Uterine Lesions and Their Association to Invitro Fertilization(IVF) or Intracytoplasmic Sperm Injection(ICSI) Outcome
Study Details
Study Description
Brief Summary
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To study the effect of uterine wall , intracavitary , cervical as well as cervical canal lesion on the outcome of IVF/ICSI cycle.
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To establish a score for prediction of IVF/ICSI cycle success .
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
IVF is one of the most successful treatment of fertility, (1) however, several IVF cycles fail to achieve pregnancy (2).failure defined as three or more failed attempts of ICSI (3). Implantation failure is a complex in nature, may be due to structural or functional causes (3, 4).
that previously undiagnosed, misinterpreted initial diagnoses, or subtle newly added intrauterine abnormalities may be a significant cause of IVF failure (5, 6), studies say that intra-uterine pathologies represent 40-50 % of causes of ICSI failure (7, 8), hysteroscopic removal of endometrial polyps, submucous fibroids, uterine septum, or intrauterine adhesions could increase the pregnancy rate (9). so, Evaluation of the uterine cavity may become a routine investigation before assisted reproductive technology(ART) procedures (10).
In this study, we evaluate the relationship between the different uterine and cervical pathologies and decreased live birth rate.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Group A Women with hysteroscopically or ultrasonographic detected uterine anomalies(adenomyosis,fibroid) intracavitary lesions ( like polyp, adhesion or septum) and those with detected endometrial abnormalities (like hypervascularization,pale endometrium) ,cervical lesion and cervical canal lesion or pelvic lesion |
Procedure: IVF
In vitro fertilization
|
| Group B Matched women (eg. Age,parity, BMI, ovarian reserve….) with no uterine or ovarian abnormalities assessed by hysteroscopy or ultrasonography. |
Procedure: IVF
In vitro fertilization
|
Outcome Measures
Primary Outcome Measures
- Pregnancy rate [Baseline]
Pregnancy rate with IVF/ICSI with uterine lesions
Eligibility Criteria
Criteria
Inclusion Criteria:
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Women between 18 and 38 years old.
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An indication for IVF/ICSI..
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Women with BMI between 18.5 : 29.9 .
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Women with normal antimullerian hormone(AMH), antral follicle count(AFC) (good responders).
Exclusion Criteria:
Refusal to join the study.
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Women with age less than 18 and more than 38 .
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Women with BMI less than 18.5 and more than 30 .
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Untreated tubal hydrosalpinges.
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Poor responders as assessed by AFC 4 or less ,AMH O.8 ng/dl (nice 2013).
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Assiut University
Investigators
- Study Director: Momen Kamel, Prof.dr, Assiut University
Study Documents (Full-Text)
None provided.More Information
Publications
- Dicker D, Ashkenazi J, Feldberg D, Farhi J, Shalev J, Ben-Rafael Z. The value of repeat hysteroscopic evaluation in patients with failed in vitro fertilization transfer cycles. Fertil Steril. 1992 Oct;58(4):833-5.
- Levi Setti PE, Colombo GV, Savasi V, Bulletti C, Albani E, Ferrazzi E. Implantation failure in assisted reproduction technology and a critical approach to treatment. Ann N Y Acad Sci. 2004 Dec;1034:184-99. Review.
- Rai R, Regan L. Recurrent miscarriage. Lancet. 2006 Aug 12;368(9535):601-11. Review.
- Uterine lesions and ICSI