Transcranial and Rapid Magnetic Stimulation for Gait Apraxia Due to Normal Pressure Hydrocephalus and Cerebral Ischemia

Sponsor

Devathasan Neurology Practice Pte Ltd (Other)

Overall Status

Unknown status

CT.gov ID

NCT00494689

Collaborator

(none)

Enrollment

Locations

Duration (Months)

Patients Per Site

0.2

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The investigator(neurologist) has published a study in International Congress Series, in the 15th International Conference of Biomagnetism Vancouver Proceedings 2006,and Science Direct website, of 15 patients with brain ischemia and dilated ventricles who improve when treated with transcranial monitoring or low ultrasound wave intensity (milliwatts) and with rapid magnetic stimulation which is also a diagnostic tool routinely used by many neurophysiologists. Before, these patients will progress and may need a brain shunt called Ventriculo-peritoneal shunt. He and collaborators now would like to do a double study as this appears to be a cheap and effective alternative treatment and help patients to walk again.

Condition or Disease	Intervention/Treatment	Phase
Walking Cognitive Function

Detailed Description

The transcranial monitoring intensity would be equivalent to the well known CLOTBUST study (<300mw/sq cm)for one hour, using two probes.

All will be treated as an outpatient and there is no form of infusion or interventional treatment.

The rapid magnetic stimulation is at about 50a/us, 15Hz, 1000 pulses with 10 sec pause for ten days along the skull vault. Informed consent will be obtained. 30 patients will be recruited and sham treatment would be just applying probe without power for transcranial and for magnetic stimulation coil will be angled away. Data will be compiled by a separate blinded investigator and so with the statistics. VP shunt failure patients, which is common, will be included. Barthel's daily living index and standard cognitive tests will be used to assess results.

Study Design

Study Type:

Observational

Anticipated Enrollment :

30 participants

Observational Model:

Case-Control

Time Perspective:

Prospective

Study Start Date :

Jan 1, 2002

Anticipated Study Completion Date :

Jun 1, 2007

Outcome Measures

Primary Outcome Measures

Eligibility Criteria

Criteria

Ages Eligible for Study:

N/A and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

cerebral ischemia with our without hydrocephalus and gait apraxia

Exclusion Criteria:

all other conditions which contribute to walking difficulty e.g. bad knees; or spondylosis; parkinson's or paralytic strokes

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Devathasan Neurology Practice #11-16 MEMC	Singapore		Singapore	228510
2	Devathasan Neurology Practice	Singapore		Singapore	228510

Sponsors and Collaborators

Devathasan Neurology Practice Pte Ltd

Investigators

Study Chair: Weng Kiong Aw Yong, Bsc (QUT), Freelancer Computer Programmer and data control

Study Documents (Full-Text)

None provided.

More Information

Publications

Devathasan G, Dinesh D. Rapid magnetic stimulation with sonolysis for gait apraxia due to to normal pressure hyprocephalus and cerebral ischemia. International Congress Series xx (2007)xxx-xxx( in press)

Responsible Party:

, ,

ClinicalTrials.gov Identifier:

NCT00494689

Other Study ID Numbers:

First Posted:

Jul 2, 2007

Last Update Posted:

Jul 2, 2007

Last Verified:

Jun 1, 2007

Keywords provided by , ,

transcranial sonolysis or monitoring

rapid magnetic stimulation

cerebral ischemia

hydrocephalus

Barthel's index

Additional relevant MeSH terms:

Hydrocephalus

Study Results

No Results Posted as of Jul 2, 2007