Variables Predicting Reintubation After Thymectomy in Patients With Myasthenia Gravis
Study Details
Study Description
Brief Summary
Myasthenia gravis (MG) is an autoimmune disease that is characterized by muscle weakness and fatigue. The role of the thymus in MG has been suggested by the evidence that 10% to 15% of patients present with a thymoma and at least 60% with thymus hyperplasia or dysplasia.Beneficial effects of thymectomy in patients with MG have been described in 40% to 90%.Few studies have looked at the incidence of reintubation (not just within 24 hours after extubation), the factors associated with reintubation, and patient outcome.
Premature extubation may lead to hypercarbia, hypoxemia, pulmonary hypertension, right heart failure, and myocardial ischemia. Additionally, it subjects the patient to the physical risks of reintubation, including esophageal intubation, laryngeal trauma, and pulmonary aspiration. The purpose of the present study was to determine the incidence of reintubation, the variables associated with reintubation, and patient outcome
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Inclusion was based on the availability of all the following possible predictive pre-operative variables: age, gender, weight, height, body mass index, diabetes, creatinine, duration of MG, severity of MG (based on Osserman's classification), pathological type of MG, history of myasthenic crisis, dose of pyridostigmine, use of a steroid hormone, and use of an immunosuppressant.operative variables: postoperative pulmonary infection, total duration of hospital stay, duration of ICU stay, and duration of postoperative hospital stay. Variables were collected by research assistants and maintained in a computer database.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| reintubation Reestablish of invasive mechanical ventilation |
Other: reintubation
Reintubation was defied by the reinstitution of invasive mechanical ventilation following extubation at any time
|
| not reintubation Favourable respiratory function |
Other: reintubation
Reintubation was defied by the reinstitution of invasive mechanical ventilation following extubation at any time
|
Outcome Measures
Primary Outcome Measures
- Risk Factors for Reintubation [an average of 30 days]
the reintubation rate was analyzed with logistic regression
Eligibility Criteria
Criteria
Inclusion Criteria:
-
younger than 75 years
-
absence of heart failure as the primary indication for mechanical ventilation •Acute Physiology and Chronic Health Evaluation (APACHE) II score less than 12 points on day of extubation
-
body mass index less than 30
Exclusion Criteria:
•preoperative moderate-to-severe chronic obstructive pulmonary disease
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Genglong Liu | Guangzhou | Guangdong | China | 510080 |
Sponsors and Collaborators
- First Affiliated Hospital, Sun Yat-Sen University
Investigators
- Principal Investigator: Genglong Liu, First Affiliated Hospital, Sun Yat-Sen University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- Reintubation