The Use of Near Infrared Spectroscopy (NIRS) to Estimate Intracranial Pressure (ICP)
Study Details
Study Description
Brief Summary
The aim of this study is to determine whether we can predict the intracranial pressure using near infra-red spectroscopy
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
The management of intracranial hypertension requires the presence of an intracranial pressure monitor. We are investigating whether the waveforms obtained from a near infrared spectroscopy device can predict what the intracranial pressure is non-invasively.
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Patients with intracranial hypertension who are intubated and ventilated in the ICU will be recruited
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we will record there intracranial pressure and systemic arterial pressure
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recordings from the near infrared device will be recorded and analysed off-line
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we will correlate the waveform tracings from near infrared spectroscopy and the arterial tracing
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Intracranial hypertension Patients with raised intracranial pressure |
Outcome Measures
Primary Outcome Measures
- Intracranial elastance [Participants will be followed while an arterial line and intracranial pressure monitor is present duing the ICU admission. This is expected to be an average of 5 days.]
Intracranial elastance (δP/δV)will be measured by dividing the pulse pressure of an invasive arterial blood pressure by the amplitude of high frequency oscillations in the near infrared (NIR) absorbance waveforms.
Eligibility Criteria
Criteria
Inclusion Criteria:
Patients with an intracranial pressure monitor and arterial catheter who are admitted to the ICU
Exclusion Criteria:
Less than 18 years
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of Virginia | Charlottesville | Virginia | United States | 22908 |
Sponsors and Collaborators
- University of Virginia
Investigators
- Principal Investigator: Bhiken Naik, MBBCh, University of Virginia
Study Documents (Full-Text)
None provided.More Information
Publications
- Brain Trauma Foundation; American Association of Neurological Surgeons; Congress of Neurological Surgeons; Joint Section on Neurotrauma and Critical Care, AANS/CNS, Carney NA. Guidelines for the management of severe traumatic brain injury. Methods. J Neurotrauma. 2007;24 Suppl 1:S3-6. Erratum in: J Neurotrauma. 2008 Mar;25(3):276-8. Carney, Nancy A [added].
- Lee JK, Kibler KK, Benni PB, Easley RB, Czosnyka M, Smielewski P, Koehler RC, Shaffner DH, Brady KM. Cerebrovascular reactivity measured by near-infrared spectroscopy. Stroke. 2009 May;40(5):1820-6. doi: 10.1161/STROKEAHA.108.536094. Epub 2009 Mar 12.
- Rosenberg JB, Shiloh AL, Savel RH, Eisen LA. Non-invasive methods of estimating intracranial pressure. Neurocrit Care. 2011 Dec;15(3):599-608. doi: 10.1007/s12028-011-9545-4.
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