Val-Dia score: Validation of a Diagnostic Score for Encephalitis to Assess the Risk of Autoimmune Origin
Study Details
Study Description
Brief Summary
The investigators wish to test a diagnostic risk score for autoimmune encephalitis in case of encephalitis, previously validated by two American teams, in a retrospective analysis, according to the clinical and paraclinical data available in our database of the Reference Centre for Autoimmune Encephalitis and Paraneoplastic Neurological Syndromes of Professor Honnorat for patients with NMDAr, anti LGi1, anti CASPR2, anti GABAbr and anti GAD antibodies.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| NMDAr patients Patients > or = 18 years old presenting with auto-immune encephalitis, defined according to the Graus criteria, with neuronal antibodies : - Anti NMDAr |
Other: Clinical score of Granillo and al.
Compare the performance of the clinical prediction score of confirmed autoimmune encephalitis according to the type of antibody isolated from the CSF.
|
| LGI1 patients Patients > or = 18 years old presenting with auto-immune encephalitis, defined according to the Graus criteria, with neuronal antibodies : - Anti LGI1 |
Other: Clinical score of Granillo and al.
Compare the performance of the clinical prediction score of confirmed autoimmune encephalitis according to the type of antibody isolated from the CSF.
|
| CASPR2 patients Patients > or = 18 years old presenting with auto-immune encephalitis, defined according to the Graus criteria, with neuronal antibodies : - Anti CASPR2 |
Other: Clinical score of Granillo and al.
Compare the performance of the clinical prediction score of confirmed autoimmune encephalitis according to the type of antibody isolated from the CSF.
|
| GABAb patients Patients > or = 18 years old presenting with auto-immune encephalitis, defined according to the Graus criteria, with neuronal antibodies : - Anti GABAb |
Other: Clinical score of Granillo and al.
Compare the performance of the clinical prediction score of confirmed autoimmune encephalitis according to the type of antibody isolated from the CSF.
|
| GAD patients Patients > or = 18 years old presenting with auto-immune encephalitis, defined according to the Graus criteria, with neuronal antibodies : - Anti GAD |
Other: Clinical score of Granillo and al.
Compare the performance of the clinical prediction score of confirmed autoimmune encephalitis according to the type of antibody isolated from the CSF.
|
Outcome Measures
Primary Outcome Measures
- Validation of a diagnostic score for encephalitis to assess the risk of autoimmune origin. [At baseline]
Comorbidities assessed by the Charlson score
- Symptoms in the acute phase [At baseline]
- Mode of onset of disease [At baseline]
- Results of lumbar puncture [At baseline]
- Results of antineuronal antibodies in CSF [At baseline]
- Results of antineuronal antibodies in serum [At baseline]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Age > 18 years old
-
Patient with a definite auto-immune encephalitis (Graus and al. 2016)
Exclusion Criteria:
-
Uncomplete data in acute phase
-
Patient with several antibodies
-
Opposition
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Centre de référence des syndromes neurologiques paranéoplasiques et encéphalites auto-immunes | Lyon | France |
Sponsors and Collaborators
- Hospices Civils de Lyon
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 69HCL23_0627