cantonale, Bellinzona
- Politecnico di Milano
- Clinical Trial Unit Ente Ospedaliero Cantonale
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- OBV-GASTRO-001