Measurement of Glucose Metabolism in Humans: Effect of Recurrent Hypoglycemia on Hypothalamic GABA
Study Details
Study Description
Brief Summary
You are invited to participate in a study designed to investigate the effects of diabetes mellitus, high and low glucose, and high blood insulin on the brain. You were selected as a possible participant because you fit into one of the following categories. a) you are either healthy and competent, are not pregnant and you have no known medical disease and therefore your glucose metabolism will be typical of a normal person, or b) you have diabetes.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
Glucose is a major fuel for most organs in the human body, particularly the brain. How and where the body uses glucose is regulated by a number of hormones, for instance insulin and glucagon. In a number of diseases, in particular diabetes mellitus, the glucose supply to the brain may be different than normal, which may be a cause for reduced glucose awareness.
The purpose of this study is to determine the effects of altered glucose metabolism on the brain. For example, patients with long duration diabetes mellitus lose their ability to secrete the hormones necessary to protect them against hypoglycemia, which may be due to alterations in glucose availability to the human brain.
To measure these effects, we will use intravenous infusions of glucose and insulin.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: type 1 diabetes type 1 diabetes >5 years duration |
Other: hypoglycemia (low blood sugar) and MRI
hypoglycemia (low blood sugar) and MRI
|
| Placebo Comparator: healthy controls
|
Other: hypoglycemia (low blood sugar) and MRI
hypoglycemia (low blood sugar) and MRI
|
Outcome Measures
Primary Outcome Measures
- Change in Euglycemic GABA level in hypothalamus using MRI [Baseline to 2 month]
MRI measurement of GABA in the hypothalamus
Eligibility Criteria
Criteria
Inclusion Criteria:
-
well controlled type 1 diabetes (hemoglobin A1c <7.5%)
-
age 18-65
-
healthy controls
Exclusion Criteria:
-
history of stroke, seizures, neurosurgical procedures, or arrhythmias
-
use of drugs that can alter GABA metabolism (such as benzodiazepines).
-
Subjects must also meet requirements for a study in the magnet, which includes weight less than 300 lbs and the absence of metallic substances in their body.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of Minnesota | Minneapolis | Minnesota | United States | 55455 |
Sponsors and Collaborators
- University of Minnesota
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 1511M80568