The Effects of Using Fertile Chip in Sperm Selection for Intracytoplasmic Sperm Injection in Unexplained Infertility
Study Details
Study Description
Brief Summary
The aim of the current study is to evaluate to effectiveness of sperm selection by using fertile chip in unexplained infertile couples on intracytoplasmic sperm injection (ICSI) cycles.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 3 |
Detailed Description
The aim of the current study is to evaluate to effectiveness of sperm selection by using fertile chip in unexplained infertile couples on intracytoplasmic sperm injection (ICSI) cycles. On study arm sperm selection will be performed by using special microchannel system which is called fertile chip (FC) without using sperm wash procedure. This FC system leads to select lineer motile progressive sperm selection. In control group, sperm selection will be performed by classical way which sperm will be undertaken to sperm wash by gradient method.
After selection of sperm in both arms, ICSI will be performed. The outcomes of ICSI schedule will be assesed by fertilization and clinical pregnancy rates.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Active Comparator: fertile chip sperm selection by using fertile chip and conventional methods |
Device: fertile chip
a new method for sperm selection on ivf cycles by using microchannel system.
|
| No Intervention: classical ICSI procedure unexplained infertile couples who will be undertaken intracytoplasmic sperm injection (ICSI) for fertilisation |
Outcome Measures
Primary Outcome Measures
- increase fertilisation rate [2 days]
Secondary Outcome Measures
- Clinical pregnancy rates [10 months]
Other Outcome Measures
- The number of freezing embryos [6 months]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
between 20-37 year-old women
-
normal tubal patency, normal uterine cavity, normal ovulation,
-
between 20-40 year-old men
-
normal semen analyse by WHO criterias
-
unexplained infertile couples
Exclusion Criteria:
-
poor ovarian reserve which is diagnosed by Bologna criterias
-
abnormal semen analyse by WHO sperm criterias
-
abnormal ovulation problems,tubal patency or uterine cavity
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Baskent University Faculty of Medicine Department of Obstetrics and Gynecology Division of Reproductive and Endocrinology Unit | Adana | Yüreğir | Turkey |
Sponsors and Collaborators
- Baskent University
Investigators
- Study Director: Esra Bulgan Kılıçdağ, MD, Division of Reproductive and Endocrinology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, Baskent University, Adana, Turkey
Study Documents (Full-Text)
None provided.More Information
Publications
- Asghar W, Velasco V, Kingsley JL, Shoukat MS, Shafiee H, Anchan RM, Mutter GL, Tüzel E, Demirci U. Selection of functional human sperm with higher DNA integrity and fewer reactive oxygen species. Adv Healthc Mater. 2014 Oct;3(10):1671-9. doi: 10.1002/adhm.201400058. Epub 2014 Apr 17.
- Collins JA, Crosignani PG. Unexplained infertility: a review of diagnosis, prognosis, treatment efficacy and management. Int J Gynaecol Obstet. 1992 Dec;39(4):267-75. Review.
- Moghissi KS, Wallach EE. Unexplained infertility. Fertil Steril. 1983 Jan;39(1):5-21. Review.
- Practice Committee of the American Society for Reproductive Medicine. Definitions of infertility and recurrent pregnancy loss. Fertil Steril. 2008 Jun;89(6):1603. doi: 10.1016/j.fertnstert.2008.03.002. Epub 2008 May 16.
- Templeton AA, Penney GC. The incidence, characteristics, and prognosis of patients whose infertility is unexplained. Fertil Steril. 1982 Feb;37(2):175-82.
- Zini A, Finelli A, Phang D, Jarvi K. Influence of semen processing technique on human sperm DNA integrity. Urology. 2000 Dec 20;56(6):1081-4.
- KA15/132