Safety Study of Increasing Doses of Combretastatin in Combination With Bevacizumab (Avastin) in Patients With Advanced Solid Tumors

Sponsor

Mateon Therapeutics (Industry)

Overall Status

Completed

CT.gov ID

NCT00395434

Collaborator

(none)

Enrollment

Locations

Duration (Months)

Patients Per Site

2.5

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to determine the safety and tolerability of three dose levels of combretastatin A4 phosphate (CA4P) given intravenously (IV) in combination with bevacizumab every 14 days in patients with advanced solid tumors. The maximum tolerated dose will be defined if it is at one of the three dose levels under study.

Condition or Disease	Intervention/Treatment	Phase
Tumors	Drug: Combretastatin A4 Phosphate (CA4P) Drug: Bevacizumab (Avastin)	Phase 1

Study Design

Study Type:

Interventional

Anticipated Enrollment :

20 participants

Allocation:

Non-Randomized

Intervention Model:

Parallel Assignment

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

OXC4P1-105: A Phase I Study of the Safety, Tolerability, and Antitumor Activity of Escalating Doses of Combretastatin A4 Phosphate Given in Combination With Bevacizumab to Subjects With Advanced Solid Tumors

Study Start Date :

Sep 1, 2006

Actual Primary Completion Date :

Jan 1, 2007

Actual Study Completion Date :

Jan 1, 2007

Outcome Measures

Primary Outcome Measures

safety and tolerability of the combination therapy assessed by analysis of adverse events []
safety and tolerability of the combination therapy assessed by analysis of laboratory tests []
safety and tolerability of the combination therapy assessed by analysis of other assessments within the protocol []

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Histopathologically or cytologically confirmed malignant solid tumors that have failed standard therapy or for which no life prolonging treatment exists
Measurable disease as defined by the Response Evaluation Criteria in Solid Tumors (RECIST) criteria
At least 4 weeks since any prior immunotherapy, chemotherapy or radiation therapy prior to first dose of study drug (six weeks for therapy known to be associated with delayed toxicity such as nitrosoureas or mitomycin-C)
Age > or = to 18 years old
Adequate bone marrow function:
absolute granulocyte count (neutrophils and bands) > or = to 1500 cells/mm3;
platelet count > or = to 100,000 cells/mm3;
hemoglobin > or = to 9 g/dL.
Adequate renal function (glomerular filtration calculated by Cockcroft/Gault formula or measure urine creatinine clearance > or = to 50 mL/minute)
Adequate hepatic function:
bilirubin less than or = to 1.5 mg/dL;
aspartate transaminase (AST) and alanine transaminase (ALT) less than or = to 2.5 times the institutional upper limit of normal (ULN) (or less than or = to 5 times ULN if liver metastases are present).
Eastern Cooperative Oncology Group (ECOG) performance status 0-2
Life expectancy of > or = to 12 weeks
Written, signed, dated, and witnessed (if applicable as per International Conference on Harmonization [ICH] guidelines) Independent Ethics Committee (IEC) approved informed consent form before any study specific screening procedures are performed
Fertile subjects must abstain from sexual intercourse or use effective birth control.
All women of child bearing potential (WOCBP) must have a negative serum pregnancy test within 72 hours of first dose.

Exclusion Criteria:

Contraindications, allergies or sensitivity to the use of the study medications or any other products required for participation in this study (i.e. contrast agents)
Presence of central nervous system (CNS) metastases
Diagnosed squamous non-small cell lung cancer (NSCLC)
History of gastrointestinal perforations
Surgery within 28 days of screening visit or a surgical incision that is not fully healed. Any surgery planned during the study period.
Proteinuria >1 g/24 hours by 24 hour urine collection (perform 24 hour urine collection if > 1+ on dipstick)
Recent hemoptysis (occurrence within the past 3 months)
Prior therapy with CA4P or bevacizumab, or other agents which target vascular endothelial growth factor (VEGF) or VEGFR signaling such as Sorafenib and Sutent
Prior radiation involving > 30% of the bone marrow
Radical radiotherapy to the thorax or abdomen at any time or post-operative radical radiotherapy to the pelvis. Palliative radiotherapy treatments are acceptable. Subjects with rectal primaries who have received pre-operative pelvic radiotherapy or chemoradiation are eligible if the small bowel was mobile and not stuck to the tumor.
Active autoimmune disorder(s)
Immunocompromised, including subjects known to be human immunodeficiency virus (HIV) positive
Active infection requiring antibiotic therapy or any other serious intercurrent illness
History of angina (stable or severe, even if controlled with medications), myocardial infarction, congestive heart failure (CHF), non-controlled atrial arrhythmias or clinically significant arrhythmias including conduction abnormality, nodal junctional arrhythmias and dysrhythmias, sinus bradycardia or tachycardia, supraventricular arrhythmias, atrial fibrillation or flutter, syncope or vasovagal episodes
Electrocardiogram (ECG) with evidence of prior myocardial infarction (e.g., significant Q waves), QTc > 450 msec or other clinically significant abnormalities
Taking any drug(s) known to prolong the QTc interval, which cannot be interrupted for at least four days during each treatment cycle.
Known significant heart wall abnormality or heart muscle damage as evidenced on multiple-gated acquisition (MUGA) scan or echocardiogram (this is not a required screening investigation)
Uncontrolled hypertension (defined as blood pressure consistently greater than 150/100 irrespective of medication). Or controlled hypertension requiring use of > 2 classes of anti-hypertensives.
Uncontrolled hypokalemia and/or hypomagnesemia
Symptomatic peripheral vascular disease or cerebrovascular disease
Psychiatric disorders or other conditions rendering subjects incapable of complying with the requirements of the protocol
Receiving concurrent hormonal therapy with the exception of gonadotropin-releasing hormone (GnRH) agonists in subjects with hormone refractory prostate cancer, hormone replacement therapy (HRT), oral contraceptives, and megestrol acetate used for anorexia/cachexia
Receiving anticoagulation with warfarin, heparin or low molecular weight heparin other than low dose (1 mg) warfarin for maintenance of central line patency
Women who are currently pregnant, nursing, or planning a pregnancy; or women who have a positive pregnancy test.
Receiving concurrent antineoplastic therapy (radiation therapy, cytotoxic or biologic therapy)
Participation in an investigational drug or device trial within 30 days of entering the study.