Effect of Transcranial Magnetic Stimulation on Dynamic Cerebral Autoregulation in Healthy Adults
Study Details
Study Description
Brief Summary
The purpose of this study is to determine the effect of transcranial magnetic stimulation with different stimulation modes ( 1Hz, 10Hz, sham stimulation ) on cerebral autoregulation.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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N/A |
Detailed Description
Current studies have shown that repetitive transcranial magnetic stimulation (TMS) can change the excitability of nerve cells, improve intracerebral artery blood supply, and even reduce the degree of neurological impairment in patients with ischemic stroke.Dynamic cerebral autoregulation (dCA), refers to a complex process in which small intracranial arteries contract or relax to maintain relatively stable cerebral blood volume when systemic arterial blood pressure changes, which can predict the prognosis of patients with ischemic stroke. In this study, we hypothesis that TMS provides neuro-protection by means of improving dCA.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Low-frequency rTMS Group Healthy adults treated with 1Hz repetitive transcranial magnetic stimulation (rTMS) |
Procedure: 1 Hz Repetitive transcranial magnetic stimulation
After enrollment, healthy adults received rTMS once a day (stimulation plan: stimulation of M1 region on the dominant hemisphere at 1Hz)
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| Experimental: High-frequency rTMS Group Healthy adults treated with 10Hz repetitive transcranial magnetic stimulation (rTMS) |
Procedure: 10 Hz Repetitive transcranial magnetic stimulation
After enrollment, healthy adults received rTMS once a day (stimulation plan: stimulation of M1 region on the dominant hemisphere at 10Hz)
|
| Sham Comparator: Control group The Control group received rTMS with sham transcranial magnetic stimulation (sham-rTMS) |
Procedure: Sham Repetitive transcranial magnetic stimulation
After enrollment, healthy adults received sham-rTMS once a day with the same parameters as the 10 Hz rTMS group, but the coil rotated 90° away from the scalp
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Outcome Measures
Primary Outcome Measures
- The differences of phase difference (PD) at 30 minutes after transcranial magnetic stimulation under different stimulation modes (1Hz, 10 Hz, sham stimulation). [0-30minutes]
A cerebral autoregulation parameter derived from transfer function analysis. Continuous cerebral blood flow velocities of bilateral middle cerebral artery will be assessed noninvasively using transcranial Doppler. Spontaneous arterial blood pressure will be simultaneously recorded using a servo-controlled plethysmograph on the left or right middle finger with an appropriate finger cuff size. Transfer function analysis will be used to derive the cerebral autoregulatory parameter.
Secondary Outcome Measures
- To compare the difference of phase difference (PD) at 1hour, 6hours and 24hours after transcranial magnetic stimulation under different stimulation modes (1Hz, 10Hz, sham stimulation). [0-1hour; 0-6hours; 0-24hours]
A cerebral autoregulation parameter derived from transfer function analysis. Continuous cerebral blood flow velocities of bilateral middle cerebral artery will be assessed noninvasively using transcranial Doppler. Spontaneous arterial blood pressure will be simultaneously recorded using a servo-controlled plethysmograph on the left or right middle finger with an appropriate finger cuff size. Transfer function analysis will be used to derive the cerebral autoregulatory parameter.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Age≥18 years, < 60 years, both genders；
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Willing to participate and sign the informed consent；
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Bilateral temporal windows were well penetrated;
Exclusion Criteria:
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Complaints of previous or existing chronic organic diseases ( stroke, Parkinson 's disease, hypertension, diabetes, etc. ), mental diseases ( bipolar disorder, personality disorder, schizophrenia, etc. ), or cognitive impairment;
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Suffering from infectious diseases in late one month;
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Pregnancy or breast-feeding;
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Sleep disorders, anxiety and depression,
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Alcohol or drug abuse;
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History of prescription drugs or over-the-counter (OTC) drugs in the past 2 weeks;
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History of epilepsy or family history of epilepsy;
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Implants ( stents or metals );
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Other conditions that the researchers think are not suitable for the project.
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Yi Yang
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- TMSCA-HA