Usefulness of Interferon-gamma Release Assay in Diagnosing Pulmonary Nodules
Study Details
Study Description
Brief Summary
Among the causes of the solitary pulmonary nodule (SPN), benign causes including tuberculosis was noted on 15 to 60 percents in various studies.
Although the characteristics of chest imaging is helpful in diagnosis and percutaneous needle biopsy for pulmonary nodule has been represented high diagnostic yield in many reports, but still surgical biopsy has been needed in definite diagnosis of pulmonary nodules in many cases.
The aim of this study is to evaluate the usefulness of interferon-gamma release assay in addition to the percutaneous needle biopsy, in diagnosis of pulmonary nodules.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
Among the patients who failed to diagnosis by percutaneous needle biopsy and needed to have Surgical biopsy, thirty percents of the patients were diagnosed as benign nodules and about six percents were diagnosed as tuberculosis in Seoul National University Hospital during 2007-2008.
The investigators want to know whether conducting an interferon-gamma release assay in addition to percutaneous needle biopsy is helpful in diagnosis of lung nodules.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| IGRA in solitary pulmonary nodules Inpatients who undergo percutaneous needle biopsy for diagnosis of pulmonary nodules in Seoul National University hospital for six months are going to be included. Patients who are not tolerable for PCNB or do not agree the enrollment of study will be excluded. |
Outcome Measures
Primary Outcome Measures
- Positive rate of the interferon-gamma release assay [within 36hrs after blood sampling]
the result of the interferon-gamma release assay is reported in three different categories as positive, negative or indeterminate. We want to know whether the positive rate of the interferon-gamma release asssay would be significantly different according to the pathologic diagnosis of lung nodules confirmed by percutaneous needle biopsy.
Secondary Outcome Measures
- Positive rate of the Tuberculin skin test [48hours after tuberculin skin test]
We will conduct Tuberculin skin test and evaluate the whether the positive rate of the Tuberculin skin test would be different according to the pathologic diagnosis of lung nodules confirmed by percutaneous needle biopsy.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Age> 18 years
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in patients with solitary pulmonary nodule
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who had percutaneous needle biopsy for diagnosis of lung nodule
Exclusion Criteria:
- patients who do not agree the study enrollment
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Young Whan Kim | Seoul | Korea, Republic of | 110-744 | |
| 2 | Young Whan Kim | Seoul | Korea, Republic of | 110-744 |
Sponsors and Collaborators
- Seoul National University Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- SeoulNUH-IGRA-01