TJEZ: Tongji-Ezhou Study
Study Details
Study Description
Brief Summary
Tongji-Ezhou study (TJEZ) is a prospective cohort study launched at 2013 in EZhou city, Hubei province, with the goal of recruiting and assessing 10,000 individuals and then following them for at least 2 decades. In addition, blood samples would be collected every 3-5 years among 6000 of them to investigate the nutritional biomarkers and potential determinants of chronic diseases such as obesity, type 2 diabetes, metabolic syndrome, and cardiovascular disease.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Egang hospital physical examination center
|
Other: Dietary and environmental exposure (Observational study)
|
| Ezhou CDC physical examination center
|
Other: Dietary and environmental exposure (Observational study)
|
Outcome Measures
Primary Outcome Measures
- Incidence of diabetes [5 years]
Type 2 diabetes was diagnosed when FPG ≥ 7.0 mmol/L and/or OGTT2h ≥ 11.1 mmol/L, or using diabetic medication (self-report).
- Incidence of metabolic syndrome [5 years]
Metabolic syndrome is defined as using the updated National Cholesterol Education Program/Adult Treatment Panel III criteria for Asian Americans. These criteria require three or more of the following components: (1) central obesity (waist circumference of ≥90 cm for men or ≥80 cm for women), (2) triglycerides of ≥1.7 mmol/L, (3) HDL-C of <1.03 mmol/L for men or <1.30 mmol/L for women, (4) blood pressure of ≥130/85 mmHg or on medication for hypertension, and (5) fasting glucose of ≥5.6 mmol/L.
- Diabetic complications [mean follow up of 10 years]
Development of diabetic complications
- Incidence of cardiovascular diseases [mean follow up of 10 years]
Cardiovascular death, stroke, myocardial infarction, heart failure
Eligibility Criteria
Criteria
Inclusion Criteria:
- (i) permanent residence in Ezhou district (minimum of 9 months); (ii) written informed consent; (iii) age ≥ 20 years old at the time of enrolling in the study.
Exclusion Criteria:
- (i) with chemotherapy or radiotherapy for cancer and other severe diseases.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Huazhong University of Science and Technology | Wuhan | Hubei | China | 430030 |
Sponsors and Collaborators
- Huazhong University of Science and Technology
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- TJEZ2013