Role of Non-contrast MDCT in the Assessment of Upper Urinary Tract Calculi Post ESWL to Predict Its Success Rate
Study Details
Study Description
Brief Summary
Urinary stones are a common disease affecting one in 11 people . Their clinical presentation varies from being silent to severe loin pain owing to urinary obstruction. Currently, ESWL is the treatment of choice for most renal calculi ⩽30 mm, with success rates of 60-99%. Although many treatment options exist, ESWL has the advantages of simplicity and non-invasiveness. In contrast, failure of a first ESWL attempt requires a follow-up ESWL procedure, or an alternative procedure, both of which increase medical costs.
Advancements in imaging have significantly contributed to this process. In the mid- 1990s, computed tomography (CT) began to replace intravenous urography (IVU), abdominal films (KUB), and ultrasound (US) in stone diagnosis. Studies demonstrated that CT had superior sensitivity and specificity for stone diagnosis compared to the aforementioned modalities. Now non-contrast multidetector CT (NC-MDCT) is the gold standard for the detection of urinary system calculi. CT is also clinically useful as it can show alternate renal and non-renal pathology if present.
Many factors have been reported to predict ESWL outcome, such as skin-to-stone distance (SSD), stone size, stone location, multiplicity, the energy used, and Hounsfield Unit (HU) values measured by non-contrast computed tomography (NCCT).
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
Excellent fragmentation results are produced using ESWL. However, the retention of post-ESWL fragments in the kidney continues to be a significant medical issue. Only 32% of calcium stone patients in research were found to remain stone-free for 12 months following ESWL, according to the results. As a result, it appears that fragment growth and persistence are frequent after ESWL [10].
The first ESWL residual that is accessible must undergo a thorough stone analysis to properly carry out the subsequent treatments to prevent relapse or recurrent stone because stone-free rates after ESWL are directly connected to stone placement, size, number, and composition
Study Design
Outcome Measures
Primary Outcome Measures
- ct follow up during swl [3 weeks]
Correlation between the stone density before and during ESWL sessions to determine if this predicts the success prevent new ESWL.
- stone Hounsfield [3weeks]
Determine the role of the density of the residual stone fragments in the prediction of the complication during ESWL.
Secondary Outcome Measures
- density of stone and other factors [3weeks]
Correlate between stone density and other factors in the prediction of the success of ESWL.
Eligibility Criteria
Criteria
Inclusion Criteria:
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patients older than 18 years.
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stone size up to 25 mm for renal pelvic stones and up to 15 mm for upper ureteric stones.
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SSD < 11 cm.
Exclusion Criteria:
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any patient with contraindications to ESWL as
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uncontrolled urinary infection.
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clotting alterations.
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aortic or renal artery aneurysm.
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pregnancy.
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serious skeletal malformations.
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serious obesity and or contraindications to CT as pregnancy.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Assiut University Hospital | Assiut | Egypt | 11751 |
Sponsors and Collaborators
- Assiut University
Investigators
- Study Director: gehan sayed, MD, Assiut University
- Study Director: Doria mohamed, md, Assiut University
Study Documents (Full-Text)
None provided.More Information
Publications
- Johnson EK, Faerber GJ, Roberts WW, Wolf JS Jr, Park JM, Bloom DA, Wan J. Are stone protocol computed tomography scans mandatory for children with suspected urinary calculi? Urology. 2011 Sep;78(3):662-6. doi: 10.1016/j.urology.2011.02.062. Epub 2011 Jun 30.
- Rassweiler JJ, Renner C, Chaussy C, Thuroff S. Treatment of renal stones by extracorporeal shockwave lithotripsy: an update. Eur Urol. 2001 Feb;39(2):187-99. doi: 10.1159/000052435.
- Weld KJ, Montiglio C, Morris MS, Bush AC, Cespedes RD. Shock wave lithotripsy success for renal stones based on patient and stone computed tomography characteristics. Urology. 2007 Dec;70(6):1043-6; discussion 1046-7. doi: 10.1016/j.urology.2007.07.074.
- Wolf JS Jr, Clayman RV. Percutaneous nephrostolithotomy. What is its role in 1997? Urol Clin North Am. 1997 Feb;24(1):43-58. doi: 10.1016/s0094-0143(05)70353-0.
- MDCT in ESWL