Tissue Sample Collection From Patients With Fanconi Anemia

• Sponsor: OHSU Knight Cancer Institute (Other)
• Overall Status: Completed
• CT.gov ID: NCT00899522
• Collaborator: National Cancer Institute (NCI) (NIH)
• Enrollment: 8
• Location: 1
• Duration (Months): 93
• Patients Per Site Per Month: 0.1

Study Details

Study Description

Brief Summary

RATIONALE: Collecting and storing samples of tumor tissue from patients with Fanconi anemia to test in the laboratory may help the study of cancer in the future.

PURPOSE: This laboratory study is collecting and storing tumor tissue samples from patients with Fanconi anemia.

Condition or Disease	Intervention/Treatment	Phase
Fanconi Anemia; Unspecified Adult Solid Tumor, Protocol Specific; Unspecified Childhood Solid Tumor, Protocol Specific	Other: biologic sample preservation procedure; Procedure: biopsy

Detailed Description

OBJECTIVES:

• Acquire rare solid tumor samples from patients with Fanconi anemia in order to create a Fanconi Anemia Cell Repository at the Oregon Health and Science University Cancer Institute.

• Study repository tissue using a variety of molecular methods, including gene microarrays.

• Develop cancer cell lines that are publicly available from tissue archived from patients with Fanconi anemia.

OUTLINE: Tumor biopsies are collected from patients with Fanconi anemia and archived for future molecular studies, cell line generation, and general usage by the research community at large. Medical information about the patient's cancer is also archived.

PROJECTED ACCRUAL: Not specified.

Study Design

• Study Type: Observational
• Actual Enrollment: 8 participants
• Observational Model: Case-Control
• Time Perspective: Retrospective
• Official Title: Fanconi Anemia Cancer Cell Repository
• Study Start Date: Aug 1, 2005
• Actual Primary Completion Date: Mar 1, 2013
• Actual Study Completion Date: May 1, 2013

Outcome Measures

Primary Outcome Measures

1. Creation of a Fanconi Anemia Cell Repository using rare solid tumor samples from patients with Fanconi anemia [Duration of the study]

2. Study tissue samples by molecular methods, including gene microarrays [Duration of the study]

3. Development of cancer cell lines from tissue archived from patients with Fanconi anemia [Duration of the study]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 1 Year to 55 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

DISEASE CHARACTERISTICS:

• Confirmed Fanconi anemia

• Confirmed malignant solid tumor

• Biopsy of tumor tissue available

PATIENT CHARACTERISTICS:

• Not specified

PRIOR CONCURRENT THERAPY:

• Not specified

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Knight Cancer Institute at Oregon Health and Science University	Portland	Oregon	United States	97239-3098

Sponsors and Collaborators

• OHSU Knight Cancer Institute
• National Cancer Institute (NCI)

Investigators

• Principal Investigator: Grover C. Bagby, MD, OHSU Knight Cancer Institute

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Grover Bagby, Professor Emeritus, OHSU Knight Cancer Institute
• ClinicalTrials.gov Identifier: NCT00899522
• Other Study ID Numbers: IRB00001100; P30CA069533; OHSU-HEM-03022-LX; OHSU-IRB00001100; OSHU-CR00003822; CDR0000445453
• First Posted: May 12, 2009
• Last Update Posted: Dec 4, 2017
• Last Verified: Nov 1, 2017

• Keywords provided by Grover Bagby, Professor Emeritus, OHSU Knight Cancer Institute: Fanconi anemia; unspecified adult solid tumor, protocol specific; unspecified childhood solid tumor, protocol specific
• Additional relevant MeSH terms: Neoplasms; Fanconi Syndrome; Anemia; Fanconi Anemia

Study Results

No Results Posted as of Dec 4, 2017