T-REX: Timing of Resistance Exercise in Type 1 Diabetes
Study Details
Study Description
Brief Summary
The aims of the current study are
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to compare the effects of acute morning and afternoon resistance exercise on blood glucose levels in people with type 1 diabetes.
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to compare the effects of morning and afternoon resistance exercise training on cardiometabolic health outcomes in people with type 1 diabetes
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Placebo Comparator: Control Habitual physical activity |
Behavioral: Habitual physical activity levels
Participants will be asked to maintain their normal activity levels
|
| Active Comparator: Morning exercise Exercise training between 6-10am |
Behavioral: Morning exercise
Between 6-10am participants will attend the gym and perform 10 min of warm up exercise, 3 sets of 7 resistance exercises ( leg press, calf press, leg curl, chest press, lateral raise, seated row and plank)
|
| Active Comparator: Afternoon exercise Exercise training between 4-8pm |
Behavioral: Afternoon exercise
Between 4-8pm participants will attend the gym and perform 10 min of warm up exercise, 3 sets of 7 resistance exercises ( leg press, calf press, leg curl, chest press, lateral raise, seated row and plank)
|
Outcome Measures
Primary Outcome Measures
- Change in muscle strength [Change from baseline to 12 weeks]
Sum of one repetition maximum for the 7 resistance exercise
- Change in interstitial glucose time in range [Change from 6 hours before (baseline) to 6 hours after (post-exercise) an exercise training session]
Interstitial glucose time in range (3.9-10mmol/L) measured via continuous glucose monitoring
Secondary Outcome Measures
- Change in appendicular skeletal muscle mass [Change from baseline to 12 weeks]
Measured by DEXA
- Change in whole body fat mass [Change from baseline to 12 weeks]
Measured by DEXA
- Change in physical function [Change from baseline to 12 weeks]
Measured by the short performance physical battery
- Change in HbA1c [Change from baseline to 12 weeks]
HbA1c concentration
- Change in interstitial glucose average [Change from 6 hours before (baseline) to 6 hours after (post-exercise) an exercise training session]
Interstitial average glucose measured via continuous glucose monitoring
- Change in interstitial glucose variability [Change from 6 hours before (baseline) to 6 hours after (post-exercise) an exercise training session]
Interstitial glucose variability measured via continuous glucose monitoring
- Change in interstitial glucose time in hypoglycaemia [Change from 6 hours before (baseline) to 6 hours after (post-exercise) an exercise training session]
Interstitial glucose time in range (<3.9mmol/L) measured via continuous glucose monitoring
- Change in interstitial glucose time in hyperglycaemia [Change from 6 hours before (baseline) to 6 hours after (post-exercise) an exercise training session]
Interstitial glucose time in range (>10mmol/L) measured via continuous glucose monitoring
Eligibility Criteria
Criteria
Inclusion Criteria:
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Physician confirmed type 1 diabetes for at least 1 year
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Stable insulin therapy for 3 months prior to the study
Exclusion Criteria:
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BMI of 45 or higher
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BP of 160/100mmHg or higher
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autonomic neuropathy
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severe proliferative retinopathy
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joint or limb injuries preventing weight-bearing activity
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autonomic neuropathy
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severe proliferative retinopathy
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any other medical condition that prevents participants from exercising safely.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Dasman Diabetes Institute | Kuwait City | Kuwait | 15462 |
Sponsors and Collaborators
- Dasman Diabetes Institute
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- RA HM-2023-009