A Study to Assess the Efficacy and Safety of Risankizumab in Participants With Ulcerative Colitis

Sponsor

AbbVie (Industry)

Overall Status

Enrolling by invitation

CT.gov ID

NCT03398135

Collaborator

(none)

942

Enrollment

424

Locations

Arms

68.8

Anticipated Duration (Months)

2.2

Patients Per Site

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to evaluate safety and efficacy of risankizumab in participants with ulcerative colitis (UC) in participants who responded to induction treatment with risankizumab in a prior AbbVie study of risankizumab in UC.

This study consists of three sub-studies: Substudy 1 is a 52-week, randomized, double-blind, placebo-controlled maintenance study; Substudy 2 is 52-week, randomized, exploratory maintenance study; and Substudy 3 is an open-label long-term extension study for participants who completed Substudy 1 or 2, or participants who responded to induction treatment in Study M16-067 with no final endoscopy due to the Covid-19 pandemic.

Condition or Disease	Intervention/Treatment	Phase
Ulcerative Colitis (UC)	Drug: risankizumab Drug: placebo for risankizumab	Phase 3

Study Design

Study Type:

Interventional

Anticipated Enrollment :

942 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Masking:

Triple (Participant, Investigator, Outcomes Assessor)

Primary Purpose:

Treatment

Official Title:

A Multicenter, Randomized, Double-Blind, Placebo Controlled 52-Week Maintenance and an Open-Label Extension Study of the Efficacy and Safety of Risankizumab in Subjects With Ulcerative Colitis

Actual Study Start Date :

Aug 28, 2018

Anticipated Primary Completion Date :

Dec 15, 2023

Anticipated Study Completion Date :

May 23, 2024

Arms and Interventions

Arm	Intervention/Treatment
Placebo Comparator: Substudy 1: Double-blind Placebo Participants randomized to receive placebo for risankizumab administered by subcutaneous (SC) injection.	Drug: placebo for risankizumab subcutaneous (SC) injection
Experimental: Substudy 1: Double-blind Risankizumab Dose 1 Participants randomized to receive risankizumab dose 1 administered by subcutaneous (SC) injection.	Drug: risankizumab subcutaneous (SC) injection Other Names: ABBV-066 BI 655066 SKYRIZI
Experimental: Substudy 1: Double-blind Risankizumab Dose 2 Participants randomized to receive risankizumab dose 2 administered by subcutaneous (SC) injection.	Drug: risankizumab subcutaneous (SC) injection Other Names: ABBV-066 BI 655066 SKYRIZI
Experimental: Substudy 2: Open-label (OL) Clinical Assessment Risankizumab Participants randomized to receive risankizumab dose 1 administered by subcutaneous (SC) injection.	Drug: risankizumab subcutaneous (SC) injection Other Names: ABBV-066 BI 655066 SKYRIZI
Experimental: Substudy 2: OL Therapeutic Drug Monitoring Risankizumab Participants randomized to receive risankizumab dose 1 administered by subcutaneous (SC) injection.	Drug: risankizumab subcutaneous (SC) injection Other Names: ABBV-066 BI 655066 SKYRIZI
Experimental: Substudy 3: OL Extension Risankizumab Participants who completed Sub-study 1 or 2 receive open-label risankizumab in Sub-study 3.	Drug: risankizumab subcutaneous (SC) injection Other Names: ABBV-066 BI 655066 SKYRIZI

Outcome Measures

Primary Outcome Measures

Sub-Study 1: Percentage of Participants with Clinical Remission per Adapted Mayo Score [Week 52]
Clinical remission per Adapted Mayo Score.
Sub-Study 3: Percentage of Participants with Adverse Events (AE) [Up to Week 300]
An Adverse Event (AE) is defined as any untoward medical occurrence in a participant or clinical investigation participant administered a pharmaceutical product and which does not necessarily have a causal relationship with this treatment.

Secondary Outcome Measures

Sub-Study 1: Percentage of Participants with Endoscopic Improvement [Week 52]
Endoscopic improvement per endoscopy subscore.
Sub-Study 1: Percentage of Participants with Clinical Remission per Full Mayo Score in Participants with a Full Mayo Score of 6 to 12 at Baseline (of Induction) [Week 52]
Clinical remission per full Mayo Score.
Sub-Study 1: Percentage of Participants who Discontinued Corticosteroid Use, in Participants Taking Steroids at Baseline (of induction). [Week 52]
Percentage of participants who discontinued corticosteroid use, in participants taking steroids at baseline (of induction).
Sub-Study 1: Percentage of Participants with Clinical Remission per Adapted Mayo Score in Participants with a Clinical Remission at Week 0 [Week 52]
Clinical remission per Adapted Mayo Score.
Sub-Study 1: Percentage of Participants who Discontinued Corticosteroid Use, Remained Corticosteroid Free for 90 days and Achieved Clinical Remission in Participants who were Taking Steroids at Baseline (of induction) [Week 52]
Participants who discontinued corticosteroid use.
Sub-Study 1: Percentage of Participants with Clinical Response per Adapted Mayo Score [Week 52]
Clinical response per Adapted Mayo Score.
Sub-Study 1: Percentage of Participants Achieving Histologic-Endoscopic Mucosal Improvement [Week 52]
Percentage of participants achieving histologic-endoscopic mucosal improvement.
Sub-Study 1: Percentage of Participants with Endoscopic Remission [Week 52]
Endoscopic remission per endoscopy subscore.
Sub-Study 1: Percentage of Participants with Endoscopic Improvement in Participants with Endoscopic Improvement at Week 0 [Week 52]
Endoscopic improvement per endoscopy subscore.
Sub-Study 1: Percentage of Participants with Ulcerative Colitis (UC) Related Hospitalization [Through Week 52]
Participants with a UC event that results in admission to the hospital.
Sub-Study 1: Percentage of Participants with Histologic Remission [Week 52]
Histologic remission per Geboes Score.
Sub-Study 1: Percentage of Participants who Reported No Abdominal Pain [Week 52]
Percentage of participants who reported no abdominal pain.
Sub-Study 1: Percentage of Participants who Reported No Bowel Urgency [Week 52]
Percentage of participants who reported no bowel urgency.
Sub-Study 1: Percentage of Participants with Mucosal Healing [Week 52]
Mucosal healing defined as endoscopic and histologic remission.
Sub-Study 1: Change in Inflammatory Bowel Disease Questionnaire (IBDQ) [Baseline (Week 0) to Week 52]
The IBDQ is used to assess the quality of life of patients with inflammatory bowel disease.
Sub-Study 1: Percentage of Participants with Ulcerative Colitis (UC)-Related Surgeries [Through Week 52]
Participants who underwent surgery related to UC.
Sub-Study 1: Change in Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) [Week 0 to Week 52]
The FACIT-Fatigue is a validated tool that measures an individual's level of fatigue during their usual daily activities over the past week.
Sub-Study 1: Percentage of Participants who Reported No Nocturnal Bowel Movements [Week 52]
Percentage of participants who reported no nocturnal bowel movements.
Sub-Study 1: Percentage of Participants who Reported No Tenesmus [Week 52]
Percentage of participants who reported no tenesmus.
Sub-Study 1: Change in Number of Fecal Incontinence Episodes per Week [Baseline (Week 0) to Week 52]
Change in number of fecal incontinence episodes per week.
Sub-Study 1: Change in Number of Days per Week with Sleep Interrupted due to UC Symptoms [Baseline (Week 0) to Week 52]
Change in number of days per week with sleep interrupted due to UC symptoms.
Sub-Study 1: Change in 36-Item Short Form Health Status Survey (SF-36) [Baseline (Week 0) to Week 52]
The SF-36 is an indicator of overall health status.

Eligibility Criteria

Criteria

Ages Eligible for Study:

16 Years to 80 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Participants who have completed Study M16-067 and have achieved clinical response as defined in the protocol.

Exclusion Criteria:

Participants who have a known hypersensitivity to risankizumab or the excipients of any of the study drugs or the ingredients of chinese hamster ovary (CHO) or had an adverse event (AE) during Studies M16-067 that in the Investigator's judgment makes the participant unsuitable for this study.
Participant is considered by the Investigator, for any reason, to be an unsuitable candidate for the study.
Participant is not in compliance with prior and concomitant medication requirements throughout Studies M16-067.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Southern California Res. Ctr. /ID# 169659	Coronado	California	United States	92118-1408
2	Hoag Memorial Hosp Presbyterian /ID# 218347	Irvine	California	United States	92618
3	UC San Diego Health System /ID# 160430	La Jolla	California	United States	92093
4	United Medical Doctors /ID# 158574	Los Alamitos	California	United States	90720-3309
5	Gastrointestinal Biosciences Clinical Trials, LLC /ID# 200934	Los Angeles	California	United States	90067-2001
6	UCSF Center for Colitis and Crohn's Disease /ID# 201209	San Francisco	California	United States	94115-3011
7	Cedars-Sinai Medical Center-West Hollywood /ID# 163848	West Hollywood	California	United States	90048
8	Peak Gastroenterology Associates, PC /ID# 165838	Colorado Springs	Colorado	United States	80907
9	Rocky Mountain Pediatric Gastroenterology /ID# 207173	Lone Tree	Colorado	United States	80124-6798
10	Medical Research Center of CT /ID# 160287	Hamden	Connecticut	United States	06518
11	Yale Univ Digestive Diseases /ID# 213265	New Haven	Connecticut	United States	06510
12	South Lake Pain Institute, Inc /ID# 162859	Clermont	Florida	United States	34711
13	Ctr for Advanced Gastroenterol /ID# 202820	Maitland	Florida	United States	32751-6108
14	University of Miami /ID# 160456	Miami	Florida	United States	33136
15	Coral Research Clinic /ID# 158608	Miami	Florida	United States	33186-4643
16	South Florida Research Ph I-IV, Inc. /ID# 161844	Miami	Florida	United States	33193
17	Gastroenterology Group Naples /ID# 165210	Naples	Florida	United States	34102
18	Advanced Research Institute, Inc /ID# 161945	New Port Richey	Florida	United States	34653
19	Advent Health /ID# 160393	Orlando	Florida	United States	32803
20	Endoscopic Research, Inc. /ID# 206709	Orlando	Florida	United States	32803
21	Omega Research Maitland, LLC /ID# 203105	Orlando	Florida	United States	32808
22	Lenus Research & Medical Group /ID# 169727	Sweetwater	Florida	United States	33172
23	Clinical Research Trials of Florida, Inc. /ID# 201794	Tampa	Florida	United States	33607
24	AdventHealth Tampa /ID# 170482	Tampa	Florida	United States	33613-4680
25	Gastroenterology Associates of Central Georgia, LLC /ID# 160513	Macon	Georgia	United States	31201
26	The University of Chicago Medical Center /ID# 160511	Chicago	Illinois	United States	60637-1443
27	DM Clinical Research/Southwest /ID# 165009	Oak Lawn	Illinois	United States	60453
28	Indiana University /ID# 167250	Indianapolis	Indiana	United States	46202
29	Univ Kansas Med Ctr /ID# 226601	Kansas City	Kansas	United States	66160
30	Cotton-O'Neil Clinical Res Ctr /ID# 160367	Topeka	Kansas	United States	66606
31	Robley Rex VA Medical Center /ID# 218647	Louisville	Kentucky	United States	40206
32	Houma Digestive Health Special /ID# 158377	Houma	Louisiana	United States	70360
33	Delricht Research /ID# 206817	New Orleans	Louisiana	United States	70115
34	Nola Research Works, LLC /ID# 161356	New Orleans	Louisiana	United States	70115
35	Louisana Research Center, LLC /ID# 201205	Shreveport	Louisiana	United States	71105-6800
36	Massachusetts General Hospital - Crohn's and Colitis Center /ID# 164257	Boston	Massachusetts	United States	02114
37	University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 159430	Ann Arbor	Michigan	United States	48109
38	Center for Digestive Health /ID# 160300	Troy	Michigan	United States	48098-6363
39	Mayo Clinic - Rochester /ID# 200455	Rochester	Minnesota	United States	55905-0001
40	Quality Clinical Research Inc. /ID# 167312	Omaha	Nebraska	United States	68114-3723
41	Weill Cornell Medicine /ID# 165884	New York	New York	United States	10022
42	Columbia Univ Medical Center /ID# 161929	New York	New York	United States	10032-3725
43	Lenox Hill Hospital /ID# 168469	New York	New York	United States	10075
44	Manhattan Clinical Research, LLC /ID# 211803	New York	New York	United States	10279
45	DiGiovanna Institute for Medical Education & Research /ID# 171128	North Massapequa	New York	United States	11758
46	Univ Rochester Med Ctr /ID# 161660	Rochester	New York	United States	14642
47	Atrium Health Carolinas Medical Center /ID# 158543	Charlotte	North Carolina	United States	28203
48	Plains Clinical Research Center, LLC /ID# 169729	Fargo	North Dakota	United States	58104-5925
49	Cleveland Clinic Main Campus /ID# 209235	Cleveland	Ohio	United States	44195
50	The Ohio State University /ID# 164713	Columbus	Ohio	United States	43210
51	Optimed Research, Ltd. /ID# 167112	Columbus	Ohio	United States	43235
52	Great Lakes Medical Research, LLC /ID# 201778	Mentor	Ohio	United States	44060-6211
53	ProMedica Physicians Digestive Healthcare /ID# 215622	Sylvania	Ohio	United States	43560-2767
54	Digestive Disease Specialists /ID# 170777	Oklahoma City	Oklahoma	United States	73112
55	Adult Gastroenterology Associates - Gen 1 Research /ID# 208873	Tulsa	Oklahoma	United States	74136-7823
56	Penn State Milton S. Hershey Medical Center /ID# 230474	Hershey	Pennsylvania	United States	17033-2360
57	University of Pennsylvania /ID# 166262	Philadelphia	Pennsylvania	United States	19104-5502
58	Digestive Disease Associates, LTD /ID# 232406	Wyomissing	Pennsylvania	United States	19610-2002
59	Gastroenterology Associates, P.A. of Greenville /ID# 160457	Greenville	South Carolina	United States	29615-3593
60	Gastro One /ID# 160373	Germantown	Tennessee	United States	38138
61	East Tennessee Research Institute /ID# 168744	Johnson City	Tennessee	United States	37604
62	Vanderbilt University Medical Center /ID# 160567	Nashville	Tennessee	United States	37232-0011
63	Inquest Clinical Research /ID# 165686	Baytown	Texas	United States	77521-2415
64	Texas Digestive Disease Consultants /ID# 209951	Cedar Park	Texas	United States	78613-5028
65	Texas Digestive Disease Consultants /ID# 209799	Cedar Park	Texas	United States	78613
66	DHAT Research Institute /ID# 158235	Garland	Texas	United States	75044-2208
67	Vilo Research Group Inc /ID# 207657	Houston	Texas	United States	77017-2337
68	Baylor College of Medicine - Baylor Medical Center /ID# 158230	Houston	Texas	United States	77030-3411
69	Centex Studies, Inc. - Houston /ID# 201221	Houston	Texas	United States	77058
70	Caprock Gastro Research, LLC /ID# 215433	Lubbock	Texas	United States	79424-3017
71	Clinical Associates in Research Therapeutics of America, LLC /ID# 161364	San Antonio	Texas	United States	78212
72	Southern Star Research Institute, LLC /ID# 168774	San Antonio	Texas	United States	78229-5390
73	Baylor Scott & White Center for Diagnostic Medicine /ID# 204132	Temple	Texas	United States	76508
74	Tyler Research Institute, LLC /ID# 166799	Tyler	Texas	United States	75701-4464
75	Gastro Health & Nutrition - Victoria /ID# 164308	Victoria	Texas	United States	77904
76	Advanced Research Institute /ID# 160465	Ogden	Utah	United States	84403
77	Gastroenterology Consultants of Southwest Virginia /ID# 218142	Roanoke	Virginia	United States	24014-1372
78	Virginia Mason Medical Center /ID# 160432	Seattle	Washington	United States	98101
79	Gedyt /ID# 243424	Ciudad Autonoma de Buenos Aire	Ciuadad Autonoma De Buenos Aires	Argentina	1115
80	Cemic /Id# 167805	Ciudad Autonoma de Buenos Aire	Ciuadad Autonoma De Buenos Aires	Argentina	1431
81	Hospital Provincial del Centenario /ID# 170896	Rosario	Santa Fe	Argentina	2000
82	Sanatorio 9 de Julio /ID# 167803	San Miguel de Tucuman	Tucuman	Argentina	4000
83	Hospital Privado Univesitario /ID# 167802	Cordoba		Argentina	5016
84	Duplicate_Universitaetsklinikum St.Poelten /ID# 169049	St. Poelten	Niederoesterreich	Austria	3100
85	Ordensklinikum Linz GmbH Barmherzige Schwestern /ID# 216043	Linz	Oberoesterreich	Austria	4010
86	Medizinische Universitaet Graz /ID# 169052	Graz	Steiermark	Austria	8036
87	Medizinische Universitaet Wien /ID# 169051	Vienna	Wien	Austria	1090
88	Landeskrankenhaus Salzburg-Universitätsklinikum der PMU (LKH) /ID# 200686	Salzburg		Austria	5020
89	Cliniques Universitaires de Bruxelles Hopital Erasme /ID# 200256	Brussels	Bruxelles-Capitale	Belgium	1070
90	UCL Saint-Luc /ID# 200260	Woluwe-Saint-Lambert	Bruxelles-Capitale	Belgium	1200
91	CHU UCL Namur - site Godinne /ID# 200259	Godinne	Namur	Belgium	5530
92	Universitair Ziekenhuis Leuven /ID# 170829	Leuven	Vlaams-Brabant	Belgium	3000
93	Imelda Ziekenhuis /ID# 211101	Bonheiden		Belgium	2820
94	CHU de Liege /ID# 200257	Liege		Belgium	4000
95	Groupe Sante CHC - Clinique du MontLegia /ID# 200255	Liege		Belgium	4000
96	AZ-Delta /ID# 200258	Roeselare		Belgium	8800
97	Instituto Goiano de Gastroenterologia e Endoscopia Digestiva /ID# 157683	Goiânia	Goias	Brazil	74535-170
98	Hospital Nossa Senhora das Graças /ID# 157677	Curitiba	Parana	Brazil	80810-040
99	Hospital de Clinicas de Porto Alegre /ID# 157670	Porto Alegre	Rio Grande Do Sul	Brazil	90035-903
100	Upeclin Fmb - Unesp /Id# 157691	Botucatu	Sao Paulo	Brazil	18618-686
101	Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto - USP /ID# 157668	Ribeirão Preto	Sao Paulo	Brazil	14051-140
102	Faculdade de Medicina do ABC /ID# 163993	Santo André	Sao Paulo	Brazil	09060-870
103	Kaiser Clinica e Hospital Dia /ID# 157686	Sao Jose Do Rio Preto	Sao Paulo	Brazil	15015-110
104	UMHAT Kaspela EOOD /ID# 200795	Plovdiv		Bulgaria	4001
105	MHAT Hadzhi Dimitar /ID# 207947	Sliven		Bulgaria	8800
106	Second Multiprofile Hospital f /ID# 200794	Sofia		Bulgaria	1202
107	UMHAT Sveti Ivan Rilski /ID# 210798	Sofia		Bulgaria	1431
108	UMHAT Tsaritsa Joanna - ISUL /ID# 209978	Sofia		Bulgaria	1527
109	University of Calgary /ID# 169125	Calgary	Alberta	Canada	T2N 4Z6
110	Allen Whey Khye Lim Professional Corporation /ID# 169770	Edmonton	Alberta	Canada	T5R 1W2
111	Covenant Health /ID# 169128	Edmonton	Alberta	Canada	T6K 4B2
112	Fraser Clinical Trials Inc /ID# 169116	New Westminster	British Columbia	Canada	V3L 3W4
113	Percuro Clinical Research, Ltd /ID# 169123	Victoria	British Columbia	Canada	V8V 3M9
114	London Health Sciences Center /ID# 169117	London	Ontario	Canada	N6A 5W9
115	Scott Shulman Medicine Professional Corporation /ID# 169127	North Bay	Ontario	Canada	P1B 2H3
116	Toronto Digestive Disease Asso /ID# 169120	Vaughan	Ontario	Canada	L4L 4Y7
117	CISSS de Chaudière-Appalaches, Hôpital Hotel-Dieu de Lévis /ID# 214379	Levis	Quebec	Canada	G6V 3Z1
118	CIUSSS de l'est de l'Ile-de-Montreal - Hopital Maisonneuve-Rosemont /ID# 169122	Montreal	Quebec	Canada	H1T 2M4
119	Royal Victoria Hospital / McGill University Health Centre /ID# 169118	Montreal	Quebec	Canada	H4A 3J1
120	Servicio de Salud Araucanía Norte Hospital Victoria /ID# 213152	Victoria	Araucania	Chile	4720843
121	Complejo Asistencial Dr. Sotero del Rio /ID# 169386	Santiago	Region Metropolitana Santiago	Chile	8207257
122	Hospital Guillermo Grant Benavente de Concepción /ID# 210762	Concepción		Chile	4070038
123	Hospital Las Higueras /ID# 167094	Talcahuano		Chile	1740000
124	The First Affiliated Hospital of Anhui Medical University /ID# 211227	Hefei	Anhui	China	230022
125	The Sixth Affiliated Hosp Sun /ID# 211229	Guangzhou	Guangdong	China	510655
126	The Second Hospital of Hebei Medical University /ID# 213019	Shijiazhuang	Hebei	China	050000
127	Renmin Hospital of Wuhan University /ID# 212867	Wuhan	Hubei	China	430060
128	Nanjing Drum Tower Hospital /ID# 227438	Nanjing	Jiangsu	China	210008
129	Jiangsu Province Hospital /ID# 211234	Nanjing	Jiangsu	China	210029
130	Wuxi People's Hospital /ID# 218797	Wuxi	Jiangsu	China	214023
131	The First Affiliated Hospital of Nanchang University /ID# 212182	Nanchang	Jiangxi	China	330006
132	The First Hospital of Jilin University /ID# 212277	Changchun	Jilin	China	130021
133	General Hospital of Ningxia Medical University /ID# 213912	Yinchuan City	Ningxia	China	750000
134	Tangdu Hospital of The Fourth Military Medical University, PLA /ID# 215505	Xi'an	Shaanxi	China	710038
135	Shanghai East Hospital /ID# 218796	Pudong New District	Shanghai	China	200136
136	Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 210960	Shanghai	Shanghai	China	200065
137	Renji Hospital, Shanghai Jiaotong University School of Medicine /ID# 211230	Shanghai	Shanghai	China	200127
138	Shanghai General Hospital /ID# 226652	Shanghai	Shanghai	China	201600
139	Xijing Hospital /ID# 210708	Xian	Shanxi	China	710032
140	West China Hospital, Sichuan University /ID# 211275	Chengdu	Sichuan	China	610041
141	The second Affiliated hospital of Zhejiang University school of Medicine /ID# 211024	Hangzhou	Zhejiang	China	310009
142	Sir Run Run Shaw Hospital,Meical School Zhejiang University /ID# 211062	Hangzhou	Zhejiang	China	310018
143	Beijing Friendship Hospital /ID# 211061	Beijing		China	100032
144	The Second Xiangya Hospital of Central South University /ID# 211196	Changsha		China	410011
145	Huai'an First People's Hospital /ID# 239197	Huaian		China	223399
146	Shengjing Hospital of China Medical University /ID# 211643	Shenyang		China	110022
147	Union Hospital affiliated to Tongji Medical College of Huazhong University of Sc /ID# 211070	Wuhan		China	420022
148	Tongji Hospital Tongji Medical College Huazhong University of Science and Techno /ID# 211069	Wuhan		China	430030
149	Instituto Medico de Alta Tecnologia Oncomédica S.A /ID# 207041	Monteria	Cordoba	Colombia	230002
150	Corporacion Hospitalaria Juan Cuidad Sede Denominada Hospital Universitario Mayo /ID# 158736	Bogota DC	Cundinamarca	Colombia	111221
151	Hospital Universitario San Vic /ID# 171488	Medellin		Colombia	50010
152	Clinical Hospital Dubrava /ID# 157598	Zagreb	Grad Zagreb	Croatia	10000
153	Klinicki bolnicki centar Zagreb /ID# 157594	Zagreb	Grad Zagreb	Croatia	10000
154	Klinicki bolnicki centar Zagreb /ID# 201915	Zagreb	Grad Zagreb	Croatia	10000
155	UHC Osijek /ID# 157595	Osijek	Osjecko-baranjska Zupanija	Croatia	31000
156	Klinicki bolnicki centar Split /ID# 157596	Split	Splitsko-dalmatinska Zupanija	Croatia	21000
157	Fakultni nemocnice u sv. Anny v Brne /ID# 239158	Brno		Czechia	656 91
158	Nemocnice Ceske Budejovice a.s. /ID# 225228	Ceske Budejovice		Czechia	370 01
159	Hepato-Gastroenterologie HK, s.r.o. /ID# 163389	Hradec Kralove		Czechia	500 12
160	Fakultni nemocnice Ostrava /ID# 225568	Ostrava		Czechia	708 52
161	Bispebjerg and Frederiksberg Hospital /ID# 208953	Copenhagen NV	Hovedstaden	Denmark	2400
162	Kobenhavns Universitet - Hvidovre Hospital (HH) /ID# 205093	Hvidovre	Hovedstaden	Denmark	2650
163	Sjællands Universitetshospital /ID# 200073	Roskilde	Sjælland	Denmark	4000
164	Odense Universitets Hospital /ID# 209502	Odense C		Denmark	5000
165	Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 201824	Alexandria		Egypt	21131
166	Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 226795	Alexandria		Egypt	21131
167	Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 226796	Alexandria		Egypt	21131
168	Air Force Specialized Hospital /ID# 170984	Cairo		Egypt
169	National Liver Institute /ID# 171042	Menoufiya		Egypt	35111
170	Chu de Nice-Hopital L'Archet Ii /Id# 207881	Nice	Alpes-Maritimes	France	06200
171	APHM - Hopital Nord /ID# 225826	Marseille	Bouches-du-Rhone	France	13015
172	CHU Bordeaux - Hopital Haut Leveque /ID# 207883	Pessac CEDEX	Gironde	France	33604
173	CHU Montpellier - Hôpital Saint Eloi /ID# 223781	Montpellier Cedex 5	Herault	France	34295
174	Hopital Beaujon /ID# 207876	Clichy	Ile-de-France	France	92110
175	CHU de SAINT ETIENNE - Hopital Nord /ID# 207882	St. Priest En Jarez	Loire	France	42270
176	CHRU Nancy - Hôpitaux de Brabois /ID# 207877	Vandœuvre-lès-Nancy	Meurthe-et-Moselle	France	54500
177	CHU Amiens-Picardie Site Sud /ID# 207880	Amiens CEDEX 1	Somme	France	80054
178	Clinique Jules Verne /ID# 240977	Nantes		France	44300
179	Universitaetsklinikum Freiburg /ID# 162038	Freiburg	Baden-Wuerttemberg	Germany	79106
180	Praxis fuer Gastroenterologie /ID# 166154	Heidelberg	Baden-Wuerttemberg	Germany	69121
181	Universitatsklinikum Mannheim /ID# 162039	Mannheim	Baden-Wuerttemberg	Germany	68167
182	Universitaetsklinikum Ulm /ID# 164994	Ulm	Baden-Wuerttemberg	Germany	89081
183	Universitaetsklinikum Erlangen /ID# 159373	Erlangen	Bayern	Germany	91054
184	Praxiszentrum fuer Gastroenterologie /ID# 219072	Grevenbroich	Nordrhein-Westfalen	Germany	41515
185	Universitaetsklinikum Koeln /ID# 164993	Köln	Nordrhein-Westfalen	Germany	50937
186	Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 159379	Kiel	Schleswig-Holstein	Germany	24105
187	Gastroenterologische Spezialpraxis am Wittenbergplatz /ID# 219146	Berlin		Germany	10787
188	MVZ fuer Gastroenterlogie am Bayerischen Platz /ID# 159380	Berlin		Germany	10825
189	Charite Universitaetsklinikum Berlin - Campus Benjamin Franklin /ID# 210508	Berlin		Germany	12203
190	DRK Kliniken Berlin Westend /ID# 166155	Berlin		Germany	14050
191	Stadtisches Klinikum Braunschweig /ID# 163694	Braunschweig		Germany	38126
192	Agaplesion Markus Krankenhaus /ID# 159375	Frankfurt am Main		Germany	60431
193	Gastroenterologie Opernstrasse /ID# 163690	Kassel		Germany	34117
194	EUGASTRO GmbH /ID# 219071	Leipzig		Germany	04103
195	Klinikum Lueneburg /ID# 163692	Lueneburg		Germany	21339
196	Gastroenterologische Gemeinschaftspraxis Minden /ID# 162037	Minden		Germany	32423
197	LMU Klinikum Campus Grosshadern /ID# 210484	München		Germany	81377
198	Universitaetsklinikum Regensburg /ID# 163693	Regensburg		Germany	93042
199	General Hospital of Athens Ippokratio /ID# 229190	Athens	Attiki	Greece	11527
200	General Hospital of Athens Laiko /ID# 206438	Athens	Attiki	Greece	11527
201	General Hospital of Chest Diseases of Athens SOTIRIA /ID# 170910	Athens	Attiki	Greece	11527
202	Tzaneio general hospital of Piraeus /ID# 206437	Piraeus	Attiki	Greece	18536
203	University General Hospital of Heraklion PA.G.N.I /ID# 165327	Heraklion	Kriti	Greece	71500
204	General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 217479	Athens		Greece	10676
205	General Hospital of Nikaia-Piraeus "Agios Panteleimon"- general hospital dytikis /ID# 165313	Pireaus		Greece	18454
206	Theageneio Anticancer Hospital /ID# 165329	Thessaloniki		Greece	54639
207	Soroka University Medical Center /ID# 171093	Be'er Sheva	HaDarom	Israel	8443901
208	The Chaim Sheba Medical Center /ID# 211279	Ramat Gan	Tel-Aviv	Israel	5265601
209	Rambam Health Care Campus /ID# 171096	Haifa		Israel	3109601
210	Shaare Zedek Medical Center /ID# 163543	Jerusalem		Israel	91031
211	Hadassah Medical Center-Hebrew University /ID# 171092	Jerusalem		Israel	91120
212	Rabin Medical Center /ID# 167402	Petakh Tikva		Israel	4941492
213	University of Catanzaro /ID# 200124	Catanzaro	Calabria	Italy	88100
214	Ospedale Sant Orsola Malpighi /ID# 155627	Bologna	Emilia-Romagna	Italy	40138
215	Policlinico Universitario Campus Bio-Medico /ID# 163994	Rome	Lazio	Italy	00128
216	Azienda Ospedaliera San Camillo Forlanini /ID# 155628	Rome	Lazio	Italy	00152
217	Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 171223	Rome	Lazio	Italy	00161
218	ASST Rhodense/Presidio Ospedaliero di Rho /ID# 211450	Rho	Milano	Italy	20017
219	Istituto Clinico Humanitas /ID# 155626	Rozzano	Milano	Italy	20089
220	Fondazione PTV Policlinico Tor Vergata /ID# 158020	Rome	Roma	Italy	00133
221	IRCCS Ospedale Sacro Cuore Don Calabria /ID# 164029	Negrar	Verona	Italy	37024
222	A.O. Per L'Emergenza Cannizzaro /ID# 164039	Catania		Italy	95126
223	Ospedale Policlinico San Martino /ID# 164030	Genova		Italy	16132
224	ASST Fatebenefratelli Sacco-Ospedale Sacco /ID# 155623	Milano		Italy	20157
225	ASST Grande Ospedale Metropolitano Niguarda /ID# 170959	Milano		Italy	20162
226	Azienda Ospedaliero-Universitaria di Modena /ID# 201818	Modena		Italy	41124
227	UOC Medicina Interna e Gastroe /ID# 155624	Rome		Italy	00168
228	Aichi Medical University Hospital /ID# 164227	Nagakute-shi	Aichi	Japan	480-1195
229	Nagoya City University Hospital /ID# 164229	Nagoya shi	Aichi	Japan	467-8602
230	Daido Clinic /ID# 211478	Nagoya-shi	Aichi	Japan	457-8511
231	Nagoya University Hospital /ID# 164230	Nagoya-shi	Aichi	Japan	4668560
232	Fujita Health University Hospital /ID# 164313	Toyoake-shi	Aichi	Japan	470-1192
233	National Hospital Organization Hirosaki General Medical Center /ID# 164216	Hirosaki-shi	Aomori	Japan	036-8545
234	Tokatsu Tsujinaka Hospital /ID# 164310	Abiko-shi	Chiba	Japan	270-1168
235	Chiba University Hospital /ID# 209633	Chiba-shi	Chiba	Japan	260-8677
236	Tsujinaka Hospital Kashiwanoha /ID# 225968	Kashiwa-shi	Chiba	Japan	277-0871
237	Toho University Sakura Medical Center /ID# 164219	Sakura-shi	Chiba	Japan	285-8741
238	Fukuoka University Chikushi Hospital /ID# 209056	Chikushino-shi	Fukuoka	Japan	818-8502
239	Saiseikai Fukuoka Genaral Hospital /ID# 225640	Fukuoka-shi	Fukuoka	Japan	810-0001
240	Fukuoka University Hospital /ID# 226723	Fukuoka-shi	Fukuoka	Japan	814-0180
241	Kurume University Hospital /ID# 164237	Kurume-shi	Fukuoka	Japan	830-0011
242	Gifu University Hospital /ID# 208490	Gifu-shi	Gifu	Japan	501-1194
243	Ogaki Municipal Hospital /ID# 226009	Ogaki-shi	Gifu	Japan	503-8502
244	National Hospital Organization Takasaki General Medical Center /ID# 164312	Takasaki-shi	Gunma	Japan	370-0829
245	NHO Fukuyama Medical Center /ID# 164315	Fukuyama-shi	Hiroshima	Japan	720-8520
246	Hiroshima University Hospital /ID# 164240	Hiroshima-shi	Hiroshima	Japan	734-8551
247	Asahikawa Medical University Hospital /ID# 164324	Asahikawa-shi	Hokkaido	Japan	078-8510
248	Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 164215	Sapporo-shi	Hokkaido	Japan	060-0033
249	Sapporo Medical University Hospital /ID# 164278	Sapporo-shi	Hokkaido	Japan	060-8543
250	Sapporo IBD Clinic /ID# 225967	Sapporo-shi	Hokkaido	Japan	064-0919
251	Sapporo Higashi Tokushukai Hospital /ID# 208493	Sapporo-shi	Hokkaido	Japan	065-0033
252	Aoyama Clinic /ID# 164236	Kobe-shi	Hyogo	Japan	650-0015
253	Hyogo College of Medicine College Hospital /Id# 164238	Nishinomiya-shi	Hyogo	Japan	663-8501
254	Kanazawa University Hospital /ID# 169221	Kanazawa-shi	Ishikawa	Japan	920-8641
255	Sameshima Hospital /ID# 211182	Kagoshima-shi	Kagoshima	Japan	892-0846
256	Tokai University Hospital /ID# 209207	Isehara-shi	Kanagawa	Japan	259-1193
257	Gokeikai Ofuna Chuo Hospital /ID# 169296	Kamakura-shi	Kanagawa	Japan	247-0056
258	St. Marianna University Hospital /ID# 226730	Kawasaki-shi	Kanagawa	Japan	216-8511
259	Kitasato University Hospital /ID# 169223	Sagamihara-shi	Kanagawa	Japan	252-0375
260	Colo-proctology Center Matsushima Clinic /ID# 225915	Yokohama-shi	Kanagawa	Japan	220-0045
261	Showa University Fujigaoka Hospital /ID# 209606	Yokohama-shi	Kanagawa	Japan	227-8501
262	Mie University Hospital /ID# 203635	Tsu-shi	Mie	Japan	514-8507
263	Yokkaichi Hazu Medical Center /ID# 164316	Yokkaichi-shi	Mie	Japan	510-0016
264	Tohoku University Hospital /ID# 164276	Sendai-shi	Miyagi	Japan	9808574
265	Nagasaki University Hospital /ID# 205326	Nagasaki-shi	Nagasaki	Japan	852-8501
266	Nara Medical University Hospital /ID# 169222	Kashihara-shi	Nara	Japan	634-8522
267	Kinshukai Infusion Clinic /ID# 226992	Osaka-shi	Osaka	Japan	530-0011
268	Osaka Medical and Pharmaceutical University Hospital /ID# 226036	Takatsuki-shi	Osaka	Japan	569-8686
269	Saga University Hospital /ID# 209273	Saga-shi	Saga	Japan	849-8501
270	Tokitokai Tokito clinic /ID# 164218	Saitama-shi	Saitama	Japan	336-0963
271	Shiga University of Medical Science Hospital /ID# 164323	Otsu-shi	Shiga	Japan	520-2192
272	Hamamatsu University Hospital /ID# 226729	Hamamatsu-shi	Shizuoka	Japan	431-3192
273	Matsuda Hospital /ID# 226831	Hamamatsu-shi	Shizuoka	Japan	432-8061
274	NHO Shizuoka Medical Center /ID# 164314	Sunto-gun	Shizuoka	Japan	411-8611
275	Tokyo Medical And Dental University Hospital /ID# 164225	Bunkyo-ku	Tokyo	Japan	113-8519
276	St.Luke's International Hospital /ID# 225969	Chuo-ku	Tokyo	Japan	104-8560
277	Tokai University Hachioji Hospital /ID# 227102	Hachioji-shi	Tokyo	Japan	192-0032
278	Teikyo University Hospital /ID# 225594	Itabashi-ku	Tokyo	Japan	173-8606
279	The Jikei University Hospital /ID# 164279	Minato-ku	Tokyo	Japan	105-8471
280	Kitasato University Kitasato Institute Hospital /ID# 164222	Minato-ku	Tokyo	Japan	108-8642
281	Kyorin University Hospital /ID# 164226	Mitaka-shi	Tokyo	Japan	181-8611
282	NTT Medical Center Tokyo /ID# 225595	Shinagawa-ku	Tokyo	Japan	141-8625
283	Keio University Hospital /ID# 203630	Shinjuku-ku	Tokyo	Japan	160-8582
284	Japanese Red Cross Wakayama Medical Center /ID# 171196	Wakayama-shi	Wakayama	Japan	640-8558
285	Wakayama Medical University Hospital /ID# 169485	Wakayama-shi	Wakayama	Japan	641-8510
286	Yamagata University Hospital /ID# 171481	Yamagata-shi	Yamagata	Japan	990-9585
287	Tokuyama Central Hospital /ID# 226857	Shunan-shi	Yamaguchi	Japan	745-8522
288	Hayang University GuriHospital /ID# 158661	Guri	Gyeonggido	Korea, Republic of	11923
289	CHA University Bundang Medical Center /ID# 158669	Seongnam si	Gyeonggido	Korea, Republic of	13496
290	The Catholic University of Korea, ST. Vincent's Hospital /ID# 158664	Suwon	Gyeonggido	Korea, Republic of	16247
291	Kangbuk Samsung Hospital /ID# 158666	Seoul	Seoul Teugbyeolsi	Korea, Republic of	03181
292	Yonsei University Health System Severance Hospital /ID# 158660	Seoul	Seoul Teugbyeolsi	Korea, Republic of	03722
293	Inje University Haeundae Hospital /ID# 203027	Busan		Korea, Republic of	48108
294	Dong-A University Hospital /ID# 158665	Busan		Korea, Republic of	49201
295	Pusan National University Hospital /ID# 158670	Busan		Korea, Republic of	49241
296	Yeungnam University Medical Center /ID# 158662	Daegu		Korea, Republic of	42415
297	The Catholic University of Korea, Daejeon St.Mary's Hospital /ID# 242379	Daejeon		Korea, Republic of	34943
298	Samsung Medical Center /ID# 158663	Seoul		Korea, Republic of	06351
299	Pauls Stradins Clinical University Hospital /ID# 160205	Riga		Latvia	1002
300	VCA Polyclinic Aura /ID# 160204	Riga		Latvia	1035
301	Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 201142	Kaunas		Lithuania	50161
302	Vilnius University Hospital Santaros Klinikos /ID# 201144	Vilnius		Lithuania	08661
303	Universiti Sains Malaysia /ID# 200633	Kelantan		Malaysia	16150
304	JM Research SC /ID# 206518	Cuernavaca	Morelos	Mexico	62290
305	Unidad de Atencion Medica e Investigacion en Salud /ID# 206515	Merida	Yucatan	Mexico	97000
306	Health Pharma Professional Research S.A de C.V /ID# 206516	Del. Benito Juárez		Mexico	03810
307	Academisch Medisch Centrum /ID# 157965	Amsterdam		Netherlands	1105 AZ
308	Elisabeth Tweesteden Ziekenhuis /ID# 163738	Tilburg		Netherlands	5022 GC
309	Tauranga Hospital /ID# 212793	Tauranga South	Bay Of Plenty	New Zealand	3112
310	Christchurch Hospital /ID# 205337	Christchurch	Canterbury	New Zealand	8011
311	Waikato Hospital /ID# 212788	Hamilton	Waikato	New Zealand	3240
312	Wellington Regional Hospital /ID# 205338	Newtown	Wellington	New Zealand	6021
313	Hutt Hospital /ID# 212787	Lower Hutt		New Zealand	5010
314	Dunedin Hospital /ID# 212791	Otago		New Zealand	9016
315	Vistamed /ID# 210106	Wroclaw	Dolnoslaskie	Poland	53-149
316	NZOZ Vitamed /ID# 213358	Bydgoszcz	Kujawsko-pomorskie	Poland	85-079
317	Gastromed /Id# 231065	Torun	Kujawsko-pomorskie	Poland	87-100
318	Centrum Medyczne Plejady /ID# 170635	Krakow	Malopolskie	Poland	30-363
319	WIP Warsaw IBD Point Profesor Kierkus /ID# 216103	Warsaw	Mazowieckie	Poland	00-728
320	Centrum Zdrowia MDM /ID# 170283	Warszawa	Mazowieckie	Poland	00-635
321	Centralny Szpital Kliniczny MSWiA w Warszawie /ID# 170286	Warszawa	Mazowieckie	Poland	02-507
322	Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie Panstwowy Instytut Bada /ID# 170285	Warszawa	Mazowieckie	Poland	02-781
323	NZOZ Vivamed /ID# 216308	Warszawa	Mazowieckie	Poland	03-580
324	Endoskopia Sp. z o.o. /ID# 170284	Sopot	Pomorskie	Poland	81-756
325	NZOZ All-Medicus /ID# 170282	Katowice	Slaskie	Poland	40-659
326	H-T. Centrum Medyczne - Endoterapia /ID# 231501	Tychy	Slaskie	Poland	43-100
327	Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 165576	Guimaraes	Braga	Portugal	4835-044
328	Centro Hospitalar Universitário do Algarve, EPE - Hospital de Portimão /ID# 166563	Portimão	Faro	Portugal	8500-338
329	Centro Hospitalar de Entre Douro e Vouga /ID# 166048	Santa Maria Da Feira	Porto	Portugal	4520-211
330	Hospital Garcia de Orta, EPE /ID# 165579	Almada		Portugal	2805-267
331	Centro Hospitalar e Universitario de Coimbra, EPE /ID# 166050	Coimbra		Portugal	3000-075
332	Centro Hospitalar Universitario Lisboa Central, EPE - Hospital dos Capuchos /ID# 165578	Lisboa		Portugal	1169-050
333	Centro Hospitalar Universitario de Sao Joao, EPE /ID# 165577	Porto		Portugal	4200-319
334	Centro Hosp de Tondela-Viseu /ID# 166049	Viseu		Portugal	3504-509
335	Ponce Medical School Foundation /ID# 222825	Ponce		Puerto Rico	00716-0377
336	VA Caribbean Healthcare System /ID# 222779	San Juan		Puerto Rico	00921-3201
337	Clinica GASTRO MED SRL /ID# 224156	Cluj-Napoca	Cluj	Romania	400380
338	Sana Monitoring /Id# 224154	Bucharest		Romania	011025
339	Fundeni Clinical Institute /ID# 171259	Bucharest		Romania	022328
340	Fundeni Clinical Institute /ID# 224155	Bucharest		Romania	022328
341	Duplicate_Centrul Medical Tuculanu SRL /ID# 171263	Timisoara		Romania	300168
342	Cabinet Particular Policlinic Algomed /ID# 171260	Timișoara		Romania	300002
343	Interdisctrict Multidisciplinary Hospital /ID# 204921	Anzorey	Kabardino-Balkarskaya Respublika	Russian Federation	361350
344	GBUZ Allergology and Immunology Center of Ministry of Health of Kabardino-Bal /ID# 233974	Nalchik	Kabardino-Balkarskaya Respublika	Russian Federation	360001
345	Immanuel Kant Baltic Federal University /ID# 204920	Kaliningrad	Kaliningradskaya Oblast	Russian Federation	236016
346	Kuzbass Regional Clinical Hospital /ID# 165759	Kemerovo	Kemerovskaya Oblast	Russian Federation	650099
347	Uninova Medical Center /ID# 229786	Saint Petersburg	Leningradskaya Oblast	Russian Federation	198218
348	Arsvita Clinic /ID# 208947	Korolev	Moskovskaya Oblast	Russian Federation	141077
349	Perm Clinical Center of the Federal Medical and Biological Agency /ID# 227456	Perm	Permskiy Kray	Russian Federation	614109
350	City Clinical Hospital #40 /ID# 204927	Sestroretsk	Sankt-Peterburg	Russian Federation	197706
351	Regional Clinical Hospital #1 /ID# 165763	Tyumen	Tyumenskaya Oblast	Russian Federation	625023
352	Clinic of New Technologies of Medicine /ID# 204926	Dzerzhinskiy		Russian Federation	140091
353	First Moscow State Medical University n.a I.M. Sechenov /ID# 204981	Moscow		Russian Federation	119992
354	National Medical Research Center of Coloproctology n.a. A. N. Ryzhikh /ID# 203513	Moscow		Russian Federation	123423
355	Central Clinical Hospital RZHD Medicine /ID# 204922	Moscow		Russian Federation	129128
356	Novosibirski Gastrocenter /ID# 229852	Novosibirsk		Russian Federation	630007
357	Euromedservice /ID# 204918	Pushkin		Russian Federation	196603
358	International Medical Center SOGAZ /ID# 206832	St. Petersburg		Russian Federation	191186
359	Ulyanovsk Regional Clinical Hospital /ID# 204923	Ulyanovsk		Russian Federation	432017
360	Clinical Hosp Center Zvezdara /ID# 200150	Belgrade	Beograd	Serbia	11000
361	University Clinical Center Serbia /ID# 200153	Belgrade	Beograd	Serbia	11000
362	Clin Hosp Ctr Bezanijska Kosa /ID# 202060	Belgrade	Beograd	Serbia	11080
363	Clinical Center Vojvodina /ID# 156876	Novi Sad	Vojvodina	Serbia	21000
364	Clinical Hospital Center Dr Dragisa Misovic - Dedinje /ID# 224927	Belgrade		Serbia	11040
365	General Hospital Leskovac /ID# 224198	Leskovac		Serbia	16000
366	KL Ling Gastroenterology and Liver Clinic /ID# 206563	Singapore		Singapore	228510
367	Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 164348	Banska Bystrica		Slovakia	975 17
368	KM Management, spol. s.r.o. /ID# 206603	Nitra		Slovakia	949 01
369	Fakultna nemocnica s poliklinikou Nove Zamky /ID# 224100	Nove Zamky		Slovakia	940 34
370	GASTRO I., s.r.o. /ID# 164345	Presov		Slovakia	080 01
371	Univ Medical Ctr Ljubljana /ID# 210628	Ljubljana		Slovenia	1000
372	Farmovs (Pty) Ltd /Id# 207538	Bloemfontein	Free State	South Africa	9301
373	Clinresco Centers /ID# 239825	Johannesburg	Gauteng	South Africa	1619
374	Spoke Research Inc /ID# 229906	CAPE TOWN Milnerton	Western Cape	South Africa	7441
375	Allergy & Immunology (AIU) /ID# 171439	Cape Town	Western Cape	South Africa	7700
376	Dr JP Wright /ID# 171142	Cape Town	Western Cape	South Africa	7708
377	Private Practice Dr MN Rajabally /ID# 171141	Cape Town	Western Cape	South Africa	7800
378	Hospital Arquitecto Marcide - Complejo Hospitalario Universitario de Ferrol /ID# 159463	Ferrol	A Coruna	Spain	15405
379	Hospital de Cabuenes /ID# 170745	Gijon	Asturias	Spain	33394
380	Consorci Corporacio Sanitaria Parc Tauli Sabadell /ID# 159473	Sabadell	Barcelona	Spain	08208
381	Hospital Universitario Puerta de Hierro, Majadahonda /ID# 159466	Majadahonda	Madrid	Spain	28222
382	Hospital Alvaro Cunqueiro CHUVI /ID# 167359	Vigo	Pontevedra	Spain	36213
383	Hospital Clinic de Barcelona /ID# 159462	Barcelona		Spain	08036
384	Hospital Universitario Reina Sofia /ID# 167062	Cordoba		Spain	14004
385	Hospital Universitario La Paz /ID# 159471	Madrid		Spain	28046
386	Complejo Hospitalario Universitario de Pontevedra /ID# 216183	Pontevedra		Spain	36071
387	Hospital Universitario de Salamanca /ID# 159469	Salamanca		Spain	37711
388	Hospital Universitario Virgen Macarena /ID# 159969	Sevilla		Spain	41009
389	Hospital Universitario Miguel Servet /ID# 159468	Zaragoza		Spain	50009
390	Alingsas lasarett /ID# 202075	Alingsas	Vastra Gotalands Lan	Sweden	441 33
391	Sahlgrenska University Hospital Molndal /ID# 202841	Molndal	Vastra Gotalands Lan	Sweden	431 80
392	Danderyds sjukhus AB /ID# 202036	Stockholm		Sweden	182 88
393	Universitätsspital Zürich /ID# 202908	Zürich	Zuerich	Switzerland	8091
394	Inselspital, Universitätsspital Bern /ID# 202909	Bern		Switzerland	3010
395	China Medical University Hospital /ID# 160194	Taichung City		Taiwan	40447
396	Chung Shan Medical University Hospital /ID# 171426	Taichung		Taiwan	40201
397	Taichung Veterans General Hospital /ID# 171433	Taichung		Taiwan	40705
398	National Taiwan University Hospital /ID# 162188	Taipei City		Taiwan	100
399	Taipei Veterans General Hosp /ID# 171436	Taipei City		Taiwan	11217
400	Linkou Chang Gung Memorial Hospital /ID# 222878	Taoyuan City		Taiwan	333
401	Acibadem Kozyatagi Hospital /ID# 213277	Kadikoy	Istanbul	Turkey	34742
402	Erciyes University Medical Fac /ID# 171283	Melikgazi	Kayseri	Turkey	38030
403	Ankara Univ Medical Faculty /ID# 167205	Ankara		Turkey	06590
404	Inonu Universitesi Turgut Ozal /ID# 203980	Battalgazi/malatya		Turkey	44280
405	Uludag University Medical Faculty /ID# 204179	Bursa		Turkey	16059
406	Fırat University Medical Facul /ID# 171285	Elazig		Turkey	23100
407	Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty /ID# 167202	Istanbul		Turkey	34098
408	Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi /ID# 171290	Istanbul		Turkey	34899
409	Sisli Etfal Train & Res Hosp /ID# 171415	Sisli		Turkey	34371
410	CNE Regional Clinical Hospital of Ivano-Frankivsk RC /ID# 203366	Ivano-frankivsk		Ukraine	76018
411	Municipal Nonprofit Enterprise Kherson city clinical hospital n.a. Y.Y. Karabel /ID# 224349	Kherson		Ukraine	73000
412	Kyiv Municipal Clinical Hospital #18 /ID# 224347	Kyiv		Ukraine	01030
413	Medical Center "OK!Clinic+" /ID# 205484	Kyiv		Ukraine	02091
414	CNPE of Kyiv Regional Council Kyiv Regional Hospital /ID# 224344	Kyiv		Ukraine	04073
415	Royal Devon and Exeter NHS Trust Hospital /ID# 157614	Exeter	Devon	United Kingdom	EX2 5DW
416	University Hospital Southampton NHS Foundation Trust /ID# 210814	Southampton	Hampshire	United Kingdom	SO16 6YD
417	Barts Health NHS Trust /ID# 157617	London	London, City Of	United Kingdom	E1 2ES
418	Barnsley Hospital NHS Foundation Trust /ID# 202771	Barnsley		United Kingdom	S75 2EP
419	Cambridge University Hospitals NHS Foundation Trust /ID# 158046	Cambridge		United Kingdom	CB2 0QQ
420	NHS Lothian /ID# 208801	Edinburgh		United Kingdom	EH3 9HE
421	Liverpool University Hospitals NHS Foundation Trust /ID# 203860	Liverpool		United Kingdom	L7 8XP
422	King's College Hospital NHS Foundation Trusts /ID# 158762	London		United Kingdom	SE5 9RS
423	The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 158047	Newcastle Upon Tyne		United Kingdom	NE7 7DN
424	St George's University Hospitals NHS Foundation Trust /ID# 208379	Tooting		United Kingdom	SW17 0QT