Transperineal Versus Transrectal Prostate Biopsy
Study Details
Study Description
Brief Summary
Background: Prostate biopsies are essential to diagnose prostate cancer (PCa). Transrectal prostate biopsies (TR-PB) are commonly performed, however disadvantages include the requirement of antibiotic prophylaxis (AP) and higher complication rates than transperineal prostate biopsies (TP-PB). Guidelines still recommend the use of AP for TP-PB due to the limited evidence regarding complication rates after their omission. However, the rising rates of antibiotic resistance is of concern. The aim of this study was to compare the complication and detection rates of freehand TP-PB without AP versus TR-PB with AP.
Methods: This single center retrospective study was performed in an academic hospital. TP-PB were introduced in 2019 and implemented as the main technique by late 2020. To compare the two techniques, data was collected for freehand TR-PB with AP between 2017-2018 and freehand TP-PB without AP between 2021-2022. The data from 2019 and 2020 were excluded to rule out the effects of the initial learning curve during the transition period. Primary outcome measure was post-biopsy complications occurring within 2 weeks, focusing on infectious complications. Secondary outcome measures were detection rates and upgrading/reclassification in the repeat biopsy in active surveillance (AS). Statistical analysis was performed using a Fisher exact or Chi-Squared test.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| transrectal biopsy
|
Procedure: prostate biopsy
Prostate biopsy by either transrectal or transperineal technique
|
| transperineal biopsy
|
Procedure: prostate biopsy
Prostate biopsy by either transrectal or transperineal technique
|
Outcome Measures
Primary Outcome Measures
- Complications [2 weeks]
Urinary tract infections, urinary retention, hematuria
Secondary Outcome Measures
- Detection rate [2 weeks]
Chance of detecting prostate cancer according to histopathology of needle biopsy
Eligibility Criteria
Criteria
Inclusion Criteria:
-
men who underwent prostate biopsy between 2017-2018 (transrectal)
-
men who underwent prostate biopsy between 2012-2022 (transperineal)
Exclusion Criteria:
-
positive urine culture before biopsy
-
patients in the transrectal biopsy group who did not take the prescribed course of antibiotic prophylaxis
-
incomplete medical dossier where the occurrence of a complication could not be assessed
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Maastricht University Medical Center | Maastricht | Netherlands | 6229HX |
Sponsors and Collaborators
- Maastricht University Medical Center
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- MUMC-Pbx23