SURPASS-CVOT: A Study of Tirzepatide (LY3298176) Compared With Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes

Sponsor

Eli Lilly and Company (Industry)

Overall Status

Recruiting

CT.gov ID

NCT04255433

Collaborator

(none)

12,500

Enrollment

650

Locations

Arms

52.6

Anticipated Duration (Months)

19.2

Patients Per Site

0.4

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of the trial is to assess the efficacy and safety of tirzepatide to dulaglutide in participants with type 2 diabetes and increased cardiovascular risk.

Condition or Disease	Intervention/Treatment	Phase
Type 2 Diabetes Mellitus	Drug: Tirzepatide Drug: Dulaglutide	Phase 3

Study Design

Study Type:

Interventional

Anticipated Enrollment :

12500 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Masking:

Double (Participant, Investigator)

Primary Purpose:

Treatment

Official Title:

The Effect of Tirzepatide Versus Dulaglutide on Major Adverse Cardiovascular Events in Patients With Type 2 Diabetes (SURPASS-CVOT)

Actual Study Start Date :

May 29, 2020

Anticipated Primary Completion Date :

Oct 17, 2024

Anticipated Study Completion Date :

Oct 17, 2024

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Tirzepatide Tirzepatide administered subcutaneously (SC) once a week.	Drug: Tirzepatide Administered SC Other Names: LY3298176
Active Comparator: Dulaglutide Dulaglutide administered SC once a week.	Drug: Dulaglutide Administered SC Other Names: LY2189265

Arm

Intervention/Treatment

Experimental: Tirzepatide

Tirzepatide administered subcutaneously (SC) once a week.

Drug: Tirzepatide

Administered SC

Other Names:

LY3298176

Active Comparator: Dulaglutide

Dulaglutide administered SC once a week.

Drug: Dulaglutide

Administered SC

Other Names:

LY2189265

Outcome Measures

Primary Outcome Measures

Time to First Occurrence of Death from Cardiovascular (CV) Causes, Myocardial Infarction (MI), or Stroke (MACE-3) [Randomization up to Study Completion (Approximate Maximum 54 Months)]
Time to First Occurrence of a component event of MACE-3

Secondary Outcome Measures

Time to Death from Any Cause [Randomization up to Study Completion (Approximate Maximum 54 Months)]
Time to Death from Any Cause
Time to CV Death [Randomization up to Study Completion (Approximate Maximum 54 Months)]
Time to CV Death
Time to First Occurrence of MI [Randomization up to Study Completion (Approximate Maximum 54 Months)]
Time to First Occurrence of MI
Time to First Occurrence of Stroke [Randomization up to Study Completion (Approximate Maximum 54 Months)]
Time to First Occurrence of Stroke
Time to First Occurrence of the Expanded Composite of CV Death, MI, Stroke, Coronary Revascularization, or Hospitalization for Unstable Angina [Randomization up to Study Completion (Approximate Maximum 54 Months)]
Time to First Occurrence of the Expanded Composite of CV Death, MI, Stroke, Coronary Revascularization, or Hospitalization for Unstable Angina
Cumulative Number of CV Deaths and Total (First and Recurrent) Heart Failure Events Requiring Hospitalization and/or Urgent Heart Failure Visits [End of Study (Approximate Maximum 54 Months)]
Cumulative Number of CV Deaths and Total (First and Recurrent) Heart Failure Events Requiring Hospitalization and/or Urgent Heart Failure Visits
Percentage of Participants with More than 10% Weight Loss [36 Months]
Percentage of Participants with More than 10% Weight Loss
Change from Baseline in Body Weight [Baseline, End of Study (Approximate Maximum 54 Months)]
Change from Baseline in Body Weight
Change from Baseline in Hemoglobin A1c (HbA1c) [Baseline, End of Study (Approximate Maximum 54 Months)]
Change from Baseline in HbA1c
Change from Baseline in Urinary Albumin to Creatinine Ratio [Baseline, End of Study (Approximate Maximum 54 Months)]
Change from Baseline in Urinary Albumin to Creatinine Ratio
Change from Baseline in Blood Lipids [Baseline, End of Study (Approximate Maximum 54 Months)]
Change from Baseline in Blood Lipids (Total Cholesterol, Low-Density Lipoprotein Cholesterol, High-Density Lipoprotein Cholesterol, and Triglycerides)
Time to First Occurrence of Revascularization [Randomization up to Study Completion (Approximate Maximum 54 Months)]
Time to First Occurrence of Revascularization
Time to First Occurrence of Hospitalization Due to Unstable Angina [Randomization up to Study Completion (Approximate Maximum 54 Months)]
Time to First Occurrence of Hospitalization Due to Unstable Angina
Time to First Occurrence of New or Worsening Nephropathy [Randomization up to Study Completion (Approximate Maximum 54 Months)]
Time to First Occurrence of New or Worsening Nephropathy
Cumulative Number of Primary Composite Events of CV Death and Total (First and Recurrent) MI and/or Stroke [End of Study (Approximate Maximum 54 Months)]
Cumulative Number of Primary Composite Events of CV Death and Total (First and Recurrent) MI and/or Stroke

Eligibility Criteria

Criteria

Ages Eligible for Study:

40 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Have a diagnosis of type 2 diabetes
Have confirmed atherosclerotic cardiovascular disease
HbA1c ≥7.0% to ≤10.5%
Body mass index (BMI) ≥25 kilograms per meter squared (kg/m²)

Exclusion Criteria:

Have had a major cardiovascular event within the last 60 days
Have type 1 diabetes mellitus
Have a history of severe hypoglycemia and/or hypoglycemia unawareness within the last 6 months
Are currently planning treatment for diabetic retinopathy and/or macular edema
Currently planning a coronary, carotid, or peripheral artery revascularization
Have a history of pancreatitis
Have a history of ketoacidosis or hyperosmolar state/coma
Have a known clinically significant gastric emptying abnormality, have undergone or currently planning any gastric outlet obstruction, or have undergone or currently planning any gastric bypass (bariatric) surgery or restrictive bariatric surgery
Have a history of an active or untreated malignancy or are in remission from a clinically significant malignancy for less than 5 years
Have a family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2)
Have had a blood transfusion or severe blood loss within 90 days prior to screening or have known hematological conditions that may interfere with HbA1c measurement

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University of Alabama at Birmingham Medical Center	Birmingham	Alabama	United States	35294
2	John Muir Physician Network Clinical Research Center	Concord	California	United States	94520
3	Valley Clinical Trials, Inc.	Covina	California	United States	91723
4	AMCR Institute	Escondido	California	United States	92025
5	Valley Endocrine, Fresno	Fresno	California	United States	93720
6	NorCal Medical Research, Inc	Greenbrae	California	United States	94904
7	UCSD Clinical & Translational Research Institute	La Jolla	California	United States	92037
8	Diabetes and Endocrine Associates	La Mesa	California	United States	91942
9	First Valley Medical Group	Lancaster	California	United States	93534
10	Monterey Endocrine & Diabetes Institute, Inc.	Monterey	California	United States	93940
11	Riverside County Regional Medical Center	Moreno Valley	California	United States	92555
12	Valley Clinical Trials, Inc.	Northridge	California	United States	91325
13	Diabetes Associates Medical Group	Orange	California	United States	92868
14	Pasadena Clinical Research	Pasadena	California	United States	91105
15	LCGK Research	San Carlos	California	United States	94070
16	NorCal Endocrinology and Internal Medicine - Roseville	San Ramon	California	United States	94583
17	Harbor UCLA Medical Center	Torrance	California	United States	90502
18	Coastal Metabolic Research Centre	Ventura	California	United States	93003
19	University of Colorado Hospital	Aurora	Colorado	United States	80045
20	CMR of Greater New Haven	Hamden	Connecticut	United States	06517
21	Chase Medical Research, LLC	Waterbury	Connecticut	United States	06708
22	Orlando Heart & Vascular Institute, LLC	Altamonte Springs	Florida	United States	32714
23	Excel Medical Clinical Trials	Boca Raton	Florida	United States	33434
24	Encore Medical Research	Hollywood	Florida	United States	33021
25	East Coast Institute for Research, LLC	Jacksonville	Florida	United States	32204
26	Jacksonville Center for Clinical Research	Jacksonville	Florida	United States	32216
27	Ocala Cardiovascular Research	Ocala	Florida	United States	34471
28	Cardiology Partners Clinical Research Institute, LLC-Palm Beach Gardens	Palm Beach Gardens	Florida	United States	33410
29	Charlotte Heart & Vascular Institute	Port Charlotte	Florida	United States	33952
30	Meridien Research	Saint Petersburg	Florida	United States	33709
31	Professional Health Care of Pinellas	Saint Petersburg	Florida	United States	33713
32	Cardiology Partners Clinical Research Institute - Wellington	Wellington	Florida	United States	33449
33	Clinical Research of Central Florida	Winter Haven	Florida	United States	33880
34	Ellipsis Group	Alpharetta	Georgia	United States	30022
35	Atlanta Diabetes Associates	Atlanta	Georgia	United States	30318
36	Kaiser Permanente - Dutluth, GA	Duluth	Georgia	United States	30096
37	NSC Research	Johns Creek	Georgia	United States	30024
38	Physicians Research Associates	Lawrenceville	Georgia	United States	30046
39	East Coast Institute for Research, LLC	Macon	Georgia	United States	31210
40	Atlanta Heart Specialists	Tucker	Georgia	United States	30084
41	East-West Medical Research Institute	Honolulu	Hawaii	United States	96814
42	PHREI - Pacific Health Research and Education Institute - VA Pacific Islands Health Care System	Honolulu	Hawaii	United States	96819
43	Elite Clinical Trials	Blackfoot	Idaho	United States	83221
44	Rocky Mountain Clinical Research	Idaho Falls	Idaho	United States	83404
45	Idaho State University	Pocatello	Idaho	United States	83201
46	Northwest Heart Clinical Research	Arlington Heights	Illinois	United States	60005
47	Cedar-Crosse Research Center	Chicago	Illinois	United States	60607
48	Clinical Investigation Specialists Inc	Gurnee	Illinois	United States	60031
49	Springfield Diabetes & Endocrine Center	Springfield	Illinois	United States	62711
50	University of Iowa Hospital & Clinic	Iowa City	Iowa	United States	52242
51	Iowa Diabetes and Endocrinology Research Center	West Des Moines	Iowa	United States	50265
52	University of Kansas Medical Center	Kansas City	Kansas	United States	66160
53	Cotton O'Neil Clinic	Topeka	Kansas	United States	66606
54	Cotton O'Neil Diabetes and Endocrinology Center	Topeka	Kansas	United States	66606
55	Qualmedica Research, LLC	Bowling Green	Kentucky	United States	42101
56	L-MARC Research Center	Louisville	Kentucky	United States	40213
57	Qualmedica Research, LLC	Owensboro	Kentucky	United States	42301
58	Maryland Cardiovascular Specialists	Baltimore	Maryland	United States	21229
59	MedStar Health Research Institute	Hyattsville	Maryland	United States	20782
60	Ong Medical Center	Oxon Hill	Maryland	United States	20745
61	Endocrine and Metabolic Consultants	Rockville	Maryland	United States	20852
62	Brigham and Women's Hospital	Boston	Massachusetts	United States	02115
63	Joslin Diabetes Center	Boston	Massachusetts	United States	02215
64	ActivMed Practices and Research	Methuen	Massachusetts	United States	01844
65	Infinity Medical Research	North Dartmouth	Massachusetts	United States	02747
66	Arcturus Healthcare , PLC, Troy Internal Medicine Research Division	Troy	Michigan	United States	48098
67	St. John's Hospital	Edina	Minnesota	United States	55435
68	HealthEast Medical Research Institute	Maplewood	Minnesota	United States	55109
69	St Cloud Hospital/Central Minnesota Heart Center	Saint Cloud	Minnesota	United States	56303
70	StudyMetrix Research	Saint Peters	Missouri	United States	63303
71	Clinvest Research LLC	Springfield	Missouri	United States	65807
72	Mercy Research - Smith Glynn Callaway	Springfield	Missouri	United States	65807
73	Billings Clinic	Billings	Montana	United States	59101
74	Mercury Street Medical Group, PLLC	Butte	Montana	United States	59701
75	Omaha VA Medical Center	Omaha	Nebraska	United States	68105
76	University of Nebraska Medical Center	Omaha	Nebraska	United States	68198
77	Palm Research Center Tenaya	Las Vegas	Nevada	United States	89128
78	Palm Research Center Tenaya	Las Vegas	Nevada	United States	89148
79	Southern Nh Diabetes and Endocrinology	Nashua	New Hampshire	United States	03060
80	Albany Medical College	Albany	New York	United States	12203
81	Great Lakes Medical Research, LLC	Westfield	New York	United States	14787
82	Atrium Health - Department of Family Medicine Research	Charlotte	North Carolina	United States	28207
83	Duke University Medical Center	Durham	North Carolina	United States	27710
84	PMG Research Inc., d/b/a PMG of Piedmont Healthcare	Mooresville	North Carolina	United States	28117
85	PMG Research of Wilmington	Wilmington	North Carolina	United States	28401
86	Lillestol Research LLC	Fargo	North Dakota	United States	58104
87	Cleveland Clinic Foundation	Cleveland	Ohio	United States	44195
88	Intend Research, LLC	Norman	Oklahoma	United States	73069
89	Heritage Valley Medical Group, Inc.	Beaver	Pennsylvania	United States	15009
90	Capital Area Research, LLC	Camp Hill	Pennsylvania	United States	17011
91	Diabetes & Endocrinology Consultants of Pennsylvania, LLC	Feasterville	Pennsylvania	United States	19053
92	Thomas Jefferson University	Philadelphia	Pennsylvania	United States	19107
93	Northeast Endocrine Metabolic Associates	Philadelphia	Pennsylvania	United States	19114
94	Preferred Primary Care Physicians	Pittsburgh	Pennsylvania	United States	15236
95	Cardiology Consultants of Philadelphia	Yardley	Pennsylvania	United States	19067
96	Ralph H. Johnson VA Medical Center	Charleston	South Carolina	United States	29401
97	Tribe Clinical Research, LLC	Greenville	South Carolina	United States	29607
98	PMG Research of Charleston, LLC	Mount Pleasant	South Carolina	United States	29464
99	Black Hills Cardiovascular Research Group	Rapid City	South Dakota	United States	57701
100	Holston Medical Group	Bristol	Tennessee	United States	37620
101	PMG Research of Knoxville	Knoxville	Tennessee	United States	37938
102	Endocrine Clinic	Memphis	Tennessee	United States	38119
103	Private Practice - Dr. Osvaldo A. Brusco	Corpus Christi	Texas	United States	78414
104	Dallas Diabetes Research Center	Dallas	Texas	United States	75230
105	Cardiovascular Research Institute of Dallas	Dallas	Texas	United States	75231
106	North Texas Endocrine Center	Dallas	Texas	United States	75231
107	Research Institute of Dallas	Dallas	Texas	United States	75231
108	Galenos Research	Dallas	Texas	United States	75251
109	Academy of Diabetes, Thyroid and Endocrine	El Paso	Texas	United States	79935
110	Diabetes and Thyroid Center of Fort Worth	Fort Worth	Texas	United States	76132
111	Horizon Clinical Research Group	Houston	Texas	United States	77070
112	Southern Endocrinology Associates	Mesquite	Texas	United States	75149
113	North Hills Medical Research	North Richland Hills	Texas	United States	76180
114	South Texas Veterans Administration Health Care	San Antonio	Texas	United States	78229
115	Consano Clinical Research, LLC	Shavano Park	Texas	United States	78231
116	Northwest Houston Heart Center	Tomball	Texas	United States	77375-4536
117	Physicians' Research Options	Draper	Utah	United States	84020
118	Advanced Research Institute	Ogden	Utah	United States	84405
119	Kalo Clinical Research	Salt Lake City	Utah	United States	84102
120	Wasatch Clinical Research, LLC	Salt Lake City	Utah	United States	84107
121	Virginia Heart	Falls Church	Virginia	United States	22042
122	VA Puget Sound Health Care System	Seattle	Washington	United States	98108
123	Rockwood Clinic Research Center	Spokane	Washington	United States	99202
124	MultiCare Good Samaritan Hospital	Tacoma	Washington	United States	98405
125	Wenatchee Valley Hospital & Clinics	Wenatchee	Washington	United States	98801
126	Clinical Investigation Specialists Inc	Kenosha	Wisconsin	United States	53144
127	Instituto de Investigaciones Clínicas Bahia Blanca	Bahía Blanca	Buenos Aires	Argentina	B8000
128	Centro OMI	Caba	Buenos Aires	Argentina	C1015ABO
129	CEDIC	Caba	Buenos Aires	Argentina	C1060ABN
130	Mautalen Salud e Investigación	Caba	Buenos Aires	Argentina	C1128AAF
131	Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada	Caba	Buenos Aires	Argentina	C1425AGC
132	Glenny Corp SA- BIOCLINICA Argentina	Caba	Buenos Aires	Argentina	C1430CKE
133	Stat Research S.A.	Capital Federal	Buenos Aires	Argentina	1023
134	Centro de Investigaciones Metabólicas (CINME)	Ciudad Autónoma de Buenos Aire	Buenos Aires	Argentina	1056
135	Instituto de Investigaciones Clínicas Mar del Plata	Mar del Plata	Buenos Aires	Argentina	B7600FZN
136	DIM Clinica Privada	Ramos Mejía	Buenos Aires	Argentina	1704
137	Instituto de Investigaciones Clínicas Rosario (IIC-Rosario)- Sanatorio Delta	Rosario	Buenos Aires	Argentina	S2000BIF
138	Go Centro Medico San Nicolás	San Nicolás	Buenos Aires	Argentina	B2900DPA
139	Instituto de Investigaciones Clinicas Zarate	Zárate	Buenos Aires	Argentina	2800
140	Centro Médico Viamonte	Buenos Aires	Ciudad Autónoma De Buenos Aire	Argentina	C1120AAC
141	CEMEDIAB	C.a.b.a.	Ciudad Autónoma De Buenos Aire	Argentina	C1205AAO
142	CIPREC	Caba	Ciudad Autónoma De Buenos Aire	Argentina	C1061AAS
143	Centro Medico Privado San Vicente Diabetes	Cordoba	Córdoba	Argentina	5006
144	Instituto Médico Catamarca	Rosario	Santa Fe	Argentina	2000
145	Grupo Colaborativo Rosario	Rosario	Santa Fe	Argentina	S2002OJN
146	Centro de Investigaciones Médicas Tucuman	SAN M. DE Tucuman	Tucumán	Argentina	T4000AXL
147	Investigaciones Clínicas Tucumán	San Miguel de Tucuman	TUC	Argentina	T4000NIL
148	CEMEDIC	Buenos Aires		Argentina	1407
149	Asociación de Beneficencia Hospital Sirio Libanés	Buenos Aires		Argentina	C1419AHN
150	CIDIM-Centro Integral de Diagnostico por Imagenes Marchegiani	Cordoba		Argentina	5000
151	Cent Priva Especiali Médicas Ambulatorias Inve Clin CEMAIC	Cordoba		Argentina	X5008HHW
152	Centro Universitario de Investigación en Farmacologia Clinica (CUIFC)	Corrientes		Argentina	3400
153	Instituto de Cardiologia de Corrientes	Corrientes		Argentina	3400
154	Centro Diabetológico Dr. Waitman	Córdoba		Argentina	5000
155	Sanatorio Parque	Salta		Argentina	4400
156	Sanatorio Norte	Santiago del Estero		Argentina	4200
157	Clínica Mayo	Tucuman		Argentina	T4000IHE
158	Boden Collaboration for Obesity, Nutrition, Exercise & Eating Disorders	Camperdown	New South Wales	Australia	2006
159	Nepean Family Metabolic Health Service	Kingswood	New South Wales	Australia	2747
160	The AIM Centre / Hunter Diabetes Centre	Merewether	New South Wales	Australia	2291
161	Illawarra Shoalhaven Local Health District	Wollongong	New South Wales	Australia	2500
162	Core Research Group	Brisbane	Queensland	Australia	4064
163	The Townsville Hospital	Douglas	Queensland	Australia	4814
164	Royal Brisbane and Women's Hospital	Herston	Queensland	Australia	4029
165	Mater Adult Hospital Brisbane	South Brisbane	Queensland	Australia	4700
166	Gold Coast University Hospital	Southport	Queensland	Australia	4215
167	Heart and Vascular Institute	Adelaide	South Australia	Australia	5000
168	Royal Adelaide Hospital	Adelaide	South Australia	Australia	5000
169	Southern Adelaide Diabetes & Endocrine Services	Oaklands Park	South Australia	Australia	5046
170	Launceston General Hospital	Launceston	Tasmania	Australia	7250
171	Box Hill Hospital Outpatients	Box Hill	Victoria	Australia	3128
172	Monash Cardiovascular Research Centre	Clayton	Victoria	Australia	3168
173	Barwon Health - The Geelong Hospital	Geelong	Victoria	Australia	3220
174	Austin Health - Heidelberg Repatriation Hospital	Heidelberg Heights	Victoria	Australia	3081
175	School of Medicine, Fremantle Hospital	Fremantle	Western Australia	Australia	6160
176	GenesisCare - Wexford Medical Centre WA	Murdoch	Western Australia	Australia	6150
177	GenesisCare	Joondalup		Australia	6027
178	Universitätsklinikum Graz	Graz	Steiermark	Austria	8036
179	Universitätsklinikum Salzburg	Salzburg		Austria	5020
180	Klinik Landstraße	Wien		Austria	1030
181	Zentrum für klinische Studien Dr Hanusch Gmbh	Wien		Austria	1060
182	AKH	Wien		Austria	1090
183	Krankenhaus Hietzing	Wien		Austria	1130
184	Imelda General Hospital	Bonheiden	Antwerpen	Belgium	2820
185	AZ Klina	Brasschaat	Antwerp	Belgium	2930
186	Onze Lieve Vrouw Ziekenhuis Aalst	Aalst	Oost-Vlaanderen	Belgium	9300
187	VITAZ	Sint-Niklaas	Oost-Vlaanderen	Belgium	9100
188	ZNA Jan Palfijn	Merksem	Vlaams Gewest	Belgium	2170
189	AZ Delta	Roeselare	West Flanders	Belgium	8800
190	AZ Sint-Jan AV	Brugge		Belgium	8000
191	ULB Erasme	Brussels		Belgium	1070
192	Universitair Ziekenhuis Antwerpen	Edegem		Belgium	2650
193	UZ Brussel	Jette		Belgium	1090
194	AZ Groeninge	Kortrijk		Belgium	8500
195	Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg	Leuven		Belgium	3000
196	CHU de Liège	Liege		Belgium	4000
197	AZ Damiaan Oostende	Oostende		Belgium	8400
198	Centro de Pesq. em Diabetes e Doencas Endocrino Metabol.	Fortaleza	Ceará	Brazil	60430-350
199	CEDOES	Vitoria	Espirito Santo	Brazil	29055-450
200	QUANTA - Medicina Nuclear Alto da XV	Curitiba	Paraná	Brazil	80045-170
201	Centro de Pesquisas em Diabetes	Porto Alegre	Rio Grande Do Sul	Brazil	90430-001
202	Loema Instituto de Pesquisa Clinica	Campinas	São Paulo	Brazil	13010-001
203	Instituto de Pesquisa clinica de Campinas	Campinas	São Paulo	Brazil	13060-080
204	CECIP - Centro de Estudos do Interior Paulista	Jaú	São Paulo	Brazil	17201-130
205	Faculdade de Medicina do ABC	Santo André	São Paulo	Brazil	09060-870
206	ISPEM - Instituto São José dos Campos em Pesquisas Médicas	São José dos Campos	São Paulo	Brazil	12243-280
207	Instituto Brasil de Pesquisa Clínica - IBPCLIN	Rio de Janeiro		Brazil	20241180
208	IPEC - Instituto de Pesquisa Clínica	São Paulo		Brazil	01223-001
209	CPQuali Pesquisa Clínica	São Paulo		Brazil	01228-000
210	CPCLIN	São Paulo		Brazil	01228-200
211	CEPIC - Centro Paulista de Investigação Clínica	São Paulo		Brazil	04266-010
212	Hospital da Clinicas da Faculdade de Medicina da USP	São Paulo		Brazil	05403-000
213	LMC Clinical Research Inc. (Calgary)	Calgary	Alberta	Canada	T2H 2G4
214	Dr. T.G. Elliott, Inc.	Vancouver	British Columbia	Canada	V5Y 3W2
215	Dr. M.B. Jones Inc.	Victoria	British Columbia	Canada	V8V 4A1
216	Winnipeg Clinic	Winnipeg	Manitoba	Canada	R3C 0N2
217	Queen Elizabeth II Health Sciences Center	Halifax	Nova Scotia	Canada	B3H 1V7
218	LMC Clinical Research Inc. (Montreal)	Barrie	Ontario	Canada	L4N 7L3
219	LMC Clinical Research Inc. (Brampton)	Brampton	Ontario	Canada	L6S 0C6
220	Aggarwal and Associates Limited	Brampton	Ontario	Canada	L6T 0G1
221	Cambridge Cardiac Care Centre	Cambridge	Ontario	Canada	N1R 6V6
222	LMC Clinical Research Inc. (Montreal)	Concord	Ontario	Canada	L4K 4M2
223	LMC Clinical Research Inc. (Montreal)	Etobicoke	Ontario	Canada	M9R 4E1
224	Milestone Research Inc.	London	Ontario	Canada	N5W 6A2
225	St Joseph Health Care	London	Ontario	Canada	N6A 4V2
226	LMC Clinical Research Inc. (Montreal)	Nepean	Ontario	Canada	K2J 0V2
227	North York Diagnostic and Cardiac Centre	North York	Ontario	Canada	M6B 3H7
228	LMC Clinical Research Inc. (Oakville)	Oakville	Ontario	Canada	L6M 1M1
229	Private Practice - Dr. James Cha	Oshawa	Ontario	Canada	L1J 2K1
230	Kawartha Cardiology Clinical Trials	Peterborough	Ontario	Canada	K9J 0B2
231	Bluewater Clinical Research Group Inc.	Sarnia	Ontario	Canada	N7T 4X3
232	Diabetes Clinic	Smiths Falls	Ontario	Canada	K7A 4W8
233	Janik Research Corporation	Sudbury	Ontario	Canada	P3B 4H5
234	Canadian Phase Onward Inc	Toronto	Ontario	Canada	M3J 2C5
235	LMC Clinical Research Inc. (Montreal)	Toronto	Ontario	Canada	M4G 3E8
236	Diabetes Heart Research Centre	Toronto	Ontario	Canada	M6G 1M2
237	Dr. Anil K. Gupta Medicine Professional Corporation	Toronto	Ontario	Canada	M9V 4B4
238	ViaCar Recherche Clinique	Greenfield Park	Quebec	Canada	J4V 2G8
239	Centre de Recherche Clinique de Laval	Laval	Quebec	Canada	H7T 2P5
240	Manna Research	Lévis	Quebec	Canada	G6W 0M5
241	Clinique Sante Cardio MC	Montreal	Quebec	Canada	H1T 3Y7
242	CR A&E Centre de Recherche Inc.	Quebec City	Quebec	Canada	G1N 4V3
243	Beijing Anzhen Hospital, Capital Medical University	Beijing	Beijing	China	100029
244	Peking University First Hospital	Beijing	Beijing	China	100034
245	Peking University People's Hospital	Beijing	Beijing	China	100044
246	Beijing Friendship Hospital Affiliate of Capital University	Beijing	Beijing	China	100050
247	The First Hospital of Lanzhou University	Lanzhou	Gansu	China	730000
248	Lanzhou university second hospital	Lanzhou	Gansu	China	730030
249	The First Affiliated Hospital, Sun-Yat Sen University	Guangzhou	Guangdong	China	510080
250	The Fourth Affiliated Hospital of Harbin Medical University	Harbin	Heilongjiang	China	150001
251	First Huai'an Hospital Affiliated to Nanjing Medical University	Huai'an	Jiangsu	China	223300
252	Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School	Nanjing	Jiangsu	China	210000
253	The First Hospital of Nanjing	Nanjing	Jiangsu	China	210006
254	Zhongda Hospital Southeast University	Nanjing	Jiangsu	China	210009
255	The Second Affiliated Hospital of Nanjing Medical University	Nanjing	Jiangsu	China	210011
256	Affiliated Hospital of Jiangsu University	Zhenjiang	Jiangsu	China	212000
257	The First Affiliated Hospital of Nanchang University	Nanchang	Jiangxi	China	330006
258	Pingxiang People's Hospital	Pingxiang	Jiangxi	China	337055
259	China-Japan Union Hospital of Jilin University	Changchun	Jilin	China	100853
260	The People's Hospital of Liaoning Province	Shenyang	Liaoning	China	110000
261	General Hospital of Ningxia Medical University	Yinchuan	Ningxia	China	750004
262	The First Afflicated Hospital of Xian Jiaotong University	Xian	Shan XI	China	710061
263	Jinan Central Hospital	Jinan	Shandong	China	250013
264	Tianjin Medical University General Hospital	Tianjin	Tianjin	China	300052
265	People's Hospital of Hunan Province	Changsha		China	410002
266	MUDr. Tomas Edelsberger	Krnov	Moravskoslezský Kraj	Czechia	79401
267	Diabet2 s.r.o., Diabetologicka a interni ambulance	Praha 1	Prague	Czechia	11000
268	Milan Kvapil s.r.o., Diabetologicka ambulance	Praha	Praha 4	Czechia	14900
269	Diacentrum Brandys n.L. s.r.o.	Brandys Nad Labem-Stara Bolesl		Czechia	25001
270	Diabetologicka a obezitologicka ambulance	Ceske Budejovice		Czechia	370 11
271	Interni a diabetologicka ordinace, s.r.o.	Nachod		Czechia	54701
272	LF UK - Fakultni poliklinika	Praha 2		Czechia	128 08
273	MUDr. Michala Pelikanova s.r.o.	Praha 4		Czechia	140 00
274	ResTrial s.r.o.	Praha 8		Czechia	181 00
275	MUDr. Barbora Diepoltova, Diabetologie Praha 9	Praha 9		Czechia	19014
276	Hopital G et R Laennec	Nantes	Cedex 01	France	44093
277	CHU Rangueil	Toulouse	Cedex 9	France	31059
278	Centre Hospitalier Sud Francilien	Corbeil-Essonnes		France	91100
279	CHU De Dijon Hopital Du Bocage	Dijon Cedex		France	21079
280	Hôtel-Dieu du Creusot - site Harfleur	Le Creusot		France	71200
281	Groupe Hospitalier Paris Saint Joseph - Site Saint-Michel	Paris Cedex 14		France	75674
282	Hôpital Bichat - Claude-Bernard	Paris		France	75018
283	Hopital Lariboisière	Paris		France	75475
284	CHU de Bordeaux, Hopital du Haut Leveque	Pessac Cedex		France	33604
285	CHU Brabois	Vandoeuvre Les Nancy		France	54500
286	Groupe hospitalier mutualiste Les Portes du sud	Venissieux		France	69200
287	Diabetesinstitut Heidelberg	Heidelberg	Baden-Württemberg	Germany	69115
288	Marienhospital Stuttgart	Stuttgart	Baden-Württemberg	Germany	70199
289	Praxis Sauter & Sauter & Vorbach	Wangen	Baden-Württemberg	Germany	88239
290	Studienzentrum Bamberg	Bamberg	Bavaria	Germany	96049
291	Praxis Dr. med. Ilka Simon-Wagner	Lichtenfels	Bavaria	Germany	96215
292	Studienzentrum Aschaffenburg	Aschaffenburg	Bayern	Germany	63739
293	CDG Studienambulanz Hartard	München	Bayern	Germany	80809
294	ZKS Dr. Lüdemann	Falkensee	Brandenburg	Germany	14612
295	Diabetes Zentrum Dr. Tews	Gelnhausen	Hessen	Germany	63571
296	Diabetologische Schwerpunktpraxis Marck Linn Pickel	Pohlheim	Hessen	Germany	35415
297	ClinPhenomics GmbH & Co KG, Studienzentrum	Frankfurt	Hesse	Germany	60596
298	Praxis Oedeme - Diabetologische Schwerpunktpraxis	Lüneburg	Niedersachsen	Germany	21339
299	Herz - und Diabeteszentrum Nordrhein - Westfalen, Bad Oeynhausen	Bad Oeynhausen	Nordrhein-Westfalen	Germany	32545
300	Praxis Bonnermann/Lorra	Bochum	Nordrhein-Westfalen	Germany	44869
301	Diabeteszentrum DO, Diabetische Schwerpunktpraxis Dortmund	Dortmund	Nordrhein-Westfalen	Germany	44137
302	InnoDiab Forschung Gmbh	Essen	Nordrhein-Westfalen	Germany	45136
303	Medizentrum Essen Borbeck	Essen	Nordrhein-Westfalen	Germany	45355
304	Institut für Diabetesforschung GmbH Münster	Münster	Nordrhein-Westfalen	Germany	48145
305	Diabetologikum Ludwigshafen/Die Praxis am Ludwigsplatz	Ludwigshafen am Rhein	Rheinland-Pfalz	Germany	67059
306	Diabetologische Schwerpunktpraxis Diabetologikum Speyer	Speyer	Rheinland-Pfalz	Germany	67346
307	Practice Dr.med. Denger and Dr.med. Pfitzner	Friedrichsthal	Saarland	Germany	66299
308	Praxis Dr. V. Wenzl-Bauer	Rehlingen-Siersburg	Saarland	Germany	66780
309	Schwerpunktpraxis Diabetes	Saint Ingbert-Oberwürzbach	Saarland	Germany	66386
310	Hausarzt- und Diabetologische Schwerpunktpraxis Hohenmölsen - Weiβenfels	Hohenmölsen	Sachsen-Anhalt	Germany	06679
311	SMO.MD GmbH	Magdeburg	Sachsen-Anhalt	Germany	39120
312	AmBeNet GmbH	Leipzig	Sachsen	Germany	04107
313	Arztpraxis Christine Kosch Pirna	Pirna	Sachsen	Germany	01796
314	MVZ Riesa, Medizinisches Versorgungzentrum am Klinikum Döbel	Riesa	Sachsen	Germany	01587
315	Cardiologicum Dresden und Pirna	Dresden	Saxony	Germany	01277
316	Universitätsstudienzentrum für Stoffwechselerkrankungen	Dresden	Saxony	Germany	01307
317	SIBAmed Studienzentrum GmbH & Co. KG	Leipzig	Saxony	Germany	04103
318	Gemeinschaftspraxis Dr.Täschner/Dr. Bonigut	Leipzig	Saxony	Germany	04249
319	Praxis für Innere Medizin Toralf Schwarz	Zwenkau	Saxony	Germany	04442
320	Universitätsklinikum Schleswig-Holstein	Lübeck	Schleswig-Holstein	Germany	23562
321	RED-Institut GmbH	Oldenburg	Schleswig-Holstein	Germany	23758
322	Dr. Joachim Weimer	Reinfeld	Schleswig-Holstein	Germany	23858
323	Gemeinschaftspraxis für Diabetologie	Eisenach	Thüringen	Germany	99817
324	Institut für klinische Forschung und Entwicklung	Berlin		Germany	10437
325	Diabetespraxis Dr. Hermann Braun	Berlin		Germany	13187
326	Dres. Jung Gemeinschaftspraxis	Deggingen		Germany	73326
327	ZKS Suedbrandenburg	Elsterwerda		Germany	04910
328	Praxis am Markt - Dr. Bernd Becker	Essen		Germany	45355
329	MVZ im Altstadt-Carree Fulda GmbH	Fulda		Germany	36037
330	Diabetologische Schwerpunktpraxis Harburg	Hamburg		Germany	21073
331	Diabetes-Zentrum Wilhelmsburg	Hamburg		Germany	21109
332	Diabeteszentrum Hamburg West	Hamburg		Germany	22607
333	MVZ am Bahnhof Spandau	Spandau		Germany	13597
334	Gemeinschaftspraxis Prof. Dr. med. Stephan Jacob, Dr. med. Frohmut Jacob	Villingen-Schwenningen		Germany	78048
335	Iatriko Paleou Falirou Medical Center	Paleo Faliro	Attikí (Region)	Greece	17562
336	General Hospital of Athens "G. Gennimatas"	Athens	Attikí	Greece	11527
337	Attikon General University Hospital	Chaidari	Attikí	Greece	12462
338	AHEPA University General Hospital of Thessaloniki	Thessaloniki	Kentrikí Makedonía	Greece	546 36
339	General Hospital of Thessaloniki Papageorgiou	N. Efkarpia	Thessaloniki	Greece	56403
340	Thermi Clinic	Thessaloniki	Thessaloníki	Greece	570 01
341	University General Hospital of Larissa	Larissa	Thessalía	Greece	41110
342	Athens Euroclinic	Athens		Greece	115 21
343	Hippokration University Hopsital	Thessaloniki		Greece	54642
344	Euromedica - General Clinic of Thessaloniki	Thessaloniki		Greece	54645
345	Studium Egeszseghaz Kft	Kalocsa	Bács-Kiskun	Hungary	6300
346	SZTE AOK Belgyogyaszati Klinika	Szeged	Csongrad	Hungary	6725
347	DRC Gyogyszervizsgalo Kozpont Kft.	Balatonfüred	EU	Hungary	8230
348	Fejér Megyei Szent György Egyetemi Oktató Kórház	Szekesfehervar	Fejér	Hungary	8000
349	Kenezy Gyula Korhaz es Rendelointezet	Debrecen	Hajdu-Bihar	Hungary	4031
350	Debreceni Egyetem Klinikai Kozpont Belgyogyaszati Intezet	Debrecen	Hajdu-Bihar	Hungary	4032
351	Pharma 4 Trial	Gyöngyös	Heves	Hungary	3200
352	Kanizsai Dorottya Korhaz	Nagykanizsa	Zala	Hungary	8800
353	Szent Margit Rendelintézet	Budapest		Hungary	1032
354	ClinDiab Kft.	Budapest		Hungary	1089
355	Szent János Kórház	Budapest		Hungary	1125
356	Magyar Honvedseg Egeszsegugyi Kozpont	Budapest		Hungary	1134
357	Strazsahegy Medicina Bt.	Budapest		Hungary	H1171
358	Markhot Ferenc Korhaz	Eger		Hungary	3300
359	Selye Janos Korhaz-Rendelointezet	Komarom		Hungary	2900
360	CLINFAN Szolgáltató Kft	Szekszard		Hungary	7100
361	Zala Megyei Szent Rafael Kórház	Zalaegerszeg		Hungary	8900
362	Care Hospital	Hyderabad	Andhra Pradesh	India	500 035
363	Sir Ganga Ram Hospital	New Delhi	Delhi	India	110060
364	Gujarat Endocrine Center	Ahmedabad	Gujarat	India	380006
365	CIMS Hospital Private Limited	Ahmedabad	Gujarat	India	380060
366	Bangalore Diabetes Centre	Bangalore	Karnataka	India	560043
367	CHL Hospital Indore	Indore	Madhya Pradesh	India	452008
368	Topiwala National Medical College & B. Y. L. Nair Charitable Hospital	Mumbai	Maharashtra	India	400008
369	Kingsway Hospital	Nagpur	Maharashtra	India	440001
370	Seth GS Medical College & KEM Hospital	Mumbai	Maharshtra	India	400012
371	Dr Mohan's Diabetes Research Foundation	Chennai	Tamil Nadu	India	600086
372	Apollo Gleneagles Hospitals Kolkata	Kolkata	West Bengal	India	700054
373	Batra Hospital & Medical Research Centre	New Delhi		India	110 062
374	G.B. Pant Institute of Postgraduate Medical Education & Research	New Delhi		India	110002
375	All India Institute of Medical Sciences	New Delhi		India	110029
376	Sheba Medical Center	Ramat Gan	HaMerkaz	Israel	5262100
377	Ha'Emek Medical Center	Afula		Israel	1834111
378	Barzilai Medical Center	Ashkelon		Israel	7830604
379	Clalit Health Services, Atlit	Atlit		Israel	3035001
380	Soroka Medical Center	Beer Sheva		Israel	151 MAILBOX
381	Clinical Research Unit Hillel Yaffe M.C	Hadera		Israel	38100
382	Rambam Medical Center	Haifa		Israel	3109601
383	Bnai Zion Medical Center	Haifa		Israel	3339419
384	Linn Medical Center	Haifa		Israel	3515209
385	Edith Wolfson Medical Center	Holon		Israel	5822012
386	Shaare Zedek Medical Center	Jerusalem		Israel	9103102
387	Hadassah Medical Center	Jerusalem		Israel	911201
388	Hadassah Medical Center	Jerusalem		Israel	91120
389	Clalit Health Services -Diabetes and Endocrinology Clinic Jerusalem	Jerusalem		Israel	93106
390	Hadassah Medical Center	Jerusalem		Israel	97654
391	Meir Medical Center	Kfar Saba		Israel	4428164
392	Galilee Medical Center	Nahariya		Israel	22100
393	Holy Family Hospital	Nazareth		Israel	16100
394	Internal Medicine D, Ha'Sharon Hospital	Petach Tikwa		Israel	49372
395	Rabin Medical Center	Petah Tiqva		Israel	49100
396	Sheba Medical Center	Ramat Gan		Israel	5266202
397	Institute of Diabetes and Endocrinology Kaplan Medical Center	Rehovot		Israel	76100
398	ZIV Medical Center	Safed		Israel	13100
399	Clalit Health Services - Sakhnin Community Clinic	Sakhnin		Israel	3081000
400	Tel Aviv Sourasky Medical Center	Tel Aviv		Israel	6423906
401	Centro Cardiologico Monzino	Milan	Milano	Italy	20138
402	Ospedale san Giovanni di Dio-Diabetologia	Olbia	Olbia-Tempio	Italy	07026
403	Policlinico di Tor Vergata	Roma	Rome	Italy	00133
404	Ospedale Maggiore	Chieri	Turin	Italy	10023
405	Azienda Ospedaliera Policlinico Consorziale	Bari		Italy	70124
406	Azienda Ospedaliera Papa Giovanni XXIII	Bergamo		Italy	24127
407	IRCCS - AOU di Bologna	Bologna		Italy	40138
408	Ospedale Garibaldi-Nesima	Catania		Italy	95122
409	Policlinico Mater Domini	Catanzaro		Italy	88100
410	Fondazione Universitaria degli Studi G D'Annunzio	Chieti		Italy	66100
411	Azienda Ospedaliera Universitaria Careggi	Firenze		Italy	50134
412	Ospedale Maggiore di Milano	Milano		Italy	20122
413	A.O.U. Università degli Studi della Campania Luigi Vanvitelli	Napoli		Italy	80138
414	AOUP Paolo Giaccone	Palermo		Italy	90127
415	Azienda Ospedaliera Di Parma	Parma		Italy	43100
416	Fondazione Salvatore Maugeri Clinica del lavoro	Pavia		Italy	27100
417	Azienda Ospedlaliero-Univeristaria Pisana, Stabilimento Ospedaliero di Cisanello	Pisa		Italy	56125
418	Policlinico Gemelli - Università Cattolica del Sacro Cuore	Roma		Italy	00168
419	Ospedale San Giovanni Calibita Fatebenefratelli	Roma		Italy	00186
420	Ospedale Civile Maggiore Borgo Trento	Verona		Italy	37126
421	Uji-Tokushukai Medical Center	Uji	Kyoto	Japan	611 0041
422	Takatsuki Red Cross Hospital	Takatsuki	Osaka	Japan	569-1045
423	The Institute of Medical Science, Asahi Life Foundation	Chuo-ku	Tokyo	Japan	103-0002
424	Tokyo-Eki Center-building Clinic	Chuo-ku	Tokyo	Japan	103-0027
425	Fukuwa Clinic	Chuo-ku	Tokyo	Japan	104-0031
426	Medical Corporation Sato Medical clinic	Ootaku	Tokyo	Japan	143-0015
427	Jinnouchi Hospital	Kumamoto		Japan	862-0976
428	AMC Nishiumeda Clinic	Osaka		Japan	530-0001
429	Sakurabashi Watanabe Hospital	Osaka		Japan	530-0001
430	Asan Medical Center	Seoul	Korea	Korea, Republic of	05505
431	Seoul St. Mary's Hospital	Seoul	Korea	Korea, Republic of	06591
432	Seoul National University Hospital	Seoul	Seoul, Korea	Korea, Republic of	03080
433	Hallym University Kangnam Sacred Heart Hospital	Seoul	Seoul-teukbyeolsi [Seoul]	Korea, Republic of	07441
434	Ulsan University Hospital	Ulsan	Ulsan-Kwangyǒkshi	Korea, Republic of	44033
435	Keimyung University Dongsan Hospital	Daegu		Korea, Republic of	42601
436	Yonsei University Wonju Severance Christian Hospital	Gangwon-do		Korea, Republic of	26426
437	Korea University Anam Hospital	Seoul		Korea, Republic of	02841
438	Severance Hospital, Yonsei University Health System	Seoul		Korea, Republic of	03722
439	Kyunghee University Hospital at Gangdong	Seoul		Korea, Republic of	05278
440	Fundacion Cardiovascular de Aguascalientes A.C.	Aguascalientes	AGS	Mexico	20230
441	Hospital Cardiologica Aguascalientes	Aguascalientes	AGS	Mexico	20230
442	CINCAME	Tijuana	Baja California	Mexico	22500
443	Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares	Mexico	D.f.	Mexico	11650
444	Diseno y Planeacion en Investigacion Medica	Guadalajara	Jalisco	Mexico	44130
445	Unidad de Investigaci�n Cl�nica Cardiometabolica de Occidente	Guadalajara	Jalisco	Mexico	44150
446	Centro de Investigación Médica Integral S.C.	Guadalajara	Jalisco	Mexico	44160
447	Universidad de Guadalajara	Guadalajara	Jalisco	Mexico	44340
448	Instituto Jalisciense de Investigacion en Diabetes y Obesida	Guadalajara	Jalisco	Mexico	44600
449	Unidad de patologia Clinica	Guadalajara	Jalisco	Mexico	44650
450	Salud Cardiovascular	Guadalajara	Jalisco	Mexico	44860
451	Centro de Inv. Medica de Occidente, SC	Zapopan	Jalisco	Mexico	45116
452	Instituto de Diabetes, Obesidad y Nutricion	Cuernavaca	Morelos	Mexico	62250
453	Hospital Universitario de Monterrey	Monterrey	Nuevo Leon	Mexico	64460
454	Cardiolink Clin Trials S.C.	Monterrey	Nuevo León	Mexico	64060
455	Hospital Universitario "Dr. Jose Eleuterio Gonzalez"	Monterrey	Nuevo León	Mexico	64460
456	Unidad Médica para la Salud Integral	San Nicolás de los Garza	Nuevo León	Mexico	66465
457	Centro Para el Desarrollo de la Medicina y de Asistencia Medica S.C	Culiacán	Sinaloa	Mexico	80230
458	Centro de Estudios de Investigacion Metabolicos y Cardiovasculares	Madero	Tamaulipas	Mexico	89440
459	Consultorio de Medicina especializada del Sector Privado	Xalapa	Veracruz	Mexico	91193
460	Medical Care and Research SA de CV	Merida	Yucatán	Mexico	97070
461	Centro de Investigacion Medica Aguascalientes	Aguascalientes		Mexico	20116
462	Investigacion en Salud y Metabolismo S.C	Chihuahua		Mexico	31110
463	Lahoja Asociación para la Investigación y Farmacovigilancia S.C.	Durango		Mexico	34000
464	Centro De Estudios Clinicos De Queretaro S.C.	Querétaro		Mexico	76000
465	Ziekenhuis Bethesda	Hoogeveen	Drenthe	Netherlands	7909 AA
466	Emotional Brain FlevoResearch	Almere	Flevoland	Netherlands	1311 RL
467	Rijnstate Arnhem	Arnhem	Gelderland	Netherlands	6815 AD Ar
468	Ziekenhuis Gelderse Vallei	Ede	Gelderland	Netherlands	6716 RP
469	Canisius-Wilhelmina Ziekenhuis	Nijmegen	Gelderland	Netherlands	6532 SZ
470	Ziekenhuis Amstelland	Amstelveen	Noord-Holland	Netherlands	1186 AM
471	Jeroen Bosch Hospital	's-Hertogenbosch	North Brabant	Netherlands	5223 GZ
472	Amsterdam VUmc	Amsterdam	North Holland	Netherlands	1081 HV
473	Amsterdam AMC - Research Vasculaire Geneeskunde	Amsterdam		Netherlands	1105 AZ AM
474	Reinier de Graaf Delft	Delft		Netherlands	2625
475	Het Van Weel-Bethesda Ziekenhuis	Dirksland		Netherlands	3247 BW Di
476	Slingeland Ziekenhuis	Doetinchem		Netherlands	7009 BL
477	Spaarne Gasthuis, Haarlem Zuid	Haarlem		Netherlands	2035 RC
478	Röpcke-Zweers Ziekenhuis Hardenberg	Hardenberg		Netherlands	7772 SE
479	Universitair Medisch Centrum St Radboud Nijmegen	Nijmegen		Netherlands	6500 HB
480	Franciscus Gasthuis Rotterdam - Cardiologie	Rotterdam		Netherlands	3045 PM
481	Diakonessenhuis	Utrecht		Netherlands	3582 KE Ut
482	UMC Utrecht, Dept. of Internal Medicine, MDL	Utrecht		Netherlands	3584 CX
483	NZOZ Regionalna Poradnia Diabetologiczna	Wroclaw	Dolnośląskie	Poland	50-127
484	Gabinety TERPA	Lublin	Lubelskie	Poland	20-333
485	NZOZ Medica	Lublin	Lubelskie	Poland	20-538
486	ETG NETWORK Sp. z o.o.	Warszawa	Mazowieckie	Poland	02-793
487	Centrum Medyczne AMED	Warszawa	Mazowiecki	Poland	00-215
488	Medyczne Centrum Diabetologiczno Endokrynologiczno Metaboliczne DIAB-ENDO-MET	Krakow	Małopolskie	Poland	31-261
489	SN ZOZ Lege Artis Poradnia Diabetologiczna	Bialystok	Podlaskie	Poland	15-404
490	Centrum Badan Klinicznych PI-House sp. z o.o.	Gdansk	Pomorskie	Poland	80-546
491	NZOZ Przychodnia Specjalistyczna Andrzej Wittek, Henryk Rudzki	Ruda Slaska	Slaskie	Poland	41-709
492	OMEDICA Medical Center	Poznan	Wielkopolskie	Poland	60-111
493	Gaja Poradnie Lekarskie Maciej Wiza	Poznan	Wielkopolskie	Poland	61-251
494	NS ZOZ Osrodek Diabetologiczny " Popula"	Bialystok		Poland	15-445
495	NZOZ CenterMed Lublin	Lublin		Poland	20-044
496	Praktyka Lekarska	Poznan		Poland	61-655
497	Instytut Diabetologii Sp. z o.o	Warsaw		Poland	04-376
498	Poradnia Chorob Metabolicznych	Wierzchoslawice		Poland	33-122
499	Wojewódzki Zespól Specjalistycznej Opieki Zdrowotnej	Wroclaw		Poland	50-403
500	Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna	Lodz	Łódzkie	Poland
501	NZOZ Salvia CM	Katowice	Śląskie	Poland	40-772
502	Advanced Clinical Research, LLC	Bayamón		Puerto Rico	00960
503	Manati Center for Clinical Research Inc	Manati		Puerto Rico	00674
504	Research and Cardiovascular Corp.	Ponce		Puerto Rico	00717
505	GCM Medical Group, PSC - Hato Rey Site	San Juan		Puerto Rico	00917
506	San Juan Hospital Research Unit	San Juan		Puerto Rico	00936
507	Private Practice - Dr. Diana Barbonta	Alba Iulia	Alba	Romania	510053
508	SC Endodigest SRL	Oradea	Bihor	Romania	410151
509	Centrul Medical Grandmed	Oradea	Bihor	Romania	410159
510	C.M.D.T.A. Neomed	Brasov	Brașov	Romania	500283
511	Nicodiab	Bucharest	București	Romania	010507
512	Geea Medical Easy Diet	Bucharest	București	Romania	010627
513	Centrul Medical NutriLife	Bucharest	București	Romania	013761
514	Gama Diamed	Mangalia	Constanța	Romania	905500
515	Top Diabet SRL	Craiova	Jud Dolj	Romania	200678
516	SC Minimed SRL	Bacau	Jud. Bacau	Romania	600164
517	CMI DNBM Dr. Pop Lavinia	Baia Mare	Maramures	Romania	430222
518	SC Dentosim Queen SRL	Targu-Mures	Mures	Romania	540098
519	Diabmed Dr. Popescu Alexandrina	Ploiesti	Prahova	Romania	100179
520	Dianutrilife Medica	Ploiesti	Prahova	Romania	100561
521	Institutul National de Diabet Nutritie si Boli Metabolice	Bucharest	Sector 2	Romania	020475
522	Centru Medical Dr. Negrisanu	Timisoara	Timis	Romania	300456
523	SC CMI Dr. Pletea Noemi SRL	Bacau		Romania	600154
524	Diamed Obesity	Galați		Romania	800501
525	SC Olimpia Med SRL	Iași		Romania	700400
526	Centrul Medical Consultmed	Iași		Romania	700514
527	Moscow City Clinical Hospital Number 52	Moscow	Moskva	Russian Federation
528	Rostov State Medical University	Rostov-on-Don	Rostovskaya Oblast'	Russian Federation	344091
529	LLC Medical Consultations and Research center - PRAKTIKA	Yaroslavl	Yaroslavskaya Oblast'	Russian Federation	150003
530	Arkhangelsk First City Clinical Hospital n.a. E.E. Volosevich	Arkhangelsk		Russian Federation	163001
531	Arkhangelsk Clinical Oncological Dispensary	Arkhangelsk		Russian Federation	163045
532	FSBI "National Medical Research Center for Preventive Medicine" of MOH of Russian Fed	Moscow		Russian Federation	101990
533	National Endocrinology Research Center of the Ministry of Health	Moscow		Russian Federation	117036
534	First Moscow State Medical University	Moscow		Russian Federation	119435
535	FSBI "National Medical Research Center of Cardiology" of MOH of Russian Federation	Moscow		Russian Federation	121552
536	FSBI "National Medical Research Center of Cardiology" of MOH of Russian Federation	Moscow		Russian Federation	121552
537	Moscow City Clinical Hospital Number 52	Moscow		Russian Federation	123182
538	First Moscow State Medical University n.a. Sechenov	Moscow		Russian Federation	123423
539	Pirogov Russian National Research Medical University	Moscow		Russian Federation	127644
540	M. F. Vladimirskiy Moscow Regional Research Clinical Institute	Moscow		Russian Federation	129110
541	Novosibirsk Regional Clinical Hospital	Novosibirsk		Russian Federation	630087
542	Ryazan Regional Clinical Cardiology Dispensary	Ryazan		Russian Federation	390026
543	Ryazan Regional Clinical Cardiology Dispensary	Ryazan		Russian Federation	390026
544	Russian Medical Military Academy n.a. S.M. Kirov	Saint Petersburg		Russian Federation	194044
545	Saint-Petersburg City Hospital of Saint Elizabeth	Saint Petersburg		Russian Federation	195257
546	ASTARTA Research Site	Saint Petersburg		Russian Federation	199226
547	SPb SBIH "City Mariinskaya Hospital"	Saint-Petersburg		Russian Federation	194104
548	Regional Clinical Hospital	Saratov		Russian Federation	410053
549	Syktyvkar Consulting Diagnostic Center	Syktyvkar		Russian Federation	167981
550	Siberian State Medical University of Roszdrav	Tomsk		Russian Federation	634055
551	Tomsk Regional Clinical Hospital	Tomsk		Russian Federation	634063
552	MUZ Clinical Hospital #2	Yaroslavl		Russian Federation	150010
553	Sin Azucar	Malacky	Bratislavský Kraj	Slovakia	901 01
554	DIAB sro	Roznava	Košický Kraj	Slovakia	048 01
555	Tatratrial s.r.o.	Rožňava	Košický Kraj	Slovakia	04801
556	FUNKYSTUFF s.r.o.	Nove Zamky	Nitriansky Kraj	Slovakia	940 02
557	MEDI-DIA s.r.o.	Sabinov	Prešovský Kraj	Slovakia	083 01
558	DIA-MED CENTRUM s.r.o.	Puchov	Trenčiansky Kraj	Slovakia	020 01
559	DIA-MED CENTRUM s.r.o.	Bratislava		Slovakia	84102
560	IN-DIA, s.r.o.	Lucenec		Slovakia	98401
561	DIABETOL s.r.o.	Presov		Slovakia	08001
562	Diabetes Centrum s.r.o	Trencin		Slovakia	91101
563	Centro Periférico de Especialidades Bola Azul	Almeria	Almería	Spain	04009
564	Hospital Quiron Infanta Luisa	Sevilla	Andalucía	Spain	41010
565	Hospital Universitario Central de Asturias	Oviedo	Asturias	Spain	33011
566	Hospital Virgen del Camino	Sanlucar de Barrameda	Cadiz	Spain	11540
567	Hospital Virgen de las Montanas	Villamartin	Cadiz	Spain	11650
568	Hospital Clinico Universitario de Valladolid	Valladolid	Castilla Y Leon	Spain	47010
569	Naval Hospital	Ferrol	La Coruna	Spain	15405
570	CHUS - Hospital Clinico Universitario	Santiago de Compostela	La Coruna	Spain	15706
571	Hospital Universitario Principe de Asturias	Alcala de Henares	Madrid	Spain	28805
572	Hospital Universitario Quironsalud Madrid	Pozuelo de Alarcon	Madrid	Spain	28223
573	Hospital Universitario de La Ribera	Alcira	Valencia	Spain	46600
574	Hospital Unviersitario Virgen Nieves	Granada		Spain	18014
575	Complexo Hospitalario Universitario A Coruña, CHUAC	La Coruña		Spain	15006
576	Hospital Universitario Ramón y Cajal	Madrid		Spain	28034
577	Hospital Universitario La Paz	Madrid		Spain	28046
578	Centro Especialidades San Jose Obrero (Barbarela)	Malaga		Spain	29006
579	Hospital Universitario Virgen Macarena	Sevilla		Spain	41009
580	Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE)	Seville		Spain	41003
581	Hospital General Universitario de Valencia	Valencia		Spain	46014
582	CEIM Hospital Universitario y Politecnico la Fe	Valencia		Spain	46026
583	Sahlgrenska Universitetssjukhuset	Göteborg	Gothenburg	Sweden	41345
584	ProbarE i Skåne	Lund	Skåne	Sweden	22222
585	Dalecarlia Clinical Research Center	Rättvik		Sweden	79530
586	Citydiabetes,Serafen	Stockholm		Sweden	11221
587	AKP - Avdelningen för Kliniska Prövningar	Örebro		Sweden	70185
588	Östersunds Sjukhus	Östersund		Sweden	83183
589	Changhua Christian Hospital	Changhua City	Changhua County	Taiwan	50006
590	Hualien Tzu-Chi Hospital	Hualien City	Hualien County	Taiwan	970
591	Hsinchu Mackay Memorial Hospital	Hsinchu City		Taiwan	300
592	Chang Gung Memorial Hospital - Kaohsiung Branch	Kaohsiung		Taiwan	83301
593	Taichung Veterans General Hospital	Taichung		Taiwan	40705
594	National Cheng-Kung Uni. Hosp.	Tainan		Taiwan	704
595	Chi-Mei Medical Center	Tainan		Taiwan	71004
596	Taipei Veterans General Hospital	Taipei		Taiwan	11217
597	Chang Gung Memorial Hospital - Linkou	Taoyuan City		Taiwan	333
598	Eskisehir Osmangazi Universitesi Tıp Fakultesi	Eskişehir	Eskisehir	Turkey	26480
599	Istanbul Medeniyet University	Istanbul	Kadıkoy	Turkey	34722
600	Kocaeli University Medical Faculty Hospital	Izmit	Kocaeli	Turkey	41380
601	Mersin University Medical Faculty	Yenişehir	Mersin	Turkey	33343
602	Baskent Universitesi Adana Uygulama ve Arastirma Merkezi Yuregir Hastanesi	Adana		Turkey	01240
603	Ankara University Medicine Hospital	Ankara		Turkey	06230
604	Akdeniz University Medical Faculty	Antalya		Turkey	07059
605	Aydin Adnan Menderes Universitesi	Aydin		Turkey	09010
606	Pamukkale University Medical Faculty, Fahri Goksin Oncology Centre	Denizli		Turkey	20070
607	Dicle Üniversitesi	Diyarbakir		Turkey	21280
608	Atatürk Üniversitesi	Erzurum		Turkey	25240
609	Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi	Gaziantep		Turkey	27310
610	Koç Üniversitesi Hastanesi	Istanbul		Turkey	34010
611	Dr. Sadi Konuk Egitim ve Arastirma Hastanesi	İstanbul		Turkey	34147
612	Acıbadem Atakent Hastanesi	Istanbul		Turkey	34303
613	Fatih Sultan Mehmet Training and Research Hospital	Istanbul		Turkey	34752
614	Ege University Medicine of Faculty	Izmir		Turkey	35100
615	Dokuz Eylül Üniversitesi	Izmir		Turkey	35340
616	Erciyes University Hospital	Kayseri		Turkey	38039
617	Inonu Universitesi Turgut Ozal Tıp Merkezi	Malatya		Turkey	44282
618	City Clinical Hospital No. 2	Kharkiv	Kharkivska Oblast	Ukraine	61037
619	Medical Center of Limited Liability Company "Medical Center "Consilium Medical"	Kiev	Kyiv	Ukraine	4050
620	Municipal non-profit enterprise "Consultative-diagnostic center №20" of Odesa city council	Odessa	Odeska Oblast	Ukraine	65114
621	Poltova Oblast Clinical Hospital IM.M.V.Sklifosovskoho	Poltava	Poltavska Oblast	Ukraine	36000
622	Sumy State University/Sumy Regional Clinical hospital	Sumy	Sumy Oblast	Ukraine	40018
623	Regional Public Institution "Chernivtsi Regional Endocrinology Center"	Chernivtsi		Ukraine	58022
624	Ukrainian State Research Institute of medical and social problems of disability	Dnipro		Ukraine	49000
625	Dnipro City Clinical Hospital #9	Dnipro		Ukraine	49023
626	GI L.T. Malaya TI Namsu	Kharkiv		Ukraine	61039
627	LEC Communal Inst Hc Kharkiv City Clinical Hosp #8	Kharkiv		Ukraine	61176
628	International Institute of Clinical Trials LLC	Kyiv		Ukraine	02091
629	LLC Medbud-Clinic Medical Center	Kyiv		Ukraine	03037
630	ARTEM Med Service/Rehabilitation	Kyiv		Ukraine	04050
631	V.P. Komisarenko Institute of Endocrinology and Metabolism of NAMS of Ukraine	Kyiv		Ukraine	04114
632	V.P. Komisarenko Institute of Endocrinology and Metabolism of NAMS of Ukraine	Kyiv		Ukraine	04114
633	Polyclinic of Communal 4th city clinical hospital	Lviv		Ukraine	79000
634	Lviv Regional State Clinical Treatment and Diagnostic Endocrinology Center	Lviv		Ukraine	79010
635	Communal Enterprise "Odesa Regional Clinical Hospital"	Odesa		Ukraine	65000
636	Poltava city clinical hospital #1	Poltava		Ukraine	36038
637	Vinnytsia Regional Clinical Highly Specialized Endocrinology Center	Vinnytsia		Ukraine	21000
638	Municipal Institution City Hospital #7	Zaporizhzhia		Ukraine	69118
639	Staploe Medical Centre	Ely	Cambridgeshire	United Kingdom	CB7 5JD
640	Knowle House Surgery	Plymouth	Devon	United Kingdom	PL5 3JB
641	The Royal Cornwall Hospital	Truro	England	United Kingdom	TR1 3LJ
642	Leicester General Hospital	Leicester	Leicestershire	United Kingdom	LE5 4PW
643	Aberdeen Royal Infirmary	Aberdeen	Scotland	United Kingdom	AB25 2ZP
644	Ninewells Hospital	Dundee	Scotland	United Kingdom	DD1 9SY
645	Glasgow Royal Infirmary	Glasgow	Scotland	United Kingdom	G31 2ER.
646	Ipswich Hospital	Ipswich	Suffolk	United Kingdom	IP4 5PD
647	Morriston Hospital	Swansea	Wales	United Kingdom	SA6 6NL
648	Southmead Hospital	Bristol		United Kingdom	BS10 5NB
649	Hull Royal Infirmary - MAIN	Hull		United Kingdom	HU3 2RW
650	University Hospital Aintree	Liverpool		United Kingdom	L9 7AL

Sponsors and Collaborators

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Investigators

Study Director: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST), Eli Lilly and Company