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The Use of Transcranial Direct Current Stimulation (tDCS) to Study Implicit Motor Learning on Patients With Brain Injury

Sponsor
National Taiwan University Hospital (Other)
Overall Status
Withdrawn
CT.gov ID
NCT01127789
Collaborator
(none)
0
Enrollment
1
Location
1
Arm
32.1
Duration (Months)
0
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to study motor learning and recovery of patients with brain damage caused by traumatic brain injury or stroke with transcranial direct current stimulation (tDCS). It is hypothesized that anodal tDCS on the lesion side and/or cathodal tDCS on the healthy side of motor cortex could improve the recovery of motor function such as learning.

Condition or Disease Intervention/Treatment Phase
  • Device: Transcranial Direct Current Stimulation
 Phase 1

Detailed Description

We aim to apply transcranial direct current stimulation (tDCS) to study the recovery process of motor learning on the patients with brain damage caused by traumatic brain injury or stroke. Both anodal and cathodal tDCS will be used to test whether the increase of motor cortical activity by anodal tDCS over lesional side or the decrease of brain activity by cathodal tDCS on healthy side will improve the learning skill (SRTT: serial reaction time task). The result could help to understand the mechanism of motor and cognitive recovery after brain damage, and further rationalize the application of non-invasive brain stimulation such as tDCS for patient rehabilitation.

Study Design

Study Type:
Interventional
Actual Enrollment :
0 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Double (Participant, Investigator)
Primary Purpose:
Treatment
Official Title:
The Use of Transcranial Direct Current Stimulation (tDCS) to Study Implicit Motor Learning on Patients With Brain Injury
Study Start Date :
Mar 1, 2010
Actual Primary Completion Date :
Mar 1, 2011
Actual Study Completion Date :
Nov 1, 2012

Arms and Interventions

Arm Intervention/Treatment
Experimental: non-invasive brain stimulation

Device: Transcranial Direct Current Stimulation
Transcranial Direct Current Stimulation
Other Names:
  • Chanttanooga ionto Dual Channel Stimulator

    		•

    Outcome Measures

    Primary Outcome Measures

    1. Reaction time (millisecond) [24 hours post intervention]

      Primary outcome measure is the average reaction time of 360 trials from each block -- the task is composed of 8 blocks. After intervention, 3 blocks will be re-tested for 3 times to evaluate the consolidating effect of tDCS on motor learning.

    Secondary Outcome Measures

    1. Error rate (percentage) [24 hours post intervention]

      Secondary outcome measure is the error rate of each block which will be re-tested for 3 times after intervention. The aim is to evaluate the motor learning effect during and after tDCS.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 65 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • TBI or stroke patients

    • with partially preserved fine motor function

    Exclusion Criteria:

    • with metal clips in head or device (e.g. pacemaker)

    • with active CNS drugs

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Dpt. Physical Medicine and Rehabilitation, NTUH Taipei Taiwan 100

    Sponsors and Collaborators

    • National Taiwan University Hospital

    Investigators

    • Principal Investigator: Wen-Shiang Chen, MD, PhD, Dpt. Physical Medicine and Rehabilitation, NTUH Taipei, Taiwan

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    National Taiwan University Hospital
    ClinicalTrials.gov Identifier:
    NCT01127789
    Other Study ID Numbers:
    • 200910005R
    First Posted:
    May 21, 2010
    Last Update Posted:
    Dec 21, 2012
    Last Verified:
    Nov 1, 2012
    Additional relevant MeSH terms:
    Brain Injuries
    Brain Injuries, Traumatic
    Wounds and Injuries

    Study Results

    No Results Posted as of Dec 21, 2012