A Study of Nelfinavir Added to Cisplatin Chemotherapy Concurrent With Pelvic Radiation for Locally Advanced Cervical Cancer (II-IVA)

Sponsor

Abramson Cancer Center of the University of Pennsylvania (Other)

Overall Status

Completed

CT.gov ID

NCT02363829

Collaborator

(none)

Enrollment

Location

Arm

60.5

Actual Duration (Months)

0.1

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Patients 18 years of age and older with clinical stages IIA, IIB, IIIA, IIIB, IVA cervical carcinoma limited to the pelvis will receive twice daily oral nelfinavir (NFV) and weekly IV cisplatin in combination as radiosensitizers with daily whole pelvic external beam and intracavitary radiation brachytherapy.

Condition or Disease	Intervention/Treatment	Phase
Uterine Cervix Cancer	Drug: Nelfinavir Biological: Cisplatin	Phase 1

Study Design

Study Type:

Interventional

Actual Enrollment :

6 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

A Phase I Study of Nelfinavir Added to Cisplatin Chemotherapy Concurrent With Pelvic Radiation for Locally Advanced Cervical Cancer (II-IVA)

Actual Study Start Date :

Feb 1, 2015

Actual Primary Completion Date :

Feb 17, 2020

Actual Study Completion Date :

Feb 17, 2020

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Treatment Nelfinavir and Cisplatin	Drug: Nelfinavir Biological: Cisplatin

Arm

Intervention/Treatment

Experimental: Treatment

Nelfinavir and Cisplatin

Drug: Nelfinavir

Biological: Cisplatin

Outcome Measures

Primary Outcome Measures

Number of Adverse Events [2 years]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

Female

Accepts Healthy Volunteers:

Inclusion Criteria:

All patients with primary, previously untreated, histologically confirmed invasive carcinoma of the uterine cervix (any cell type). Clinical stages IIA, IIB, IIIA, IIIB, IVA. A representative H & E stained slide showing documentation of the primary invasive cancer is required.
Patients must have adequate bone marrow, renal and hepatic function:

Laboratory work must be performed within 30 days prior to start of study treatment.

ANC ≥ 1,500/μL; Platelet count ≥ 100,000/μL; Creatinine < 2.0 mg/dL; Total Bilirubin ≤ 1.5 times normal; SGOT ≤ 3 times normal.

Patients with a ECOG/GOG Performance Status of 0, 1, or 2.
Patients with ureteral obstruction must be treated with stent or nephrostomy tube.
Patients of childbearing potential must use an effective form of birth control."Patients receiving oral contraceptives should be instructed that alternate or additional contraceptive measures should be used during therapy with VIRACEPT. "
Confirmed seronegative HIV status within 3 months prior to start of study treatment.
Patients must be at least 18 years of age.
Patients must have signed an approved informed consent and authorization permitting release of personal health information.

Exclusion criteria

Patients with Stage IA, IB or IVB disease.
Patients who have known metastases to other organs outside the radiation field at the time of the original clinical and surgical staging.
Patients who have received previous pelvic or abdominal radiation, cytotoxic chemotherapy, or previous therapy of any kind for this malignancy.
Patients with septicemia or severe infection.
Patients who have circumstances that will not permit completion of this study or the required follow-up.
Patients who are pregnant at the time of diagnosis and do not wish pregnancy termination prior to initiation of treatment.
Patients with renal abnormalities, such as pelvic kidney, horseshoe kidney, or renal transplantation, that would require modification of radiation fields.
Patients with other concomitant malignancies (with the exception of non-melanoma skin cancer), who had (or have) any evidence of other cancer present within the last 5 years.
Patients with GI tract disease resulting in an inability to take oral medication, malabsorption syndrome, a requirement for IV alimentation, prior surgical procedures affecting absorption, uncontrolled inflammatory GI disease (e.g., Crohn's, ulcerative colitis).
Patients with poorly controlled diabetes mellitus despite medication.
Patients taking anti-arythmic agents such as amiodarone, quinidine, rifampin, ergot derivatives such as ergotamine, St John's Wort, HMG-CoA reductase inhibitors such as lovastatin, neuroleptic such as pimozide, sedatives such as midazolam and triazolam among other CYP3A4 and CYP2C19 substrates.
Patients with Phenylketonuria

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Abramson Cancer Center of the University of Pennsylvania	Philadelphia	Pennsylvania	United States	19104

Sponsors and Collaborators

Abramson Cancer Center of the University of Pennsylvania

Investigators

Principal Investigator: Fiona Simpkins, MD, Abramson Cancer Center of the University of Pennsylvania
Principal Investigator: Lilie Lin, MD, Abramson Cancer Center of the University of Pennsylvania