Testing the Persuasiveness of Pro-inoculation Arguments

• Sponsor: University of Pennsylvania (Other)
• Overall Status: Not yet recruiting
• CT.gov ID: NCT05804825
• Collaborator: (none)
• Enrollment: 300
• Location: 1
• Arms: 2
• Anticipated Duration (Days): 6
• Patients Per Site Per Month: 1521.9

Study Details

Study Description

Brief Summary

The investigators will recruit a national sample of parents of 7-10-year-olds to complete an argument strength ranking for either a simple forwarding message or between 3 and 6 randomly selected arguments from an overall set of 50 to 100 messages identified from various online sources. Parents will rate each message they see on measures of perceived argument strength/PME. Parents will also answer sociodemographic questions and then rank the believability of a set of anti-vaccine messages identified in a different study. Study findings will contribute valuable information to understanding the effectiveness of different inoculation messages.

Condition or Disease	Intervention/Treatment	Phase
Vaccination Hesitancy; Human Papillomavirus Vaccination; Vaccine Refusal	Behavioral: Argument inoculation messages; Behavioral: Simple forewarning message	N/A

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 300 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Intervention Model Description: randomized discrete choice modeling experiment designrandomized discrete choice modeling experiment design
• Masking: None (Open Label)
• Primary Purpose: Other
• Official Title: Message Testing Protocol for Misinformation Concerns
• Anticipated Study Start Date: Jun 1, 2023
• Anticipated Primary Completion Date: Jun 7, 2023
• Anticipated Study Completion Date: Jun 7, 2023

Arms and Interventions

Arm	Intervention/Treatment
Active Comparator: Simple forewarning message Participants will receive a simple short forewarning message to read and rate.	Behavioral: Simple forewarning message; Participants will be presented with a simple forewarning message.
Experimental: Argument inoculation messages Participants will view a random sample of 3 text-only short messages (from a corpus of 100 arguments) to read and rate.	Behavioral: Argument inoculation messages; Participants will then be presented with arguments randomly selected by the Qualtrics software algorithm from the full set of messages.

Outcome Measures

Primary Outcome Measures

1. Argument strength/PME [The outcome measure will be assessed immediately after the participant has viewed each pro-HPV vaccine message if they are in the multiple message condition, or the simple message if they are in the simple message condition stimuli during the survey.]

   Arguments will be rated for their argument strength/message effectiveness

2. Misinformation believability [The outcome measure will be assessed immediately after the participant has viewed each misinformation message during the survey.]

   A rating of the believability/ credibility of vaccine misinformation

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

1. Male or female parent or legal guardian of an adolescent ages 7-10

2. Age eligible child has not yet received any doses of the HPV vaccine

3. Resides in the United States

4. English speaking

5. Completed informed consent

Exclusion Criteria:

1. Unable to read English at a 6th grade literacy level

2. Age < 18

3. Does not have a child within the age range of 7-10

4. Age-eligible child has received 1 or more doses of the HPV vaccine

5. Does not have a social media account on one or more of the following platforms OR does not read online news stories: Twitter, Instagram, YouTube, Facebook (feasibility testing only - survey participation will not have this exclusion criteria)

6. Unwilling or unable to provide informed consent to study participation

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	UPenn	Philadelphia	Pennsylvania	United States	19104

Sponsors and Collaborators

• University of Pennsylvania

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: University of Pennsylvania
• ClinicalTrials.gov Identifier: NCT05804825
• Other Study ID Numbers: dfjgehea
• First Posted: Apr 7, 2023
• Last Update Posted: Apr 7, 2023
• Last Verified: Apr 1, 2023

• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Keywords provided by University of Pennsylvania: misinformation; HPV vaccine; vaccine hesitancy

Study Results

No Results Posted as of Apr 7, 2023