HPEEP: Tracheal Positive Pressure During High Flow Nasal Oxygen Administration in Critically Ill Patients: a Physiologic Study.
Study Details
Study Description
Brief Summary
High flow nasal cannula administration in critically ill patients is frequently used to improve acute respiratory failure or to prevent respiratory failure after extubation.
It acts generating a mild positive pressure in the airways and by reducing respiratory effort of patients.
However to the best of our knowledge, no study to date has directly measured the amount of positive pressure generated in the trachea of patients.
The primary aim, therefore, of this study measures this positive pressure after extubation in critically ill patients.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| CRITICALLY ILL PATIENTS CRITICALLY ILL PATIENTS AFTER INVASIVE MECHANICAL VENTILATION READY TO BE EXTUBATED. |
Device: HIGH FLOW NASAL OXYGEN
BEFORE EXTUBATION, AN AIRWAY EXCHANGE CATHETER (AEC) WILL BE PUT INTO THE PATIENTS' TRACHEA AND IT WILL REMAIN IN SITE AFTER EXTUBATION. THROUGH AN AEC CONNECTED TO A PRESSURE MONITOR, IT WILL BE RECORDED TRACHEAL PRESSURE DURING SPONTANEOUSLY BREATHING PATIENT AT DIFFERENT FLOW RATES OF HFNC THAT WILL BE APPLIED JUST AFTER EXTUBATION.
MEANWHILE, VITAL PARAMETERS RECORDED WITH A MULTIPARAMETRIC MONITOR WILL BE RECORDED.
FINALLY, MONITORING OF ELECTRICAL ACTIVITY OF DIAPHRAGM WILL BE RECORDED THROUGH A DEDICATED NASOGASTRIC TUBE TO EVALUATE IT AT DIFFERENT FLOW RATES.
Other Names:
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Outcome Measures
Primary Outcome Measures
- HFNC-PEEP [3 HOURS]
THE LEVEL OF POSITIVE AIRWAY PRESSURE GENERATED BY DIFFERENT FLOW RATES OX OXYGEN WILL BE RECORDED. FLOW RATE STARTS AT 10 L/MIN AND IT WILL BE INCREASED A 10 L/MIN STEP EVERY 30 MINUTES UNTIL 60 L/MIN.
Secondary Outcome Measures
- HFNC-EADI [3 HOURS]
ELECTRICAL ACTIVITY OF THE DIAPHRAGM WILL BE RECORDED THROUGH A DEDICATED NASOGASTRIC TUBE DURING ALL THE PROCESS. FLOW RATE STARTS AT 10 L/MIN AND IT WILL BE INCREASED A 10 L/MIN STEP EVERY 30 MINUTES UNTIL 60 L/MIN.
Eligibility Criteria
Criteria
Inclusion Criteria: CRITICALLY ILL PATIENTS AFTER MECHANICAL VENTILATION LASTED AT LEAST 72 HOURS
- age 18-80 years
Exclusion Criteria:
-
COPD stage >1 according to GOLD classification
-
end stage organ disease (liver, kidney, heart, lung)
-
neuromuscular disease
-
neoplasm
-
previous tracheostomy
-
obesity with BMI > 35 Kg/m2
-
non collaborative patient
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Cristian Deana | Udine | Italy | 33100 |
Sponsors and Collaborators
- Azienda Sanitaria-Universitaria Integrata di Udine
Investigators
- Principal Investigator: Cristian Deana, MD, Health Integrated Agency of Friuli Centrale, via Pozzuolo 330, 33100 Udine, Italy
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- HPEEP