Use of Indirect Calorimetry in Obesity
Study Details
Study Description
Brief Summary
The investigators will retrospectively analyze and compare data of 2 groups of overweight and obese patients: subjects who followed a diet based on Resting Energy Expenditure (REE) measured by indirect calorimetry and subjects who followed a diet based on REE estimated by the Harris-Benedict equation. Propensity score adjustment will be used to adjust for known differences between the 2 groups
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Indirect Calorimetry group (IC group) Group who performed indirect calorimetry. REE measured by indirect calorimetry. |
Diagnostic Test: Indirect calorimetry
Indirect calorimetry will be performed by using an open-circuit calorimeter (Sensor Medics, Italy). Indirect calorimetry is the reference method for energy expenditure determination. A canopy hood covered the patient's head and expired air is extracted by a pump to be analyzed by metabolic cart sensors; flow rate is directly measured with a digital turbine flowmeter. After an overnight fast, patients will asked to lay supine in complete physical rest, not sleeping or talking for approximately 20-25 minutes, at a room temperature ranged between 22 and 24°C. The mean REE for each participant considers the last 15-20 minutes of measurements corresponding to steady state.
Software of calorimeter will be set for minute-by-minute reading report of VO2 (Oxygen flow) and VCO2 (Carbon dioxide flow) measurement.
Parameters obtained by Indirect Calorimetry will be the Resting Energy Expenditure and the Respiratory Quotient (RQ)
|
| NO Indirect Calorimetry group (NO-IC group) Group who did not perform indirect calorimetry. Resting Energy Expenditure calculated by Harris-Benedict formula |
Outcome Measures
Primary Outcome Measures
- Weight in Indirect Calorimetry group and in NO Indirect Calorimetry group [18 months]
To compare body weight variation (kg) in two groups of overweight or obese patients: subjects who followed a diet formulated on REE measured by IC (IC group) and subjects who followed a diet based on REE predicted by the Harris-Benedict formula (NO-IC group)
- BMI in Indirect Calorimetry group and in NO Indirect Calorimetry [18 months]
To compare BMI variation (kg/m^2) in two groups of overweight or obese patients: subjects who followed a diet formulated on REE measured by IC (IC group) and subjects who followed a diet based on REE predicted by the Harris-Benedict formula (NO-IC group)
Secondary Outcome Measures
- Weight in male/female in Indirect Calorimetry group and in NO indirect Calorimetry group [18 months]
To identify gender differences in weight variation (kg) between IC and NO-IC groups
- BMI in male/female in Indirect Calorimetry group and in NO indirect [18 months]
To identify gender differences in BMI variation (kg/m^2) between IC and NO-IC groups
Other Outcome Measures
- Weight in adequate to predicted REE and in NOT adequate to predicted REE subpopulations [18 months]
to compare body weight variation (kg) in two sub-populations of the IC-group: subjects with adequate to predicted REE and subjects with not adequate to predicted REE
- BMI in adequate to predicted REE and in NOT adequate to predicted REE subpopulations [18 months]
to compare BMI variation in two sub-populations of the IC-group: subjects with adequate to predicted REE and subjects with not adequate to predicted REE
- Weight in subjects with RQ<0.9 and subjects with RQ>0.9 [18 months]
to compare body weight variation in 2 subpopulation of the IC group: subjects with an RQ ≤ 0.9 and subjects with RQ > 0.9.
- BMI in subjects with RQ<0.9 and subjects with RQ>0.9 [18 months]
BMI variation in 2 subpopulation of the IC group: subjects with an RQ ≤ 0.9 and subjects with RQ > 0.9.
- Glucose in Indirect Calorimetry group and in NO Indirect Calorimetry Group [18 months]
to identify differences in glucose (mg/dl) variation between IC and NO-IC groups
- Tryglycerides in Indirect Calorimetry group and in NO Indirect Calorimetry Group [18 months]
to identify differences in tryglycerides (mg/dl) variation between IC and NO-IC groups
- Total cholesterol (mg/dl) in Indirect Calorimetry group and in NO Indirect Calorimetry Group [18 months]
to identify differences in cholesterol variation between IC and NO-IC groups
- Hemoglobin in Indirect Calorimetry group and in NO Indirect Calorimetry Group [18 months]
to identify differences in glycated hemoglobin (%) variation between IC and NO-IC groups
- Uric acid in Indirect Calorimetry group and in NO Indirect Calorimetry Group [18 months]
to identify differences in uric acid (mg/dl) variation between IC and NO-IC groups
Eligibility Criteria
Criteria
Inclusion Criteria:
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BMI >25
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Age ranging from 20 to 86 years
Exclusion Criteria:
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BMI<25
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Age <20
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Age >86
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | San Donato Hospital | San Donato Milanese | MI | Italy | 20097 |
Sponsors and Collaborators
- Ospedale San Donato
Investigators
- Principal Investigator: Livio Luzi, Professor, IRCCS Policlinico San Donato
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- CALO/Obesity