Prevention of Healthcare Associated Infections in Bone Marrow Transplant Patients

Sponsor

University of British Columbia (Other)

Overall Status

Completed

CT.gov ID

NCT02463214

Collaborator

Vancouver Coastal Health Research Institute (Other)

Enrollment

Location

Arms

Duration (Months)

1.5

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This study involves sampling bone marrow transplant patients, hospital workers and the patient room for microbes using swabs and other techniques. We send these samples to the laboratory, where they will use state-of-the art technology to identify and relate the microbes to each other. This study also involves putting copper, nickel, or titanium into some hospital rooms, and seeing whether these metals influences the growth of microbes. Some equipment in the hospital room, such as faucets and soap dispensers will be replaced by sensor-based (e.g. touchless) controls.

Condition or Disease	Intervention/Treatment	Phase
Transplantation Infection	Other: Engineered Room	N/A

Detailed Description

Bacteria and other microbes are everywhere, the majority of which are harmless. They live on our bodies, on everyday objects, in food, and in our environment. They are passed around through the many interactions with other people and our surroundings. Some are even beneficial, helping us digest our food or protecting us from infections caused by harmful microbes.

In rare instances, some of the harmful microbes can cause infections. When a microbe causes an infection while we are in healthcare facilities, they are called "Healthcare-associated infections", or "HAIs". Examples that you may have heard of include Clostridium difficile, and MRSA (methicillin-resistant Staphylococcus aureus). Vancouver General Hospital already has some of the lowest HAI rates in the country. We have dedicated hospital workers that do a great job at preventing HAIs, but we are always looking for ways to be even better.

Study Design

Study Type:

Interventional

Actual Enrollment :

45 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Masking:

None (Open Label)

Primary Purpose:

Prevention

Official Title:

Prevention of Healthcare Associated Infections in Bone Marrow Transplant Patients

Study Start Date :

Sep 1, 2015

Actual Primary Completion Date :

Mar 1, 2018

Actual Study Completion Date :

Mar 1, 2018

Arms and Interventions

Arm	Intervention/Treatment
No Intervention: Standard Room Standard bone marrow transplant recovery, single occupancy, room
Experimental: Engineered Room Single occupancy bone marrow transplant recovery room, engineered with touchless devices, and surfaces coated with either copper or titanium dioxide.	Other: Engineered Room Touchless devices: Hand sanitizers, faucets, paper towel dispensers, call devices, Ultraviolet C Aseptix™ Disinfection devices above bathroom doors Copper products: Room and bathroom entrance door hardware, over bed table and bed side table surfaces, chair metal arms, wardrobe handles and knobs, weigh scale, sinks, grab bars, light switch panels, toilet flush handles, faucets and handles, patient bed rails. Titanium dioxide paint: Room walls, head walls, light switches, bathroom wall shelves, toilet tank and bowl, head wall unit fixed equipment, television remote and Bed Control remote

Arm

Intervention/Treatment

No Intervention: Standard Room

Standard bone marrow transplant recovery, single occupancy, room

Experimental: Engineered Room

Single occupancy bone marrow transplant recovery room, engineered with touchless devices, and surfaces coated with either copper or titanium dioxide.

Other: Engineered Room

Touchless devices: Hand sanitizers, faucets, paper towel dispensers, call devices, Ultraviolet C Aseptix™ Disinfection devices above bathroom doors Copper products: Room and bathroom entrance door hardware, over bed table and bed side table surfaces, chair metal arms, wardrobe handles and knobs, weigh scale, sinks, grab bars, light switch panels, toilet flush handles, faucets and handles, patient bed rails. Titanium dioxide paint: Room walls, head walls, light switches, bathroom wall shelves, toilet tank and bowl, head wall unit fixed equipment, television remote and Bed Control remote

Outcome Measures

Primary Outcome Measures

Change in bioburden on surfaces [up to 28 days]
Looking to see the effectiveness of copper and titanium on the microbiota in the environment of the recovery room.

Eligibility Criteria

Criteria

Ages Eligible for Study:

19 Years to 75 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria (Patients):

undergoing allogenic bone marrow transplant for acute myeloid leukemia
will be admitted to the leukemia and bone marrow transplant service at Vancouver General Hospital
admission to the ward anticipated to be approximately 28 days

Exclusion Criteria (Patients):

allergies to copper, nickel or titanium
patients admitted for stays anticipated to be less than 28 days

Inclusion Criteria (Health care worker):

undergoing allogenic bone marrow transplant for acute myeloid leukemia
caring for patient enrolled in the study as a primary nurse

Exclusion Criteria (Health care worker):

allergies to copper, nickel or titanium

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Vancouver General Hospital	Vancouver	British Columbia	Canada	V5Z 1M9

Sponsors and Collaborators

University of British Columbia
Vancouver Coastal Health Research Institute

Investigators

Principal Investigator: Linda Hoang, MD FRCPC, The University of British Columbia
Principal Investigator: Elizabeth Bryce, MD FRCPC, The University of British Columbia
Principal Investigator: Patrick Tang, MD PhD FRCPC, Sidra Medical and Research Center

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Linda Hoang, Medical Microbiologist, BC Centre for Disease Control, University of British Columbia

ClinicalTrials.gov Identifier:

NCT02463214

Other Study ID Numbers:

H15-00662

First Posted:

Jun 4, 2015

Last Update Posted:

Apr 17, 2019

Last Verified:

Apr 1, 2019

Additional relevant MeSH terms:

Infections

Communicable Diseases

Cross Infection

Study Results

No Results Posted as of Apr 17, 2019