A Study to Evaluate the Long-Term Safety and Efficacy of Upadacitinib (ABT-494) in Participants With Ulcerative Colitis (UC)

Sponsor

AbbVie (Industry)

Overall Status

Active, not recruiting

CT.gov ID

NCT03006068

Collaborator

(none)

950

Enrollment

491

Locations

Arms

90.9

Anticipated Duration (Months)

1.9

Patients Per Site

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This study is designed to evaluate the long-term safety and efficacy of Upadacitinib in participants with ulcerative colitis (UC) who have not responded at the end of the induction period in Study M14-234 Substudy 1, who have had loss of response during the maintenance period of Study M14-234 Substudy 3, or who have successfully completed Study M14-234 Substudy 3.

Condition or Disease	Intervention/Treatment	Phase
Ulcerative Colitis (UC)	Drug: Upadacitinib (ABT-494) Drug: Placebo	Phase 3

Study Design

Study Type:

Interventional

Anticipated Enrollment :

950 participants

Allocation:

Non-Randomized

Intervention Model:

Parallel Assignment

Masking:

Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

Primary Purpose:

Treatment

Official Title:

A Phase 3 Multicenter, Long-Term Extension Study to Evaluate the Safety and Efficacy of Upadacitinib (ABT-494) in Subjects With Ulcerative Colitis

Actual Study Start Date :

Jan 31, 2017

Anticipated Primary Completion Date :

Aug 28, 2024

Anticipated Study Completion Date :

Aug 28, 2024

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Participants receiving Upadacitinib (ABT-494) Dose A or Dose B The participants in this arm will receive Upadacitinib (ABT-494) dose A or dose B.	Drug: Upadacitinib (ABT-494) Upadacitinib (ABT-494) will be administered orally. Other Names: RINVOQ
Experimental: Participants receiving Placebo The participants in this arm will receive placebo until study is unblinded.	Drug: Placebo Placebo will be administered orally.
Experimental: Participants receiving Upadacitinib (ABT-494) Dose C The participants in this arm will receive Upadacitinib (ABT-494) dose C.	Drug: Upadacitinib (ABT-494) Upadacitinib (ABT-494) will be administered orally. Other Names: RINVOQ
Experimental: Participants receiving Upadacitinib (ABT-494) Dose B The participants in this arm will receive Upadacitinib (ABT-494) dose B.	Drug: Upadacitinib (ABT-494) Upadacitinib (ABT-494) will be administered orally. Other Names: RINVOQ
Experimental: Participants receiving Upadacitinib (ABT-494) Dose A The participants in this arm will receive Upadacitinib (ABT-494) dose A.	Drug: Upadacitinib (ABT-494) Upadacitinib (ABT-494) will be administered orally. Other Names: RINVOQ

Outcome Measures

Primary Outcome Measures

Assessing Treatment-Emergent Adverse Events [Up to 288 Weeks]
Treatment-emergent adverse events are defined as events that begin or worsen either on or after the first dose of the study drug and within 30 days after the last dose of the study drug in the analysis period.

Eligibility Criteria

Criteria

Ages Eligible for Study:

16 Years to 75 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Note: Participants aged 16 or 17 may enroll in M14-234 or M14-675 where locally permissible

Participant has not achieved clinical response at the end of the induction period (Week 8) in Study M14-234 Substudy 1, has had loss of response during the maintenance period of Study M14-234 Substudy 3, or has successfully completed Study M14-234 Substudy 3. During the COVID-19 pandemic, for participants with missing endoscopy at Week 8, Week 16 or Week 52 due to the COVID-19 pandemic in Studies M14-234 Substudy 2, M14-234 Substudy 3 and M14-675, participants may be enrolled if certain criteria are met.
If female, participant must meet the criteria for Contraception Recommendations.
Women of childbearing potential must have a negative urine pregnancy test at Week 0 visit.
Participant is judged to be in otherwise good health as determined by the principal investigator based upon clinical evaluations performed during the preceding study (Study M14-234).
Must be able and willing to give written informed consent and to comply with the requirements of this study protocol.

Exclusion Criteria:

For any reason participant is considered by the investigator to be an unsuitable candidate.
Female participant with a positive pregnancy test at the final visit of Study M14-234 or who is considering becoming pregnant during the study or within 30 days after the last dose of study drug.
Participant with an active or recurrent infection that based on the investigator's clinical assessment makes the participant an unsuitable candidate for the study. Participants with ongoing infections undergoing treatment may be enrolled BUT NOT dosed until the infection has been successfully treated.
Current evidence of active tuberculosis (TB); current evidence of latent tuberculosis and for any reason the participant cannot take full course of TB prophylaxis treatment as required per protocol.
Participant with a poorly controlled medical condition, such as uncontrolled diabetes, unstable ischemic heart disease, moderate or severe congestive heart failure (New York Heart Association class III or IV), recent cerebrovascular accidents and any other condition which, in the opinion of the investigator or sponsor, would put the subject at risk by participation in this study.
Participants have malignancy, high-grade dysplasia, un-removed low-grade dysplasia of the gastrointestinal tract diagnosed at the endoscopy performed at the final visit of Study M14-234.
History of any malignancy except for successfully treated nonmelanoma skin cancer (NMSC) or localized carcinoma in situ of the cervix from evaluations performed in Study M14-234.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	East View Medical Research, LLC /ID# 171184	Mobile	Alabama	United States	36606
2	CB Flock Research Corporation /ID# 165986	Mobile	Alabama	United States	36608
3	Delsol Research Management, Ll /Id# 170130	Chandler	Arizona	United States	85224
4	Arizona Arthritis & Rheumatology Research, PLLC /ID# 169823	Sun City	Arizona	United States	85306
5	Digestive Disease Consultants, A Division of Arizona Digestive Health, P.C /ID# 211886	Tempe	Arizona	United States	85284-2604
6	Adobe Clinical Research LLC /ID# 155249	Tucson	Arizona	United States	85712
7	University of Arizona /ID# 150568	Tucson	Arizona	United States	85724
8	Citrus Valley Gastroenterology /ID# 151915	Covina	California	United States	91722-3797
9	Newport Huntington Medical Group /ID# 217006	Huntington Beach	California	United States	92648-5994
10	UC San Diego Health System /ID# 155187	La Jolla	California	United States	92093
11	United Medical Doctors /ID# 207467	Los Alamitos	California	United States	90720-3309
12	TLC Clinical Research Inc /ID# 216830	Los Angeles	California	United States	90048
13	Gastrointestinal Biosciences Clinical Trials, LLC /ID# 157082	Los Angeles	California	United States	90067-2001
14	Facey Medical Foundation /ID# 203135	Mission Hills	California	United States	91345
15	United Medical Doctors - Murrieta /ID# 151213	Murrieta	California	United States	92563
16	InSite Digestive Health Care - Oxnard /ID# 163417	Oxnard	California	United States	93030
17	Inland Empire Clinical Trials, LLC /ID# 216163	Rialto	California	United States	92377
18	San Diego Clinical Trials /ID# 212121	San Diego	California	United States	92120
19	Medical Assoc Research Grp /ID# 169149	San Diego	California	United States	92123
20	Univ of California San Francis /ID# 164583	San Francisco	California	United States	94158
21	Delta Waves, Inc. /ID# 151727	Colorado Springs	Colorado	United States	80918
22	South Denver Gastroenterology /ID# 151224	Lone Tree	Colorado	United States	80124
23	Western States Clinical Res /ID# 158078	Wheat Ridge	Colorado	United States	80033-2896
24	Western Connecticut Medical Group /ID# 169211	Danbury	Connecticut	United States	06810-6000
25	Medical Research Center of CT /ID# 150534	Hamden	Connecticut	United States	06518
26	West Central Gastroenterology /ID# 155242	Clearwater	Florida	United States	33762
27	Moonshine Research Center, Inc /ID# 152534	Doral	Florida	United States	33166
28	Universal Axon Clinical Research /ID# 213463	Doral	Florida	United States	33166
29	Palmetto Research, LLC /ID# 151724	Hialeah	Florida	United States	33016
30	Nature Coast Clinical Research - Inverness /ID# 154070	Inverness	Florida	United States	34452-4717
31	Encore Borland-Groover Clinical Research /Id# 170913	Jacksonville	Florida	United States	32256
32	SIH Research Mumtaz, Inc /ID# 163199	Kissimmee	Florida	United States	34741-4161
33	Cfagi Llc /Id# 202018	Maitland	Florida	United States	32751-6108
34	University of Miami /ID# 215443	Miami	Florida	United States	33136
35	Advanced Pharma /ID# 151723	Miami	Florida	United States	33147
36	New Horizon Research Center /ID# 152475	Miami	Florida	United States	33165-3372
37	Crystal Pharmacology Research /ID# 151848	Miami	Florida	United States	33165
38	Coral Research Clinic /ID# 150524	Miami	Florida	United States	33186-4643
39	Advanced Research Institute, Inc /ID# 163093	New Port Richey	Florida	United States	34653
40	Endoscopic Research, Inc. /ID# 151725	Orlando	Florida	United States	32803
41	Omega Research Maitland, LLC /ID# 200271	Orlando	Florida	United States	32808
42	Clinical Research Trials of Florida, Inc. /ID# 201791	Tampa	Florida	United States	33607
43	University of South Florida /ID# 214494	Tampa	Florida	United States	33612
44	AdventHealth Tampa /ID# 200274	Tampa	Florida	United States	33613-4680
45	Gastroenterology Associates of Central Georgia, LLC /ID# 165783	Macon	Georgia	United States	31201
46	Infinite Clinical Trials /ID# 215342	Riverdale	Georgia	United States	30274
47	Atlanta Gastroenterology Spec /ID# 150565	Suwanee	Georgia	United States	30024
48	Next Innovative Clinical Research - Chicago /ID# 217323	Chicago	Illinois	United States	60605-2168
49	University of Chicago /ID# 150564	Chicago	Illinois	United States	60637
50	NorthShore University HealthSystem /ID# 150570	Evanston	Illinois	United States	60201
51	Northwest Health Care Associates /ID# 151591	Hoffman Estates	Illinois	United States	60169
52	Carle Foundation Hospital /ID# 151155	Urbana	Illinois	United States	61801
53	MediSphere Medical Research Center /ID# 152080	Evansville	Indiana	United States	47714-8011
54	Indianapolis Gastroenterology /ID# 162914	Indianapolis	Indiana	United States	46237
55	University of Iowa Hospitals and Clinics /ID# 157059	Iowa City	Iowa	United States	52242
56	Cotton-O'Neil Clinical Res Ctr /ID# 167183	Topeka	Kansas	United States	66606
57	Tri-State Gastroenterology /ID# 169812	Crestview Hills	Kentucky	United States	41017
58	Houma Digestive Health Special /ID# 151851	Houma	Louisiana	United States	70360
59	Nola Research Works, LLC /ID# 153365	New Orleans	Louisiana	United States	70115
60	Louisana Research Center, LLC /ID# 150526	Shreveport	Louisiana	United States	71105-6800
61	University of Maryland Med Ctr /ID# 150529	Baltimore	Maryland	United States	21201
62	Gastro Center of Maryland /ID# 200024	Columbia	Maryland	United States	21045
63	Massachusetts General Hospital /ID# 165678	Boston	Massachusetts	United States	02114
64	University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 151158	Ann Arbor	Michigan	United States	48109
65	Huron Gastroenterology Assoc /ID# 152712	Ann Arbor	Michigan	United States	48197
66	Clin Res Inst of Michigan, LLC /ID# 153031	Chesterfield	Michigan	United States	48047
67	Revival Research Institute, LLC /ID# 207281	Southfield	Michigan	United States	48034-1659
68	Center for Digestive Health /ID# 161983	Troy	Michigan	United States	48098-6363
69	Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinic /ID# 157487	Wyoming	Michigan	United States	49519
70	Mayo Clinic - Rochester /ID# 151681	Rochester	Minnesota	United States	55905-0001
71	Minnesota Gastroenterology PA /ID# 151682	Saint Paul	Minnesota	United States	55114
72	University of Mississippi Medical Center /ID# 213140	Jackson	Mississippi	United States	39216-4500
73	Southern Therapy and Advanced Research (STAR) LLC /ID# 170713	Jackson	Mississippi	United States	39216
74	Washington University-School of Medicine /ID# 150537	Saint Louis	Missouri	United States	63110
75	Las Vegas Medical Research /ID# 153052	Las Vegas	Nevada	United States	89113
76	Dartmouth-Hitchcock Medical Center /ID# 150566	Lebanon	New Hampshire	United States	03756
77	AGA Clinical Research Associates, LLC /ID# 153048	Egg Harbor Township	New Jersey	United States	08234
78	Atlantic Digestive Health Inst /ID# 150527	Morristown	New Jersey	United States	07960
79	Rutgers Robert Wood Johnson /ID# 155247	New Brunswick	New Jersey	United States	08901
80	Duplicate_University of New Mexico Department of Internal Medicine /ID# 214399	Albuquerque	New Mexico	United States	87131-0001
81	Montefiore Medical Center - Moses Campus /ID# 150559	Bronx	New York	United States	10467
82	Advantage Clinical Trials /ID# 163940	Bronx	New York	United States	10468
83	NY Scientific /ID# 152708	Brooklyn	New York	United States	11235
84	NYU Langone Long Island Clinical Research Association /ID# 155271	Great Neck	New York	United States	11021
85	Columbia Univ Medical Center /ID# 163409	New York	New York	United States	10032-3725
86	DiGiovanna Institute for Medical Education & Research /ID# 201534	North Massapequa	New York	United States	11758
87	Premier Medical Group - GI Division /ID# 153366	Poughkeepsie	New York	United States	12601
88	Gastro Group of Rochester /ID# 151080	Rochester	New York	United States	14618-5703
89	Richmond University Medical Center /ID# 201860	Staten Island	New York	United States	10310-1664
90	Digestive Health Partners, P.A /ID# 167238	Asheville	North Carolina	United States	28801
91	Atrium Health Carolinas Medical Center /ID# 157060	Charlotte	North Carolina	United States	28203
92	Charlotte Gastroenterology and Hepatology, PLLC /ID# 150561	Charlotte	North Carolina	United States	28207
93	Atlantic Gastroenterology Clinical Research /ID# 151901	Greenville	North Carolina	United States	27834
94	Clinical Trials of America /ID# 153453	Winston-Salem	North Carolina	United States	27103
95	Wake Forest Baptist Medical Center /ID# 150528	Winston-Salem	North Carolina	United States	27157-0001
96	Plains Clinical Research Center, LLC /ID# 170291	Fargo	North Dakota	United States	58104-5925
97	Consultants for Clinical Research /ID# 151683	Cincinnati	Ohio	United States	45219
98	University of Cincinnati /ID# 164584	Cincinnati	Ohio	United States	45267-0585
99	The Ohio State University /ID# 169417	Columbus	Ohio	United States	43210
100	Optimed Research, Ltd. /ID# 169697	Columbus	Ohio	United States	43235
101	Hometown Urgent Care and Resea /ID# 200066	Dayton	Ohio	United States	45424
102	Dayton Gastroenterology, Inc. /ID# 167632	Englewood	Ohio	United States	45415
103	Great Lakes Medical Research, LLC /ID# 201773	Mentor	Ohio	United States	44060-6211
104	Ohio Clinical Research Partner /ID# 154074	Mentor	Ohio	United States	44060
105	Hightower Clinical /ID# 216338	Oklahoma City	Oklahoma	United States	73102
106	Digestive Disease Specialists /ID# 201057	Oklahoma City	Oklahoma	United States	73112
107	Options Health Research, LLC /ID# 150569	Tulsa	Oklahoma	United States	74104
108	Healthcare Research Consultant /ID# 163096	Tulsa	Oklahoma	United States	74135
109	Northwest Gastroenterology Clinic /ID# 152528	Portland	Oregon	United States	97210
110	Guthrie Medical Group, PC /ID# 150533	Sayre	Pennsylvania	United States	18840
111	Penn State Health Colonnade /ID# 150267	State College	Pennsylvania	United States	16803-2309
112	Pharmacorp Clinical Trials /ID# 153363	Charleston	South Carolina	United States	29412
113	Gastroenterology Associates, P.A. of Greenville /ID# 150557	Greenville	South Carolina	United States	29615-3593
114	Gastro One /ID# 151154	Germantown	Tennessee	United States	38138
115	East Tennessee Research Institute /ID# 203611	Johnson City	Tennessee	United States	37604
116	Quality Medical Research /ID# 203427	Nashville	Tennessee	United States	37211
117	Vanderbilt University Medical Center /ID# 153364	Nashville	Tennessee	United States	37232-0011
118	TX Clinical Research Institute /ID# 151528	Arlington	Texas	United States	76012
119	Inquest Clinical Research /ID# 164636	Baytown	Texas	United States	77521-2415
120	Texas Digestive Disease Consultants /ID# 209806	Cedar Park	Texas	United States	78613-5028
121	Texas Digestive Disease Consultants /ID# 209949	Cedar Park	Texas	United States	78613-5028
122	Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 200771	Dallas	Texas	United States	75246
123	DHAT Research Institute /ID# 151221	Garland	Texas	United States	75044-2208
124	Vilo Research Group Inc /ID# 212626	Houston	Texas	United States	77017-2337
125	CliniCore International, LLC /ID# 152078	Houston	Texas	United States	77027-6812
126	Baylor College of Medicine - Baylor Medical Center /ID# 150538	Houston	Texas	United States	77030-3411
127	Centex Studies, Inc. - Houston /ID# 201217	Houston	Texas	United States	77058
128	GI Specialists of Houston /ID# 202337	Houston	Texas	United States	77070-4347
129	Caprock Gastro Research /ID# 215116	Lubbock	Texas	United States	79424-3017
130	Clinical Associates in Research Therapeutics of America, LLC /ID# 167954	San Antonio	Texas	United States	78212
131	Southern Star Research Institute, LLC /ID# 169397	San Antonio	Texas	United States	78229-5390
132	Carl R. Meisner Medical Clinic /ID# 171270	Sugar Land	Texas	United States	77478
133	Baylor Scott & White Center for Diagnostic Medicine /ID# 204777	Temple	Texas	United States	76508
134	Tyler Research Institute, LLC /ID# 169147	Tyler	Texas	United States	75701-4464
135	Gastro Health & Nutrition - Victoria /ID# 167764	Victoria	Texas	United States	77904
136	HP Clinical Research /ID# 163941	Bountiful	Utah	United States	84010
137	Advanced Research Institute /ID# 162640	Ogden	Utah	United States	84403
138	Utah Gastroenternology - St. Mark's Office /ID# 163097	Salt Lake City	Utah	United States	84124
139	Velocity Clinical Research - Salt Lake City /ID# 163180	West Jordan	Utah	United States	84088
140	Ctr for Gastrointestinal Healt /ID# 153369	Franklin	Virginia	United States	23851
141	Washington Gastroenterology Associates /ID# 163630	Bellevue	Washington	United States	98004
142	Virginia Mason Medical Center /ID# 153030	Seattle	Washington	United States	98101
143	The Polyclinic /ID# 165117	Seattle	Washington	United States	98122-4201
144	The Vancouver Clinic, INC. PS /ID# 162334	Vancouver	Washington	United States	98664
145	Aurora Medical Center - Grafto /ID# 151726	Grafton	Wisconsin	United States	53024
146	Wisconsin Center for Advanced Research, a division of GI Associates, LLC /ID# 151845	Milwaukee	Wisconsin	United States	53215
147	Medical College of Wisconsin /ID# 151850	Milwaukee	Wisconsin	United States	53226-3522
148	Cardio Alem /ID# 211281	San Isidro	Buenos Aires	Argentina	1642
149	Gedyt /ID# 210016	Ciudad Autonoma de Buenos Aire	Ciuadad Autonoma De Buenos Aires	Argentina	1115
150	Mautalen Salud e Investigacion /ID# 171174	Ciudad Autonoma de Buenos Aire	Ciuadad Autonoma De Buenos Aires	Argentina	1128
151	Hospital Britanico de Buenos Aires /ID# 209496	Ciudad Autonoma de Buenos Aire	Ciuadad Autonoma De Buenos Aires	Argentina	1280
152	Sanatorio 9 de Julio /ID# 150215	San Miguel de Tucuman	Tucuman	Argentina	4000
153	Hospital Privado Univesitario /ID# 164186	Cordoba		Argentina	5016
154	Macquarie University Hospital /ID# 211953	Macquarie University	New South Wales	Australia	2109
155	Mater Misericordiae Limited /ID# 212686	South Brisbane	Queensland	Australia	4101
156	Griffith University /ID# 211954	Southport	Queensland	Australia	4222
157	Monash Medical Centre /ID# 150218	Clayton	Victoria	Australia	3168
158	St Vincent's Hospital Melbourne /ID# 152503	Fitzroy Melbourne	Victoria	Australia	3065
159	Fiona Stanley Hospital /ID# 211641	Murdoch	Western Australia	Australia	6150
160	Ordensklinikum Linz GmbH Barmherzige Schwestern /ID# 150462	Linz	Oberoesterreich	Austria	4010
161	Klinik Landstrasse /ID# 162867	Vienna	Wien	Austria	1030
162	Medizinische Universitaet Wien /ID# 150616	Vienna	Wien	Austria	1090
163	Landeskrankenhaus Salzburg-Universitätsklinikum der PMU (LKH) /ID# 150463	Salzburg		Austria	5020
164	Vitebsk Regional Advanced Clin /ID# 169592	Витебск		Belarus	210001
165	Universitair Ziekenhuis Leuven /ID# 150468	Leuven	Vlaams-Brabant	Belgium	3000
166	AZ Maria Middelares /ID# 150466	Gent		Belgium	9000
167	AZ-Delta /ID# 150467	Roeselare		Belgium	8800
168	University Clinical Centre of the Republic of Srpska /ID# 150223	Banja Luka	Republika Srpska	Bosnia and Herzegovina	78000
169	University Clinical Centre of the Republic of Srpska /ID# 150712	Banja Luka	Republika Srpska	Bosnia and Herzegovina	78000
170	University Clinical Center Tuzla /ID# 150224	Tuzla	Tuzlanski	Bosnia and Herzegovina	75000
171	University Clinical Hospital Mostar /ID# 150711	Mostar		Bosnia and Herzegovina	88000
172	Clinical Center University of Sarajevo /ID# 150222	Sarajevo		Bosnia and Herzegovina	71000
173	Instituto Goiano de Gastroenterologia e Endoscopia Digestiva /ID# 153744	Goiânia	Goias	Brazil	74535-170
174	Hospital Nossa Senhora das Graças /ID# 152488	Curitiba	Parana	Brazil	80810-040
175	Hospital de Clinicas de Porto Alegre /ID# 153745	Porto Alegre	Rio Grande Do Sul	Brazil	90035-903
176	Upeclin Fmb - Unesp /Id# 152493	Botucatu	Sao Paulo	Brazil	18618-686
177	Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto - USP /ID# 152492	Ribeirão Preto	Sao Paulo	Brazil	14051-140
178	Faculdade de Medicina do ABC /ID# 152489	Santo André	Sao Paulo	Brazil	09060-870
179	Kaiser Clinica e Hospital Dia /ID# 152491	Sao Jose Do Rio Preto	Sao Paulo	Brazil	15015-110
180	University of Calgary /ID# 151818	Calgary	Alberta	Canada	T2N 4Z6
181	Allen Whey Khye Lim Professional Corporation /ID# 211169	Edmonton	Alberta	Canada	T5R 1W2
182	University of Alberta - Zeidler Ledcor Centre /ID# 151824	Edmonton	Alberta	Canada	T6G 2X8
183	Covenant Health /ID# 158931	Edmonton	Alberta	Canada	T6K 4B2
184	Okanagan Clinical Trials /ID# 153179	Kelowna	British Columbia	Canada	V1Y 1Z9
185	Percuro Clinical Research, Ltd /ID# 150479	Victoria	British Columbia	Canada	V8V 3M9
186	Hamilton Health Sciences - McMaster University Medical Centre /ID# 150477	Hamilton	Ontario	Canada	L8S 4K1
187	Ottawa Hospital Research Institute /ID# 151817	Ottawa	Ontario	Canada	K1H 8L6
188	Medicor Research Inc /ID# 151825	Sudbury	Ontario	Canada	P3A 1W8
189	Toronto Digestive Disease Asso /ID# 150475	Vaughan	Ontario	Canada	L4L 4Y7
190	CISSS de la Monteregie /ID# 159271	Greenfield Park	Quebec	Canada	J4V 2H1
191	CHAU- Hotel-Dieu de Levis /ID# 150473	Levis	Quebec	Canada	G6V 3Z1
192	Recherche GCP Research /ID# 151819	Montreal	Quebec	Canada	H1M 1B1
193	Crchum /Id# 167170	Montreal	Quebec	Canada	H2X 0A9
194	Royal Victoria Hospital / McGill University Health Centre /ID# 170013	Montreal	Quebec	Canada	H4A 3J1
195	CIUSSS de l'Estrie - CHUS /ID# 150478	Sherbrooke	Quebec	Canada	J1G 2E8
196	Research Group /ID# 203177	Santiago	Region Metropolitana De Santiago	Chile	2540364
197	M y F Estudios Clínicos /ID# 200112	Santiago	Region Metropolitana Santiago	Chile	7750495
198	Centro de Investigaciones Clínicas Viña del Mar /ID# 150226	Viña del Mar	Valparaíso	Chile	2540488
199	Hospital Guillermo Grant Benavente de Concepción /ID# 212425	Concepción		Chile	4070038
200	CTR Estudios Clinicos /ID# 200111	Providencia		Chile	7500571
201	Hospital Clinico Universidad De Los Andes /ID# 207427	Santiago		Chile	7501504
202	The First Affiliated Hospital, Sun Yat-sen University /ID# 150517	Guangzhou	Guangdong	China	510080
203	The Sixth Affiliated Hosp Sun /ID# 150518	Guangzhou	Guangdong	China	510655
204	Affiliated Taihe Hospital of Hubei University of Medicine /ID# 216407	Shiyan	Hubei	China	442700
205	Tongji Hospital Tongji Medical College Huazhong University of Science and Techno /ID# 167089	Wuhan	Hubei	China	430022
206	Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 167079	Wuhan	Hubei	China	430022
207	The First Affiliated Hospital of Nanchang University /ID# 212185	Nanchang	Jiangxi	China	330006
208	The First Hospital of Jilin University /ID# 210087	Changchun	Jilin	China	130021
209	Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 150523	Shanghai	Shanghai	China	200065
210	Duplicate_Shanghai Tenth People's Hospital /ID# 150522	Shanghai	Shanghai	China	200072
211	Renji Hospital, Shanghai Jiaotong University School of Medicine /ID# 165826	Shanghai	Shanghai	China	200127
212	The second Affiliated hospital of Zhejiang University school of Medicine /ID# 165813	Hangzhou	Zhejiang	China	310009
213	Sir Run Run Shaw Hospital,Meical School Zhejiang University /ID# 150516	Hangzhou	Zhejiang	China	310018
214	Xiangya Hospital Central South University /ID# 167230	Changsha		China	410008
215	West China Hospital, Sichuan University /ID# 167041	Chengdu		China	610041
216	Shengjing Hospital of China Medical University /ID# 166921	Shenyang		China	110022
217	Tianjin Medical University General Hospital /ID# 170605	Tianjin		China	300052
218	Instituto Medico de Alta Tecnologia Oncomédica S.A /ID# 207052	Monteria	Cordoba	Colombia	230002
219	Corporacion Hospitalaria Juan Cuidad Sede Denominada Hospital Universitario Mayo /ID# 152811	Bogota DC	Cundinamarca	Colombia	111221
220	Hospital Universitario de San /ID# 155388	Medellin		Colombia
221	Duplicate_Klinicka bolnica Dubrava Zagreb /ID# 150228	Zagreb	Grad Zagreb	Croatia	10000
222	Klinicki bolnicki centar Zagreb /ID# 150262	Zagreb	Grad Zagreb	Croatia	10000
223	Klinicki bolnicki centar Zagreb /ID# 150715	Zagreb	Grad Zagreb	Croatia	10000
224	Poliklinika Solmed /ID# 211567	Zagreb	Grad Zagreb	Croatia	10000
225	Duplicate_Klinicki bolnicki centar Osijek /ID# 150229	Osijek	Osjecko-baranjska Zupanija	Croatia	31000
226	Klinicki bolnicki centar Rijeka /ID# 150714	Rijeka	Primorsko-goranska Zupanija	Croatia	51000
227	Klinicki bolnicki centar Split /ID# 213989	Split	Splitsko-dalmatinska Zupanija	Croatia	21000
228	Zadar General Hospital /ID# 150261	Zadar		Croatia	23000
229	Hepato-Gastroenterologie HK, s.r.o. /ID# 150946	Hradec Kralove		Czechia	500 12
230	CTCenter MaVe s.r.o. /ID# 150903	Olomouc		Czechia	779 00
231	ARTROSCAN s.r.o. /ID# 150502	Ostrava		Czechia	722 00
232	Nemocnice Pardubickeho kraje, a.s. /ID# 213541	Pardubice		Czechia	530 03
233	Nemocnice Milosrdnych sester sv. Karla Boromejskeho v Praze /ID# 216224	Praha		Czechia	118 33
234	Axon Clinical, s.r.o. /ID# 152477	Praha		Czechia	140 00
235	ISCARE a.s. /ID# 209279	Praha		Czechia	190 00
236	East Tallinn Central Hospital /ID# 150488	Kesklinna Linnaosa	Harjumaa	Estonia	10138
237	North Estonia Medical Centre /ID# 160871	Mustamäe Linnaosa	Harjumaa	Estonia	13419
238	Tartu University Hospital /ID# 150489	Tartu Linn	Tartumaa	Estonia	50406
239	West Tallinn Central Hospital /ID# 150490	Tallinn		Estonia	10617
240	Tampere University Hospital /ID# 150376	Tampere	Pirkanmaa	Finland	33520
241	Duplicate_Helsinki Univ Central Hospital /ID# 154283	Helsinki		Finland	00290
242	Keski-Suomen Sairaala Nova /ID# 155665	Jyvaskyla		Finland	40620
243	Laakarikeskus Ikioma /ID# 150377	Mikkeli		Finland	50100
244	Turku University Hospital /ID# 169895	Turku		Finland	20520
245	Chu de Nice-Hopital L'Archet Ii /Id# 152608	Nice	Alpes-Maritimes	France	06200
246	HCL - Hôpital Lyon Sud /ID# 152540	Pierre Benite CEDEX	Auvergne-Rhone-Alpes	France	69495
247	CHRU Lille - Hopital Claude Huriez /ID# 152609	Lille	Hauts-de-France	France	59037
248	CHU Montpellier - Hôpital Saint Eloi /ID# 200088	Montpellier Cedex 5	Herault	France	34295
249	CHD Vendée- La Roche-sur-Yon - Les Oudairies /ID# 165749	La Roche Sur Yon		France	85000
250	Duplicate_CHU de Saint-Etienne, Hopital Nord /ID# 165756	SAINT-ETIENNE Cedex 1		France	42270
251	Universitatsklinikum Mannheim /ID# 150405	Mannheim	Baden-Wuerttemberg	Germany	68167
252	Universitaetsklinikum Tuebingen Medizinische Klinik /ID# 151698	Tubingen	Baden-Wuerttemberg	Germany	72076
253	Universitatsklinikum Munster /ID# 150402	Munster	Niedersachsen	Germany	48149
254	Gastroenterologische Gemeinschaftspraxis Herne /ID# 214575	Herne	Nordrhein-Westfalen	Germany	44623
255	Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 215812	Saarbrücken	Saarland	Germany	66111
256	Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 161871	Kiel	Schleswig-Holstein	Germany	24105
257	MVZ fuer Gastroenterlogie am Bayerischen Platz /ID# 151697	Berlin		Germany	10825
258	Agaplesion Markus Krankenhaus /ID# 161870	Frankfurt am Main		Germany	60431
259	Medizinisches Versorgungszentrum Portal 10 /ID# 207136	Muenster		Germany	48155
260	Praxis medicum /ID# 150404	Wiesbaden		Germany	65189
261	General Hospital of Athens Laiko /ID# 208672	Athens	Attiki	Greece	11527
262	General Hospital of Chest Diseases of Athens SOTIRIA /ID# 202101	Athens	Attiki	Greece	11527
263	University General Hospital of Heraklion PA.G.N.I /ID# 150236	Heraklion	Kriti	Greece	71500
264	General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 150406	Athens		Greece	10676
265	University General Hospital of Ioannina /ID# 164247	Ioannina		Greece	45500
266	Theageneio Anticancer Hospital /ID# 164187	Thessaloniki		Greece	54639
267	General Hospital of Thessaloniki Hippokrateio /ID# 209522	Thessaloniki		Greece	54642
268	Markusovszky Egyetemi Oktatokorhaz /ID# 150410	Szombathely	Vas	Hungary	9700
269	Bekes Megyei Kozponti Korhaz /ID# 151601	Bekescsaba		Hungary	5600
270	Semmelweis Egyetem /ID# 150409	Budapest		Hungary	1085
271	Meditres Kft. /ID# 151597	Kecskemet		Hungary	6000
272	Soproni Erzsebet Oktato Korhaz es Rehabilitacios Intezet /ID# 151599	Sopron		Hungary	9400
273	Mentahaz Maganorvosi Kozpont /ID# 206977	Szekesfehervar		Hungary	8000
274	Beaumont Hospital /ID# 150414	Beaumont	Dublin	Ireland	D09 XR63
275	St James Hospital /ID# 150413	Dublin 8	Dublin	Ireland	D08 NHY1
276	St Vincent's University Hospital /ID# 150411	Elm Park	Dublin	Ireland	D04 T6F4
277	Mercy University Hospital /ID# 153794	Cork		Ireland	T12 WE28
278	University Hospital Galway /ID# 150412	Galway		Ireland	H91 YR71
279	Soroka University Medical Center /ID# 156562	Beer Sheva	HaDarom	Israel	8410101
280	Rambam Health Care Campus /ID# 150416	Haifa		Israel	3109601
281	Shaare Zedek Medical Center /ID# 163139	Jerusalem		Israel	91031
282	Hadassah Medical Center-Hebrew University /ID# 165119	Jerusalem		Israel	91120
283	Azienda Ospedaliera San Camillo Forlanini /ID# 151362	Rome	Lazio	Italy	00152
284	ASST Rhodense/Presidio Ospedaliero di Rho /ID# 216673	Rho	Milano	Italy	20017
285	Istituto Clinico Humanitas /ID# 151363	Rozzano	Milano	Italy	20089
286	Fondazione PTV Policlinico Tor Vergata /ID# 150425	Rome	Roma	Italy	00133
287	Presidio Columbus-Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Un /ID# 150420	Rome	Roma	Italy	00168
288	IRCCS Ospedale Sacro Cuore Don Calabria /ID# 201726	Negrar	Verona	Italy	37024
289	IRCCS Azienda Ospedaliero-Universitaria di Bologna /ID# 150424	Bologna		Italy	40138
290	ASST Fatebenefratelli Sacco - Ospedale Fatebenefratelli e Oftalmico /ID# 150605	Milano		Italy	20121
291	Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico /ID# 150421	Milan		Italy	20122
292	A.O. Ospedali Riuniti Villa Sofia - Cervello /ID# 150263	Palermo		Italy	90146
293	Aichi Medical University Hospital /ID# 151994	Nagakute-shi	Aichi	Japan	480-1195
294	Nagoya City University Hospital /ID# 151949	Nagoya shi	Aichi	Japan	467-8602
295	Nagoya University Hospital /ID# 152728	Nagoyashi	Aichi	Japan	4668560
296	Toyohashi Municipal Hospital /ID# 171470	Toyohashi-shi	Aichi	Japan	441-8570
297	Ieda Hospital /ID# 157782	Toyota-shi	Aichi	Japan	470-1219
298	Hirosaki National Hospital /ID# 152761	Hirosaki-shi	Aomori	Japan	036-8545
299	Tokatsu Tsujinaka Hospital /ID# 214964	Abiko-shi	Chiba	Japan	270-1168
300	Tsujinaka Hospital Kashiwanoha /ID# 209572	Kashiwa-shi	Chiba	Japan	277-0871
301	Toho University Sakura Medical Center /ID# 151935	Sakura-shi	Chiba	Japan	285-8741
302	Juntendo University Urayasu Hospital /ID# 208783	Urayasu-shi	Chiba	Japan	279-0021
303	Fukui Prefectural Hospital /ID# 210450	Fukui-shi	Fukui	Japan	910-8526
304	Fukuoka University Chikushi Hospital /ID# 152627	Chikushino-shi	Fukuoka	Japan	818-8502
305	Saiseikai Fukuoka Genaral Hospital /ID# 209481	Fukuoka-shi	Fukuoka	Japan	810-0001
306	Kyushu University Hospital /ID# 152525	Fukuoka-shi	Fukuoka	Japan	812-8582
307	Kitakyushu Municipal Med Ctr /ID# 152589	Kitakyushu	Fukuoka	Japan	8020077
308	Kurume University Hospital /ID# 151977	Kurume-shi	Fukuoka	Japan	830-0011
309	Ogaki Municipal Hospital /ID# 208226	Ogaki-shi	Gifu	Japan	503-8502
310	NHO Fukuyama Medical Center /ID# 206294	Fukuyama-shi	Hiroshima	Japan	720-8520
311	Hiroshima University Hospital /ID# 151952	Hiroshima-shi	Hiroshima	Japan	734-8551
312	Asahikawa Medical University Hospital /ID# 170281	Asahikawa-shi	Hokkaido	Japan	078-8510
313	Obihiro kosei Hospital /ID# 210425	Obihiro-shi	Hokkaido	Japan	080-0024
314	Sapporo Tokushukai Hospital /ID# 209449	Sapporo-shi	Hokkaido	Japan	004-0041
315	Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 151705	Sapporo-shi	Hokkaido	Japan	060-0033
316	Sapporo Medical University Hospital /ID# 206493	Sapporo-shi	Hokkaido	Japan	060-8543
317	Sapporo Higashi Tokushukai Hospital /ID# 208495	Sapporo-shi	Hokkaido	Japan	065-0033
318	Aoyama Clinic /ID# 152048	Kobe-shi	Hyogo	Japan	650-0015
319	Hyogo College of Medicine College Hospital /Id# 152433	Nishinomiya-shi	Hyogo	Japan	663-8501
320	National Hospital Organization Mito Medical Center /ID# 152626	Higashi Ibaraki-gun	Ibaraki	Japan	311-3193
321	Kanazawa University Hospital /ID# 207810	Kanazawa-shi	Ishikawa	Japan	920-8641
322	Iwate Medical University Uchimaru Medical Center /ID# 203412	Morioka-shi	Iwate	Japan	020-8505
323	Imamura General Hospital /ID# 227138	Kagoshima-shi	Kagoshima	Japan	890-0064
324	Idzuro Imamura Hospital /ID# 207640	Kagoshima-shi	Kagoshima	Japan	892-0824
325	Sameshima Hospital /ID# 206673	Kagoshima-shi	Kagoshima	Japan	892-0846
326	St. Marianna University School of Medicine Hospital /ID# 209452	Kawasaki-shi	Kanagawa	Japan	216-8511
327	Yokohama City University Medical Center /ID# 169900	Yokohama shi	Kanagawa	Japan	232-0024
328	Showa University Fujigaoka Hospital /ID# 208223	Yokohama-shi	Kanagawa	Japan	227-8501
329	Japanese Red Cross Kyoto Daiichi Hosital /ID# 152358	Kyoto-shi	Kyoto	Japan	605-0981
330	Kyoto University Hospital /ID# 211808	Kyoto-shi	Kyoto	Japan	606-8507
331	Mie University Hospital /ID# 207253	Tsu-shi	Mie	Japan	514-8507
332	Yokkaichi Hazu Medical Center /ID# 214349	Yokkaichi-shi	Mie	Japan	510-0016
333	National Hospital Organization Sendai Medical Center /ID# 209529	Sendai-shi	Miyagi	Japan	983-8520
334	NHO Nagasaki Medical Center /ID# 210821	Omura-shi	Nagasaki	Japan	856-8562
335	Kenseikai Dongo Hospital /ID# 208102	Yamatotakada-shi	Nara	Japan	635-0022
336	Saiseikai Niigata Hospital /ID# 209923	Niigata-shi	Niigata	Japan	950-1104
337	Niigata University Medical & Dental Hospital /ID# 218050	Niigata-shi	Niigata	Japan	951-8520
338	Ishida Clinic of IBD and Gastroenterology /ID# 210118	Oita-shi	Oita	Japan	870-0823
339	Chikuba Hospital for Proctological and Gastrointestinal Diseases /ID# 157820	Kurashiki-shi	Okayama	Japan	710-0142
340	Okayama University Hospital /ID# 217924	Okayama-shi	Okayama	Japan	700-8558
341	Kinshukai Infusion Clinic /ID# 207866	Osaka-shi	Osaka	Japan	530-0011
342	Kitano Hospital /ID# 210396	Osaka-shi	Osaka	Japan	530-8480
343	Osaka City General Hospital /ID# 152703	Osaka-shi	Osaka	Japan	534-0021
344	Japanese Red Cross Osaka Hospital /ID# 209477	Osaka-shi	Osaka	Japan	543-8555
345	Osaka City University Hospital /ID# 152681	Osaka-shi	Osaka	Japan	545-8586
346	Toyonaka Municipal Hospital /ID# 217083	Toyonaka-shi	Osaka	Japan	560-0055
347	Saga University Hospital /ID# 209272	Saga-shi	Saga	Japan	849-8501
348	Saitama Medical Center /ID# 152019	Kawagoe-shi	Saitama	Japan	350-8550
349	Tokitokai Tokito clinic /ID# 152676	Saitama-shi	Saitama	Japan	336-0963
350	National Hospital Organization Higashi-Ohmi General Medical Center /ID# 210711	Higashi-ohmi-shi	Shiga	Japan	527-8505
351	Shimane University School of Medicine /ID# 208906	Izumo-shi	Shimane	Japan	693-0021
352	Hamamatsu University Hospital /ID# 205709	Hamamatsu-shi	Shizuoka	Japan	431-3192
353	NHO Shizuoka Medical Center /ID# 163571	Sunto-gun	Shizuoka	Japan	411-8611
354	Tokyo Medical And Dental University Hospital /ID# 152017	Bunkyo-ku	Tokyo	Japan	113-8519
355	St.Luke's International Hospital /ID# 208075	Chuo-ku	Tokyo	Japan	104-8560
356	Tokai University Hachioji Hospital /ID# 152584	Hachioji-shi	Tokyo	Japan	192-0032
357	Teikyo University Hospital /ID# 209865	Itabashi-ku	Tokyo	Japan	173-8606
358	Kitasato University Kitasato Institute Hospital /ID# 152687	Minato-ku	Tokyo	Japan	108-8642
359	Kyorin University Hospital /ID# 153195	Mitaka-shi	Tokyo	Japan	181-8611
360	Center Hospital of the National Center for Global Health and Medicine /ID# 209533	Shinjuku-ku	Tokyo	Japan	162-8655
361	Tokyo Women's Medical University Hospital /ID# 205978	Shinjuku-ku	Tokyo	Japan	162-8666
362	Yamagata University Hospital /ID# 171468	Yamagata-shi	Yamagata	Japan	990-9585
363	Tokuyama Central Hospital /ID# 216995	Shunan-shi	Yamaguchi	Japan	745-8522
364	Yamanashi Prefectural Central Hospital /ID# 151909	Kofu-shi	Yamanashi	Japan	400-8506
365	Shoyukai Fujita Gastroenterological Hospital /ID# 216494	Takatsuki-shi		Japan	569-0086
366	Hayang University GuriHospital /ID# 150431	Guri	Gyeonggido	Korea, Republic of	11923
367	CHA University Bundang Medical Center /ID# 161567	Seongnam	Gyeonggido	Korea, Republic of	13496
368	The Catholic University of Korea, ST. Vincent's Hospital /ID# 150434	Suwon	Gyeonggido	Korea, Republic of	16247
369	Kangbuk Samsung Hospital /ID# 150435	Seoul	Seoul Teugbyeolsi	Korea, Republic of	03181
370	Yonsei University Health System Severance Hospital /ID# 161566	Seoul	Seoul Teugbyeolsi	Korea, Republic of	03722
371	Dong-A University Hospital /ID# 161568	Busan		Korea, Republic of	49201
372	Pusan National University Hospital /ID# 161569	Busan		Korea, Republic of	49241
373	Yeungnam University Medical Center /ID# 150432	Daegu		Korea, Republic of	42415
374	Asan Medical Center /ID# 159155	Seoul		Korea, Republic of	05505
375	Samsung Medical Center /ID# 150433	Seoul		Korea, Republic of	06351
376	Pauls Stradins Clinical University Hospital /ID# 153183	Riga		Latvia	1002
377	VCA Polyclinic Aura /ID# 150436	Riga		Latvia	1035
378	Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 150439	Kaunas		Lithuania	50161
379	Klaipeda Seamens Hospital /ID# 163501	Klaipeda		Lithuania	92288
380	Klaipeda University Hospital /ID# 163719	Klaipeda		Lithuania	92288
381	Duplicate_Vilnius University Hospital /ID# 164172	Vilnius		Lithuania	LT-08661
382	Hospital Sultanah Bahiyah /ID# 152310	Alor Setar	Kedah	Malaysia	05460
383	Universiti Kebangsaan Malaysia (UKM) Medical Centre /ID# 152313	Kuala Lumpur	Selangor	Malaysia	56000
384	Hospital Ampang /ID# 152311	Ampang		Malaysia	68000
385	Uni Malaya MC /ID# 150440	Kuala Lumpur		Malaysia	59100
386	Morales Vargas Centro de Investigacion S.C. /ID# 211327	Leon	Guanajuato	Mexico	37000
387	Clinica de Investigacion en Reumatologia y Obesidad S.C. /ID# 202334	Guadalajara	Jalisco	Mexico	44650
388	Centro Regiomontano de Estudios Clínicos ROMA S.C /ID# 150265	Monterrey	Nuevo Leon	Mexico	64610
389	Radboud Universitair Medisch Centrum /ID# 151701	Nijmegen	Gelderland	Netherlands	6525 GA
390	Erasmus Medisch Centrum /ID# 150619	Rotterdam	Zuid-Holland	Netherlands	3015 GD
391	Academisch Medisch Centrum /ID# 150617	Amsterdam		Netherlands	1105 AZ
392	Leids Universitair Medisch Centrum /ID# 152625	Leiden		Netherlands	2333 ZA
393	Universitair Medisch Centrum Utrecht /ID# 152776	Utrecht		Netherlands	3584 CX
394	Akershus Universitetssykehus_MAIN /ID# 150622	Lorenskog	Akershus	Norway	1478
395	Universitetssykehuset Nord-Norge /ID# 152836	Tromsø	Troms	Norway	9019
396	Gastromed /Id# 216198	Torun	Kujawsko-pomorskie	Poland	87-100
397	Centrum Medyczne Reuma Park w Warszawie /ID# 150624	Warsaw	Mazowieckie	Poland	02-691
398	Centrum Zdrowia MDM /ID# 150626	Warszawa	Mazowieckie	Poland	00-635
399	Centralny Szpital Kliniczny MSWiA w Warszawie /ID# 150627	Warszawa	Mazowieckie	Poland	02-507
400	NZOZ Vivamed /ID# 216743	Warszawa	Mazowieckie	Poland	03-580
401	Instytut Pomnik - Centrum Zdrowia Dziecka /ID# 215733	Warszawa	Mazowieckie	Poland	04-730
402	Endoskopia Sp. z o.o. /ID# 152940	Sopot	Pomorskie	Poland	81-756
403	Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 151616	Guimaraes	Braga	Portugal	4835-044
404	Centro Hospitalar de Entre Douro e Vouga /ID# 152336	Santa Maria Da Feira	Porto	Portugal	4520-211
405	Unidade Local de Saúde do Alto Minho, EPE - Hospital Conde de Bertiandos /ID# 151618	Ponte de Lima	Viana Do Castelo	Portugal	4990-041
406	Hospital Garcia de Orta, EPE /ID# 151622	Almada		Portugal	2805-267
407	CCA Braga - Hospital de Braga /ID# 151617	Braga		Portugal	4710-243
408	Centro Hospitalar Universitario Lisboa Central, EPE - Hospital dos Capuchos /ID# 151620	Lisboa		Portugal	1169-050
409	Centro Hospitalar Universitário de Lisboa Norte, EPE - Hospital de Santa Maria /ID# 151615	Lisboa		Portugal	1649-035
410	Centro Hospitalar Universitario de Sao Joao, EPE /ID# 151619	Porto		Portugal	4200-319
411	School of Medicine University of Puerto Rico-Medical Science Campus /ID# 150629	San Juan		Puerto Rico	00935
412	Immanuel Kant Baltic Federal University /ID# 202129	Kaliningrad	Kaliningradskaya Oblast	Russian Federation	236016
413	Duplicate_NW State Medical Univ na Mechn /ID# 169332	St. Petersburg	Leningradskaya Oblast	Russian Federation	191015
414	Perm Clinical Center of the Federal Medical and Biological Agency /ID# 150634	Perm	Permskiy Kray	Russian Federation	614109
415	Medical Company Hepatolog /ID# 200208	Samara	Samarskaya Oblast	Russian Federation	443063
416	LLC Novaya Klinika /ID# 208106	Pyatigorsk	Stavropol Skiy Kray	Russian Federation	357500
417	Kazan State Medical University /ID# 166040	Kazan	Tatarstan, Respublika	Russian Federation	420012
418	Olla-Med Clinic /ID# 215334	Moscow		Russian Federation	105554
419	Republican hospital named after V.A. Baranov /ID# 206508	Petrozavodsk		Russian Federation	185019
420	Euromedservice /ID# 208968	Pushkin		Russian Federation	196603
421	Duplicate_Stavropol State Medical Univ /ID# 150635	Stavropol		Russian Federation	355017
422	Clinical Hosp Center Zvezdara /ID# 150641	Belgrade	Beograd	Serbia	11000
423	Military Medical Academy /ID# 150643	Belgrade	Beograd	Serbia	11000
424	University Clinical Center Serbia /ID# 150642	Belgrade	Beograd	Serbia	11000
425	Clin Hosp Ctr Bezanijska Kosa /ID# 150640	Belgrade	Beograd	Serbia	11080
426	University Clinical Center of Nis /ID# 151902	NIS	Nisavski Okrug	Serbia	18000
427	University Clinical Center Kragujevac /ID# 150644	Kragujevac	Sumadijski Okrug	Serbia	34000
428	Clinical Center Vojvodina /ID# 150759	Novi Sad	Vojvodina	Serbia	21000
429	General Hospital Leskovac /ID# 217882	Leskovac		Serbia	16000
430	National University Hospital /ID# 150583	Singapore		Singapore	119074
431	Gleneagles Medical Centre /ID# 206020	Singapore		Singapore	258499
432	Tan Tock Seng Hospital /ID# 150646	Singapore		Singapore	308433
433	Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 150869	Banska Bystrica		Slovakia	975 17
434	Medak s.r.o. /ID# 150550	Bratislava		Slovakia	851 01
435	Slovak Research Center Team Me /ID# 150240	Ilava		Slovakia	019 01
436	B+B MED, s.r.o. /ID# 150584	Kosice		Slovakia	040 01
437	Fakultna nemocnica s poliklinikou Nove Zamky /ID# 211371	Nove Zamky		Slovakia	940 34
438	GASTRO I., s.r.o. /ID# 150585	Presov		Slovakia	080 01
439	MD Search /ID# 157524	Boksburg North	Gauteng	South Africa	1460
440	Clinresco Centers /ID# 163625	Johannesburg	Gauteng	South Africa	1619
441	Lenasia Clinical Trial Centre /ID# 214361	Johannesburg	Gauteng	South Africa	1820
442	Wits Clinical Research , Wits Health Consortium (PTY) Ltd /ID# 157730	Johannesburg	Gauteng	South Africa	2193
443	Wits Clinical Research Site /ID# 150586	Johannesburg	Gauteng	South Africa	2193
444	Spoke Research Inc /ID# 162203	CAPE TOWN Milnerton	Western Cape	South Africa	7441
445	Kingsbury Hospital /ID# 150587	Cape Town	Western Cape	South Africa	7708
446	Private Practice Dr MN Rajabally /ID# 155145	Cape Town	Western Cape	South Africa	7800
447	Hospital Clínico Universitario de Santiago-CHUS /ID# 171492	Santiago de Compostela	A Coruna	Spain	15706
448	Hospital Unversitario Marques de Valdecilla /ID# 216621	Santander	Cantabria	Spain	39008
449	Hospital Universitario Dr. Negrin /ID# 203965	Las Palmas de Gran Canaria	Las Palmas	Spain	35019
450	Hospital Universitario A Coruna - CHUAC /ID# 203912	A Coruna		Spain	15006
451	Hospital Clinic de Barcelona /ID# 150598	Barcelona		Spain	08036
452	Hospital Universitario Reina Sofia /ID# 154031	Cordoba		Spain	14004
453	Hospital Universitario Ramon y Cajal /ID# 171491	Madrid		Spain	28034
454	Hospital Universitario La Paz /ID# 214541	Madrid		Spain	28046
455	Hospital Clinico Universitario de Salamanca /ID# 150590	Salamanca		Spain	37007
456	Hospital Universitario y Politecnico La Fe /ID# 150591	Valencia		Spain	46026
457	Sahlgrenska University Hospital /ID# 152326	Gothenburg	Vastra Gotalands Lan	Sweden	413 45
458	Universitätsspital Basel /ID# 161732	Basel	Basel-Stadt	Switzerland	4031
459	Kantonsspital St. Gallen /ID# 152601	St. Gallen	Sankt Gallen	Switzerland	9007
460	Universitätsspital Zürich /ID# 152603	Zürich	Zuerich	Switzerland	8091
461	Inselspital, Universitätsspital Bern /ID# 152602	Bern		Switzerland	3010
462	Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 150606	Kaohsiung		Taiwan	807
463	China Medical University Hospital /ID# 150600	Taichung City		Taiwan	40447
464	Chung Shan Medical University Hospital /ID# 150603	Taichung		Taiwan	40201
465	National Cheng Kung University Hospital /ID# 151751	Tainan		Taiwan	704
466	National Taiwan University Hospital /ID# 150604	Taipei City		Taiwan	100
467	Taipei Veterans General Hosp /ID# 151750	Taipei City		Taiwan	11217
468	Erciyes University Medical Fac /ID# 150495	Melikgazi	Kayseri	Turkey	38030
469	Istanbul University Cerrahpasa Faculty of Medicine /ID# 150491	Cerrahpasa		Turkey	34098
470	Umraniye Training and Res Hosp /ID# 163136	Istanbul		Turkey	34764
471	Duplicate_Marmara University Medical Fac /ID# 214573	Istanbul		Turkey	34899
472	Mersin University Medical /ID# 163135	Mersin		Turkey	33343
473	Gazi Universitesi Tip Fakultes /ID# 150493	Yenimahalle		Turkey	06560
474	Medical Center of the "Health /ID# 162501	Vinnytsya	Vinnytska Oblast	Ukraine	21009
475	Municipal Enterprise "I.I. Mechnikov Dnipropetrovsk Regional Clinical Hospital" /ID# 207731	Dnipro		Ukraine	49005
476	CNCE of Kharkiv Regional Council Regional Clinical Hospital /ID# 206941	Kharkiv		Ukraine	61058
477	PE PMC Acinus, Medical and Diagnostic Center /ID# 217219	Kropyvnytskyi		Ukraine	25006
478	Kyiv Municipal Clinical Hospital #18 /ID# 150505	Kyiv		Ukraine	01030
479	Medical Center CONSILIUM MEDICAL /ID# 217448	Kyiv		Ukraine	04050
480	CNPE of Kyiv Regional Council Kyiv Regional Hospital /ID# 217374	Kyiv		Ukraine	04073
481	Lviv Regional Clinical Hospital /ID# 150508	Lviv		Ukraine	79010
482	Municipal Non-Commercial Enterprise Odesa Regional Clinical Hospital of the Od /ID# 162502	Odesa		Ukraine	65025
483	MNPE Vinnytsia Regional Clinical Hospital n.a. M.I. Pyrohov /ID# 216302	Vinnytsia		Ukraine	21028
484	Royal Devon and Exeter NHS Trust Hospital /ID# 150510	Exeter	Devon	United Kingdom	EX2 5DW
485	Hampshire Hospitals NHS Foundation Trust /ID# 150511	Basingstoke	Essex	United Kingdom	RG24 9NA
486	Barts Health NHS Trust /ID# 150515	London	London, City Of	United Kingdom	E1 2ES
487	NHS Greater Glasgow and Clyde /ID# 163788	Glasgow	Scotland	United Kingdom	G12 0XH
488	Royal United Hospitals Bath /ID# 154211	Bath		United Kingdom	BA1 3NG
489	University Hospitals Birmingham NHS Foundation Trust /ID# 150513	Birmingham		United Kingdom	B15 2TH
490	Calderdale and Huddersfield NHS Foundation Trust /ID# 217659	Huddersfield		United Kingdom	HX3 0PW
491	St George's University Hospitals NHS Foundation Trust /ID# 208376	Tooting		United Kingdom	SW17 0QT