TRACERxRenal: TRACERx Renal CAPTURE Sub-study
Study Details
Study Description
Brief Summary
TRACERx Renal: This is a translational study, which, aims to develop prognostic and predictive biomarkers for patients with renal cell carcinoma (RCC).
CAPTURE Sub-study: Covid-19 antiviral response in a pan-tumour immune monitoring study
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
|
Detailed Description
There is a need for improved understanding of renal cell carcinoma (RCC) biology in order to characterise the mechanisms of metastatic progression, drug resistance, develop predictive & prognostic biomarkers and to identify novel therapeutic targets for this disease. The TRACERx consortium was established to achieve this using large longitudinal clinical studies, in collaboration with laboratory, advanced sequencing and informatics expertise to identify the relationships between intratumour heterogeneity and clinical outcome.
Response and Resistance: TRACERx Renal is a prospective longitudinal cohort study. It will draw on the methodology already being used within the TRACERx Lung & (planned) Breast studies as part of the TRACERx consortium.
Primary Endpoint
• To validate ITH index and WGII as stage and grade independent prognostic markers of progression free survival in patients with ccRCC
The Investigators plan to collect the following biological samples:
-
Blood sample/s, urine and tumour biopsy tissue taken prior to any neoadjuvant treatment that might be administered.
-
Blood sample/s, urine and tumour biopsy tissue taken prior to any ablative procedure
-
Blood sample/s, urine and nephrectomy tissue taken at the time of nephrectomy.
-
Blood sample/s, urine and tumour tissue taken at the time of palliative metastasectomy/surgery.
-
Blood and urine sample/s taken at routine follow up.
-
Blood sample/s, urine and tumour biopsy taken at time of disease progression.
-
Blood sample/s and/or archival tissue specimens that are no longer required by the local pathologist for diagnostic purposes
-
Blood sample/s and/or archival tissue specimens that are no longer required by the local pathologist for diagnostic purposes from study patient family members
CAPTURE sub-study:
There is an urgent need to quantify the risk of COVID-19 illness in patients with cancer and to understand what impact anti-cancer treatments have on the immune system's response to the SARS-CoV-2 virus. There is also a need to understand how the pandemic impacts Health Care Workers (HCWs) who may be exposed to the virus in the course of their clinical duties and who are at risk to transmit the virus to vulnerable patients and colleagues in the asymptomatic phase of infection.
The CAPTURE study is a long-term study. We are establishing large observational cohorts with an intentionally broad inclusion of different tumour types and treatment schedules. In CAPTURE, we will enrol both patients infected and uninfected by the virus, and patients with all types of cancer (blood and solid cancers), and of all walks of the clinical journey (in remission, follow-up, having treatment or undergoing surgery). We also will enrol HCWs within the hospital from all sectors of care delivery - from nurses to doctors, administrative staff to catering staff, allied health and support workers.
The study will enrol patients/participants into three groups:
Group A: patients with confirmed or suspected COVID-19 and a history of cancer (n=200) Group
B: patients without a history of COVID-19 infection and a history of cancer (n=1000) Group C:
Hospital staff with or without a history of COVID-19 (n=200)
Comprehensive, longitudinal clinical annotation, participant questionnaires, meticulous and frequent sampling and long-term follow-up of these groups will allow robust and rapid insights that are urgently needed to guide clinical and workforce management.
This knowledge is required well beyond the current pandemic as cancer and SARSCo-V2 will coincide in the same patients, and especially given the uncertainty regarding the nature and duration of immunity in cancer patients who develop the illness and the effectiveness of vaccines in the cancer population. This study will provide us with detailed information on how to safely manage cancer patients by both minimising the risk of infection but maintaining their cancer treatment.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| All patients In London renal cell carcinoma patients undergo nephrectomy at centres for urological oncology, including the Royal Marsden, Guy's and St Thomas', St Georges, Charing Cross and Kings Hospitals. It is not uncommon for the same patients to undergo palliative resection for metastatic sites of disease. The majority of tissue from these resections does not undergo routine histopathological examination. As such, it is ethically feasible to use these specimens for laboratory research in the presence of patient consent. Practically, these specimens are often large, thereby offering considerable scope for a range of molecular analyses. CAPTURE Sub-study: We plan to enrol patients/participants into three groups: Group A: patients with confirmed or suspected COVID-19 and a history of cancer Group B: patients without a history of COVID-19 infection and a history of cancer Group C: Hospital staff with or without a history of COVID-19 |
Outcome Measures
Primary Outcome Measures
- To validate ITH index and WGII as stage and grade independent prognostic markers of progression free survival in patients with ccRCC mutation in a gene of interest [From trial activation until trial closure approximately 1st September 2023]
Outcomes will be quantified using descriptive statistics with the intention of providing hypothesis-generating data for use in future studies.
- CAPTURE Sub-study: Describe the population characteristics between SARS-CoV-2 positive and negative cancer patients [From sub-study activation until trial closure approximately 2027]
Outcomes will be quantified using descriptive statistics
Eligibility Criteria
Criteria
TRACERx Renal Inclusion Criteria:
-
Age 18- years or older
-
Patients with histopathologically confirmed renal cell carcinoma, or suspected renal cell carcinoma, proceeding to neoadjuvant therapy and/or nephrectomy/metastasectomy, or identified as having progressive disease
-
Or in patients undergoing nephrectomy for non-malignant disease
-
Medical and/or surgical management in accordance with national and/or local guidelines
-
Written informed consent
Exclusion Criteria:
-
Any concomitant medical or psychiatric problems which, in the opinion of the investigator, would prevent completion of treatment or follow-up
-
Lack of adequate tissue
CAPTURE Inclusion criteria
-
Documented informed consent
-
Age 18 years or older
-
Confirmed cancer diagnosis (irrespective of cancer type, disease burden or treatment)
-
Group A: Suspected infection with SARS-CoV-2 or positive test for SARS-CoV-2
-
Group B: no clinical indication to test for SARS-CoV-2 (by current Trust guidelines*) or tested negative for SARS-CoV-2
-
Group C: Volunteers without cancer with SARS-CoV-2 (symptomatic and asymptomatic) and those without clinical indication (current national guidelines*) for SARS-CoV-2 testing or tested negative for SARS-CoV-2
Exclusion criteria
• Medical or psychological condition that would preclude informed consent
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Edinburgh Western General Hospital | Edinburgh | Scotland | United Kingdom | EH4 2XU |
| 2 | Guy's & St Thomas Hospital | London | UK | United Kingdom | SE1 9RT |
| 3 | Barts Health NHS Trust | London | United Kingdom | E1 2EF | |
| 4 | Royal Free Hospital | London | United Kingdom | NW3 2QC |
Sponsors and Collaborators
- Royal Marsden NHS Foundation Trust
- The Francis Crick Institute
Investigators
- Principal Investigator: Samra Turajlic, Royal Marsden NHS Foundation Trust
Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
None provided.- CCR 3723