Transient ECG Changes in Patients With Acute Biliary Disease

Sponsor

Ziv Hospital (Other)

Overall Status

Unknown status

CT.gov ID

NCT01706068

Collaborator

(none)

100

Enrollment

Location

17.9

Duration (Months)

5.6

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Background:

The importance of ischemic ECG changes including St segment elevation, ST segment depression or T wave inversion that indicate myocardial ischemia are well established and require appropriate investigation and treatment.

However, there is an abundance of clinical situation, with apparently ischemic ECG change not indicate traditionally coronary artery related ischemia and therefore require prompt recognition and treatment of underlying condition, that may be serious and life-threatened. For example of such conditions are pericarditis, myocarditis, aortic dissection, electrolyte abnormalities, intracranial hemorrhage and hypothermia.

Together with them, an ECG ST segment changes may appeared in abdominal serious illness such as pancreatitis and cholecystitis(17,18,19,20,23). Whereas in pancreatitis various vasoactive and toxic for myocardium substances released, the cause of ST segment changes in cholecystitis are discussed and includes tachycardia , vagal reflexes, changed in plasma rennin activity resulted by distension of the gallbladder.

The certain proportion of the patients with ECG changes actually didn't have coronary artery disease(9,15) or other acute cardiac condition and therefore require treatment of the underlie illness only without spend the time for cardiac investigation or special treatment(1,3,4,7,8). Some kind of treatment may be even harmful for the patients with abdominal illness such as thrombolytic, anticoagulant, aggressive antiaggregant therapy or unnecessary cardiac catheterization.

In the medical literature the investigators found some case reports and works about the ECG changes in acute biliary disease in patient with knowing cardiac disease and without it, but actually incidence of ECG changes that suggest but not represent an acute coronary illness isn't knowing.

Therefore this is necessary to investigate actually incidence of ECG changes that mimic acute coronary syndrome in acute cholecystitis and acute biliary disease and determined clinical and laboratory characteristics that helps to differentiate this patients.

Condition or Disease	Intervention/Treatment	Phase
Acute Cholecystitis Biliary Colic Acute Cholangitis

Study Design

Study Type:

Observational

Anticipated Enrollment :

100 participants

Observational Model:

Case-Only

Time Perspective:

Retrospective

Official Title:

Transient ECG Changes in Patients With Acute Biliary Disease

Study Start Date :

Nov 1, 2012

Anticipated Primary Completion Date :

Nov 1, 2013

Anticipated Study Completion Date :

May 1, 2014

Outcome Measures

Primary Outcome Measures

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 75 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Patients from age 18 and up to 75years old.
Causes of admission to the ED are acute cholecystitis, biliary colic, acute cholangitis
The patient is willing to participate in the study and is able to sign an informed consent form.

Exclusion Criteria:

Elective hospitalization with known and not acute condition.
Inability to give inform consent .
Sepsis as complication of illness.
Chronic ECG changes known by medical history.
Knowing history of IHD.
Previous cardiac catheterization with documented stenosis of at least 1 major coronary artery equal or more 50%.