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HITPET: The Effects of Short-time High-intensity Interval Training on Tissue Glucose and Fat Metabolism in Healthy Subjects and Patients With Type 2 Diabetes

Sponsor
Turku University Hospital (Other)
Overall Status
Unknown status
CT.gov ID
NCT01344928
Collaborator
European Foundation for the Study of Diabetes (Other), Ministry of Education and Culture, Finland (Other), Orion Farmos Research Foundation (Other), Academy of Finland (Other), Turku PET Centre (Other), University of Turku (Other), Verve Research, Oulu, Finland (Other), University of Helsinki (Other)
1
Location
2
Arms

Study Details

Study Description

Brief Summary

The objectives of this study are to investigate the effects of short-time high-intensity interval training on tissue glucose and fat metabolism in healthy lean subjects and type 2 diabetic patients using modern and noninvasive imaging methods positron emission tomography (PET), magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS).

Condition or Disease Intervention/Treatment Phase
  • Behavioral: HIT exercise intervention
  • Behavioral: Aerobic exercise intervention
 N/A

Study Design

Study Type:
Interventional

Arms and Interventions

Arm Intervention/Treatment
Experimental: HIT training

Behavioral: HIT exercise intervention
Active Comparator: Aerobic exercise training

Behavioral: Aerobic exercise intervention

Outcome Measures

Primary Outcome Measures

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    40 Years to 55 Years
    Sexes Eligible for Study:
    Male
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    The healthy patients

    1. Age 40-55

    2. BMI 18.5-30

    3. Fasting plasma glucose less than 6.1 mmol/l

    4. Normal glucose tolerance test (OGTT)

    The type 2 diabetic patients:

    1. Age-, sex-, and BMI-matched with the study subjects in the phase 1

    2. In a good treatment balance

    3. Glycated haemoglobin (HbA1c) less than 7.5 mmol/l

    4. Two hours glucose value in oral glucose tolerance test (OGTT) less than 10.0 mmol/l

    Exclusion Criteria:

    The healthy patients

    1. Blood pressure > 140/90 mmHg

    2. Any chronic disease

    3. Any chronic medical defect or injury which hinder/interfere everyday life

    4. History of anorexia nervosa or bulimia

    5. History of rest or exercise-induced asthma

    6. Previous use of anabolic steroids, additives or any other substrates

    7. Smoking of tobacco, taking of snuffs, or use of narcotics.

    8. Significant use of alcohol

    9. Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results

    10. Presence of any ferromagnetic objects that would make MR imaging contraindicated

    11. Current or history of regular and systematic exercise training

    12. VO2max >40 ml/min/kg

    The type 2 diabetic patients:

    1. Any other chronic disease than diabetes

    2. Blood pressure > 140/90 mmHg

    3. Any chronic medical defect or injury which hinder/interfere everyday life

    4. History of anorexia nervosa or bulimia

    5. History of rest or exercise-induced asthma

    6. Smoking of tobacco, taking of snuffs, or use of narcotics.

    7. Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results

    8. Presence of any ferromagnetic objects that would make MRI imaging contraindicated

    9. Current or history of regular and systematic exercise training

    10. VO2max >40 ml/ min/kg

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Turku PET Centre Turku Finland 20521

    Sponsors and Collaborators

    • Turku University Hospital
    • European Foundation for the Study of Diabetes
    • Ministry of Education and Culture, Finland
    • Orion Farmos Research Foundation
    • Academy of Finland
    • Turku PET Centre
    • University of Turku
    • Verve Research, Oulu, Finland
    • University of Helsinki

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    , ,
    ClinicalTrials.gov Identifier:
    NCT01344928
    Other Study ID Numbers:
    • 95/180/2010
    First Posted:
    Apr 29, 2011
    Last Update Posted:
    Apr 29, 2011
    Last Verified:
    Apr 1, 2011
    Additional relevant MeSH terms:
    Diabetes Mellitus, Type 2

    Study Results

    No Results Posted as of Apr 29, 2011