Transcranial Magnetic Treatment (TMS) in Unipolar Depression

• Sponsor: St. Joseph's Healthcare Hamilton (Other)
• Overall Status: Completed
• CT.gov ID: NCT00186784
• Collaborator: Queen's University, Kingston, Ontario (Other)
• Enrollment: 21
• Location: 1
• Duration (Months): 126.9
• Patients Per Site Per Month: 0.2

Study Details

Study Description

Brief Summary

Repetitive Transcranial Magnetic Stimulation (rTMS) can improve mood and decrease sadness in patients with depression.

In this study, the investigators seek to increase their understanding about how rTMS improves depression, and to determine which form of rTMS is most effective for depression, when used in combination with antidepressant medication.

Condition or Disease	Intervention/Treatment	Phase
Unipolar Depression	Procedure: Transcranial Magnetic Stimulation (TMS)	Early Phase 1

Detailed Description

Patients will be assigned for 4 treatment arms, receiving either left high frequency plus right low frequency, or left high frequency plus right sham, or left sham, plus right low frequency, or left sham plus right sham treatment. All subjects will receive treatments for 10 days and will be followed for another 4 weeks.

Study Design

• Study Type: Interventional
• Actual Enrollment: 21 participants
• Allocation: Randomized
• Intervention Model: Single Group Assignment
• Masking: Double (Participant, Investigator)
• Primary Purpose: Treatment
• Official Title: Repetitive Transcranial Magnetic Stimulation (rTMS) in Unipolar Depression
• Study Start Date: Dec 1, 2000
• Actual Primary Completion Date: Jul 1, 2011
• Actual Study Completion Date: Jul 1, 2011

Outcome Measures

Primary Outcome Measures

1. Hamilton Depression Rating Scale [Pre TMS and post TMS]

2. Beck Depression Rating Scale [pre TMS and post TMS]

Secondary Outcome Measures

1. Quantitive Electroencephalographic(QEEG)activity and measures of regional cerebral blood flow [pre TMS and post TMS as well as post phase II, second set of TMS]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 65 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• Major Depression

• No physical health problems

Exclusion Criteria:

• History of Epilepsy

• Metal in the head/neck or skull

• Pacemaker

• Pregnancy

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	St.Joseph's Healthcare, rTMS Laboratory, Mood Disorders Program, 100 West Fifth Street	Hamilton	Ontario	Canada	L8N 3K7

Sponsors and Collaborators

• St. Joseph's Healthcare Hamilton
• Queen's University, Kingston, Ontario

Investigators

• Principal Investigator: Gary Hasey, MD, McMaster University

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• ClinicalTrials.gov Identifier: NCT00186784
• Other Study ID Numbers: TMS1871
• First Posted: Sep 16, 2005
• Last Update Posted: Aug 3, 2011
• Last Verified: Aug 1, 2011

• Keywords provided by , ,: Repetitive Transcranial Magnetic Stimulation; TMS
• Additional relevant MeSH terms: Depression; Depressive Disorder

Study Results

No Results Posted as of Aug 3, 2011