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Understand the Association Between Peritoneal Dialysis Status and Gene Polymorphisms of VEGF and KDR

Sponsor
RenJi Hospital (Other)
Overall Status
Completed
CT.gov ID
NCT04888065
Collaborator
(none)
200
Enrollment
1
Location
31.7
Actual Duration (Months)
6.3
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Peritoneal dialysis (PD) is an effective and successful way of renal replacement therapy. The initial transport status is related to distribution of blood vessels and micro inflammation state in peritoneum before PD. Vascular endothelial growth factor(VEGF) and its receptor, kinase insert domain containing receptor(KDR) may play important roles on initial transport status.

This study include 200 PD patients from Renji Hospital in Shanghai, China. According to the 4h D/P Cr within three months of starting PD therapy, we analyzed the association between the polymorphisms of VEGF and KDR and initial peritoneal transport property.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    200 participants
    Observational Model:
    Cohort
    Time Perspective:
    Retrospective
    Official Title:
    Gene Polymorphisms of VEGF and KDR Are Associated With Initial High Transport Status in Peritoneal Dialysis
    Actual Study Start Date :
    May 10, 2018
    Actual Primary Completion Date :
    Oct 30, 2020
    Actual Study Completion Date :
    Dec 30, 2020

    Outcome Measures

    Primary Outcome Measures

    1. The relationship between VEGF and KDR Gene polymorphisms and initial transport status in peritoneal dialysis [For each patient, the outcome would be cross sectional measured at the time the patient does first/initial Peritoneal Equilibration Test. The data collection time period of the study is within 3 months.]

      According to the 4h dialysate over plasma ratio for creatinine （D/P Cr） within three months of starting PD therapy, patients were divided into high transport(H) or high average transport(HA) (H/HA) group and low transport(L) or low average transport(LA) (L/LA) group. Gene polymorphisms of selected VEGF and KDR SNPs were analyzed using extracted blood DNA from these patients. We aimed to investigate the relationship between VEGF and KDR gene polymorphisms and initial peritoneal transport property.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    N/A and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    1. Patients are Han Chinese;

    2. Patients prepare for dialysis in our center, and start PD within 3 months after abdominal catheterization;

    3. Patients successfully complete the first peritoneal equilibration test(PET);

    4. Follow up regularly in our PD center.

    Exclusion Criteria:

    1. Patients from hemodialysis to peritoneal dialysis;

    2. Patients who need peritoneal dialysis due to transplant-renal loss;

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Renji Hospital Shanghai Shanghai China 310115

    Sponsors and Collaborators

    • RenJi Hospital

    Investigators

    • Principal Investigator: YUE QIAN, MD, RenJi Hospital

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    RenJi Hospital
    ClinicalTrials.gov Identifier:
    NCT04888065
    Other Study ID Numbers:
    • 2018-220
    First Posted:
    May 17, 2021
    Last Update Posted:
    May 17, 2021
    Last Verified:
    Apr 1, 2021
    Individual Participant Data (IPD) Sharing Statement:
    No
    Plan to Share IPD:
    No
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No

    Study Results

    No Results Posted as of May 17, 2021