PS-GDM-2022: The Value of Second-trimester Uterine Artery Doppler Analysis in the Prediction of GDM in a Low- Risk Population
Study Details
Study Description
Brief Summary
In the current literature, there are not enough studies related to the use of uterine artery Doppler indices in the second trimester for the prediction of GDM. Considering that it may be useful in the prediction of GDM in low-risk patient groups for GDM, it was found useful to consider uterine artery Doppler analysis within the scope of this study.In this study, the investigators aimed to assess the value of second-trimester uterine artery Doppler analysis in the prediction of GDM in a low- risk population.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
This retrospective research was conducted between June 2020 and December 2021 at the Perinatology Clinic of Haseki Training and Research Hospital. Maternal age between 18 and 42 years and gestational age between 18 and 23 weeks were the inclusion criteria.Pregnant women's computerized records were used to compare the relevant data of women diagnosed with gestational diabetes and women with normal glucose tolerance . Transabdominal ultrasonography was performed for anatomical scanning, and the uterine artery Doppler was obtained using ultrasonographic devices with a 2.0-7.0 megahertz convex probe. The uterine artery waveforms were obtained using pulsed-wave Doppler with an insonation angle of 30° and a peak systolic velocity greater than 60 cm/s. Three identical waveforms were obtained consecutively on each side. In addition to recording the presence or absence of notching, the mean uterine artery pulsatility index (UAPI) was also obtained. Abnormal uterine artery Doppler was defined as a mean UAPI greater than the 95th percentile for each gestation.Increased uterine artery pulsatility index and/or diastolic notch in the uterine artery between 18-23 weeks of pregnancy can predict the risk of GDM in pregnant women.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Group 1 participants with gestational diabetes
|
Other: uterine artery doppler at 18-23 weeks of pregnancy
uterine artery doppler at 18-23 weeks of pregnancy
|
| Group 2 participants without gestational diabetes
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Other: uterine artery doppler at 18-23 weeks of pregnancy
uterine artery doppler at 18-23 weeks of pregnancy
|
Outcome Measures
Primary Outcome Measures
- Uterine artery Doppler ultrasonography in gestational diabetes mellitus [Through study completion, an average of 18 months]
To investigate and compare uterine artery pulsatility index by Doppler ultrasonography in patients with gestational diabetes mellitus (GDM) and without to non-diabetic controls.
Secondary Outcome Measures
- Prediction of GDM with uterine artery pulsatility index cut-offs [Through study completion, an average of 18 months]
Cut off values of uterine artery pulsatility index will be estimated to predict GDM
Eligibility Criteria
Criteria
Inclusion Criteria:
• Pregnant women with or without Gestational Diabetes in low- risk population
Exclusion Criteria:
-
Pregestational Diabetes
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Preeclampsia
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Intrauterine growth restriction
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Chronic Maternal Disease
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Haseki Training and Research Hospital | İstanbul | Turkey |
Sponsors and Collaborators
- Haseki Training and Research Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- PS-GDM-2022
- PS-GDM-2022