Pemafibrate to Reduce Cardiovascular OutcoMes by Reducing Triglycerides IN patiENts With diabeTes (PROMINENT)

• Sponsor: Kowa Research Institute, Inc. (Industry)
• Overall Status: Active, not recruiting
• CT.gov ID: NCT03071692
• Collaborator: Brigham and Women's Hospital (Other)
• Enrollment: 10,544
• Locations: 888
• Arms: 2
• Anticipated Duration (Months): 65.3
• Patients Per Site: 11.9
• Patients Per Site Per Month: 0.2

Study Details

Study Description

Brief Summary

The primary objective of the study is to determine whether pemafibrate administered twice daily will delay the time to first occurrence of any component of the clinical composite endpoint of:

• nonfatal Myocardial Infarction (MI)

• nonfatal ischemic stroke

• coronary revascularization; or

• Cardio Vascular (CV) death.

Condition or Disease	Intervention/Treatment	Phase
Type2 Diabetes; Dyslipidemia	Drug: K-877; Drug: Placebo	Phase 3

Detailed Description

A multi-regional clinical trial with participating sites in the following countries. India is being conducted under a previous protocol version due to regulatory requirements.

• Argentina

• Brazil

• Bulgaria

• Canada

• Colombia

• Czech Republic

• Denmark

• France

• Germany

• Hungary

• India

• Israel

• Japan

• Mexico

• Netherlands

• Poland

• Romania

• Russian Federation

• Slovakia

• South Africa

• Spain

• Ukraine

• United Kingdom

• United States

Study Design

• Study Type: Interventional
• Actual Enrollment: 10544 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
• Primary Purpose: Prevention
• Official Title: Pemafibrate to Reduce Cardiovascular OutcoMes by Reducing Triglycerides IN patiENts With diabeTes (PROMINENT)
• Actual Study Start Date: Mar 23, 2017
• Anticipated Primary Completion Date: Sep 1, 2022
• Anticipated Study Completion Date: Sep 1, 2022

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Treatment Group K-877 (pemafibrate) tablet twice daily.	Drug: K-877; 0.2mg tablet; Other Names: pemafibrate
Placebo Comparator: Control Group Matching K-877 placebo tablet twice daily.	Drug: Placebo; K-877 matching placebo tablet

Outcome Measures

Primary Outcome Measures

1. Number of patients with first occurrence of nonfatal MI, nonfatal ischemic stroke, coronary revascularization, or CV death. [Through study completion, an average of 4 years]

Secondary Outcome Measures

1. Time to first occurrence of The 4-component composite endpoint of non-fatal MI, non-fatal ischemic stroke, hospitalization for unstable angina requiring unplanned coronary revascularization or cardiovascular death [Through study completion, an average of 4 years]

2. Time to first occurrence of the 3-component composite endpoint of non-fatal MI, non-fatal ischemic stroke, or cardiovascular death [Through study completion, an average of 4 years]

3. Time to first occurrence of any component of the primary endpoint or hospitalization for Heart failure (HF) [Through study completion, an average of 4 years]

4. Time to first occurrence of any component of the primary endpoint or all-cause mortality [Through study completion, an average of 4 years]

5. Time to first occurrence of any new or worsening Peripheral artery disease (PAD) [Through study completion, an average of 4 years]

   Any new or worsening Peripheral artery disease (PAD), defined as incidence of lower extremity revascularization, intermittent claudication, rest pain, lower extremity ischemic ulceration, or major amputation with either ankle-brachial index ≤ 0.9 or other diagnostic testing (eg, toe-brachial index, angiogram, or other imaging study)

6. Time of first occurrence of individual endpoints and an analysis of total events [Through study completion, an average of 4 years]

   (evaluating time to occurrence of the first and all recurrent non-fatal MI, non-fatal ischemic stroke, coronary revascularization, or cardiovascular death).

7. Incidence of cardiovascular events [Up to 4 Years]

   Effect of pemafibrate vs placebo on cardiovascular events compared to known genetic polymorphisms in the PPARA gene

8. Lipid Endpoints [Week -3 to Month 4 (Visit 1 to Visit 5)]

   The change from Screening/Enrollment Visit (Visit 1) to Month 4 Visit (Visit 5) for the following lipid biomarkers: Total cholesterol (TC), Triglyceride(s) (TG), High-density lipoprotein cholesterol (HDL-C), non-HDL-C (calculated), Very low-density lipoprotein cholesterol (VLDL-C) (calculated), ApoA1, ApoC3, and ApoE

9. Nonfasting Remnant Cholesterol Endpoint [Week 0 to Month 6 (Visit 2 to Visit 6)]

   The change from Randomization Visit (Visit 2) to Month 6 Visit (Visit 6) for nonfasting remnant cholesterol

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

1. Fasting TG ≥ 200 mg/dL (2.26 mmol/L) and < 500 mg/dL (5.65 mmol/L) at Visit 1 (Screening/Enrollment Visit) or Visit 1.1 (Retest)

2. HDL-C ≤ 40 mg/dL (1.03 mmol/L) at Visit 1 (Screening/Enrollment Visit) or Visit 1.1 (Retest)

3. Type 2 diabetes of longer than 12 weeks duration documented in medical records, for example: local laboratory evidence through medical record review of elevated HbA1c (≥ 6.5% [48 mmol/mol]), elevated plasma glucose (fasting ≥ 126 mg/dL [7.0 mmol/L], 2-hour ≥ 200 mg/dL [11.1 mmol/L] during oral glucose tolerance testing, or random value ≥ 200 mg/dL with classic symptoms, or currently taking medication for treatment of diabetes; AND either

4. Age ≥ 50 years if male or ≥ 55 years if female (primary prevention cohort); OR

5. Age ≥ 18 years and established systemic atherosclerosis (secondary prevention cohort), defined as any 1 of the following:

• 1. Prior MI or ischemic (non-hemorrhagic) stroke
• 1. Coronary angiographic lesion of ≥ 60% stenosis in a major epicardial vessel or ≥ 50% left main stenosis
• 1. Asymptomatic carotid disease with ≥ 70% carotid artery stenosis
• 1. Symptomatic carotid disease with ≥ 50% carotid artery stenosis
• 1. Symptomatic lower extremity PAD (ie, intermittent claudication, rest pain, lower extremity ischemic ulceration, or major amputation with either ankle-brachial index ≤ 0.9 or other diagnostic testing [eg, toe-brachial index, angiogram, or other imaging study])
• 1. Prior arterial revascularization procedure (including coronary, carotid, or peripheral angioplasty/stenting, bypass, or atherectomy/endarterectomy)

Exclusion Criteria:

1. Current or planned use of fibrates or agents with PPAR-α agonist activity (eg, saroglitazar) within 6 weeks (42 days) of Visit 1 (Screening/Enrollment Visit). Note: PPAR-γ agonists (eg, glizatones such as pioglitazone and rosiglitazone) are allowed

2. Known sensitivity to PPAR-α agonists or tablet excipients

3. Initiation of, or change in, current TG-lowering therapy within 12 weeks of Visit 1 (if applicable). Note: TG-lowering therapy is defined as niacin > 100 mg/day or dietary supplements or prescription omega-3 fatty acids > 1 g/day

4. Type 1 diabetes mellitus

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Synexus Clinical Research US, Inc.	Birmingham	Alabama	United States	35211
2	University of Alabama at Birmingham	Birmingham	Alabama	United States	35233
3	VA Medical Center - Birmingham	Birmingham	Alabama	United States	35233
4	Alabama Clinical Therapeutics, LLC	Birmingham	Alabama	United States	35235
5	Fundamental Research, LLC	Gulf Shores	Alabama	United States	36542
6	Mobile Heart Specialists, PC	Mobile	Alabama	United States	36608
7	Terence T. Hart, MD	Tuscumbia	Alabama	United States	35674
8	Synexus Clinical Research US, Inc.	Chandler	Arizona	United States	85224-6279
9	Synexus Clinical Research US, Inc.	Mesa	Arizona	United States	85206
10	Arizona Arthritis & Rheumatology Research, PLLC	Peoria	Arizona	United States	85381
11	Phoenix Veterans Adminstration Health Care System	Phoenix	Arizona	United States	85012
12	Synexus Clinical Research US, Inc.	Phoenix	Arizona	United States	85050
13	Clinical Research Institute of Arizona, LLC	Surprise	Arizona	United States	85374
14	Synexus Clinical Research US, Inc.	Tucson	Arizona	United States	85712
15	Eclipse Clinical Research	Tucson	Arizona	United States	85745
16	Central Arkansas Veterans Healthcare System	Little Rock	Arkansas	United States	72205
17	Clinical Research Alliance, Inc	Alhambra	California	United States	91801
18	Aurora Care Clinic	Costa Mesa	California	United States	92627
19	AMCR Institute, Inc.	Escondido	California	United States	92025
20	National Institute of Clinical Research	Huntington Beach	California	United States	92648-1717
21	VA Loma Linda Healthcare System	Loma Linda	California	United States	92354
22	VA Long Beach Healthcare System	Long Beach	California	United States	90822
23	Eastside Clinical Research Associates	Los Angeles	California	United States	90022
24	VA Greater Los Angeles Healthcare System	Los Angeles	California	United States	90073
25	Richard S. Cherlin, MD	Los Gatos	California	United States	95032
26	Northridge Clinical Research Inc.	Northridge	California	United States	91324
27	Palo Alto Division	Palo Alto	California	United States	94304
28	Huntington Hospital - Research Department	Pasadena	California	United States	91105
29	Rancho Cucamonga Clinical Research	Rancho Cucamonga	California	United States	91730
30	MD Strategies Research Centers	San Diego	California	United States	92119
31	Alex Harrison, MD Inc.	Santa Maria	California	United States	93454
32	Santa Rosa Cardiology Medical Group, Inc.	Santa Rosa	California	United States	95404
33	Blue Coast Cardiology	Vista	California	United States	92083
34	Lynn Institute of Denver	Aurora	Colorado	United States	80012
35	New West Physicians, PC	Golden	Colorado	United States	80401
36	Southwest Family Medicine	Littleton	Colorado	United States	80127
37	Chase Medical Research, LLC	Waterbury	Connecticut	United States	06708
38	VA Connecticut Healthcare Sys	West Haven	Connecticut	United States	06516-2770
39	Cardiology Physicians, PA	Newark	Delaware	United States	19713
40	Bay Pines VA Healthcare System	Bay Pines	Florida	United States	33744
41	Meridien Research	Bradenton	Florida	United States	34201
42	Clinical Research Of Brandon, LLC	Brandon	Florida	United States	33511
43	Clearwater Cardiovascular Consultants	Clearwater	Florida	United States	33756
44	Daytona Heart Group	Daytona Beach	Florida	United States	32114
45	Cohen Medical Research Associates, LLC	Delray Beach	Florida	United States	33446
46	Malcom Randall VA Medical Center	Gainesville	Florida	United States	32608
47	Pines Clinical Research, Inc.	Hollywood	Florida	United States	33024
48	Homestead Cardiac & Vein Center	Homestead	Florida	United States	33030
49	Westside Center for Clinical Research	Jacksonville	Florida	United States	32205
50	Jacksonville Center for Clinical Research	Jacksonville	Florida	United States	32216
51	Health Awareness, Inc.	Jupiter	Florida	United States	33458
52	Meridien Research	Lakeland	Florida	United States	33805
53	Clearwater Cardiovascular & Interventional Consultants	Largo	Florida	United States	33777
54	University of Miami	Miami	Florida	United States	33136
55	Advanced Medical Research Institute	Miami	Florida	United States	33174
56	Ocala Research Institute, Inc.	Ocala	Florida	United States	34471
57	Morgan Medical Management & Consultants Inc.	Ocala	Florida	United States	34474
58	Endocrine Associates of Florida	Ocoee	Florida	United States	34761
59	Research Physicians Network Alliance	Orlando	Florida	United States	32803
60	Andres Patron, D.O., P.A	Pembroke Pines	Florida	United States	33026
61	DBC Research, Corp	Pembroke Pines	Florida	United States	33029
62	Langhorne Cardiology Consultants, Inc.	Pensacola	Florida	United States	32501
63	Clearwater Cardiovascular Consultants	Safety Harbor	Florida	United States	34695
64	Professional Health Care of Pinellas	Saint Petersburg	Florida	United States	33713
65	James A. Haley VA Medical Center	Tampa	Florida	United States	33612
66	Clinical Research of Central Florida	Winter Haven	Florida	United States	33880
67	Emory University	Atlanta	Georgia	United States	30322
68	Atlanta Heart Specialists, LLC	Cumming	Georgia	United States	30041
69	VA Medical Center - Atlanta	Decatur	Georgia	United States	30033
70	Alta Pharmaceutical Research Center, Inc.	Dunwoody	Georgia	United States	30338
71	Atlanta Heart Specialists, LLC	Tucker	Georgia	United States	30084
72	Christie Clinic, LLC	Champaign	Illinois	United States	61822
73	Apex Medical Research, AMR, Inc.	Chicago	Illinois	United States	60607
74	Clinical Investigation Specialists, Inc.	Gurnee	Illinois	United States	60031
75	Edward Hines Jr. VA Hospital	Hines	Illinois	United States	60141
76	Advocate Health and Hospitals Corp	Normal	Illinois	United States	61761
77	Captain James A. Lovell Federal Health Care Center	North Chicago	Illinois	United States	60064
78	Specialty Physicians of Illinois	Olympia Fields	Illinois	United States	60461
79	Community Hospital of Anderson and Madison County, Inc.	Anderson	Indiana	United States	46011
80	Synexus Clinical Research US, Inc.	Evansville	Indiana	United States	47714
81	Deaconess Clinic	Evansville	Indiana	United States	47725
82	VA Medical Center - Indianapolis	Indianapolis	Indiana	United States	46202
83	Cardiovascular Research of Northwest Indiana, LLC	Munster	Indiana	United States	46321
84	Buynak Clinical Research	Valparaiso	Indiana	United States	46383
85	West Broadway Clinic	Council Bluffs	Iowa	United States	51501
86	Iowa Diabetes and Endocrinology Research Center, PLC	Des Moines	Iowa	United States	50314
87	The Iowa Clinic, PC	West Des Moines	Iowa	United States	50266
88	University of Kansas Medical Center Research Institute, Inc.	Kansas City	Kansas	United States	66160
89	VA Eastern Kansas Health Care	Leavenworth	Kansas	United States	66048
90	The Research Group of Lexington, LLC	Lexington	Kentucky	United States	40503
91	Robley Rex VA Medical Center	Louisville	Kentucky	United States	40206
92	Cambridge Medical Trials	Alexandria	Louisiana	United States	71301
93	Cardiovascular Associates Research, LLC	Covington	Louisiana	United States	70433
94	Centex Studies Inc.	Lake Charles	Louisiana	United States	70601
95	Overton Brooks VA Medical Center	Shreveport	Louisiana	United States	71101
96	Southern Maine Health Care	Biddeford	Maine	United States	04005
97	Baltimore VA medical centre	Baltimore	Maryland	United States	21201
98	University of Maryland School of Medicine	Baltimore	Maryland	United States	21201
99	Maryland Cardiovascular Specialists	Baltimore	Maryland	United States	21229
100	Medstar Health Research Institute	Hyattsville	Maryland	United States	20782
101	Delmarva Heart Research Foundation, Inc.	Salisbury	Maryland	United States	21804
102	Joslin Diabetes Center	Boston	Massachusetts	United States	02215
103	Pentucket Medical Associates	Haverhill	Massachusetts	United States	01830
104	South Shore Internal Medicine Associates	Milton	Massachusetts	United States	02186
105	University of Michigan	Ann Arbor	Michigan	United States	48105
106	Veterans Affairs Ann Arbor Healthcare System	Ann Arbor	Michigan	United States	48105
107	Northern Pines Health Center	Buckley	Michigan	United States	49620
108	Cadillac Clinical Research, LLC	Cadillac	Michigan	United States	49601
109	AA MRC LLC Ahmed Arif Medical Research Center	Flint	Michigan	United States	48504
110	Sparrow Clinical Research Institute	Lansing	Michigan	United States	48912
111	Covenant Medical Center, Inc.	Saginaw	Michigan	United States	48602
112	Minneapolis Heart Institute Foundation	Minneapolis	Minnesota	United States	55407
113	Synexus Clinical Research US, Inc.	Richfield	Minnesota	United States	55432
114	CentraCare Heart & Vascular	Saint Cloud	Minnesota	United States	56303-1900
115	HealthEast Medical Research Institute	Saint Paul	Minnesota	United States	55102
116	GV Montgomery VA Medical Center	Jackson	Mississippi	United States	39216
117	Kansas City VA Medical Center	Kansas City	Missouri	United States	64128
118	Synexus Clinical Research US, Inc.	Saint Louis	Missouri	United States	63141
119	Kalispell Regional Medical Center dba Glacier View Research Institute	Kalispell	Montana	United States	59901
120	VA Nebraska-Western Iowa Health Care System	Omaha	Nebraska	United States	68105
121	University of Nebraska Medical Center	Omaha	Nebraska	United States	68198-4120
122	Synexus Clinical Research US, Inc.	Papillion	Nebraska	United States	68046
123	Synexus Clinical Research US, Inc.	Henderson	Nevada	United States	89052
124	Red Rock Clinical Research LLC	Las Vegas	Nevada	United States	89146
125	VA Sierra Nevada Health Care System	Reno	Nevada	United States	89502
126	Southern New Hampshire Diabetes and Endocrinology	Nashua	New Hampshire	United States	03063
127	Monmouth Cardiology Associates	Eatontown	New Jersey	United States	07724
128	NJ Heart	Linden	New Jersey	United States	07036
129	The Valley Hospital	Ridgewood	New Jersey	United States	07450
130	Raymond G. Murphy VA Medical Center	Albuquerque	New Mexico	United States	87108
131	Endocrine Group, L.L.P.	Albany	New York	United States	12206
132	Stratton Veterans Affairs Medical Center - Albany	Albany	New York	United States	12208
133	Buffalo VA Medical Center	Buffalo	New York	United States	14215
134	Winthrop Cardiology Associates	Mineola	New York	United States	11501
135	Icahn School of Medicine at Mount Sinai	New York	New York	United States	10029
136	SUNY Upstate Medical University	Syracuse	New York	United States	13210
137	VA Medical Center - Syracuse	Syracuse	New York	United States	13210
138	Randolph Medical Associates	Asheboro	North Carolina	United States	27203
139	OnSite Clinical Solutions, LLC	Asheville	North Carolina	United States	28801
140	Kernodle Clinic, Inc., Dept. of the Private Diagnostic Clinic, PLLC	Burlington	North Carolina	United States	27215
141	Cary Research Group, LLC	Cary	North Carolina	United States	27518
142	PMG Research of Cary, LLC	Cary	North Carolina	United States	27518
143	Novant Health - Heart and Vascular Institute	Charlotte	North Carolina	United States	28204
144	The Presbyterian Hospital	Charlotte	North Carolina	United States	28204
145	Focus Clinical Research Solutions	Charlotte	North Carolina	United States	28277
146	Medication Management, LLC	Greensboro	North Carolina	United States	27408
147	Triad Clinical Trials, LLC	Greensboro	North Carolina	United States	27410
148	Clinical Trials of America-NC, LLC	Hickory	North Carolina	United States	28601
149	PMG Research of Hickory, LLC	Hickory	North Carolina	United States	28601
150	Research Institute of the Carolinas, PLC	Mooresville	North Carolina	United States	28117
151	Diabetes and Endocrinology Consultants	Morehead City	North Carolina	United States	28557
152	Pinehurst Medical Clinic Inc	Pinehurst	North Carolina	United States	28374
153	PMG Research of Raleigh, LLC	Raleigh	North Carolina	United States	27609
154	PMG Research of Rocky Mount, LLC	Rocky Mount	North Carolina	United States	27804
155	PMG Research of Salisbury, LLC	Salisbury	North Carolina	United States	28144
156	Carolina Research Center, Inc.	Shelby	North Carolina	United States	28150-3803
157	Synexus Clinical Research US, Inc.	Akron	Ohio	United States	44311
158	OhioHealth Heart & Vascular Physicians (Heartcare, Inc.) - Athens	Athens	Ohio	United States	45701
159	Aultman Hospital	Canton	Ohio	United States	44710
160	Hometown Urgent Care & Occupational Health	Cincinnati	Ohio	United States	45215
161	Cincinnati Veterans Affairs Medical Center	Cincinnati	Ohio	United States	45267
162	Louis Stokes Cleveland Dept of VA Medical Center	Cleveland	Ohio	United States	44106
163	Prestige Clinical Research Center	Franklin	Ohio	United States	45005
164	Craig S Thompson MD LLC	Marion	Ohio	United States	43302
165	Intend Research	Norman	Oklahoma	United States	73069
166	Lynn Institute of Norman	Norman	Oklahoma	United States	73069
167	Oklahoma City Clinic - Central	Oklahoma City	Oklahoma	United States	73104
168	South Oklahoma Heart Research Group	Oklahoma City	Oklahoma	United States	73135
169	Heart Clinic of Southern Oregon	Medford	Oregon	United States	97504
170	Chambersburg Hospital	Chambersburg	Pennsylvania	United States	17201
171	AMH Feasterville Family Health Care Center	Feasterville	Pennsylvania	United States	19053
172	Family Medical Associates	Levittown	Pennsylvania	United States	19056
173	VA Pittsburgh Healthcare System	Pittsburgh	Pennsylvania	United States	15240
174	Preferred Primary Care Physicians	Pittsburgh	Pennsylvania	United States	15317
175	Fay West Family Practice	Scottdale	Pennsylvania	United States	15683
176	Montgomery Medical Inc.	Smithfield	Pennsylvania	United States	15478
177	Partners in Clinical Research	Cumberland	Rhode Island	United States	02864
178	Ocean State Clinical Research Partners	Lincoln	Rhode Island	United States	02865
179	Providence Veteran Administration Medical Center	Providence	Rhode Island	United States	02908
180	Synexus Clinical Research US, Inc.	Anderson	South Carolina	United States	29621-2062
181	Ralph H. Johnson VA Medical Center	Charleston	South Carolina	United States	29401
182	Mountain View Clinical Research, Inc.	Greer	South Carolina	United States	29651
183	Piedmont Research Partners	Indian Land	South Carolina	United States	29707
184	Main Street Physician's Care - Waterway	Little River	South Carolina	United States	29566
185	Family Medicine of Sayebrook	Myrtle Beach	South Carolina	United States	29588
186	Palmetto Research Center, LLC	Spartanburg	South Carolina	United States	29302
187	Palmetto Clinical Research	Summerville	South Carolina	United States	29485
188	PMG Research of Bristol, LLC	Bristol	Tennessee	United States	37620
189	Chattanooga Medical Research, LLC	Chattanooga	Tennessee	United States	37404
190	Chattanooga Research and Medicine (CHARM)	Chattanooga	Tennessee	United States	37404
191	University Diabetes & Endocrine Consultants	Chattanooga	Tennessee	United States	37411
192	WR-ClinSearch, LLC	Chattanooga	Tennessee	United States	37421
193	Holston Medical Group, P.C.	Kingsport	Tennessee	United States	37660
194	Metro Knoxville HMA, LLC	Knoxville	Tennessee	United States	37934
195	VA Medical Center - Memphis	Memphis	Tennessee	United States	38104
196	Tennessee Valley Healthcare System	Nashville	Tennessee	United States	37232
197	Central Texas Clinical Research, LLC	Austin	Texas	United States	78705
198	Protenium Clinical Research	Dallas	Texas	United States	75208
199	VA Medical Center - Dallas	Dallas	Texas	United States	75216
200	North Texas Endocrine Center	Dallas	Texas	United States	75231
201	Research Institute of Dallas, P.A.	Dallas	Texas	United States	75231
202	Synexus Clinical Research US, Inc.	Dallas	Texas	United States	75234
203	Doctors Hospital at Renaissance	Edinburg	Texas	United States	78539
204	Texas Health Research & Education Institute	Fort Worth	Texas	United States	76104
205	Texas Health Physicians Group	Fort Worth	Texas	United States	76107
206	University of North Texas Health Science Center	Fort Worth	Texas	United States	76107
207	Diabetes and Thyroid Center of Fort Worth	Fort Worth	Texas	United States	76132
208	Rockwood Medical Clinic	Fort Worth	Texas	United States	76164
209	East Texas Cardiology PA	Houston	Texas	United States	77002
210	Endocrine Associates, LLC	Houston	Texas	United States	77004
211	Heights Doctors Clinic	Houston	Texas	United States	77008
212	Associates in Medicine	Houston	Texas	United States	77027
213	Michael E. DeBakey VA Medical Center	Houston	Texas	United States	77030
214	Southwest Clinical Trials	Houston	Texas	United States	77081
215	Protenium Clinical Research	Hurst	Texas	United States	76054
216	Houston Methodist Research Institute - CCAT Pearland	Pearland	Texas	United States	77584
217	Clinical Investigations of Texas	Plano	Texas	United States	75075
218	Consano Clinical Research, LLC	San Antonio	Texas	United States	78205
219	Sant Antonio Premiere Internal Medicine	San Antonio	Texas	United States	78220
220	Briggs Clinical Research, LLC.	San Antonio	Texas	United States	78224
221	Schnitzler Cardiovascular Consultants (SCC), PLLC	San Antonio	Texas	United States	78229-3271
222	Bandera Family Healthcare Research LLC	San Antonio	Texas	United States	78249
223	Northeast Clinical Research of San Antonio	Schertz	Texas	United States	78154
224	Spring Family Practice Associates	Spring	Texas	United States	77379
225	Northwest Houston Heart Center	Tomball	Texas	United States	77375
226	Victoria Heart & Vascular Center	Victoria	Texas	United States	77901
227	Hillcrest Family Health Clinics	Waco	Texas	United States	76710
228	Utah Cardiology, P.C. (Davis)	Farmington	Utah	United States	84025
229	VA Medical Center	White River Junction	Vermont	United States	05055
230	Burke Internal Medicine & Research	Burke	Virginia	United States	22015
231	Virginia Endocrinology Research	Chesapeake	Virginia	United States	23321
232	Carient Heart and Vascular	Manassas	Virginia	United States	20109
233	Clinical Research Partners, LLC	Richmond	Virginia	United States	23220
234	McGuire DVA Medical Center	Richmond	Virginia	United States	23249
235	Roanoke Heart Institute	Roanoke	Virginia	United States	24014
236	Suffolk Multispecialty Research	Suffolk	Virginia	United States	23435
237	Corporation Lane Internal Medicine	Virginia Beach	Virginia	United States	23462
238	Cardiology Associates of Bellin Health	Green Bay	Wisconsin	United States	54301
239	Clinical Investigation Specialists Inc	Kenosha	Wisconsin	United States	53144
240	Mayo Clinic Health System	La Crosse	Wisconsin	United States	54601
241	Meriter Medical Group, Inc.	Madison	Wisconsin	United States	53713
242	Zablocki VA Medical Center	Milwaukee	Wisconsin	United States	53295
243	Hospital Interzonal General de Agudos Dr Jose Penna	Bahia Blanca	Buenos Aires	Argentina	8000
244	Hospital Italiano Regional del Sur	Bahia Blanca	Buenos Aires	Argentina	B8001HXM
245	Hospital Italiano	Ciudad Autonoma Buenos Aires	Buenos Aires	Argentina	C1181ACH
246	CICLO	La Plata	Buenos Aires	Argentina	B1902AGY
247	Centro de Investigaciones Medicas Mar del Plata	Mar del Plata	Buenos Aires	Argentina	B7600FYK
248	Instituto de Investigaciones Clinicas	Mar del Plata	Buenos Aires	Argentina	B7600FZ
249	Instituto de Investigaciones Clinicas San Nicolas	San Nicolas	Buenos Aires	Argentina	B2900DMH
250	Instituto Clinico Metabolico	San Nicolas	Buenos Aires	Argentina	B2900DPA
251	Clinica Olivos	Vicente Lopez	Buenos Aires	Argentina	1602
252	Hospital Sirio Libanes	Caba	Ciudad Autonoma Buenos Aires	Argentina	C1419GEP
253	Sanatorio Güemes	Ciudad Autonoma de Bs. As.	Ciudad Autonoma Buenos Aires	Argentina	C1180AAX
254	Centro Medico Viamonte SRL	Ciudad Autonoma de Buenos Aires	Ciudad Autonoma Buenos Aires	Argentina	C1120AAC
255	CEMEDIC - Centro de Especialidades Medicas	Villa Luro	Ciudad Autonoma Buenos Aires	Argentina	C1440CFD
256	Centro Medico Luquez	San Vicente	Cordoba	Argentina	X5006CBI
257	Axismed S.R.L.- Clínica Mayo	San Miguel de Tucuman	Tucuman	Argentina	4000
258	Consultorio Dr. Litvak Bruno	Ciudad Autonoma Buenos Aires		Argentina	1406
259	Fundacion Favaloro	Ciudad Autonoma Buenos Aires		Argentina	C1093AAS
260	CIPREC	Ciudad Autonoma Buenos Aires		Argentina	C1119ACN
261	Investigaciones Medicas IMOBA S.R.L	Ciudad Autonoma Buenos Aires		Argentina	C1179AAB
262	Centro Medico Dra Laura Maffei Investigacion Clinica Aplicada	Ciudad Autonoma Buenos Aires		Argentina	C1425AGC
263	CEDIC Centro de Investigaciones Clinicas	Ciudad Autonoma Buenos Aires		Argentina	C1425DES
264	Instituto Cardiovascular Buenos Aires	Ciudad Autonoma Buenos Aires		Argentina	C1428ART
265	CCBR - Buenos Aires - AR	Ciudad Autonoma Buenos Aires		Argentina	C1430CKE
266	Inst. Privado de Inv. Clinicas de Cordoba	Cordoba		Argentina	X5000AAW
267	Instituto Medico DAMIC	Cordoba		Argentina	X5003DCE
268	Hospital Privado Centro Medico de Cordoba S.A	Cordoba		Argentina	X5016KEH
269	Clinica del Prado	Cordoba		Argentina	X5020AAA
270	Instituto de Cardiologia de Corrientes	Corrientes		Argentina	3400
271	Prevencion Cardiovascular Salta	Salta		Argentina	A4400CRC
272	L2IP - Instituto de Pesquisas Clínicas Ltda.	Brasília	Distrito Federal	Brazil	70200-730
273	Hospital do Coração do Brasil	Brasília	Distrito Federal	Brazil	70390903
274	CECAP - Centro de Cardiologia Clínica	Brasília	Distrito Federal	Brazil	70710-100
275	Hospital Universitário de Brasília	Brasília	Distrito Federal	Brazil	70840-091
276	Clínica de Endocrinologia e Metabologia Ltda.	Brasília	Distrito Federal	Brazil	71655-175
277	CARDIOINTERV Centro de Pesquisa S/S	Goiânia	Goiás	Brazil	74210-050
278	Via Médica	Goiânia	Goiás	Brazil	74223-130
279	HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás	Goiânia	Goiás	Brazil	74605-020
280	Hospital Felício Rocho	Belo Horizonte	Minas Gerais	Brazil	30110-060
281	CARDRESEARCH - Cardiologia Assistencial	Belo Horizonte	Minas Gerais	Brazil	30150-240
282	Sociedade Hospitalar Angelina Caron	Campina Grande do Sul	Paraná	Brazil	83430-000
283	Cline Research Center (Leite PS Consultoria Medica LTDA)	Curitiba	Paraná	Brazil	80030-480
284	Núcleo de Pesquisa Clínica S/S	Curitiba	Paraná	Brazil	80730-150
285	Paraná Medical Research Center	Maringá	Paraná	Brazil	87015-000
286	HUJBB-UFPA - Hospital Universitário João de Barros Barreto - Universidade Federal do Pará	Belém	Pará	Brazil	66073-000
287	CCBR Brasil Centro de Pesquisas e Análises Clínicas Ltda.	Rio de Janeiro	Rio Do Janeiro	Brazil	22271-100
288	Eurolatino Natal Pesquisas Médicas Ltda.	Natal	Rio Grande Do Norte	Brazil	59020-500
289	Hospital Universitário	Canoas	Rio Grande Do Sul	Brazil	92425-900
290	Hospital São Vicente de Paulo	Passo Fundo	Rio Grande Do Sul	Brazil	99010-080
291	Santa Casa de Misericórdia de Pelotas	Pelotas	Rio Grande Do Sul	Brazil	96015-290
292	Santa Casa de Misericórdia de Porto Alegre	Porto Alegre	Rio Grande Do Sul	Brazil	90035-074
293	Hospital de Clínicas de Porto Alegre	Porto Alegre	Rio Grande Do Sul	Brazil	90035-903
294	Centro de Pesquisas em Diabetes Ltda.	Porto Alegre	Rio Grande Do Sul	Brazil	90430-001
295	Centro de Pesquisa Clínica Maimônides - Maimônides Day Hospital	Porto Alegre	Rio Grande Do Sul	Brazil	90480-000
296	Centro de Pesquisa Médica Santa Maria Ltda.	Santa Maria	Rio Grande Do Sul	Brazil	97015-530
297	Maestri e Kormann Consultoria Medico Científica LTDA	Blumenau	Santa Catarina	Brazil	89010-906
298	Loema - Instituto de Pesquisa Clínica	Campinas	Sao Paulo	Brazil	13010-001
299	IPCC - Instituto de Pesquisa Clínica de Campinas	Campinas	Sao Paulo	Brazil	13060-080
300	CEMEC - Centro Multidisciplinar de Estudos Clínicos	São Bernardo do Campo	Sao Paulo	Brazil	09780-000
301	Fundação Faculdade Regional de Medicina de São José do Rio Preto	São José do Rio Preto	Sao Paulo	Brazil	15090-000
302	ISPEM - Instituto São José dos Campos em Pesquisas Médicas	São José dos Campos	Sao Paulo	Brazil	12243-280
303	CPQuali Pesquisa Clínica Ltda.	São Paulo	Sao Paulo	Brazil	01228-000
304	CPCLIN - Centro de Pesquisas Clínicas Ltda.	São Paulo	Sao Paulo	Brazil	01228-200
305	Clínica Paulista de Doenças Cardiovasculares Ltda.	São Paulo	Sao Paulo	Brazil	01323-000
306	Dr. Consulta	São Paulo	Sao Paulo	Brazil	04208-002
307	CEPIC - Centro Paulista de Investigação Clínica e Serviços Médicos	São Paulo	Sao Paulo	Brazil	04266-010
308	Hospital das Clínicas da Faculdade de Medicina da USP	São Paulo	Sao Paulo	Brazil	05403-000
309	Incor - Instituto do Coração - HCFMUSP	São Paulo	Sao Paulo	Brazil	05403-000
310	IMC - Instituto de Moléstias Cardiovasculares Tatuí	Tatuí	Sao Paulo	Brazil	18270-170
311	Santa Casa de Votuporanga	Votuporanga	Sao Paulo	Brazil	15500-003
312	MHAT 'Puls' AD	Blagoevgrad		Bulgaria	2700
313	MHAT - Blagoevgrad, EOOD	Blagoevgrad		Bulgaria	2700
314	MHAT "Yuliya Vrevska - Byala", EOOD	Byala		Bulgaria	7100
315	MHAT-Haskovo, AD	Haskovo		Bulgaria	6300
316	MHAT "Higia", AD - Pazardzhik	Pazardzhik		Bulgaria	4400
317	MHAT - Pazardzhik AD	Pazardzhik		Bulgaria	4400
318	MHAT "Sv. Pantaleymon - Pleven", OOD	Pleven		Bulgaria	5800
319	SHATC Pleven EAD	Pleven		Bulgaria	5800
320	UMHAT 'Dr. Georgi Stranski', EAD	Pleven		Bulgaria	5800
321	UMHAT "Sv. Georgi", EAD	Plovdiv		Bulgaria	4000
322	UMHAT "Kaspela", EOOD	Plovdiv		Bulgaria	4002
323	MC Rusemed ltd.	Ruse		Bulgaria	7013
324	Diagnostic Consultative Center II - Sofia OOD	Sofia		Bulgaria	1040
325	Fifth MHAT - Sofia EAD	Sofia		Bulgaria	1233
326	NMTH "Tsar Boris III"	Sofia		Bulgaria	1233
327	MHAT - "National Heart Hospital" EAD	Sofia		Bulgaria	1309
328	MHAT "Lyulin", EAD	Sofia		Bulgaria	1336
329	Acibadem City Clinic Tokuda Hospital Ead	Sofia		Bulgaria	1407
330	MC Start - d-r Todor Dimitrov EOOD	Sofia		Bulgaria	1408
331	DCC "Alexandrovska", EOOD	Sofia		Bulgaria	1431
332	UMHAT "Alexandrovska" EAD	Sofia		Bulgaria	1431
333	UMHAT 'Tsaritsa Yoanna - ISUL', EAD	Sofia		Bulgaria	1527
334	Fourth MHAT - Sofia EAD	Sofia		Bulgaria	1606
335	Diagnostic Consultation Center CONVEX EOOD	Sofia		Bulgaria	1680
336	Medical Center Kalimat	Sofia		Bulgaria	1680
337	UMHAT 'Sveta Anna' AD	Sofia		Bulgaria	1750
338	MC "Synexus - Sofia", EOOD	Sofia		Bulgaria	1784
339	UMHAT "SofiaMed", OOD	Sofia		Bulgaria	1797
340	MC "Orfey", EOOD	Stara Zagora		Bulgaria	6000
341	SHATC "Cardiolife", OOD	Varna		Bulgaria	9000
342	SHATC - Varna, EOOD	Varna		Bulgaria	9002
343	MHAT "Sv. Panteleymon", AD	Yambol		Bulgaria	8600
344	LMC Clinical Research Inc. (Calgary)	Calgary	Alberta	Canada	T2H 2G4
345	ALTA Clinical Research Inc.	Edmonton	Alberta	Canada	T5A 4L8
346	Royal Alexandra Hospital, CK Hui Heart Centre	Edmonton	Alberta	Canada	T5H 3V9
347	The Bailey Clinic	Red Deer	Alberta	Canada	T4N 6V7
348	Fraser Clinical Trials Inc.	New Westminster	British Columbia	Canada	V3L 3W4
349	Surrey Memorial Hospital	Surrey	British Columbia	Canada	V3V 0C6
350	BC Diabetes As Operated by Dr. TG Elliott, Inc.	Vancouver	British Columbia	Canada	V5Y 3W2
351	Discovery Clinical Services Ltd.	Victoria	British Columbia	Canada	V8T 5G4
352	Saint Boniface General Hospital	Winnipeg	Manitoba	Canada	R2H 2A6
353	Rivergrove Medical Clinic	Winnipeg	Manitoba	Canada	R2V 4W3
354	Winnipeg Clinic	Winnipeg	Manitoba	Canada	R3A 1R9
355	Health Sciences Centre	St. John's	Newfoundland and Labrador	Canada	NL A1B 3V6
356	LMC Clinical Research Inc. (Barrie)	Barrie	Ontario	Canada	L4N 7L3
357	LMC Clinical Research Inc. (Brampton)	Brampton	Ontario	Canada	L6S 0C9
358	Aggarwal and Associates Ltd	Brampton	Ontario	Canada	L6T 0G1
359	JBN Medical Diagnostic Services Inc.	Burlington	Ontario	Canada	L7M 4Y1
360	LMC Clinical Research dba Manna Research Inc. Burlington North	Burlington	Ontario	Canada	L7M 4Y1
361	Cambridge Cardiac Care Centre	Cambridge	Ontario	Canada	N1R 6V6
362	Joanne F. Liutkus Medicine Professional Corporation	Cambridge	Ontario	Canada	N1R 7L6
363	Saul Vizel Professional Medicine Corporation	Cambridge	Ontario	Canada	N1R 7R1
364	LMC Clinical Research Inc. (Thornhill)	Concord	Ontario	Canada	L4K 4M2
365	LMC Clinical Research Inc. (Etobicoke)	Etobicoke	Ontario	Canada	M9R 4E1
366	Dawson Road Family Medical Clinic	Guelph	Ontario	Canada	N1H 1B1
367	LMC Clinical Research Inc. (Ottawa)	Nepean	Ontario	Canada	K2J 0V2
368	LMC Clinical Research Inc. (Oakville)	Oakville	Ontario	Canada	L6M1M1
369	James Cha, MD	Oshawa	Ontario	Canada	L1J 2K1
370	The Ottawa Hospital - Riverside Campus	Ottawa	Ontario	Canada	K1H 7W9
371	Kawartha Cardiology Clinical Trials	Peterborough	Ontario	Canada	K9J 0B2
372	Scarborough Cardiology Research	Scarborough	Ontario	Canada	M1E 5E9
373	Janik Research	Sudbury	Ontario	Canada	P3E 5M4
374	Humber River Hospital	Toronto	Ontario	Canada	M3M 0B2
375	LMC Clinical Research Inc. (Bayview)	Toronto	Ontario	Canada	M4G 3E8
376	St. Michael's Hospital	Toronto	Ontario	Canada	M5B 1W8
377	LMC Clinical Research dba Manna Research Inc. Toronto	Toronto	Ontario	Canada	M9W 4L6
378	Ecogene-21	Chicoutimi	Quebec	Canada	G7H 7K9
379	ViaCar Recherche Clinique Inc	Greenfield Park	Quebec	Canada	J4V 2G8
380	Centre de Dépistage et Recherche Cardiovasculaire Rive-Sud	Longueuil	Quebec	Canada	J4M 2X1
381	Clinique de Cardiologie de Levis	Lévis	Quebec	Canada	G6V 4Z5
382	LMC Clinical Research dba Manna Research Inc. Mirabel	Mirabel	Quebec	Canada	J7J 2K8
383	CHUM Hôtel-Dieu	Montreal	Quebec	Canada	H2W 1T8
384	Applied Medical Informatics Research Inc.	Montreal	Quebec	Canada	H4A 3T2
385	Clinique Santé Cardio MC	Montréal	Quebec	Canada	H1T 3Y7
386	Recherche Clinique Sigma Inc.	Québec	Quebec	Canada	G1G 3Y8
387	Clinique Médicale St-Louis (Recherche) inc d/b/a/ Centre de Recherche Saint-Louis	Québec	Quebec	Canada	G1W 4R4
388	ALPHA Recherche Clinique	Québec	Quebec	Canada	G3K 2P8
389	LMC Clinical Research Inc. (Montreal)	Saint-Laurent	Quebec	Canada	H4T 1Z9
390	Recherche Médicale St-Jérôme Inc.	St-Jérôme	Quebec	Canada	J7Z 5T3
391	Centre Medical des Carrieres	St-Marc-des-Carrieres	Quebec	Canada	G0A 4B0
392	DIEX Recherche Quebec Inc.	Quebec		Canada	G1N 4V3
393	Institut Universitaire de Cardiologie et de Pneumologie de Quebec	Quebec		Canada	G1V 4G5
394	Clinique des maladies Lipidiques de Quebec	Quebec		Canada	G1V 4M6
395	Centro de Investigacion Medico Asistencial S.A.S	Barranquilla		Colombia	080020
396	IPS Centro Cientifico Asistencial S.A.S	Barranquilla		Colombia	080020
397	Dexa Diab Servicios Médicos Limitada.	Bogota		Colombia	110221
398	Solano y Terront Servicios Médicos Ltda.	Bogota		Colombia	110221
399	Centro Cardiovascular Aristides Sotomayor Santa Lucia S.A.S. - IPS ASTALUC S.A.S. IPS	Cartagena		Colombia	130010
400	Fundación Centro de Investigaciones Biomédicas Riescard	Espinal		Colombia	00000
401	Fundación Oftalmológica de Santander - FOSCAL	Floridablanca		Colombia	681004
402	Centro de Investigación Clínica CIC	Medellin		Colombia	050021
403	Medicentrum Beroun spol. s.r.o.	Beroun		Czechia	266 01
404	Nemocnice Milosrdnych bratri	Brno		Czechia	639 00
405	Fakultni nemocnice u sv. Anny v Brne	Brno		Czechia	65691
406	EDUMED s.r.o	Broumov		Czechia	550 01
407	Poliklinika Chocen a.s.	Chocen		Czechia	56501
408	Ordinace pro choroby srdce s.r.o.	Chomutov		Czechia	430 02
409	MUDr. Jan Hubac s.r.o.	Chrudim		Czechia	537 01
410	Nemocnice Havlickuv Brod p.o.	Havlickuv Brod		Czechia	580 22
411	Kardio-Pisova s.r.o.	Hradec Kralove		Czechia	500 02
412	MUDr. Tomas Edelsberger	Krnov		Czechia	794 01
413	EDUMED s.r.o	Nachod		Czechia	547 01
414	Agentura Science Pro Spol. s.r.o.	Olomouc		Czechia	772 00
415	PreventaMed s.r.o.	Olomouc		Czechia	77900
416	CCR Ostrava s.r.o.	Ostrava		Czechia	702 00
417	Corintez s.r.o.	Prague		Czechia	158 00
418	MUDr. Jan KVASNICKA CSc. Angiologie kardiologie a interna	Praha 10		Czechia	101 00
419	Nemocnice na Frantisku	Praha 1		Czechia	110 00
420	Vseobecna fakultni nemocnice v Praze	Praha 2		Czechia	128 00
421	ResTrial s.r.o.	Praha 8		Czechia	18100
422	Synexus Czech s.r.o.	Praha		Czechia	120 00
423	MUDr.Eva Mandakova MBA	Rakovnik		Czechia	269 01
424	Nemocnice Slany	Slany		Czechia	274 01
425	AeskuLab k.s.	Teplice		Czechia	415 01
426	Kardiologicka ambulance MUDr. Ferkl s.r.o.	Trutnov		Czechia	541 01
427	Clinical Trials Services s.r.o	Uherske Hradiste		Czechia	68601
428	MUDr. Nina Zemkova s.r.o.	Uherske Hradiste		Czechia	68601
429	Bioclinica	Aalborg		Denmark	9000
430	Ålborg Universitets Hospital	Aalborg		Denmark	9100
431	Aarhus University Hospital	Aarhus		Denmark	8200
432	Bioclinica	Ballerup		Denmark	2750
433	Amager-Hvidovre Hospital	Copenhagen S		Denmark	2300
434	Sydvestjyds Sygehus Esbjerg	Esbjerg		Denmark	6700
435	Amager-Hvidovre Hospital	Glostrup		Denmark	2600
436	Herlev og Gentofte Hospital	Hellerup		Denmark	2900
437	Herlev og Gentofte Hospital	Herlev		Denmark	2730
438	Regionshospitalet Herning-Hospitalsenheden Vest	Herning		Denmark	7400
439	Holbæk Sygehus	Holbæk		Denmark	4300
440	Sjællands Universitetshospital	Roskilde		Denmark	4000
441	OUH	Svendborg		Denmark	5700
442	Bioclinica	Vejle		Denmark	7100
443	CHU Tours - Hôpital Trousseau	Chambray Les Tours	Indre Et Loire	France	37170
444	CHU Nantes - Hopital Nord Laënnec	Nantes cedex 01	Loire Atlantique	France	44093
445	Hôpital Bichat - Claude Bernard	Paris cedex 18	Paris	France	75877
446	Universitaetsklinikum Freiburg	Freiburg	Baden Wuerttemberg	Germany	79106
447	Praxis fuer Praevention und Therapie	Villingen-Schwenningen	Baden Wuerttemberg	Germany	78048
448	Gemeinschaftspraxis Dr. Klein/ Minnich	Kuenzing	Bayern	Germany	94550
449	Klinikum der Universitaet Muenchen	Muenchen	Bayern	Germany	80336
450	Deutsches Herzzentrum Muenchen	Muenchen	Bayern	Germany	80636
451	GP Dr. Haggenmiller, PD Dr. Michael Jeserich	Naumburg	Bayern	Germany	90402
452	ZKS-Südbrandenburg -center for clinical studies Südbrandenburg GmbH	Elsterwerda	Brandenburg	Germany	04910
453	Neurologische Praxis Dr. Schoell & Kollegen	Bad Homburg	Hessen	Germany	61348
454	Synexus Clinical Research GmbH	Frankfurt	Hessen	Germany	60313
455	ClinPhenomics GmbH & Co KG	Frankfurt	Hessen	Germany	60596
456	Klinische Forschung Schwerin GmbH	Schwerin	Mecklenburg Vorpommern	Germany	19055
457	Synexus Clinical Research GmbH	Bochum	Nordrhein Westfalen	Germany	44787
458	Gemeinschaftspraxis Diabeteszentrum Dortmund Dr.med. Klaus Busch	Dortmund	Nordrhein Westfalen	Germany	44137
459	Kardiologische Praxis Gemeinschaftspraxis	Dortmund	Nordrhein Westfalen	Germany	44137
460	St. Johannes Hospital	Dortmund	Nordrhein Westfalen	Germany	44137
461	Klinikum Bielefeld gem. GmbH	Dortmund	Nordrhein Westfalen	Germany	44139
462	Zentrum fuer Praevention und Rehabilitation	Siegen	Nordrhein Westfalen	Germany	57072
463	Synexus Clinical Research GmbH	Leipzig	Sachsen	Germany	04103
464	Gemeinschaftspraxis Dr. Taeschner / Dr. Bonigut	Leipzig	Sachsen	Germany	04249
465	Dr. Uwe Böckmann / Birgit Jacobs - Diabeteszentrum Neumünster	Neumünster	Schleswig Holstein	Germany	24534
466	RED - Institut GmbH	Oldenburg	Schleswig Holstein	Germany	23758
467	Katholisches Krankenhaus "St. Johann Nepomuk"	Erfurt	Thueringen	Germany	99097
468	Diabetespraxis Prenzlauer Allee	Berlin		Germany	10409
469	Institut fuer klinische Forschung und Entwicklung Berlin GmbH	Berlin		Germany	10437
470	Studienzentrum Rankestrasse	Berlin		Germany	10789
471	Synexus Clinical Research GmbH	Berlin		Germany	12627
472	Gemeinschaftspraxis fuer innere Medizin und Diabetologie	Hamburg		Germany	22607
473	Lausmed Kft.	Baja		Hungary	6500
474	Principal SMO Kft.	Baja		Hungary	6500
475	DRC Gyogyszervizsgalo Kozpont Kft.	Balatonfured		Hungary	8230
476	Bekes Megyei Kozponti Korhaz Dr. Rethy Pal Tagkorhaz	Bekescsaba		Hungary	5600
477	Belgyogyaszati es Kardiologiai Maganrendelo	Bekescsaba		Hungary	5600
478	Clinexpert Kft.	Budapest		Hungary	1033
479	Synexus Magyarorszag Kft.	Budapest		Hungary	1036
480	CSALADGYOGYASZ Kft.	Budapest		Hungary	1083
481	Semmelweis Egyetem	Budapest		Hungary	1083
482	Borvo Clinic Kft.	Debrecen		Hungary	4025
483	Debreceni Egyetem	Debrecen		Hungary	4032
484	Meditoll Kft.	Godollo		Hungary	2100
485	Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaza	Gyula		Hungary	5700
486	Synexus Magyarorszag Egeszsegugyi Szolgaltato Kft.- Gyula DRS	Gyula		Hungary	5700
487	BKS Research Kft.	Hatvan		Hungary	3000
488	Z+P MED Egeszsegugyi, Kereskedelmi es Szolgaltato Bt.	Kalocsa		Hungary	6300
489	Somogy Megyei Kaposi Mor Oktato Korhaz	Kaposvar		Hungary	7400
490	Selye Janos Korhaz	Komarom		Hungary	2900
491	IPR Hungary Kft.	Miskolc		Hungary	3530
492	Kanizsai Dorottya Korhaz	Nagykanizsa		Hungary	8800
493	Medifarma-98 Kft.	Nyiregyhaza		Hungary	4400
494	BORBANYA PRAXIS Kft.	Nyiregyhaza		Hungary	H-4405
495	Dr. Nagy Laszlo Kardiologiai Maganrendeles	Oroshaza		Hungary	5900
496	Da Vinci Maganklinika	Pecs		Hungary	7635
497	Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz	Szekesfehervar		Hungary	8000
498	Tolna Megyei Balassa Janos Korhaz	Szekszard		Hungary	7100
499	Csolnoky Ferenc Korhaz	Veszprem		Hungary	8200
500	Zala Megyei Szent Rafael Korhaz	Zalaegerszeg		Hungary	8900
501	Vijaya Super Speciality Hospital	Nellore	Andhra Pradesh	India	524001
502	GNRC Hospital	Guwahati	Assam	India	781006
503	Loknayak Hospital	New Delhi	Delhi	India	110002
504	Sir Gangaram Hospital	New Delhi	Delhi	India	110060
505	Fortis Flight Lieutenant Rajan Dhall Hospital	New Delhi	Delhi	India	110070
506	Ahmedabad Bariatrics and Cosmetics Pvt Ltd.	Ahmedabad	Gujarat	India	380015
507	S. A. L. Hospital & Medical Institute	Ahmedabad	Gujarat	India	380054
508	DDMM Heart Institute	Nadiad	Gujarat	India	387002
509	Shri B. D. Mehta Mahavir Heart Institute	Surat	Gujarat	India	395002
510	BAPS Pramukhswami Hospital	Surat	Gujarat	India	395009
511	Sterling Hospital	Vadodara	Gujarat	India	390007
512	Rhythm Heart Institute	Vadodara	Gujarat	India	391740
513	Medanta The Medicity	Gurgaon	Haryana	India	122001
514	Fortis Hospitals Ltd.	Bangalore	Karnataka	India	560052
515	K.L.E. Society's Dr. Prabhakar Kore Hospital and Medical Research Centre	Belgaum	Karnataka	India	590010
516	JSS Hospital	Mysuru	Karnataka	India	570004
517	Medical College	Thiruvananthapuram	Kerala	India	695 011
518	Meditrina Institute Of Medical Sciences	Nagpur	Maharashtra	India	440010
519	Supe Heart & Diabetes Hospital & Research Centre	Nashik	Maharashtra	India	422002
520	7-Orange Hospital	Pimpri-Chinchwad	Maharashtra	India	411033
521	Shree Multispecialty Hospital	Pune	Maharashtra	India	411006
522	King Edward Memorial Hospital Research Centre	Pune	Maharashtra	India	411011
523	Aashirwad Hospital	Ulhasnagar	Maharashtra	India	421001
524	Institute of Medical Sciences and SUM Hospital	Bhubaneshwar	Orissa	India	751003
525	Eternal Heart Care Centre	Jaipur	Rajasthan	India	302020
526	SRM Institutes for Medical Sciences	Chennai	Tamilnadu	India	600026
527	Institute of Cardiovascular Diseases Madras Medical Mission	Chennai	Tamilnadu	India	600037
528	KRM Hospital & Research Centre	Lucknow	Uttar Pradesh	India	226010
529	Galaxy Hospital	Varanasi	Uttar Pradesh	India	221010
530	IPGMER and SSKM Hospital	Kolkata	West Bengal	India	700020
531	Maharaja Agrasen Hospital	Delhi		India	110052
532	HaEmek Medical Center	Afula		Israel	18101
533	Bnai Zion Medical Center	Haifa		Israel	31048
534	Rambam Health Care Center	Haifa		Israel	3109601
535	The Lady Davis Carmel Medical Center	Haifa		Israel	34362
536	Wolfson Medical Center	Holon		Israel	58100
537	Shaare Zedek Medical Center	Jerusalem		Israel	91031
538	Hadassah University Hospital - Ein Kerem	Jerusalem		Israel	91120
539	Galilee Medical Center	Nahariya		Israel	2210001
540	Rabin Medical Center-Beilinson Campus	Petach Tikva		Israel	49100
541	Chaim Sheba Medical Center	Ramat-Gan		Israel	52621
542	Kaplan Medical Center	Rechovot		Israel	7610001
543	Ziv Medical Center	Safed		Israel	13100
544	Tel Aviv Sourasky Medical Center	Tel Aviv		Israel	6423906
545	Diabetes Medical Center	Tel Aviv		Israel	6937947
546	Aichi Medical University Hospital	Nagakute-shi	Aichi-Ken	Japan	480-1195
547	JOHAS Chubu Rosai Hospital	Nagoya-shi	Aichi-Ken	Japan	455-8530
548	Kojunkai Daido Clinic	Nagoya-shi	Aichi-Ken	Japan	457-8511
549	NHO Nagoya Medical Center	Nagoya-shi	Aichi-Ken	Japan	460-0001
550	National Center For Geriatrics And Gerontology	Obu-shi	Aichi-Ken	Japan	474-8511
551	Fujita Health University Hospital	Toyoake-shi	Aichi-Ken	Japan	470-1192
552	Chiba University Hospital	Chiba-shi	Chiba-Ken	Japan	260-8677
553	Kioroshikai Chibanishi General Hospital	Matsudo-shi	Chiba-Ken	Japan	270-2251
554	Seikeikai New Tokyo Heart Clinic	Matsudo-shi	Chiba-Ken	Japan	271-0077
555	Ehime Prefectural Central Hospital	Matsuyama-shi	Ehime-Ken	Japan	790-0024
556	Fukuoka University Hospital	Fukuoka-shi	Fukuoka-Ken	Japan	814-0180
557	Fukuoka Tokushukai Hospital	Kasuga-shi	Fukuoka-Ken	Japan	816-0864
558	Steel Memorial Yawata Hospital	Kitakyushu-shi	Fukuoka-Ken	Japan	805-8508
559	NHO Fukuoka Higashi Medical Center	Koga-shi	Fukuoka-Ken	Japan	811-3195
560	Chiyukai Fukuoka Shinmizumaki Hospital	Onga-gun	Fukuoka	Japan	807-0051
561	Southern Tohoku Medical Clinic	Koriyama-shi	Fukushima-Ken	Japan	963-8052
562	Hoshi General Hospital	Koriyama-shi	Fukushima-Ken	Japan	963-8501
563	Nakahama Heart Clinic	Fuchu-shi	Hiroshima-Ken	Japan	726-0013
564	Nippon Kokan Fukuyama Hospital	Fukuyama-shi	Hiroshima-Ken	Japan	721-0927
565	NHO Higashihiroshima Medical Center	Higashihiroshima-shi	Hiroshima-Ken	Japan	739-0041
566	Miyanosawa Clinic of Internal Medicine and Cardiology	Sapporo-shi	Hokkaido	Japan	063-0826
567	Tanaka Cardiology Clinic	Hitachinaka-shi	Ibaraki-Ken	Japan	312-0032
568	Nakakinen Clinic Medical Corporation Kensei-kai	Naka-shi	Ibaraki-Ken	Japan	311-0113
569	Public Central Hospital of Matto Ishikawa	Hakusan-shi	Ishikawa-Ken	Japan	924-8588
570	NHI Komatsu Municipal Hospital	Komatsu-shi	Ishikawa-Ken	Japan	923-8560
571	Kuonkai Kamata Medical Clinic	Morioka-shi	Iwate-Ken	Japan	020-0866
572	Iwate Medical University Uchimaru Medical Center Hospital	Morioka-shi	Iwate-Ken	Japan	020-8505
573	Josuikai Olive Takamatsu Medical Clinic	Takamatsu-shi	Kagawa-Ken	Japan	760-0076
574	Sohken Yamamoto Clinic	Sagamihara-shi	Kanagawa-Ken	Japan	252-0311
575	NHO Yokohama Medical Center	Yokohama-shi	Kanagawa-Ken	Japan	245-8575
576	Kumamoto University Hospital	Kumamoto-shi	Kumamoto-Ken	Japan	860-8556
577	Ryubokai Higashi Diabetes and Cardiovascular Clinic	Tamana-shi	Kumamoto-Ken	Japan	865-0016
578	Ijinkai Takeda General Hospital	Kyoto-shi	Kyoto-Fu	Japan	601-1495
579	Kyoto University Hospital	Kyoto-shi	Kyoto-Fu	Japan	606-8507
580	Rakuwakai Otowa Hospital	Kyoto-shi	Kyoto-Fu	Japan	607-8062
581	Sato Hospital	Osaki-shi	Miyagi-Ken	Japan	989-6143
582	Tohoku Kosai Hospital	Sendai-shi	Miyagi-Ken	Japan	980-0803
583	Sendai Kousei Hospital	Sendai-shi	Miyagi-Ken	Japan	980-0873
584	Keiwakai Oita Oka Hospital	Oita-shi	Oita-Ken	Japan	870-0192
585	Okayama University Hospital	Okayama-shi	Okayama-Ken	Japan	700-8558
586	Okinawa Tokushukai Chubu Tokushukai Hospital	Nakagami-gun	Okinawa-Ken	Japan	901-2393
587	Iwasaki Naika Clinic	Higashiosaka-shi	Osaka-Fu	Japan	577-0802
588	Takekawa Naika Clinic	Higashiosaka-shi	Osaka-Fu	Japan	577-0803
589	Rinku General Medical Center	Izumisano-shi	Osaka-Fu	Japan	598-8577
590	Shiraiwa Medical Clinic	Kashiwara-shi	Osaka-Fu	Japan	582-0005
591	Tokushukai Kishiwada Tokushukai Hospital	Kishiwada-shi	Osaka-Fu	Japan	596-8522
592	Kansai Electric Power Hospital	Osaka-shi	Osaka-Fu	Japan	553-0003
593	National Cerebral and Cardiovascular Center	Suita-shi	Osaka-Fu	Japan	564-8565
594	Senrichuo Ekimae Clinic	Toyonaka-shi	Osaka-Fu	Japan	560-0082
595	IMS Miyoshi General Hospital	Iruma-gun	Saitama-Ken	Japan	354-0041
596	Sugiura Clinic	Kawaguchi-shi	Saitama-Ken	Japan	332-0012
597	Sanyukai Saino Clinic	Tokorozawa-shi	Saitama-Ken	Japan	359-1141
598	NHO Saitama National Hospital	Wako-shi	Saitama-Ken	Japan	351-0102
599	Shiga University of Medical Science Hospital	Otsu-shi	Shiga-Ken	Japan	520-2192
600	NHO Hamada Medical Center	Hamada-shi	Shimane-Ken	Japan	697-8511
601	Jichi Medical University Hospital	Shimotsuke-shi	Tochigi-Ken	Japan	329-0498
602	Juntendo University Hospital	Bunkyo-ku	Tokyo-To	Japan	113-8431
603	Fukuwa Clinic	Chuo-ku	Tokyo-To	Japan	103-0027
604	Tokyo-Eki Center-Building Clinic	Chuo-Ku	Tokyo-To	Japan	103-0027
605	Nomura Clinic	Itabashi-ku	Tokyo-To	Japan	173-0004
606	Hosoda Clinic	Katsushika-ku	Tokyo-To	Japan	124-0021
607	Toyukai Yutenji Medical Clinic (Yutenji Naika)	Meguro-ku	Tokyo-To	Japan	153-0053
608	Shinjuku Research Park Clinic	Shinjuku-ku	Tokyo-To	Japan	169-0073
609	Yamaguchi University Hospital	Ube-shi	Yamaguchi-Ken	Japan	755-8505
610	Centro de Investigacion Cardiovascular y Metabolica	Tijuana	Baja California Norte	Mexico	22500
611	Phytomedicamenta S.A. de C.V.	Mexico	Distrito Federal	Mexico	03100
612	Health Pharma Professional Research S.A. de C.V.	Mexico	Distrito Federal	Mexico	03810
613	Centro de Atención e Investigación en Factores de Riesgo Cardiovascular Omega S.C.	Mexico	Distrito Federal	Mexico	06700
614	Instituto Nacional de Ciencias Médicas y Nutricion Dr. Salvador Zubiran	Mexico	Distrito Federal	Mexico	14080
615	Mentrials S.A. de C.V.	Mexico	Distrito Federal	Mexico	67000
616	Centro de Investigacion Clinica del Pacifico, S.A. de C.V.	Acapulco de Juárez	Guerrero	Mexico	39670
617	Cardiologia Clinica e Intervencionista	Guadalajara	Jalisco	Mexico	44670
618	Centro de Investigacion Medica de Occidente, S.C.	Zapopan	Jalisco	Mexico	45116
619	Instituto de Diabetes, Obesidad y Nutrición S.C.	Cuautla	Morelos	Mexico	62746
620	Universidad Autonoma de Nuevo Leon, Hospital Universitario Dr. Jose Eleuterio Gonzalez	Monterrey	Nuevo León	Mexico	64460
621	Centro Medico San Francisco	Monterrey	Nuevo León	Mexico	64710
622	Unidad Medica para la Salud Integral	San Nicolas de los Garza	Nuevo León	Mexico	66465
623	Centro Integral Medico SJR S.C.	San Juan del Rio	Queretaro	Mexico	76800
624	Centro de Estudios de Investigacion Metabolicos y Cardiovasculares S.C.	Madero	Tamaulipas	Mexico	89440
625	Centro de Investigacion Cardiometabolica de Aguascalientes S.A de C.V	Aguascalientes		Mexico	20230
626	Investigacion En Salud Y Metabolismo S.C.	Chihuahua		Mexico	31237
627	Sociedad de Metabolismo y Corazon S.C	Veracruz		Mexico	91900
628	Noordwest Ziekenhuisgroep	Alkmaar		Netherlands	1815 JD
629	Ziekenhuisgroep Twente, Almelo	Almelo		Netherlands	7609 PP
630	Meander Medisch Centrum	Amersfoort		Netherlands	3813 TZ
631	Ziekenhuis Amstelland	Amstelveen		Netherlands	1186 AM
632	BovenlJ Ziekenhuis	Amsterdam		Netherlands	1034 CS
633	Amsterdam UMC, Locatie AMC	Amsterdam		Netherlands	1105 AZ
634	Gelre ziekenhuizen, locatie Lukas	Apeldoorn		Netherlands	7334 DZ
635	Rijnstate	Arnhem		Netherlands	6815 AD
636	Haga Ziekenhuis	Den Haag		Netherlands	2545 AA
637	Deventer Ziekenhuis	Deventer		Netherlands	7416 SE
638	Albert Schweitzer Ziekenhuis, Dordwijk	Dordrecht		Netherlands	3318 AT
639	Gelderse Vallei Ziekenhuis, Ede	Ede		Netherlands	6716 RP
640	Catharina Ziekenhuis Eindhoven	Eindhoven		Netherlands	5623 EJ
641	Spaarne Gasthuis, Hoofddorp	Haarlem		Netherlands	2035 RC
642	Zuyderland Medisch Centrum - Heerlen	Heerlen		Netherlands	6419 PC
643	Huisartsenpraktijk Gorecht	Hoogezand		Netherlands	9603 AE
644	Quality Care Research	Kloosterhaar		Netherlands	7694 AC
645	Leids Universitair Medisch Centrum	Leiden		Netherlands	2333 ZA
646	Bravis Ziekenhuis, Roosendaal	Roosendaal		Netherlands	4708 AE
647	Maasstad Ziekenhuis, Zuider	Rotterdam		Netherlands	3079 DZ
648	Ikazia Ziekenhuis	Rotterdam		Netherlands	3083 AN
649	Albert Schweitzer Ziekenhuis, Zwijndrecht	Sliedrecht		Netherlands	3331 LZ
650	Bernhoven Uden	Uden		Netherlands	5406 PT
651	UMC Utrecht	Utrecht		Netherlands	3508 GA
652	Diakonessenhuis, Utrecht	Utrecht		Netherlands	3582 KE
653	Maxima Medisch Centrum	Veldhoven		Netherlands	5504 DB
654	VieCuri Medisch Centrum	Venlo		Netherlands	5912 BL
655	NZOZ Centrum Medyczne KERmed	Bydgoszcz		Poland	85-231
656	KARDIOMED Janczska Kociwska Ostki PodckaRekrzSp	Elblag		Poland	82-300
657	Poradnia Kardiologiczna Jarosław Jurowiecki	Gdansk		Poland	80-286
658	Synexus Polska SCM Sp. z o.o. Gdansku	Gdansk		Poland	80-382
659	Uniwersyteckie Centrum Kliniczne	Gdansk		Poland	80-952
660	Indywidualna Specjalistyczna Praktyka Lekarska w Dziedzinie Kardiologii lek. med. Krzysztof Cymerman	Gdynia		Poland	81-157
661	Synexus Polska Sp. z o.o. Oddzial w Gdyni	Gdynia		Poland	81-537
662	Samodzielny Publiczny Specjalistyczny Szpital Zachodni im. Jana Pawla II	Grodzisk Mazowiecki		Poland	05-825
663	Synexus Polska Sp. z o.o. Oddzial w Katowicach	Katowice		Poland	40-040
664	Centrum Medyczne Pratia Katowice II	Katowice		Poland	40-084
665	SPSK Nr 7 SUM w Katowicach Gornoslaskie CM im. prof. Leszka Gieca	Katowice		Poland	40-635
666	Specjalistyczna Poradnia Kardiologiczna i Nadciśnienia Tętniczego	Kielce		Poland	25-525
667	Augustyn Monika	Krakow		Poland	30-363
668	Krakowskie Centrum Medyczne Sp. z o.o.	Krakow		Poland	31-501
669	Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Łodzi	Lodz		Poland	93-513
670	NZOZ ALL-MED Centrum Medyczne Specjalistyczne Gabinety Lekarskie	Lodz		Poland	94-048
671	Indywidualna Specjalistyczna Praktyka Lekarska	Lodz		Poland	94-255
672	KO-MED Centra Kliniczne Lublin II	Lublin		Poland	20-362
673	Clinical Best Solutions	Lublin		Poland	20-709
674	NZOZ Twoja Przychodnia	Lublin		Poland	20-857
675	NZOZ Osrodek Kardiologii Inwazyjnej -Ikardia	Naleczow		Poland	24-140
676	Medicome Sp. z o.o.	Oswiecim		Poland	32-600
677	Synexus Polska sp. z o.o. Oddzial w Poznaniu	Poznan		Poland	60-702
678	Praktyka Lekarska Ewa Krzyzagorska	Poznan		Poland	61-655
679	KO-MED Centra Kliniczne Pulawy	Pulawy		Poland	24-100
680	NZOZ Przychodnia Specjalistyczna H. Rudzki, A. Wittek	Ruda Slaska		Poland	41-709
681	Centrum Medyczne Medyk	Rzeszow		Poland	35-055
682	Clinmed Research	Skierniewice		Poland	96-100
683	NZOZ Pro-Cordis Sopockie Centrum Bad. Kardiolog.	Sopot		Poland	81-717
684	NSZOZ Medicus	Sroda Wielkopolska		Poland	63-000
685	KO-MED Centra Kliniczne Staszow	Staszow		Poland	28-200
686	Indywidualna Specjalistyczna Praktyka Lekarska dr n. med. Agnieszka Karczmarczyk Specjalista Chorob	Szczecin		Poland	71-531
687	NBR Polska	Warsaw		Poland	00-465
688	Centrum Medyczne Świat Pacjenta	Warszawa		Poland	00-631
689	Synexus Polska Sp. z o.o. Oddział w Warszawie	Warszawa		Poland	01-192
690	Centrum Zdrowia Tuchow Sp. z o.o.	Wierzchosławice		Poland	33-122
691	Synexus Polska Sp. z o.o. Oddział we Wroclawiu	Wroclaw		Poland	50-381
692	KO-MED Centra Kliniczne Zamosc	Zamosc		Poland	22-400
693	VA Medical Center - San Juan	San Juan		Puerto Rico	00927-5800
694	S.C. CMI Dr. Pletea Noemi S.R.L	Bacau		Romania	600154
695	Cabinet Medical Individual Diabet, Nutritie, Boli Metabolice Dr. Pop Lavinia	Baia Mare		Romania	430222
696	S.C Centrul Medical de Diagnostic si Tratament Ambulator Neomed S.R.L	Brasov		Romania	500283
697	Institutul de Urgenta pentru Boli Cardiovasculare "Prof. Dr. C.C. Iliescu"	Bucharest		Romania	022328
698	S.C Clinica Medicala Data Plus S.R.L	Bucuresti		Romania	010192
699	Spitalul Clinic Colentina	Bucuresti		Romania	020125
700	Spitalul Clinic de Urgenta "Sfantul Pantelimon"	Bucuresti		Romania	021659
701	S.C. Health Net S.R.L	Bucuresti		Romania	030088
702	S.C Policlinica CCBR S.R.L	Bucuresti		Romania	030463
703	CMI Dr. Stolea T. Violeta - Medic specialist diabet zaharat, nutritie si boli metabolice	Bucuresti		Romania	061072
704	S.C. Medcon S.R.L.	Buzau		Romania	120203
705	S.C Grandmed S.R.L	Oradea		Romania	410159
706	S.C Pelican Impex S.R.L	Oradea		Romania	410469
707	S.C. Bella Praxis S.R.L	Pașcani		Romania	705200
708	S.C. Diabmed Dr. Popescu Alexandrina S.R.L	Ploiesti		Romania	100163
709	CMI Dr Busegeanu Mihaela Magdalena	Ploiesti		Romania	100342
710	S.C Mediab S.R.L	Targu Mures		Romania	540142
711	S.C Medicali's S.R.L	Timisoara		Romania	300359
712	Spitalul Clinic Judetean de Urgenta "Pius Brinzeu"	Timisoara		Romania	300723
713	SBIH of Arkhangelsk region " First City Clinical hospital n.a. E. E. Volosevich"	Arkhangelsk		Russian Federation	163001
714	TSHI "Altay Territorial Cardiologocal dispensary"	Barnaul		Russian Federation	656055
715	SEIHPE "Ural SMA of RosZdrav" b.o. LLC "City Hospital #41"	Ekaterinburg		Russian Federation	620026
716	FSHI "MSU of MoIA of RF of Kemerovo Region"	Kemerovo		Russian Federation	650000
717	FSBI "Scientific-research Institute for Complex Problems of cardiovascular disease"	Kemerovo		Russian Federation	650002
718	NSIH "Departmental Hospital on Station Kemerovo of OJSC "Russian Railways"	Kemerovo		Russian Federation	650055
719	SAIH "Kemerovo Regional Clinical Hospital"	Kemerovo		Russian Federation	650066
720	TSBIH "Krasnoyarsk Interdistrict Clinical Hospital of Emergency Medical Care n.a. N.S. Karpovich	Krasnoyarsk		Russian Federation	660062
721	SBIH of Moscow "City Clinical Hospital n.a.Bakhrushinykh"	Moscow		Russian Federation	107 014
722	SBHI "City Polyclinic #2 of Healthcare department of city of Moscow"	Moscow		Russian Federation	117556
723	FSBIH "Central Clinical Hospital of Russian Academy of Sciences"	Moscow		Russian Federation	117593
724	FSBI "Central Clinical Hospital with Polyclinic of the Department for Presidential Affairs of the RF	Moscow		Russian Federation	121359
725	SBEI HPE "Moscow State Medical and Dentistry University n.a. A. I. Evdokimov" of the MoH of the RF	Moscow		Russian Federation	127473
726	SBEI HPE "Moscow State Medical and Dentistry University n.a. A. I. Evdokimov" of the MoH of the RF	Moscow		Russian Federation	129301
727	Murmansk Regional Clinical Hospital named after Bayandin	Murmansk		Russian Federation	183047
728	SBIH of Novosibirsk Region "Clinical Emergency Hospital #2"	Novosibirsk		Russian Federation	630008
729	SBIH of Novosibirsk region "City Clinical Hospital # 19"	Novosibirsk		Russian Federation	630068
730	FSBSI "Scientific Research Institute of Therapy and Preventive Medicine"	Novosibirsk		Russian Federation	630089
731	LLC "RC Medical"	Novosibirsk		Russian Federation	630091
732	BIH of Omsk region "Clinical Medico-Sanitary Unit # 9	Omsk		Russian Federation	644018
733	Llc Ultramed	Omsk		Russian Federation	644024
734	SBIH of Perm territory " City Clinical Hospital # 2 n.a. Fedor Khristoforovich Gral"	Perm		Russian Federation	614068
735	State Budgetary Healthcare Institution Clinical Medical Sani	Perm		Russian Federation	614077
736	SHI "Perm Regional Hospital of War Veterans"	Perm		Russian Federation	614097
737	City Emergency Hospital #2	Rostov-on-Don		Russian Federation	344068
738	CJSC Clinic complex	Saint-Petersburg		Russian Federation	190013
739	FSBI North-West Federal Medical Research Center n.a. V.A. Almazov of MoH RF	Saint-Petersburg		Russian Federation	194156
740	Saint-Petersburg SBHI "City outpatient clinic #28"	Saint-Petersburg		Russian Federation	195427
741	Pavlov First Saint Petersburg State Medical University	Saint-Petersburg		Russian Federation	197022
742	SPb SBIH "City Pokrovskaya Hospital"	Saint-Petersburg		Russian Federation	199106
743	LLC Medical Center Mart	Saint-Petersburg		Russian Federation	199178
744	SIH "Saratov City Clinical Hospital # 2 n.a. V.I. Razumovskiy"	Saratov		Russian Federation	410028
745	SPb SBIH "City Hospital # 40 of Kurortnyi region"	Sestroretsk		Russian Federation	197706
746	SPb SBIH "City Multy-field Hospital # 2"	St. Petersburg		Russian Federation	194354
747	LLC "Institute of Medical Examinations"	St. Petersburg		Russian Federation	196084
748	Llc "Medinet"	St. Petersburg		Russian Federation	197136
749	SPb SBIH "Nikolaevskaya Hospital"	St. Petersburg		Russian Federation	198510
750	FSBI "Research Institute for Cardiology" of Siberian Branch RAMS	Tomsk		Russian Federation	634012
751	SHI "Regional Clinical Hospital"	Tver		Russian Federation	170036
752	SHI Ulyanovsk Reg Clinical Hospital	Ulyanovsk		Russian Federation	432063
753	Yaroslavl Regional Clinical Hospital of War Veterans	Yaroslavl		Russian Federation	150047
754	Alian s.r.o.	Bardejov		Slovakia	085 01
755	Thyreomedical s.r.o.	Bardejov		Slovakia	08501
756	Metabol KLINIK s.r.o.	Bratislava		Slovakia	81108
757	Galenum, s.r.o.	Bratislava		Slovakia	821 07
758	DIAFA s.r.o.	Bratislava		Slovakia	82102
759	Diabet, spol. s.r.o.	Bratislava		Slovakia	82108
760	Kardiovaskularne centrum, s.r.o.	Bratislava		Slovakia	83101
761	Kardiologicka, interna a sonograficka amb. Kardio-Sanus, sro	Bratislava		Slovakia	84108
762	MEDISPEKTRUM PLUS s.r.o.	Bratislava		Slovakia	85101
763	MUDr. Vladimir Gergel, s.r.o.	Bratislava		Slovakia	85101
764	ENDIAMED, s.r.o.	Dolny Kubin		Slovakia	02601
765	MEDICUS plus s.r.o.	Komarno		Slovakia	94501
766	Human-Care s.r.o.	Kosice		Slovakia	04001
767	Sukromna interna a kardiologicka ambulancia	Kosice		Slovakia	04001
768	DIA- Kontrol s.r.o.	Levice		Slovakia	93401
769	CELL B, s.r.o.	Levice		Slovakia	93405
770	KARDIO 1 s.r.o.	Lucenec		Slovakia	984 39
771	IN-DIA s.r.o.	Lucenec		Slovakia	98401
772	MUDr. Zuzana Ochodnicka,	Nitra		Slovakia	94911
773	Fakultna nemocnica s poliklinikou Nove Zamky	Nove Zamky		Slovakia	94002
774	DIABETOL s.r.o.	Presov		Slovakia	08001
775	Medispol s.r.o.	Presov		Slovakia	08001
776	Nemocnica s poliklinikou sv. Barbory Roznava a.s.	Roznava		Slovakia	04801
777	Peter Farkas MD, s.r.o.	Sahy		Slovakia	93601
778	Interna SK s.r.o.	Svidnik		Slovakia	08901
779	Nemocnica arm. generala L. Svobodu Svidnik, a.s.,	Svidnik		Slovakia	08901
780	Diabetes centrum, s.r.o.	Trencin		Slovakia	91101
781	JAL s.r.o.	Trnava		Slovakia	91701
782	MEDIVASA s.r.o.	Zilina		Slovakia	01001
783	Cardiology Clinical Research	Alberton	Gauteng	South Africa	1449
784	Johese Clinical Research: Unitas	Centurion	Gauteng	South Africa	0157
785	Medicross Roodepoort Clinical Research	Johannesburg	Gauteng	South Africa	1724
786	Lenasia Clinical Trial Centre	Johannesburg	Gauteng	South Africa	1827
787	Wits Clinical Research	Johannesburg	Gauteng	South Africa	2013
788	Clinresco Centres (Pty) Ltd	Kempton Park	Gauteng	South Africa	1619
789	Synexus SA - Stanza Clinical Research Centre	Mamelodi East	Gauteng	South Africa	0122
790	Seeber, M	Pretoria	Gauteng	South Africa	0002
791	Emmed Research	Pretoria	Gauteng	South Africa	0084
792	Synexus SA Watermeyer Clinical Research Centre	Pretoria	Gauteng	South Africa	0184
793	Johese Clinical Research: Midstream	Pretoria	Gauteng	South Africa	1692
794	Limpopo Clinical Research Initiative	Thabazimbi	Limpopo	South Africa	0380
795	Dr AA Mahomed Medical Centre	Moloto	Mpumalanga	South Africa	1022
796	Synexus Helderberg Clinical Research Centre	Cape Town	Western Cape	South Africa	7130
797	Corbod Research	Cape Town	Western Cape	South Africa	7500
798	Tread Research	Cape Town	Western Cape	South Africa	7500
799	Tiervlei Trial Centre	Cape Town	Western Cape	South Africa	7530
800	Cape Town Medical Research Centre	Cape Town	Western Cape	South Africa	7580
801	Paarl Research Centre	Cape Town	Western Cape	South Africa	7646
802	Groote Schuur Hospital Lipid Laboratory	Cape Town	Western Cape	South Africa	7925
803	Dr JM Engelbrecht Practice	Somerset West	Western Cape	South Africa	7130
804	Helderberg Research Institute	Somerset West	Western Cape	South Africa	7130
805	Hospital Universitari Germans Trias i Pujol	Badalona	Barcelona	Spain	08916
806	Hospital Virgen del Camino	Sanlucar de Barrameda	Cádiz	Spain	11540
807	Hospital Universitario Reina Sofia	Cordoba	Córdoba	Spain	14004
808	Complejo Hospitalario Universitario A Coruña	A Coruña	La Coruña	Spain	15006
809	Complejo Hospitalario Universitario de Santiago	Santiago de Compostela	La Coruña	Spain	15706
810	Hospital Virgen del Mar	Almeria		Spain	04120
811	Hospital del Mar	Barcelona		Spain	08003
812	Hospital Quironsalud Barcelona	Barcelona		Spain	08023
813	Hospital de la Santa Creu i Sant Pau	Barcelona		Spain	08025
814	Hospital Universitari Vall d'Hebron	Barcelona		Spain	08035
815	Hospital Universitario Ramon y Cajal	Madrid		Spain	28034
816	Hospital Regional Universitario de Malaga	Málaga		Spain	29010
817	Nuevas tecnologías en Diabetes y Endocrinología	Sevilla		Spain	41003
818	Hospital Quironsalud Infanta Luisa	Sevilla		Spain	41010
819	Hospital Universitario Virgen Macarena	Sevilla		Spain	41071
820	Cherkasy Regional Cardiological Center	Cherkasy		Ukraine	18009
821	CI Cherkasy RH of Cherkasy Regional Council	Cherkasy		Ukraine	18009
822	CMI CCH#3 Dep of Ther# w the beds of card profile HSEI of UBSMU	Chernivtsi		Ukraine	58000
823	RCI Chernivtsi Regional Endocrinology Center Policlinic Dept SHEI of UBSMU	Chernivtsi		Ukraine	58022
824	CI Dnipropetrovsk City Cl Hosp #9 of Dniprop Reg Council SI DMA of MOH of Ukr Ch of Endocrinology	Dnipro		Ukraine	49000
825	Medical Center of Limited Liability Company Medical Center Clinic of Family Medicine	Dnipro		Ukraine	49038
826	Regional CH Dept of Endocrinology SHEI Ivano-Frankivsk NMU	Ivano-Frankivsk		Ukraine	76008
827	CI Ivano-Frankivsk Reg Cl Card Center Dept of Chronic Ischemic Heart Dis SHEI Ivano-Frank NMU	Ivano-Frankivsk		Ukraine	76018
828	Ivano-Frankivsk CCH Dept of Therapy #1 SHEI Ivano-Frankivsk NMU	Ivano-Frankivsk		Ukraine	76018
829	CHI Kharkiv City Student Hosp Therap dept Nat Pharm Univer	Kharkiv		Ukraine	61002
830	CNE Prof. O.O. Shalimov Kharkiv City Clinical Hospital #2 KCC	Kharkiv		Ukraine	61037
831	GI L.T.Malaya Therapy National Institute of the NAMS of Ukraine	Kharkiv		Ukraine	61039
832	State Institution LT Malaya Inst. of Ther. of AMS of Ukraine	Kharkiv		Ukraine	61039
833	Railway Transport Kharkiv CH #1 of Healthcare Center Branch of PJSC Ukr Railway	Kharkiv		Ukraine	61103
834	Railway Transport Kharkiv CH#1 of Healthcare Center Branch of PJSC Ukrainian Railway	Kharkiv		Ukraine	61103
835	MC Doctor Alex Dept of General Practice-Family Medicine Kharkiv MA of PGE	Kharkiv		Ukraine	61106
836	CNE City Clin Hosp #8 of KCC Dept of Therapy Kharkiv MA of PGE of MOHU	Kharkiv		Ukraine	61176
837	CI Ye.Ye.Karabelesh Kherson City Clinical Hosp.	Kherson		Ukraine	73000
838	KCCC of Endocr Dept of General Endocrine Pathology O. O. Bogomolets NMU	Kyiv		Ukraine	01004
839	Kyiv CCH #12 Dept of Therapy O.O.Bogomolets NMU	Kyiv		Ukraine	01103
840	LLC Treatment and Diagnostic Center Adonis Plus	Kyiv		Ukraine	02002
841	MC of PHEI Institute of General Practice - Family Medicine	Kyiv		Ukraine	02002
842	Medical Center Blagomed Plus LLC	Kyiv		Ukraine	02081
843	Med Center 'Ok!Clinic+' of International Institute of Clinical Trials LLC	Kyiv		Ukraine	02091
844	MC of Subsidiary Production Unit Med Scient Pract Union Medbud of PJSc Holding Company Kyivmiskbud	Kyiv		Ukraine	03037
845	Kyiv CH on Railway Transport #2 of Branch Center of Healthcare Public Company Ukr Railway	Kyiv		Ukraine	03049
846	Med Center of Eurolab LLC Policlinic Outpatient Dept O.O.Bogomolets NMU	Kyiv		Ukraine	03110
847	SI National Scientific Centre of Radiation Medicine of NAMSU	Kyiv		Ukraine	03115
848	SI NSC M.D. Strazhesko Institute of Cardiology of NAMSU	Kyiv		Ukraine	03680
849	SI NSС M.D. Strazhesko Institute of Cardiology of NAMSU	Kyiv		Ukraine	03680
850	Department of Medical Services and Rehabilitation of State Joint Stock Holding Company Artem	Kyiv		Ukraine	04050
851	Medical Center of Limited Liability Company Medical Center Concilium Medical	Kyiv		Ukraine	04050
852	CI of Kyiv RC Regional Clinical Hospital #2	Kyiv		Ukraine	04053
853	SI V.P.Komisarenko Institute of E&M of NAMSU	Kyiv		Ukraine	04114
854	SI V.P.Komisarenko Institute of Endocrinology and Metabolism of NAMSU	Kyiv		Ukraine	04114
855	Lviv Reg St Clin Treatment - Diagnostic Endocrin Center, Dept of Polyclinic, D.Galytskyy Lviv NMU	Lviv		Ukraine	79010
856	Lviv Communal 4th City Clinical Hospital	Lviv		Ukraine	79011
857	Center of Reconstructive & Restorative Medicine (University Clinic) of Odessa National Medical Uni	Odesa		Ukraine	65000
858	CI Sumy City Clinical Hospital #1 Dept of Therapy Sumy SU Med Inst	Sumy		Ukraine	40021
859	Ternopil City Municipal Hospital #2 Dept of Gastroenterology Ternopil I.Ya. Gorbachevskyi SMU	Ternopil		Ukraine	46023
860	Transcarpathian Regional Clinical Cardiology Dispansery	Uzhgorod		Ukraine	88014
861	Private Small Enterprise Medical Center Pulse	Vinnytsia		Ukraine	21001
862	Vinnytsia RC Highly Special.Endocr.Center Dept of Therapy #2 M.I. Pyrogov NMU	Vinnytsia		Ukraine	21010
863	National Pirogov Memorial Medical University	Vinnytsia		Ukraine	21018
864	SRI of Invalid Rehabilitation (EST Complex) of Vinnytsia M.I.Pyrogov NMU MOHU	Vinnytsia		Ukraine	21029
865	CI Zapor CCH#10 SI ZMA PGE Ch of therapy clin pharmacol & endocrin	Zaporizhzhia		Ukraine	69001
866	CI Central City Hospital #1 of Zhytomyr	Zhytomyr		Ukraine	10002
867	Zhytomyr regional clinical hospital n.a. O.F. Gerbachevskyy	Zhytomyr		Ukraine	10002
868	Synexus Thames	Reading	Berkshire	United Kingdom	RG2 0TG
869	Mounts Bay Medical Ltd	Hayle	Cornwall	United Kingdom	TR27 5DT
870	Oak Tree Surgery	Liskeard	Cornwall	United Kingdom	PL14 3XA
871	The Alverton Practice	Penzance	Cornwall	United Kingdom	TR18 4JH
872	Rame Medical Limited	Torpoint	Cornwall	United Kingdom	PL11 2TB
873	Knowle House Surgery	Plymouth	Devon	United Kingdom	PL5 3JB
874	Torbay Hospital	Torquay	Devon	United Kingdom	TQ2 7AA
875	Synexus Clinical Research North Tees	Stockton on Tees	Durham	United Kingdom	TS19 8PE
876	Broomfield Hospital	Chelmsford	Essex	United Kingdom	CM1 7ET
877	Barts Hospital	London	Greater London	United Kingdom	EC1A 7BE
878	Manchester Royal Infirmary	Manchester	Greater Manchester	United Kingdom	M13 9WL
879	Synexus Manchester Clinical Research Centre	Manchester	Greater Manchester	United Kingdom	M15 6SX
880	Waterloo Medical Centre	Blackpool	Lancashire	United Kingdom	FY4 3AD
881	Synexus Lancashire Clinical Research Centre	Chorley	Lancashire	United Kingdom	PR7 7NA
882	Synexus Merseyside Clinical Research Centre	Liverpool	Merseyside	United Kingdom	L22 0LG
883	Synexus Hexham General Hospital	Hexham	Northumberland	United Kingdom	NE46 1QJ
884	Synexus Wales Clinical Research Centre	Cardiff	South Glamorgan	United Kingdom	CF15 9SS
885	Synexus Scotland Clinical Research Centre	Glasgow	Strathclyde	United Kingdom	G20 OSP
886	Ninewells Hospital	Dundee	Tayside Region	United Kingdom	DD1 9SY
887	Synexus Birmingham Clinical Research Centre	Birmingham	West Midlands	United Kingdom	B15 2SQ
888	Morriston Hospital	Swansea		United Kingdom	SA6 6NL

Sponsors and Collaborators

• Kowa Research Institute, Inc.
• Brigham and Women's Hospital

Investigators

• Study Director: Paul Ridker, MD, CCVDP & The Brigham and Women's Hospital
• Study Director: Aruna Pradhan, MD, CCVDP & The Brigham and Women's Hospital

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Kowa Research Institute, Inc.
• ClinicalTrials.gov Identifier: NCT03071692
• Other Study ID Numbers: K-877-302
• First Posted: Mar 7, 2017
• Last Update Posted: Aug 4, 2022
• Last Verified: Aug 1, 2022

• Studies a U.S. FDA-regulated Drug Product: Yes
• Studies a U.S. FDA-regulated Device Product: No
• Additional relevant MeSH terms: Diabetes Mellitus; Dyslipidemias

Study Results

No Results Posted as of Aug 4, 2022