Effects of Transcranial Oscillatory Direct Current Stimulation on the Functions of Cerebral Cortex in Healthy Subjects

• Sponsor: The First Hospital of Hebei Medical University (Other)
• Overall Status: Recruiting
• CT.gov ID: NCT06076044
• Collaborator: (none)
• Enrollment: 15
• Location: 1
• Arm: 1
• Anticipated Duration (Months): 7
• Patients Per Site Per Month: 2.1

Study Details

Study Description

Brief Summary

To investigate the effect of transcranial oscillatory direct current stimulation on functions of cerebral cortex (cortical excitability and frequency of eeg) in healthy subjects

Condition or Disease	Intervention/Treatment	Phase
Transcranial Direct Current Stimulation; Motor Evoked Potential; Healthy Subjects	Device: toDCS 2mA 1Hz; Device: toDCS 2mA 10Hz; Device: tDCS 1mA; Device: sham	N/A

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 15 participants
• Allocation: N/A
• Intervention Model: Single Group Assignment
• Masking: None (Open Label)
• Primary Purpose: Treatment
• Official Title: Effects of Transcranial Oscillatory Direct Current Stimulation on the Functions of Cerebral Cortex in Healthy Subjects
• Actual Study Start Date: Jun 1, 2023
• Anticipated Primary Completion Date: Nov 30, 2023
• Anticipated Study Completion Date: Dec 31, 2023

Arms and Interventions

Arm	Intervention/Treatment
Experimental: healthy subjects healthy male subjects aged 20-30 years	Device: toDCS 2mA 1Hz; The subgroup treated by transcranial oscillatory direct current stimulation of 2mA and 1Hz.; Device: toDCS 2mA 10Hz; The subgroup treated by transcranial oscillatory direct current stimulation of 2mA and 10Hz.; Device: tDCS 1mA; The subgroup treated by transcranial direct current stimulation of 1mA.; Device: sham; The subgroup treated by sham stimulation.

Outcome Measures

Primary Outcome Measures

1. MEP [before treatment and 20, 30, 40, 50, 60 minutes after treatment]

   Motor evoked potentials of the right abductor pollicis brevis were collected

2. Power Spectral Density of EEG [before treatment and right after treatment]

   The rest state EEG of the subjects was collected

Eligibility Criteria

Criteria

• Ages Eligible for Study: 20 Years to 30 Years
• Sexes Eligible for Study: Male
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• Healthy male

• Age ranges from 20 to 30 years old

• No history of neurological or psychiatric diseases, no history of chronic illness

• No positive results were found in the examination of the nervous system

• All right-handed according to Edinburgh Handedness Inventory

• The subjects voluntarily participated in this study and signed an informed consent form

Exclusion Criteria:

• Individuals with severe illnesses

• Previous history of brain surgery or epilepsy

• Individuals who experience changes in physical condition during the experiment

• Individuals with metal implants, such as pacemakers, DBS therapists, stents, etc

• Alcoholics

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	the First Hospital of Hebei Medical University	Shijiazhuang	Hebei	China	050031

Sponsors and Collaborators

• The First Hospital of Hebei Medical University

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Yuan Xing, Attending, Department of Neurology, Principal Investigator, The First Hospital of Hebei Medical University
• ClinicalTrials.gov Identifier: NCT06076044
• Other Study ID Numbers: FirstHebei
• First Posted: Oct 10, 2023
• Last Update Posted: Oct 10, 2023
• Last Verified: Oct 1, 2023

• Individual Participant Data (IPD) Sharing Statement: No
• Plan to Share IPD: No
• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No

Study Results

No Results Posted as of Oct 10, 2023