The Combination Therapy of Nanofat Grafting and PRP Compared With Microfat Grafting and PRP Synergy in Treating Striae Distensae
Study Details
Study Description
Brief Summary
Striae distensae is caused by the fracture and damage of the elastic fibers and collagen fibers, which is still a difficulty to overcome. Based on the studies demonstrated that platelet-rich plasma(PRP) has positive effect on superficial scar, and nanofat and microfat are effective in treating atrophic scar. So in this clinical trial, the investigators are going to treat striae distensae by using two combination therapies. One is nanofat grafting and PRP injection synergy, and the other one is treated by microfat grafting with PRP injection.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
The participants were randomly assigned into two groups. Group A is treated by nanofat grafting once every three months for 2 times combined with PRP injection once a month for 6 times. Group B will be treated by microfat grafting onceevery three months for 2 times combined with PRP injection once a month for 6 times. The participants were asked to come back 1、3、6、9 months after treatment for further follow-up.Before and after the treatment, the striae distensae will be assessed subjectively by satisfaction assessment, and objectively by ultrasound and immunohistochemical analysis.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Nanofat grafting and PRP injection Striae diatensae will be treated by nanofat grafting once every three months for 2 times combined with PRP injection once a month for 6 times. |
Procedure: Nanofat grafting
Nanofat grafting will be applied once every three months for 2 times.
Procedure: Platelet-rich plasma (PRP) Injection
PRP Injection will be applied once a month for 6 times.
|
| Experimental: Microfat grafting and PRP injection Striae diatensae will be treated by microfat grafting once every three months for 2 times combined with PRP injection once a month for 6 times. |
Procedure: Microfat grafting
Microfat grafting will be applied once every three months for 2 times.
Procedure: Platelet-rich plasma (PRP) Injection
PRP Injection will be applied once a month for 6 times.
|
Outcome Measures
Primary Outcome Measures
- Immunohistochemical analysis [Change from baseline at 15 months.]
The tissue extracted will be taken for immunohistochemical analysis to observe the amount of elastic fiber and collagen fiber,etc. More collagen fiber generated better outcome of the treatments.
Secondary Outcome Measures
- Ultrasound [Change from baseline dermal thickness at 3,6,9,12,15 months of the treatments.]
The striae distensae will be assessed by ultrasound in order to observe the change of dermal thickness of striae after the application of nanofat or microfat grafting with PRP injection. if the treatments worked, the dermal thickness will be increased.
- Ultrasound [Change from baseline width of striae at 3,6,9,12,15 months of the treatments.]
The striae distensae will be assessed by ultrasound in order to observe the change of width of striae after the application of nanofat or microfat grafting with PRP injection. Smaller the width better the results.
Other Outcome Measures
- Satisfaction assessments of participants: questionnaire [At 15th month.]
The participants will fill in a questionnaire about the efficacy of the treatments. Participants will choose one of the following answers 'satisfied, unchanged, not satisfied' as feedback.
Eligibility Criteria
Criteria
Inclusion Criteria:
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The striae distensae
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Age ≤ 35 years old
Exclusion Criteria:
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Skin allergy
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Cicatricial diathesis
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Skin inflammation or wound
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Platelet dysfunction syndrome
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Take anticoagulant drugs
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Acute or chronic infection
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Chronic liver disease
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Active vitiligo, psoriasis, systemic lupus erythematosus
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | The First Affiliated Hospital of Jinan University | Guangzhou | Guangdong | China | 500011 |
Sponsors and Collaborators
- First Affiliated Hospital of Jinan University
- Science and Technology Program of Guangzhou,Guangzhou Sipintang Biological technology Co., Ltd.
Investigators
- Principal Investigator: Li Ling Xiao, MD, First Affiliated Hospital of Jinan University
Study Documents (Full-Text)
More Information
Publications
- Cho C, Cho E, Kim N, Shin J, Woo S, Lee J, Lee J, Lee E, Ha J. Biophysical properties of striae rubra and striae alba in human skin: Comparison with normal skin. Skin Res Technol. 2019 May;25(3):283-288. doi: 10.1111/srt.12645. Epub 2018 Oct 22.
- Forbat E, Al-Niaimi F. Treatment of striae distensae: An evidence-based approach. J Cosmet Laser Ther. 2019;21(1):49-57. doi: 10.1080/14764172.2017.1418515. Epub 2018 Feb 16. Review.
- Hague A, Bayat A. Therapeutic targets in the management of striae distensae: A systematic review. J Am Acad Dermatol. 2017 Sep;77(3):559-568.e18. doi: 10.1016/j.jaad.2017.02.048. Epub 2017 May 24. Review.
- Watson RE, Parry EJ, Humphries JD, Jones CJ, Polson DW, Kielty CM, Griffiths CE. Fibrillin microfibrils are reduced in skin exhibiting striae distensae. Br J Dermatol. 1998 Jun;138(6):931-7.
- Xiao FirstJinanU