KNEE BDNF: Postoperative Painful Chronicization After Knee Replacement Surgery : Exploratory Study of BDNF's Kinetics
Study Details
Study Description
Brief Summary
Chronic pain is an extremely disabling disease. It is a major public health problem due to the lack of effective therapy.
Chronic postoperative pain (CPOP) is defined by a painful symptomatology in the operated area unrelated to previous pain, present for more than 3 months, and without any link to surgical complication.
The prevalence of chronicization of postoperative pain is 30% after total knee arthroplasty.
Identification of clinical, biological and psychological profiles are crucial to prevent CPOP.
A biologic factor, Brain Derived Neurotrophic Factor (BDNF) produced by a variety of cells is a key regulator of neuroplasticity. BDNF is increasingly studied in the mechanisms of cerebral sensitization and pain chronicization. The role of BDNF in pain of patients remains to be explored in a prospective study. The aim of this observational study is to compare the kinetics of BDNF after total knee arthroplasty in patients with and without CPOP.
Patients will be included in the study at the preanesthetic consultation. Serum BDNF levels will be measured preoperatively, 48h postoperatively, 3 and 6 months after surgery.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Other: Total knee arthroplasty patient operated for a total knee arthroplasty |
Diagnostic Test: blood test
blood test to explore BDNF level
|
Outcome Measures
Primary Outcome Measures
- BDNF level [preoperative to 6 months after surgery]
assessed by ELISA technique
Secondary Outcome Measures
- Pain level [preoperative to 6 months after surgery]
evaluated by Visual Analog Scale (VAS)
- Neuropathic pain diagnostic [preoperative to 6 months after surgery]
evaluated by neuropathic pain diagnostic questionnaire (DN4)
- Postoperative rehabilitation [preoperative to 6 months after surgery]
evaluated by the Brief Pain Questionary (BPI)
- Health related quality of life [preoperative to 6 months after surgery]
evaluated by the SF-12 Health Survey
- Anxiety and Depression [preoperative to 6 months after surgery]
evaluated by the Hospital Anxiety and Depression scale (HAD)
- Pain level perception [preoperative to 6 months after surgery]
evaluated by the The pain Catastrophizing Scale
- Assessment of functional capacities in knee arthritis [preoperative to 6 months after surgery]
evaluated by the Western Ontario and McMaster Universities Arthritis Index (WOMAC)
- Oxidative stress marker [preoperative to 6 months after surgery]
8-iso-prostaglandin F2α level by biochemical labeling
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Social security affiliation
-
Adult patients
-
Signed informed consent
-
Score ASA (American Society of Anesthesiology) 1-3
-
Total knee arthroplasty
Exclusion Criteria:
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Patient unable to exercise consent
-
Pregnant women
-
Vulnerable people
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Patients not included in the postoperative rehabilitation program
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Patients unable to complete the pain assessment questionnaires
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Chronic pain patients (other than knee arthrosis)
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Neuropathic pain patients (beforehand)
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Inflammatory diseases, progressive cancer, sepsis, immunosuppression known
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Department of Anesthesiology and critical care, Lapeyronie University Hospital | Montpellier | France | 34295 |
Sponsors and Collaborators
- University Hospital, Montpellier
- Institut National de la Santé Et de la Recherche Médicale, France
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- RECHMPL19_0192